Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,762 recruiting studies in this area right now.
By phase
- Not applicable2,682
- Phase 2280
- Phase 1239
- Phase 3209
- Phase 1/Phase 2208
- Phase 495
- Phase 2/Phase 349
Top conditions
- Sickle Cell Disease133
- Atopic Dermatitis124
- Congenital Heart Disease83
- Cystic Fibrosis77
- Down Syndrome51
- Genetic Disease42
- Cystic Fibrosis (CF)37
- Duchenne Muscular Dystrophy36
- Fabry Disease36
- Hemophilia A36
- Cardiac Amyloidosis35
- Retinitis Pigmentosa33
- Huntington Disease31
- Lynch Syndrome31
- Heart Failure30
- Bronchopulmonary Dysplasia29
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)29
Leading sponsors
- Assistance Publique - Hôpitaux de Paris57
- Mayo Clinic39
- Boston Children's Hospital38
- National Institute of Allergy and Infectious Diseases (NIAID)38
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Children's Hospital Medical Center, Cincinnati31
- Hospices Civils de Lyon29
- Children's Hospital of Philadelphia23
- National Human Genome Research Institute (NHGRI)23
- St. Jude Children's Research Hospital23
Where studies are running
- California324
- Maryland160
- Alabama133
- Massachusetts107
- Arizona88
- New York84
- Texas70
- Minnesota68
- Pennsylvania64
- Florida59
Recruiting studies3,762 total
- NCT06887491Enrolling by invitation
Dual-tasking (thinking + moving) program for children with Duchenne MD
This study tests whether a special program that combines thinking tasks (like counting or remembering) with physical activities can help boys with Duchenne muscular dystrophy improve their thinking, movement, and ability to do everyday tasks independently.
Ankara, CankayaAges 6–12 - NCT06880276RecruitingPhase 3
Studying QLM3003 ointment for mild or moderate eczema
This trial tests if an ointment called QLM3003 is safe and helps adults with mild to moderate atopic dermatitis (eczema). It may be a new treatment option for people whose eczema affects small areas of skin.
ShenyangAges 18–75 - NCT06880250Enrolling by invitation
Enzyme therapy study for Fabry disease patients
This trial tests if enzyme replacement therapy works well and is safe for Fabry disease. It is for people who are already prescribed this treatment.
AstrakhanAges 8–65 - NCT03928431Recruiting
Restore gut bacteria in newborns using special microbiome samples
This study looks at whether restoring a newborn’s gut bacteria (microbiome) can improve early health. Babies are treated based on the birth conditions, especially whether delivery was vaginal or by C-section.
Stockholm, Stockholm CountyAges 5 minutes–15 minutes - NCT06880094Recruiting
Genetic study of complex or inherited cleft lip and palate
This study uses a new genetic test called Optical Genome Mapping to look for hidden genetic causes of cleft lip or palate that are syndromic, complex, or run in families. It may help find answers for people who haven't gotten a genetic diagnosis yet.
AmiensAges Any age - NCT06884423Recruiting
Balloon treatment for severe diaphragmatic hernia in unborn babies
This trial tests if placing a temporary balloon in the baby's windpipe before birth can improve survival for babies with a severe form of a diaphragmatic hernia. It is for pregnant women carrying a single baby with a left-sided hernia that is more severe or a right-sided hernia, and whose liver is up in the chest.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06885801Enrolling by invitationPhase 2
New Nasal Device for Kids Having Cleft Lip Surgery
This trial tests a new nasal conformer (a small device placed in the nose after surgery) to see if it helps children who are having cleft lip repair or surgery to release nasal scarring. It may improve healing and nose shape.
Knoxville, TennesseeAges Up to 18 years - NCT06887387Recruiting
Wearable devices to monitor Long QT Syndrome
This study tests whether wearable devices can help monitor Long QT Syndrome, a heart condition. It aims to make tracking your heart easier and more convenient than clinic visits.
LondonAges 18 years+ - NCT06880653Recruiting
Exercise dose study for arthritis pain
This study looks at how different amounts of exercise affect arthritis symptoms. If you have arthritis or a related condition, you may be asked to try a specific weekly exercise goal to see if it helps your pain and mobility.
Columbia, South CarolinaAges 18 years+ - NCT06884358Recruiting
Heart and exercise capacity in Fabry disease
This study looks at how Anderson-Fabry disease affects your heart and ability to exercise. Researchers want to understand this better by testing your heart function and how well you can do physical activity.
Brescia, BresciaAges Any age - NCT06888388Recruiting
Safety of nipple-sparing mastectomy for women with high-risk genes
This study looks at the long-term safety of a type of breast surgery (nipple-sparing mastectomy) in women who carry certain inherited gene changes (BRCA1, BRCA2, PALB2, TP53, CDH1, or PTEN) that increase their risk of breast cancer. The goal is to understand how safe this surgery is over time for these women.
New Haven, ConnecticutAges 18–90 - NCT06881979Recruiting
High-tech rehab for chronic neuromuscular diseases
This study tests a high-tech rehabilitation program for people with long-term nerve and muscle conditions. It aims to help you improve your walking and daily function using advanced technology.
GenovaAges 18–80 - NCT06889454Recruiting
Heart and blood vessel changes in women with PCOS after treatment
This trial looks at how the heart's blood vessels and certain markers change in women with PCOS when they drink a sugary solution (OGTT). It checks these markers before treatment starts and again 6 and 12 months after, to help understand cardiovascular risk in PCOS.
ChaïdáriAges 18–45 - NCT06888570Enrolling by invitation
Liver health study for children & young adults with Down syndrome
This study looks at how eating patterns and body composition relate to fatty liver in children and young adults with Trisomy 21 (Down syndrome) or other genetic intellectual disabilities. It may help understand who is at risk and how to prevent liver problems.
Madrid, MadridAges 5–22 - NCT06887777RecruitingPhase 2
Testing RAVICTI for PDH deficiency in young people
This study tests if a medicine called Glycerol Phenylbutyrate (RAVICTI) is safe and helpful for children and young adults with a specific type of PDH deficiency, a rare genetic condition affecting energy use. If you qualify, you may get a new treatment option.
Paris, FranceAges 2–25 - NCT06888024Recruiting
Measuring pelvic vein blood flow with MRI
This study uses MRI scans to measure blood flow in the pelvic veins. It’s for people who either have no vein problems, or have symptoms of a compressed left iliac vein, or already have a stent in that vein. The goal is to learn more about how blood flows in these conditions.
Worcester, MassachusettsAges 18–89 - NCT06881004Recruiting
Biliary Dilation National Cohort Study in China
This study collects health information from people in China who have biliary dilation (widening of the bile ducts). It looks at their medical history and follows some patients over time to learn more about the condition.
Beijing, Beijing MunicipalityAges Up to 80 years - NCT06880016Recruiting
Lung ultrasound after surfactant in preterm babies
This study uses lung ultrasound to see how different ways of giving surfactant (a medicine for breathing problems) affect preterm babies born before 32 weeks. It may help doctors choose the best method for your baby.
Konya, KaratayAges 1 day–5 days - NCT06887283Recruiting
Essen Amyloidosis Registry Study
This study collects information from people with suspected or confirmed amyloidosis. The goal is to learn more about the condition and improve patient care.
Essen, North Rhine-WestphaliaAges 18 years+ - NCT06868784Enrolling by invitation
Thinking and daily skills in children with Duchenne
This study looks at how thinking skills (like planning and memory) affect everyday activities such as dressing or playing in children with Duchenne muscular dystrophy. It aims to find ways to help kids do better in their daily lives.
Ankara, ÇankayaAges 6–12 - NCT06879665Enrolling by invitation
Tandem trial for caregivers of TSC patients
This trial aims to improve access to interventions for Tuberous Sclerosis Complex (TSC)-related issues by working with adult caregivers. If you are an adult caring for someone with TSC, this study may help close the gap to better support and treatments.
Silver Spring, MarylandAges 18 years+ - NCT06878950Recruiting
Early feeding for babies with gastroschisis
This study tests whether starting feedings earlier than usual helps babies born with gastroschisis recover better. It aims to find a safer and more effective feeding plan for these newborns.
Los Angeles, CaliforniaAges birth–1 year - NCT06873841Recruiting
Cognitive therapy with or without biofeedback for tics in teens and young adults
This trial tests a talking therapy that helps manage tics by changing thoughts and feelings. Some people also get biofeedback, which uses sensors to help control body responses. Researchers want to see which approach works better for reducing tics in teens and young adults with Tourette's syndrome or bothersome tics.
Montreal, QuebecAges 14–21 - NCT06872333RecruitingPhase 2
Stem cell transplant from a matched sibling for blood disorders
This trial tests whether a stem cell transplant from a fully matched sibling donor can help people with serious blood disorders like sickle cell disease or thalassemia. It aims to replace the faulty blood system with a healthy one from the donor.
Minneapolis, MinnesotaAges Up to 55 years
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,762 recruiting medical genetics studies from the U.S. registry right now, out of 5,482 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.