Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,858 recruiting studies in this area right now.
By phase
- Not applicable2,771
- Phase 2284
- Phase 1235
- Phase 3216
- Phase 1/Phase 2203
- Phase 497
- Phase 2/Phase 352
Top conditions
- Sickle Cell Disease140
- Atopic Dermatitis128
- Congenital Heart Disease86
- Cystic Fibrosis78
- Down Syndrome55
- Genetic Disease42
- Duchenne Muscular Dystrophy39
- Fabry Disease38
- Hemophilia A38
- Cystic Fibrosis (CF)37
- Cardiac Amyloidosis35
- Huntington Disease32
- Lynch Syndrome32
- Heart Failure31
- Retinitis Pigmentosa31
- Bronchopulmonary Dysplasia30
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)27
Leading sponsors
- Assistance Publique - Hôpitaux de Paris62
- Boston Children's Hospital42
- National Institute of Allergy and Infectious Diseases (NIAID)38
- Mayo Clinic37
- Children's Hospital Medical Center, Cincinnati33
- Hospices Civils de Lyon32
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Riphah International University26
- Massachusetts General Hospital23
- National Cancer Institute (NCI)23
Where studies are running
- California341
- Maryland161
- Alabama131
- Massachusetts116
- New York84
- Arizona78
- Texas72
- Minnesota67
- Pennsylvania65
- Ohio57
Recruiting studies3,858 total
- NCT06512168Recruiting
Measuring aided language development in children
This study tests whether using an iPad communication app helps children with Down syndrome or cerebral palsy who have trouble speaking. It looks at how their language skills grow over time.
Orlando, FloridaAges 3.5 years–5 years - NCT06512506Recruiting
Hip Arthroscopy for Mild Hip Dysplasia Study
This study is for people with mild hip dysplasia and a labral tear. Doctors will use a camera (arthroscopy) to look inside the hip and fix the problem, aiming to ease pain and improve function.
BeijingAges Any age - NCT06512935Recruiting
Ventilator study for preterm infants with lung recovery
This study tests a new way of setting the ventilator for preterm babies born before 34 weeks who are still on a breathing machine. It aims to improve lung healing and heart function by finding the best pressure settings. The results could help your baby breathe more comfortably.
Birmingham, AlabamaAges 1 week–4 weeks - NCT06513026Recruiting
Milk for diabetes prevention
This study tests whether drinking milk daily can help prevent type 2 diabetes in people with prediabetes and a specific gene variation. You'll be asked to drink milk or a placebo drink for several weeks while researchers monitor your blood sugar and health.
The Bronx, New YorkAges 18–70 - NCT06517498Recruiting
Understanding daily life with facioscapulohumeral muscular dystrophy
This study explores how facioscapulohumeral muscular dystrophy (FSHD) affects your daily life, health, and living situation. It does not test a new treatment, but aims to better understand the challenges patients face.
Xi'an, ShaanxiAges Any age - NCT06518005RecruitingPhase 2
Gene therapy for severe Crigler-Najjar syndrome
This trial tests a new gene therapy called GNT0003, given after a pre-treatment to help it work, for people with severe Crigler-Najjar syndrome. The goal is to see if it can reduce the need for daily light treatments.
ClamartAges 18 years+ - NCT06517862RecruitingPhase 4
Extra medicines with light therapy for newborn jaundice
This trial tests if giving a zinc or bile acid medicine alongside light therapy helps break down jaundice faster in newborns. It could shorten treatment time for babies who need phototherapy in their first week of life.
Cairo, Cairo GovernorateAges 1 day–1 month - NCT06518252Recruiting
Sudden cardiac death risk in university athletes
This study looks at the risk of sudden cardiac death in athletes from the National University of Colombia. It aims to find athletes who may be at higher risk, even if they feel healthy.
Bogotá, CundinamarcaAges 18–35 - NCT06519175Recruiting
Study of leg problems in children
This study gathers information on children with leg bone or muscle problems (from birth or later) to better understand their conditions. It may help improve future care for kids with similar issues.
BolognaAges Up to 18 years - NCT06519552RecruitingPhase 1
Gene therapy study for adults with MPS type I
This study tests a new gene therapy called JWK008 for adults with MPS type I. The goal is to see if it is safe and can help improve symptoms. You may be able to join if you are 18 or older and have not had serious side effects from enzyme replacement therapy.
Chengdu, SichuanAges 18 years+ - NCT06519734Recruiting
Immune Deficiency, IUDs and Menstrual Products Study
This study looks at how well women with primary immune deficiencies can use intrauterine devices (IUDs) and other menstrual products. It aims to help doctors and patients make better choices for safe and effective period care.
ParisAges 18 years+ - NCT06520410RecruitingPhase 4
Short vitrectomy tool for children's eye surgery
This trial tests a shorter, 18-millimeter tool for vitrectomy surgery in children. It aims to see if this smaller tool is safe and works well for treating various eye problems in kids.
TaoyuanAges birth–18 years - NCT06523400RecruitingPhase 3
Mexiletine for myotonic dystrophy types 1 and 2
This trial tests a once-daily drug called mexiletine PR to see if it can help reduce muscle stiffness (myotonia) in people with myotonic dystrophy type 1 or 2. It may be a good option if you have a confirmed genetic diagnosis and are at least 16 years old.
LeuvenAges 16 years+ - NCT06523582Recruiting
Genetic study of neuroendocrine tumors in Mexican patients
This study aims to find genetic causes of neuroendocrine tumors in Mexican patients. By understanding your DNA, researchers hope to improve diagnosis and treatment for people with these rare conditions.
Mexico City, Mexico CityAges 18 years+ - NCT06524635RecruitingPhase 2
Study of lutikizumab for hidradenitis suppurativa or eczema
This study tests an investigational medicine called lutikizumab, given as shots under the skin, for people with moderate-to-severe hidradenitis suppurativa (HS) or atopic dermatitis (eczema). It looks at how the medicine affects skin changes and may help if other treatments haven’t worked.
Sacramento, CaliforniaAges 18–75 - NCT06525636RecruitingPhase 1/Phase 2
Study of a new drug (KK8123) for adults with XLH
This study tests a new investigational drug called KK8123 for adults with X-linked hypophosphatemia (XLH). It aims to see if KK8123 can safely raise low blood phosphorus levels. The trial includes two parts and may offer a new treatment option if you have not used burosumab recently.
San Francisco, CaliforniaAges 18–65 - NCT06526117RecruitingPhase 4
Stroke Prevention in Nigeria 2 Trial
This trial tests whether giving hydroxyurea (a medicine that helps prevent strokes) to children with sickle cell disease who have high-risk blood flow in their brains can stop strokes from happening. It's for kids in Nigeria who are at the peak age for stroke risk (5–12 years old).
KanoAges 5–12 - NCT06526741Recruiting
Alport Syndrome Patient Registry
This registry collects health information from people with Alport syndrome to help researchers better understand the condition and improve future treatments.
Scottsdale, ArizonaAges birth+ - NCT06526923RecruitingPhase 1/Phase 2
Testing SP-101 gene therapy for cystic fibrosis
This trial tests a new gene therapy called SP-101 for cystic fibrosis. It aims to see if SP-101 is safe and effective for improving lung function.
Kansas City, KansasAges 18–65 - NCT06527963Recruiting
Balloon types for fistula narrowing in dialysis patients
This trial compares two types of balloons used to open up narrowed areas in the blood vessels of dialysis patients. It aims to find which balloon works better for keeping the fistula working well.
Zhengzhou, HenanAges 18–75 - NCT06528418Recruiting
Breath test to find lung diseases
This study uses a simple breath test to detect different lung diseases. By analyzing the chemicals in your breath, researchers hope to find a faster, non-invasive way to diagnose lung conditions. It may be an option if you have a known lung disease and have a recent CT scan.
Guangzhou, GuangdongAges 18–100 - NCT06529874Recruiting
Pain, balance, and strength in children with sickle cell
This study looks at how children (ages 9-14) with sickle cell anemia or who are healthy handle pressure, balance, and strength. It aims to understand pain and movement better to help improve care.
GizaAges 9–14 - NCT06534307Recruiting
Long-term follow-up for children from PETN studies
This study checks on the health and development of children whose mothers took part in the PETN studies. It involves questionnaires and a physical exam for kids aged 5 and older.
Tübingen, Baden-WurttembergAges 6–18 - NCT06534554Recruiting
Improving gout care after an emergency room visit
This study looks at ways to improve how gout is managed after a visit to the emergency room. It aims to help you get better follow-up care and prevent future flares.
Birmingham, AlabamaAges 18–99
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,858 recruiting medical genetics studies from the U.S. registry right now, out of 5,764 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.