Endocrinology & metabolism
Hormones & metabolism clinical trials
Diabetes, obesity, thyroid, and other conditions of the body’s hormones and metabolism. We’re tracking 7,956 recruiting studies in this area right now.
By phase
- Not applicable5,614
- Phase 2646
- Phase 1582
- Phase 3404
- Phase 4322
- Phase 1/Phase 2299
- Phase 2/Phase 389
Top conditions
- Obesity655
- Ovarian Cancer340
- Pancreatic Cancer294
- Type 2 Diabetes275
- Diabetes208
- Diabetes Mellitus190
- Diabetes Mellitus, Type 2185
- Hypertension144
- Metabolic Syndrome138
- Type 1 Diabetes131
- Cardiovascular Diseases114
- Obesity & Overweight113
- Breast Cancer110
- Amyotrophic Lateral Sclerosis108
- Overweight103
- Pancreas Cancer94
- Colorectal Cancer90
- Endometrial Cancer88
Leading sponsors
- Mayo Clinic87
- Novo Nordisk A/S57
- University of Colorado, Denver56
- Assistance Publique - Hôpitaux de Paris55
- M.D. Anderson Cancer Center42
- National Taiwan University Hospital42
- Massachusetts General Hospital40
- Cairo University39
- IRCCS Azienda Ospedaliero-Universitaria di Bologna39
- Eli Lilly and Company38
Where studies are running
- California528
- Maryland181
- Arizona174
- Alabama173
- Texas164
- Florida161
- New York155
- Massachusetts150
- Pennsylvania117
- Colorado113
Recruiting studies7,956 total
- NCT07661056RecruitingPhase 3
Investigational drug for treating graves' disease overactive thyroid
This study tests a new medicine, BHV-1300, to see if it can safely and effectively reduce the overactive thyroid caused by Graves' disease, an autoimmune condition. It may offer a new option for people who haven't had certain prior treatments.
Tucson, ArizonaAges 18–70 - NCT07714668RecruitingPhase 2
Combination therapy for recurrent ovarian cancer
This study tests a new combination treatment for ovarian cancer that has come back after earlier treatment. It aims to see if the combination can shrink tumors or slow the disease, and it may be an option for people whose cancer has become resistant to platinum-based chemotherapy.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07795736Recruiting
Understanding growth hormone problems after brain injury
This study looks at how a traumatic brain injury might affect your body's growth hormone, which is important for energy, strength, and overall health. If you've had a brain injury and still have symptoms a year later, you may be able to help researchers learn more and possibly find better treatments.
Calgary, AlbertaAges 18–70 - NCT07470983RecruitingPhase 2
A study of a new medicine for primary aldosteronism
This study tests a new medication for primary aldosteronism, a condition where the adrenal glands make too much of a hormone that raises blood pressure. The goal is to see if it helps control blood pressure better than the current standard of care.
Chongqing, Chongqing MunicipalityAges 18 years+ - NCT07644559RecruitingPhase 2
VS-7375 for KRAS G12D pancreatic cancer
This study tests a new drug called VS-7375, combined with cetuximab, for pancreatic cancer patients whose tumors have a specific genetic mutation called KRAS G12D. The goal is to see if this combination can shrink tumors and help patients live longer.
Los Angeles, CaliforniaAges 18 years+ - NCT00344331Recruiting
Testing blood and MRI markers for Niemann-Pick type C
This study measures biochemical (blood/biologic) markers and may use clinical evaluation and MRI to better understand Niemann-Pick disease type C. It could help improve how the condition is tracked and understood over time.
Bethesda, MarylandAges 1 day–120 years - NCT06515613RecruitingPhase 1
Testing CTIM-76 for recurrent ovarian and other advanced cancers
This trial tests a new drug, CTIM-76, in people whose ovarian, testicular, or endometrial cancer has come back and is not responding to standard treatments. It aims to see if the drug can shrink tumors or stop them from growing.
Little Rock, ArkansasAges 18 years+ - NCT07391774RecruitingPhase 3
Hormone therapy with or without chemo for early breast cancer
This trial tests whether skipping chemotherapy and using only hormone therapy with a drug called ribociclib works as well as chemotherapy followed by hormone therapy with ribociclib for certain early breast cancers that have a low risk of coming back.
Jonesboro, ArkansasAges 18 years+ - NCT00027274Recruiting
Cancer risk in inherited bone marrow failure syndromes
This study looks at why people with inherited bone marrow failure syndromes (rare genetic conditions affecting blood cell production) have higher cancer risk. Researchers want to understand the genetic and medical factors that increase cancer likelihood, which could help doctors monitor and protect affected patients and their families.
Bethesda, MarylandAges 1 day–100 years - NCT07015034Recruiting
Preventing vision loss in older adults with chronic conditions
This study tests a model to help general practitioners find older patients who may be at risk of vision loss. It aims to spot problems early so treatment can start sooner.
Copenhagen, Capital RegionAges 70 years+ - NCT06274749Recruiting
Urolithin A for blood sugar in adults 55+ with extra weight
This study tests if a natural supplement called Urolithin A can help improve how your body handles sugar (glucose) in healthy adults aged 55 and older who have a higher body weight. You would take a daily capsule and come in for tests including blood work, treadmill walks, and an MRI.
Baltimore, MarylandAges 55–100 - NCT07699471RecruitingPhase 3
Study of a new drug for adults with low parathyroid hormone
This trial tests an experimental drug called Canvuparatide against a placebo to see if it can help adults with a condition called hypoparathyroidism, where the body doesn't make enough parathyroid hormone. The goal is to improve calcium levels and reduce the need for high-dose calcium and vitamin D supplements.
Homestead, FloridaAges 18 years+ - NCT07062315Enrolling by invitation
Eating at the right time for belly fat reduction
This study tests a type of intermittent fasting where you eat only during a certain window that matches your body clock. The goal is to see if this helps reduce belly fat and improve metabolic health in people who are not very active and carry extra weight around the middle.
Hong KongAges 18–65 - NCT05652478RecruitingPhase 2
How HIV prevention drugs affect metabolism in healthy people
This study tests how certain HIV prevention drugs affect the body's metabolism (how it uses energy) in healthy people. It aims to understand side effects before these drugs are used more widely, which could help make future treatments safer.
Bethesda, MarylandAges 18–55 - NCT06805695Recruiting
Long-term follow-up for iECURE trial participants
This study follows up with people who took part in an earlier iECURE trial (such as a gene therapy study) to check on their health over time. It collects information to see how safe and lasting the treatment effects are.
Aurora, ColoradoAges 7 months–1.3 years - NCT06934655RecruitingPhase 3
Starting semaglutide again after weight-loss surgery in teens
This trial tests if restarting semaglutide (a weekly injection for weight loss) soon after sleeve gastrectomy helps teens with severe obesity keep losing weight. It is for patients who were already taking semaglutide before their surgery.
Los Angeles, CaliforniaAges 12–18 - NCT06900153Recruiting
Parenting in adults with CAH (21-hydroxylase deficiency)
This study looks at parenting in adults with congenital adrenal hyperplasia (CAH) caused by 21-hydroxylase deficiency. It aims to understand how the condition affects family life so doctors can offer better support.
BordeauxAges 18 years+ - NCT06172478RecruitingPhase 2
HER3-DXd for advanced solid tumors after prior treatment
This trial tests a new targeted drug called HER3-DXd for people with several types of advanced solid tumors that have stopped responding to standard treatments. The drug is an antibody-drug conjugate, designed to deliver chemotherapy directly to cancer cells that have a protein called HER3 on their surface.
Duarte, CaliforniaAges 18 years+ - NCT07662109RecruitingPhase 3
Testing a new combo pill for type 2 diabetes
This study tests if a new medicine (elecoglipron) combined with dapagliflozin is safe and works better for adults with type 2 diabetes that isn't well controlled by diet or other medications.
Huntsville, AlabamaAges 18 years+ - NCT00029965Recruiting
Understanding rare storage diseases over time
This study follows people with rare genetic conditions (GM1, GM2, sialidosis, or galactosialidosis) that affect how the body breaks down certain substances in cells. Researchers track how these diseases progress to better understand them and potentially help future patients.
Bethesda, MarylandAges 1 day–100 years - NCT06487481RecruitingPhase 1
Radiation before surgery for recurrent adrenal cancer
This trial tests whether giving radiation before surgery helps people with adrenal cancer that has come back after previous treatment. It aims to see if this approach can improve outcomes for patients who can have surgery at the NIH.
Bethesda, MarylandAges 18–120 - NCT05497531Recruiting
Test blood DNA to help guide liver and pancreas biopsies
This pilot study checks whether a special blood test (ctDNA) can detect cancer signals and work as well as another sample method during biopsies for liver, bile duct, or pancreatic cancers. It may help doctors choose the best way to confirm the diagnosis from biopsy samples.
Orange, CaliforniaAges 18 years+ - NCT07662044RecruitingPhase 3
Studying elecoglipron for type 2 diabetes
This trial tests a new medicine called elecoglipron, taken alone or with another diabetes drug (dapagliflozin), to see if it helps control blood sugar better than a placebo. It may be an option if your current treatment isn't working well enough.
Birmingham, AlabamaAges 18 years+ - NCT07734311RecruitingPhase 3
Testing a weight-loss injection for knee arthritis pain
This study tests whether an experimental weight-loss injection can reduce knee pain in people who are obese and have knee osteoarthritis. It may help if you have been unable to lose weight through diet and exercise and have moderate knee pain.
Wuhan, HubeiAges 18–75
Common questions
- How many hormones & metabolism clinical trials are recruiting?
- Clin2 is tracking 7,956 recruiting endocrinology & metabolism studies from the U.S. registry right now, out of 12,463 we cover in this area in total.
- What does “Hormones & metabolism” cover here?
- Diabetes, obesity, thyroid, and other conditions of the body’s hormones and metabolism. We group each study into hormones & metabolism based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a hormones & metabolism trial near me?
- Use the search to filter hormones & metabolism studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.