Endocrinology & metabolism
Hormones & metabolism clinical trials
Diabetes, obesity, thyroid, and other conditions of the body’s hormones and metabolism. We’re tracking 7,959 recruiting studies in this area right now.
By phase
- Not applicable5,619
- Phase 2645
- Phase 1582
- Phase 3403
- Phase 4322
- Phase 1/Phase 2299
- Phase 2/Phase 389
Top conditions
- Obesity653
- Ovarian Cancer339
- Pancreatic Cancer294
- Type 2 Diabetes276
- Diabetes207
- Diabetes Mellitus190
- Diabetes Mellitus, Type 2186
- Hypertension143
- Metabolic Syndrome138
- Type 1 Diabetes131
- Cardiovascular Diseases114
- Obesity & Overweight113
- Breast Cancer110
- Amyotrophic Lateral Sclerosis108
- Overweight102
- Pancreas Cancer94
- Colorectal Cancer90
- Endometrial Cancer88
Leading sponsors
- Mayo Clinic87
- Novo Nordisk A/S57
- University of Colorado, Denver57
- Assistance Publique - Hôpitaux de Paris55
- M.D. Anderson Cancer Center42
- National Taiwan University Hospital42
- Massachusetts General Hospital40
- Cairo University39
- IRCCS Azienda Ospedaliero-Universitaria di Bologna39
- Eli Lilly and Company38
Where studies are running
- California531
- Maryland181
- Alabama173
- Arizona172
- Texas164
- Florida160
- New York156
- Massachusetts150
- Pennsylvania117
- Colorado113
Recruiting studies7,959 total
- NCT06487481RecruitingPhase 1
Radiation before surgery for recurrent adrenal cancer
This trial tests whether giving radiation before surgery helps people with adrenal cancer that has come back after previous treatment. It aims to see if this approach can improve outcomes for patients who can have surgery at the NIH.
Bethesda, MarylandAges 18–120 - NCT06274749Recruiting
Urolithin A for blood sugar in adults 55+ with extra weight
This study tests if a natural supplement called Urolithin A can help improve how your body handles sugar (glucose) in healthy adults aged 55 and older who have a higher body weight. You would take a daily capsule and come in for tests including blood work, treadmill walks, and an MRI.
Baltimore, MarylandAges 55–100 - NCT07318558RecruitingPhase 3
Study of Sac-TMT for advanced ovarian cancer without HRD
This trial is testing a new drug called Sac-TMT for people with advanced ovarian cancer that has not responded well to initial platinum-based chemotherapy and does not have a specific gene change called HRD. It aims to see if this drug can work better than standard treatment.
Birmingham, AlabamaAges 18 years+ - NCT05652478RecruitingPhase 2
How HIV prevention drugs affect metabolism in healthy people
This study tests how certain HIV prevention drugs affect the body's metabolism (how it uses energy) in healthy people. It aims to understand side effects before these drugs are used more widely, which could help make future treatments safer.
Bethesda, MarylandAges 18–55 - NCT07793487Enrolling by invitation
Testing a special dairy drink for gut and metabolic health
This study tests whether a special dairy product can help improve symptoms in people with irritable bowel syndrome or early signs of metabolic syndrome. Participants must be at a healthy weight and not have other major health conditions or be on certain diets.
WarsawAges 18 years+ - NCT07782164Recruiting
Irreversible electroporation for recurrent pelvic tumors
This study tests a new technique called irreversible electroporation (IRE) for treating pelvic tumors that have returned despite earlier treatment. IRE uses electrical pulses to destroy cancer cells without surgery, offering a potential option when other local treatments like surgery or radiation are not suitable.
Amsterdam, North HollandAges 18 years+ - NCT06824467RecruitingPhase 3
Maintenance Therapy Study for Recurrent Ovarian Cancer
This study tests a new maintenance treatment (sacituzumab tirumotecan) versus standard care for people with ovarian cancer that has come back after responding to platinum-based chemotherapy. The goal is to see if it can keep the cancer from growing longer and improve quality of life.
Birmingham, AlabamaAges 18 years+ - NCT06714097Recruiting
Digital twin technology for stroke and related conditions
This trial tests a digital twin system to help prevent a second stroke or brain bleed in people with stroke, Moyamoya disease, or cerebral amyloid angiopathy. The system uses your medical data to create a virtual copy of you, which doctors can use to plan your care.
Milan, MichiganAges 18 years+ - NCT07562152RecruitingPhase 3
Atebimetinib Plus Gemcitabine/Nab-Paclitaxel for New Pancreatic Cancer
This trial tests a combination of three drugs—atebimetinib (a new targeted therapy), gemcitabine, and nab-paclitaxel (two standard chemotherapy drugs)—as a first treatment for pancreatic cancer that has spread beyond the pancreas. The goal is to see if adding atebimetinib helps patients live longer and feel better.
Huntsville, AlabamaAges 18 years+ - NCT07599982Recruiting
Safety test of MODI insulin adjustment system for adults
This trial tests MODI, a smartphone app that helps automatically adjust your insulin doses based on blood sugar readings from a continuous glucose monitor. The study checks if this system is safe and helps people with type 1 or type 2 diabetes manage their blood sugar better.
Baltimore, MarylandAges 18–80 - NCT07391774RecruitingPhase 3
Hormone therapy with or without chemo for early breast cancer
This trial tests whether skipping chemotherapy and using only hormone therapy with a drug called ribociclib works as well as chemotherapy followed by hormone therapy with ribociclib for certain early breast cancers that have a low risk of coming back.
Jonesboro, ArkansasAges 18 years+ - NCT07667387RecruitingPhase 1/Phase 2
Base editing study for severe urea cycle disorders
This trial tests a new medicine called LNP.UCD.ABE that aims to fix a specific genetic change causing a severe urea cycle disorder. It uses a technique called base editing to correct the gene mutation, which may help your body break down ammonia better.
Philadelphia, PennsylvaniaAges 1 day–5 years - NCT07614984RecruitingPhase 2
Testing MK-7262 and Enlicitide for High Lipoprotein(a)
This trial tests two experimental drugs designed to lower lipoprotein(a)—a type of cholesterol particle linked to heart disease—in people whose levels remain high despite taking statins (cholesterol-lowering medications). The goal is to see if these drugs can safely reduce this risk factor.
Alexander City, AlabamaAges 18 years+ - NCT07747857RecruitingPhase 1
Study of TQF3250 capsules for type 2 diabetes with overweight or obesity
This study tests a new capsule medicine for adults with type 2 diabetes who are overweight or have obesity. The goal is to see if it helps control blood sugar and weight.
Fuzhou, FujianAges 18–70 - NCT05104710RecruitingTeam says not enrolling
Testing brain–muscle coordination as a marker in ALS
This study measures how well your nerves and muscles work together to see if it can serve as an early sign (a “biomarker”) of ALS. It may help doctors track ALS more accurately, especially in people who already seem to have ALS based on nerve testing.
Irvine, CaliforniaAges 20–90 - NCT06449677RecruitingTeam says not enrollingPhase 3
Bionic pancreas study for cystic fibrosis related diabetes
This trial tests if an automated insulin delivery system (the iLet bionic pancreas) can safely and effectively manage blood sugar in people with cystic fibrosis related diabetes (CFRD). If you have CFRD and already use insulin, this study may help you learn if a bionic pancreas works well for you.
Aurora, ColoradoAges 14 years+ - NCT05762107RecruitingTeam says not enrollingPhase 2
Drug ZT-01 to reduce low blood sugar at night
This Phase 2 study tests ZT-01 to help prevent night-time low blood sugar (hypoglycemia) in people with type 1 diabetes. It may help if you’ve had low blood sugar during sleep or are at high risk based on recent glucose monitoring.
Birmingham, AlabamaAges 18–75 - NCT04485286RecruitingTeam says not enrollingPhase 2
PET scan tracer to find lung or pancreas radiation injury
This Phase 2 study tests a special PET scan tracer to help doctors spot tissue damage after radiation treatment in people with certain lung or pancreatic cancers. The goal is to improve detection and planning around chemoradiation and surgery.
Boston, MassachusettsAges 18–80 - NCT05183165RecruitingTeam says not enrolling
Study measures copper levels in breast milk for Wilson’s disease
This study measures how much copper is present in breast milk in people with Wilson’s disease. It aims to provide safer guidance for breastfeeding during treatment, including during pregnancy.
ParisAges 18 years+ - NCT07107087Recruiting
Combined therapy for weight loss and muscle weakness in kidney dialysis
This study tests a program combining exercise, nutritional support, and omega-3 supplements to help kidney dialysis patients who have lost weight and muscle strength. It aims to improve appetite, energy levels, and physical function.
Antrim, County AntrimAges 18 years+ - NCT06938282RecruitingPhase 2
Study of HRS-4642 with immunotherapy and chemo for pancreatic cancer
This trial tests a new drug combination for pancreatic cancer that has not been treated before. It may help shrink tumors or make surgery possible for people with advanced or borderline resectable disease.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07790744Recruiting
Brain imaging study for early Parkinson's signs in people with REM sleep disorder
This study uses MRI scans to look at the brain in people with REM sleep behavior disorder (RBD), a condition that can be an early sign of Parkinson's disease. By comparing them with healthy volunteers, researchers hope to find early markers of Parkinson's that could lead to earlier diagnosis and treatment.
HvidovreAges 18 years+ - NCT07404111RecruitingPhase 1/Phase 2
Study of VV-14305 for thyroid eye disease
This study tests an investigational medication for thyroid eye disease, which causes bulging eyes and discomfort. The treatment is given as an injection near the eye, and the study will last about 12 months to see how safe and effective it is.
Livonia, MichiganAges 18–80 - NCT06540729RecruitingPhase 2
Combination treatment for ovarian clear cell cancer
This trial tests a combination of three drugs (RC48, AK104, and bevacizumab) for ovarian clear cell carcinoma, a type of ovarian cancer. The goal is to see if this combination can help shrink or control the cancer in people who have not had many prior treatments.
Guanzhou, GuangdongAges 18–75
Common questions
- How many hormones & metabolism clinical trials are recruiting?
- Clin2 is tracking 7,959 recruiting endocrinology & metabolism studies from the U.S. registry right now, out of 12,428 we cover in this area in total.
- What does “Hormones & metabolism” cover here?
- Diabetes, obesity, thyroid, and other conditions of the body’s hormones and metabolism. We group each study into hormones & metabolism based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a hormones & metabolism trial near me?
- Use the search to filter hormones & metabolism studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.