Endocrinology & metabolism
Hormones & metabolism clinical trials
Diabetes, obesity, thyroid, and other conditions of the body’s hormones and metabolism. We’re tracking 7,607 recruiting studies in this area right now.
By phase
- Not applicable5,335
- Phase 2607
- Phase 1557
- Phase 3417
- Phase 4318
- Phase 1/Phase 2288
- Phase 2/Phase 385
Top conditions
- Obesity619
- Ovarian Cancer336
- Pancreatic Cancer289
- Type 2 Diabetes276
- Diabetes192
- Diabetes Mellitus183
- Diabetes Mellitus, Type 2170
- Hypertension138
- Type 1 Diabetes130
- Metabolic Syndrome126
- Obesity & Overweight123
- Breast Cancer111
- Overweight106
- Cardiovascular Diseases105
- Amyotrophic Lateral Sclerosis102
- Colorectal Cancer92
- Pancreas Cancer90
- Endometrial Cancer87
Leading sponsors
- Mayo Clinic87
- Novo Nordisk A/S64
- University of Colorado, Denver53
- Assistance Publique - Hôpitaux de Paris52
- M.D. Anderson Cancer Center41
- Massachusetts General Hospital41
- Eli Lilly and Company40
- IRCCS Azienda Ospedaliero-Universitaria di Bologna40
- National Taiwan University Hospital40
- Cairo University38
Where studies are running
- California521
- Maryland180
- Alabama176
- Arizona170
- Florida166
- Texas158
- Massachusetts151
- New York142
- Colorado115
- Pennsylvania113
Recruiting studies7,607 total
- NCT03746769RecruitingPhase 1/Phase 2
Testing gastrin to improve results of islet cell transplant
This trial looks at whether adding gastrin can improve outcomes after an islet cell transplant for people with type 1 diabetes. It may help some participants achieve better blood sugar control, but it also requires close follow-up and immune-suppressing medications to protect the new cells.
Duarte, CaliforniaAges 18–68 - NCT06239194RecruitingPhase 1/Phase 2
MdX2001 for advanced solid tumors
This trial tests a new drug, MDX2001, for people with advanced solid tumors that have spread. The study aims to find the best dose and see how well it works.
Denver, ColoradoAges 18 years+ - NCT06430203Enrolling by invitation
Peer mentoring for Indigenous youth with diabetes
This program helps Indigenous youth and young adults with diabetes connect with peer mentors for support and guidance. It is designed to make managing diabetes feel less lonely and more manageable.
Montreal, QuebecAges 10–29 - NCT07845500RecruitingPhase 3
Monthly shot to help keep weight off after switching from semaglutide or tirzepatide
This study tests a new once-a-month medicine for people who have already been taking a weight-loss medication and want to keep the weight off. Participants will switch from their current medicine (semaglutide or tirzepatide) to the study drug.
Birmingham, AlabamaAges 18 years+ - NCT07181863Recruiting
Online support for diabetes and mental health
This trial tests a team-based program that combines diabetes care with mental health support. It aims to help you better manage both your diabetes and emotional well-being through remote check-ins and coaching.
Hamilton, OntarioAges 18 years+ - NCT07186842RecruitingPhase 1/Phase 2
Testing the safety of BNT329 for advanced CA19-9 positive tumors
This trial tests if the investigational drug BNT329 is safe and could help people with advanced solid tumors that make a marker called CA19-9. It is for those who have tried standard treatments and need new options.
Denver, ColoradoAges 18 years+ - NCT06869499Recruiting
Screening for a rare enzyme disease in patients with lung scarring
This study checks if people with certain lung changes (called interstitial lung disease) might have a rare enzyme deficiency that can cause lung and other organ problems. Finding this could lead to better treatment options.
ParisAges 15–60 - NCT07792226Recruiting
Stomach procedure for weight loss (ESG with fundal ablation)
This study tests a new procedure called endoscopic sleeve gastroplasty with fundal mucosal ablation to help with weight loss. It is an option for people with obesity who have not had success with other methods and who have not had prior stomach surgery.
Morgantown, West VirginiaAges 18 years+ - NCT07612475Enrolling by invitation
Universal type 1 diabetes screening in children
This study helps clinics add a simple blood test to well-child visits to catch type 1 diabetes early, before symptoms appear. It also asks parents and clinic staff for feedback to make screening easier and more routine.
Alexander City, AlabamaAges 1 year+ - NCT07822763Recruiting
Carbohydrate drink before weight-loss surgery for faster recovery
This study tests whether drinking a special carbohydrate drink before weight-loss surgery can help your stomach and intestines recover faster after the operation. If you have metabolic syndrome and are planning certain types of bariatric surgery, this may help you improve your recovery.
Chongqing, Chongqing MunicipalityAges 18–65 - NCT01500447Recruiting
Study of inherited causes of low puberty hormones
This study looks at families to understand inherited (genetic or family-related) reasons some people have delayed puberty or develop puberty abnormally. It may help doctors better figure out the cause of low sex hormone levels and related hormone problems.
Bethesda, MarylandAges 1 month–120 years - NCT00024804Recruiting
Understanding Bone and Mineral Health Disorders
This study tracks people with bone diseases or problems with how their body handles calcium, phosphorus, and other minerals. Researchers want to understand how these conditions develop and change over time to help improve future treatments.
Bethesda, MarylandAges 1 day–100 years - NCT07837973RecruitingPhase 2
Medicine to maintain weight loss after weight-loss shots
This study tests a new medicine called ALV-100 to see if it can help people who have already lost weight with a weight-loss injection or pill keep the weight off. You must be currently on a stable weight-loss medicine and have lost at least 10% of your body weight to join.
Birmingham, AlabamaAges 18–75 - NCT07605390Enrolling by invitation
Prescription help for heart, kidney, and diabetes care
This study tests whether a computer program can help doctors choose the best medicines for people with type 2 diabetes who also have kidney or heart problems. The goal is to improve overall health by making sure patients receive treatments that are proven to help.
Dallas, TexasAges 18 years+ - NCT07643896Recruiting
Blood test for pregnancy risk assessment using fetal cells
This study tests a new blood test that looks for fetal cells in your bloodstream to check your baby's health during pregnancy. The test is non-invasive—just a regular blood draw—and aims to help identify pregnancy risks earlier than traditional methods.
Phoenix, ArizonaAges Any age - NCT05588167Recruiting
Niemann-Pick type C patient database and genetic data study
This study collects health information and genetic samples from people diagnosed with Niemann-Pick disease type C. The goal is to build a large database that can help researchers better understand the condition and improve future care.
Bethesda, MarylandAges 3 months+ - NCT05938543Recruiting
Brain stimulation and appetite in Prader-Willi syndrome
This trial studies whether targeted brain stimulation (TMS) can help with appetite and eating feelings in people with Prader-Willi syndrome. It also includes an MRI scan to measure brain-related effects, but only if you can safely have these scans.
Belmont, MassachusettsAges 18–64 - NCT06604650Recruiting
Park-based health program for older adults in Miami
This study looks at how community park programs can help older adults stay healthy. It will use information already collected from people who are already part of the Miami-Dade Active Older Adults study.
Miami, FloridaAges 50–95 - NCT05287451Recruiting
Tube removal now, ovaries later for high cancer-risk women
This study looks at the safety of removing your fallopian tubes first (RRS) and delaying ovary removal (oophorectomy) to lower cancer risk. It focuses on women who carry certain inherited gene changes, and may help avoid earlier menopause for some people.
Chicago, IllinoisAges 18 years+ - NCT07214779RecruitingPhase 3
New drug vs chemo for platinum-resistant ovarian cancer
This study tests a new drug (INCB123667) given as a pill, compared to standard chemotherapy, for people whose ovarian cancer has stopped responding to platinum-based treatments and whose tumor has high levels of a protein called Cyclin E1. The goal is to see if the new drug works better than standard chemo for this specific type of cancer.
Anchorage, AlaskaAges 18 years+ - NCT05030545RecruitingPhase 4
PET/CT study of spironolactone or eplerenone in primary aldosteronism
This study looks at how primary aldosteronism affects the heart and blood vessels, and whether blocking its hormone signal (with spironolactone or eplerenone) changes those findings on imaging tests. It is small and focuses on people with confirmed or suspected primary aldosteronism who are being followed for heart health.
Boston, MassachusettsAges 18–85 - NCT07286266RecruitingPhase 3
Testing a new drug for platinum-resistant ovarian cancer
This phase 3 trial tests a new drug, mocertatug rezetecan, against standard treatments for ovarian cancer that no longer responds to platinum chemo. It's for people who have had 1 to 4 prior therapies and may offer a new option if you haven't tried all standard treatments yet.
Randwick, New South WalesAges 18 years+ - NCT06215716RecruitingPhase 3
Efruxifermin for NASH/MASH with liver scarring
This study tests a new medicine, efruxifermin, for people with NASH/MASH (fatty liver disease) and moderate liver scarring. It aims to see if the drug can help improve the liver's condition.
Birmingham, AlabamaAges 18–80 - NCT05990426Recruiting
Alternate day fasting during chemo for gynecologic cancers
This trial tests whether alternating between a fasting day and a normal eating day can help people recovering from gynecologic cancer surgery while they receive chemotherapy. It aims to see if this eating pattern is safe and helpful during treatment.
Chicago, IllinoisAges 18 years+
Common questions
- How many hormones & metabolism clinical trials are recruiting?
- Clin2 is tracking 7,607 recruiting endocrinology & metabolism studies from the U.S. registry right now, out of 11,814 we cover in this area in total.
- What does “Hormones & metabolism” cover here?
- Diabetes, obesity, thyroid, and other conditions of the body’s hormones and metabolism. We group each study into hormones & metabolism based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a hormones & metabolism trial near me?
- Use the search to filter hormones & metabolism studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.