Endocrinology & metabolism
Hormones & metabolism clinical trials
Diabetes, obesity, thyroid, and other conditions of the body’s hormones and metabolism. We’re tracking 7,607 recruiting studies in this area right now.
By phase
- Not applicable5,335
- Phase 2607
- Phase 1557
- Phase 3417
- Phase 4318
- Phase 1/Phase 2288
- Phase 2/Phase 385
Top conditions
- Obesity619
- Ovarian Cancer336
- Pancreatic Cancer289
- Type 2 Diabetes276
- Diabetes192
- Diabetes Mellitus183
- Diabetes Mellitus, Type 2170
- Hypertension138
- Type 1 Diabetes130
- Metabolic Syndrome126
- Obesity & Overweight123
- Breast Cancer111
- Overweight106
- Cardiovascular Diseases105
- Amyotrophic Lateral Sclerosis102
- Colorectal Cancer92
- Pancreas Cancer90
- Endometrial Cancer87
Leading sponsors
- Mayo Clinic87
- Novo Nordisk A/S64
- University of Colorado, Denver53
- Assistance Publique - Hôpitaux de Paris52
- M.D. Anderson Cancer Center41
- Massachusetts General Hospital41
- Eli Lilly and Company40
- IRCCS Azienda Ospedaliero-Universitaria di Bologna40
- National Taiwan University Hospital40
- Cairo University38
Where studies are running
- California521
- Maryland180
- Alabama176
- Arizona170
- Florida166
- Texas158
- Massachusetts151
- New York142
- Colorado115
- Pennsylvania113
Recruiting studies7,607 total
- NCT07868354RecruitingPhase 1
Switching to a new weight-loss medicine from tirzepatide
This study tests how well adults with overweight or obesity, with or without type 2 diabetes, tolerate switching from their current weight-loss medication (tirzepatide) to a new medicine called zenagamtide. It may help you understand if this new option is easier on your stomach.
Glendale, CaliforniaAges 18 years+ - NCT07830758RecruitingPhase 1
Resmetirom for fatty liver disease with heart failure
This trial tests a drug called resmetirom for people who have both a type of fatty liver disease (MASH) and a type of heart failure (HFpEF). It aims to see if the drug can help both conditions. You may be able to join if you have both conditions and meet certain health criteria.
Peoria, ArizonaAges 18 years+ - NCT07805954RecruitingPhase 3
New targeted pills for first-line metastatic pancreatic cancer
This trial tests two new targeted pills (zoldonrasib and daraxonrasib) compared to the standard chemotherapy (gemcitabine and nab-paclitaxel) as the first treatment for metastatic pancreatic cancer with a specific KRAS G12D mutation. The new pills may specifically attack cancer cells with this mutation.
Phoenix, ArizonaAges 18 years+ - NCT07770711Recruiting
Inositol and metformin with different diets for PCOS
This study compares two diet plans (Mediterranean and low-carb) along with the supplements inositol and metformin, to see which works better for weight and blood sugar control in women with PCOS and insulin resistance. It may help you manage PCOS symptoms and improve your body's response to insulin.
Diyarbakır, DiyarbakırAges 20–40 - NCT07589387Recruiting
Combined care for diabetes and blood pressure in Nigeria
This study looks at how to improve care for people who have both diabetes and high blood pressure in Nigeria. It aims to help patients manage their conditions better by offering integrated treatment and support.
AbajiAges 18 years+ - NCT07493447RecruitingEarly Phase 1
Imaging dye to help see brain tumors during surgery
This study tests a special dye (panitumumab-IRDye800) that helps surgeons see brain lesions more clearly during surgery. The dye attaches to a protein on cancer cells and lights up under a special camera, which may help remove more tumor safely.
Nashville, TennesseeAges 18 years+ - NCT04141878Recruiting
Lifestyle program to help prevent dementia in adults with diabetes risk
This trial tests a structured lifestyle program (more activity and healthier eating) to help prevent or slow memory and thinking problems. It may be helpful if you’re older but not showing major memory impairment, and you can commit to weekly study activities for about 8 months.
Walnut Creek, CaliforniaAges 60 years+ - NCT07462741Recruiting
Education program for diabetic hemodialysis patients
This study tests if a special education program helps people with diabetes who are on hemodialysis (a type of kidney treatment). The goal is to see if learning more about managing their health can improve their overall well-being.
Elâzığ, MerkezAges 18 years+ - NCT06321302RecruitingPhase 2
Study of BI 764524 for diabetic retinopathy
This study tests an investigational drug called BI 764524 for people with moderate to severe diabetic retinopathy, a complication of diabetes that can damage the retina. The goal is to see if the treatment can help prevent vision loss.
Phoenix, ArizonaAges 18 years+ - NCT07760012Recruiting
Pet scan with new tracer for solid tumors
This study uses a new imaging tracer, called 68Ga-SorB, during a PET/CT scan to look at tumors. It may help doctors see cancer more clearly. The trial is for adults with certain types of solid tumors (such as melanoma, liver, lung, breast, pancreatic, ovarian, or bile duct cancer) who need a PET/CT scan as part of their care.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07875530Recruiting
Comparing two anesthesia methods for obese patients having laparoscopic surgery
This trial compares two different anesthesia techniques for obese patients having laparoscopic surgery, to see which one works better and is safer.
Kocaeli, IzmitAges 18–65 - NCT06623396RecruitingPhase 1
Mesothelin-targeted CAR T cells for esophagogastric cancer or mesothelioma
This trial tests a new treatment that uses your own immune cells (T cells) engineered to find and attack cancer cells that have a protein called mesothelin on their surface. It is for people with advanced or recurrent esophagogastric cancer (cancer of the esophagus or stomach) or malignant peritoneal mesothelioma (a rare cancer of the lining of the abdomen). The treatment involves collecting your T cells, modifying them in a lab, and then giving them back to you after a short course of chemotherapy to help them work.
Basking Ridge, New JerseyAges 18 years+ - NCT07458347RecruitingPhase 1
Study of a new drug for advanced solid tumors with a KRAS mutation
This trial tests a new pill, KST-6051, for people with advanced solid tumors (like lung, pancreatic, or colorectal cancer) that have a specific genetic change called a KRAS mutation. The goal is to see if the drug can shrink or control the cancer, and to find the best dose.
Los Angeles, CaliforniaAges 18 years+ - NCT07020221RecruitingPhase 1/Phase 2
Study of VS-7375 for cancers with a KRAS G12D mutation
This study tests an experimental drug called VS-7375 for people with advanced solid tumors that have a specific genetic change called KRAS G12D. The goal is to see if the drug can shrink tumors or slow their growth.
Los Angeles, CaliforniaAges 18 years+ - NCT07875582Recruiting
Blood test for better pancreatic cancer diagnosis
This study looks for proteins in the blood that could help doctors tell the difference between pancreatic cancer and non-cancerous pancreatic conditions, such as chronic pancreatitis or benign cysts. By participating, you could help improve early and accurate diagnosis, which may lead to better outcomes for future patients.
IașiAges 18 years+ - NCT06007924RecruitingPhase 2
Study of two drugs for advanced thyroid cancer
This trial tests two oral medications, avutometinib and defactinib, for people with advanced thyroid cancer that has specific genetic changes. The goal is to see if these drugs can shrink tumors or slow their growth.
Basking Ridge, New JerseyAges 18 years+ - NCT07125950RecruitingPhase 2
SHR2554 plus hormone therapy for advanced breast cancer
This trial tests a new drug (SHR2554) combined with standard hormone therapy for people with advanced or metastatic breast cancer. The goal is to see if the combination helps control the cancer better.
Zhengzhou, HenanAges 18 years+ - NCT07876349Recruiting
Genetic testing program for breast and ovarian cancer risk
This study tests a program that helps primary care doctors identify women who may benefit from genetic testing for hereditary breast and ovarian cancer. The program uses family history to guide testing and aims to make it easier for patients to get tested.
New York, New YorkAges 21–75 - NCT07792954RecruitingPhase 3
Weekly weight-loss study for Chinese adults with overweight or obesity
This study tests a once-weekly medicine called PF-08653944 to see if it helps Chinese adults lose weight compared to a placebo (a pill with no active medicine). It may be an option if you have been unable to lose weight through diet alone.
Hefei, AnhuiAges 18 years+ - NCT06970457Recruiting
Exercise, body fat, and hormones in men
This study investigates how exercise affects sex hormones in men with different body types. Participants will engage in a supervised exercise program to see how it interacts with body composition.
Stillwater, OklahomaAges 18–79 - NCT06985212Recruiting
Study of acid sphingomyelinase deficiency in children and adults
This study follows people with acid sphingomyelinase deficiency (ASMD) over time to learn more about how the condition changes. You won't get any new treatment, but your participation will help doctors better understand ASMD.
Paris, FranceAges 2 years+ - NCT07658560RecruitingPhase 2
Weight loss pill study for overweight or obese adults without diabetes
This study tests an experimental pill, BGM0504, to see if it helps overweight or obese adults lose weight safely. Participants will take the pill while continuing their usual diet and exercise routine.
Beijing, Beijing MunicipalityAges 18–55 - NCT06007404Recruiting
Understanding metabolism and inflammation in teens
This study looks at how metabolism and inflammation relate to diabetes risk in teenagers. It may help researchers understand why some teens develop type 2 diabetes.
Ann Arbor, MichiganAges 14–18 - NCT07794761RecruitingPhase 3
Weekly injection for weight loss in adults with obesity in Japan
This study tests a once-weekly injection called berobenatide to see if it helps adults with obesity lose weight and improve related health problems like high blood pressure, high cholesterol, or blood sugar issues. It is for people living in Japan.
Chiba, ChibaAges 18 years+
Common questions
- How many hormones & metabolism clinical trials are recruiting?
- Clin2 is tracking 7,607 recruiting endocrinology & metabolism studies from the U.S. registry right now, out of 11,814 we cover in this area in total.
- What does “Hormones & metabolism” cover here?
- Diabetes, obesity, thyroid, and other conditions of the body’s hormones and metabolism. We group each study into hormones & metabolism based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a hormones & metabolism trial near me?
- Use the search to filter hormones & metabolism studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.