Immunology & allergy
Immune system & allergy clinical trials
Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We’re tracking 6,050 recruiting studies in this area right now.
By phase
- Not applicable2,999
- Phase 21,056
- Phase 1792
- Phase 1/Phase 2437
- Phase 3435
- Phase 4233
- Phase 2/Phase 398
Top conditions
- Multiple Sclerosis330
- Multiple Myeloma327
- Asthma193
- Lymphoma178
- Rheumatoid Arthritis131
- Type 1 Diabetes130
- Atopic Dermatitis124
- Systemic Lupus Erythematosus119
- Acute Lymphoblastic Leukemia118
- HIV Infections106
- Chronic Lymphocytic Leukemia95
- Autoimmune Diseases77
- Follicular Lymphoma70
- Rheumatoid Arthritis (RA)68
- Diabetes Mellitus, Type 163
- Hodgkin Lymphoma63
- Leukemia63
- Mantle Cell Lymphoma62
Leading sponsors
- National Institute of Allergy and Infectious Diseases (NIAID)97
- Institute of Hematology & Blood Diseases Hospital, China85
- National Cancer Institute (NCI)74
- Assistance Publique - Hôpitaux de Paris65
- AstraZeneca63
- M.D. Anderson Cancer Center58
- Novartis Pharmaceuticals58
- Mayo Clinic49
- City of Hope Medical Center48
- Memorial Sloan Kettering Cancer Center45
Where studies are running
- California496
- Maryland199
- Alabama178
- Florida149
- Arizona148
- Massachusetts116
- New York116
- Texas112
- Illinois83
- Colorado82
Recruiting studies6,050 total
- NCT07562542Recruiting
Blood test study for mastocytosis mutation detection
This study looks for a specific genetic change (KIT-D816V mutation) in the blood of adults with mast cell disorders—conditions where immune cells called mast cells cause allergic-like reactions. Understanding this mutation may help doctors better diagnose and treat your condition.
Suzhou, JiangsuAges 18 years+ - NCT07566377RecruitingPhase 2
Cord Blood Transplant for Children and Young Adults With Blood Cancer
This study tests whether using cord blood stem cells (collected from umbilical cords after birth) can help treat high-risk blood cancers in children and young adults when a matched donor is not quickly available. Cord blood transplants may help prevent cancer from coming back.
New York, New YorkAges Up to 26 years - NCT07566364RecruitingPhase 2
Mosunetuzumab for Chronic Lymphocytic Leukemia with Minimal Residual Disease
This study tests a new antibody drug called mosunetuzumab in patients with chronic lymphocytic leukemia (CLL) who have already tried other treatments and still have detectable leukemia cells in their bone marrow. The drug is designed to work in a way that might help your immune system fight the remaining cancer cells.
Houston, TexasAges 18 years+ - NCT06735495RecruitingPhase 1/Phase 2
Two-target CAR T cells for relapsed B-cell blood cancers
This trial tests a new type of immunotherapy that uses your own immune cells engineered to recognize two cancer targets (CD19 and CD22) to treat B-cell blood cancers that have come back or not responded to standard treatments. It may offer a treatment option when other therapies have stopped working.
Wuhan, HubeiAges 3–75 - NCT06734013Recruiting
Genetic testing to help diagnose liver transplant rejection
This study looks at whether genetic testing of a tissue sample (biopsy) can help doctors more accurately diagnose rejection after a liver transplant. It is for people who have already been diagnosed with rejection and have a stored tissue sample available.
BolognaAges 18 years+ - NCT03316261Recruiting
Testing newborns for type 1 diabetes risk
This study looks at infants to find how likely they are to develop type 1 diabetes later in life. If you have a newborn who is very young, you may be able to take part by allowing the study team to test them as part of early risk screening.
MunichAges 1 day–1 month - NCT00537966Recruiting
Study of new HIV infections in the Zurich area
This study enrolls people whose HIV infection is very recent or newly diagnosed (within the last few months). The researchers want to better understand early stages of HIV to improve how doctors identify and track new infections.
ZurichAges 18 years+ - NCT04039945Recruiting
Early checkup and care program for type 1 diabetes
This study looks at early diagnosis and support for people with type 1 diabetes. You may be invited to participate if a parent or guardian agrees to enroll your child.
MunichAges 2–10 - NCT06167239Recruiting
Breathing muscle training for Guillain-Barre patients on ventilators
This trial compares two methods to help people with Guillain-Barre syndrome who are having trouble breathing on their own after being on a ventilator. It tests if adjusting the ventilator's sensitivity or doing specific breathing muscle exercises can improve blood oxygen levels and help them wean off the machine.
CairoAges 20–55 - NCT06209606RecruitingEarly Phase 1
Blood test study for multiple myeloma progression
This study is testing whether a blood test that measures a protein called BCMA can help doctors know if your multiple myeloma is getting worse. You may be able to join if your myeloma has come back or not responded to at least two prior treatments, and you have not taken the drug Ruxolitinib before.
West Hollywood, CaliforniaAges 18 years+ - NCT06738134Recruiting
HIV care with extra support for heart and metabolic conditions
This trial offers a new way to manage HIV care for people who also have heart or metabolic problems like high blood pressure, diabetes, or high cholesterol. It aims to see if combining specialist care with HIV care can improve health outcomes.
ShatinAges 18 years+ - NCT06737250RecruitingPhase 2
Testing a new drug combo for relapsed brain lymphoma
This trial tests a combination of three drugs (poseltinib, rituximab, and lenalidomide) for people with primary central nervous system lymphoma that has come back or not responded to earlier treatment. The goal is to see if this new mix can help control the disease.
BusanAges 19–80 - NCT06739265RecruitingPhase 1/Phase 2
Golidocitinib plus CHOP for new T-cell lymphoma
This trial tests a new drug called golidocitinib added to standard chemotherapy (CHOP) for people newly diagnosed with certain types of T-cell lymphoma. It aims to see if the combination works better than CHOP alone.
BeijingAges 18–70 - NCT06362967RecruitingPhase 2
Lowering high antibodies before stem cell transplant
This trial tests a special treatment to lower high levels of anti-HLA antibodies before a stem cell transplant. The goal is to help the transplant succeed and reduce the risk of rejection.
Hefei, AnhuiAges 14–60 - NCT06561854RecruitingPhase 3
Comparing multiple myeloma treatment with and without dexamethasone
This trial tests whether adding dexamethasone to an antibody-based combination therapy works better for multiple myeloma that has come back after previous treatments. If you have had 1 to 3 prior therapies and are eligible for one of two standard drug regimens, this study may help find the best approach for you.
ParisAges 18 years+ - NCT07558616Recruiting
Brain Stimulation for Sleep Problems in Nerve Disorders
This study tests a non-invasive brain stimulation technique called Hi-tACS to improve sleep in people with specific nerve/immune diseases (like MS or NMOSD) or chronic insomnia who have not responded to sleep medications. The goal is to help you fall asleep and stay asleep, and feel less tired during the day.
Beijing, Beijing MunicipalityAges 18–65 - NCT07555470RecruitingPhase 2
New drugs for follicular lymphoma: mosunetuzumab and zeprumetostat
This study tests two new drugs combined together to treat follicular lymphoma (a slow-growing blood cancer). The trial enrolls patients who have never been treated, those with limited disease who want active treatment, and those whose cancer came back or didn't respond to prior therapy.
Tianjin, Tianjin MunicipalityAges 18 years+ - NCT07556484RecruitingPhase 1
Avacopan Delivery Through Feeding Tube for Severe Vasculitis
This trial tests a new way to deliver avacopan—a drug that reduces inflammation in rare blood vessel diseases (ANCA-associated vasculitis)—through a feeding tube instead of by mouth. The study measures how much of the drug reaches your bloodstream and checks if it's safe for patients with very severe disease who are on a breathing machine.
Rochester, MinnesotaAges 18 years+ - NCT07553572Recruiting
Smartphone app to track cancer symptoms during treatment
This study tests a smartphone application designed to help you monitor and manage side effects and symptoms while you're receiving chemotherapy or other systemic treatment for breast cancer, colorectal cancer, or lymphoma. The app may help your doctors catch problems early and support you throughout your treatment.
Boston, MassachusettsAges 18 years+ - NCT07554820RecruitingPhase 4
Heart Protection in Rheumatoid Arthritis With New Medications
This study compares two treatment approaches for people with active rheumatoid arthritis who also have heart disease risk factors. It tests whether a newer drug called tofacitinib, combined with cholesterol medication, can better protect the heart than traditional TNF-inhibitor treatments.
Lahore, Punjab ProvinceAges 50–85 - NCT07558850Recruiting
CAR-T Cell Therapy for Treatment-Resistant Autoimmune Diseases
This study tests a new type of immune cell therapy (CAR-T cells) designed to treat severe autoimmune diseases like rheumatoid arthritis, lupus, dermatomyositis, and scleroderma that haven't responded well to standard treatments. The therapy works by modifying your own immune cells to target and eliminate the B cells that are causing your autoimmune disease.
Nanjing, JiangsuAges 18–70 - NCT07552636Recruiting
Monitoring Giant Cell Arteritis During Treatment Tapering
This study tracks patients with giant cell arteritis (GCA, a blood vessel inflammation affecting older adults) who are in remission and tapering their steroid medications. Researchers will monitor disease activity through blood tests and patient questionnaires to understand if their condition stays stable as they reduce treatment.
AalborgAges 50 years+ - NCT07558538RecruitingEarly Phase 1
Inhaled Growth Factor Treatment for Severe Lung Failure
This early-stage trial tests whether an inhaled medication called recombinant human keratinocyte growth factor-2 (rh-KGF-2) can help patients with acute respiratory distress syndrome (ARDS)—a serious condition where the lungs cannot deliver enough oxygen to the blood. The drug is designed to help repair lung tissue damage.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT07552038Recruiting
Dental Care Management for People Living With HIV
This study looks at how dentists can best care for people with HIV. Researchers will review dental and health records at hospitals in the Pays de la Loire region to understand what works best for keeping teeth and gums healthy when you have HIV.
Nantes, NantesAges 18 years+
Common questions
- How many immune system & allergy clinical trials are recruiting?
- Clin2 is tracking 6,050 recruiting immunology & allergy studies from the U.S. registry right now, out of 9,115 we cover in this area in total.
- What does “Immune system & allergy” cover here?
- Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We group each study into immune system & allergy based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a immune system & allergy trial near me?
- Use the search to filter immune system & allergy studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.