Psychiatry
Mental health clinical trials
Depression, anxiety, and other mental-health and behavioral conditions. We’re tracking 7,779 recruiting studies in this area right now.
By phase
- Not applicable6,422
- Phase 2492
- Phase 1250
- Phase 3240
- Phase 4212
- Phase 1/Phase 294
- Phase 2/Phase 369
Top conditions
- Anxiety387
- Depression382
- Alzheimer Disease338
- Autism Spectrum Disorder239
- Dementia228
- Mild Cognitive Impairment198
- Schizophrenia184
- Major Depressive Disorder173
- Insomnia159
- Cognitive Impairment150
- Alcohol Use Disorder145
- Opioid Use Disorder143
- Stress117
- PTSD105
- Mental Health99
- Autism94
- Mild Cognitive Impairment (MCI)89
- Suicidal Ideation89
Leading sponsors
- VA Office of Research and Development104
- Yale University87
- Massachusetts General Hospital77
- Stanford University68
- Assistance Publique - Hôpitaux de Paris64
- Johns Hopkins University62
- University of California, Los Angeles58
- University of Pennsylvania53
- Karolinska Institutet51
- The University of Hong Kong51
Where studies are running
- California520
- Massachusetts267
- New York255
- Texas209
- Maryland176
- Pennsylvania170
- Florida149
- Alabama118
- Arizona109
- Illinois104
Recruiting studies7,779 total
- NCT05962424RecruitingPhase 1
Study of brain activity during thinking using electrode recordings
This Phase 1 study records electrical signals from the brain while you perform thinking tasks. The goal is to better understand how human brain circuits work during cognition, and the study may help future treatments.
Palo Alto, CaliforniaAges 18 years+ - NCT05965518Recruiting
High-intensity exercise for brain and blood-vessel health in HIV
This trial tests whether high-intensity exercise can improve blood-vessel health and brain function in adults with HIV who are not very active and have thinking/memory problems. If you qualify, you’ll be asked to safely complete exercise and other study assessments.
Birmingham, AlabamaAges 50 years+ - NCT05967364Enrolling by invitation
Career coaching training for new Air Force trainees
This study tests a career-enhancement training program delivered during different stages of Air Force training. It may help new trainees build skills for career growth across their early time in service.
Rochester, New YorkAges 18–40 - NCT05962879Recruiting
Program for teens with early psychosis-like experiences
This trial tests a new mental health program for teenagers who are having at least one psychosis-like experience and may be at risk for serious mental illness. It may help by offering structured support for both teens and their parents.
Boston, MassachusettsAges 14–19 - NCT05973461Recruiting
Exercise and virtual reality study for depression
This study looks at whether doing regular exercise and using virtual reality can help with depression symptoms, compared to not doing them. You may be included even if you do not currently have depression symptoms, as long as you meet the safety and participation requirements.
Arlington, TexasAges 18–65 - NCT05948930Recruiting
Exercise and brain training for mild memory problems
This study tests whether a mix of physical exercise and computer brain training can improve working memory in people with mild cognitive impairment (MCI). It may help by strengthening memory skills and supporting brain health through supervised activity and computer-based practice.
Baltimore, MarylandAges 50–80 - NCT05943834Recruiting
Voice testing to detect early memory and mood changes
This trial studies whether automated analysis of your voice and speech can help detect early signs of Alzheimer’s disease and mood (affective) problems. It may help identify changes sooner, using voice and questionnaire information from people who are cognitively healthy to very mildly affected.
NiceAges 50–100 - NCT05942313Recruiting
Predicting and preventing problems from opioid use during pregnancy
This study looks at ways to predict and reduce harmful outcomes for pregnant people with opioid use disorder (OUD) and their babies. It focuses on people who are already receiving ongoing medication treatment during pregnancy and will follow them around delivery at a specific hospital.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT05962229RecruitingPhase 1
Testing how synthetic nicotine is processed in regular e-cig users
This Phase 1 study tests how a synthetic nicotine product is absorbed and how the body responds (so researchers can better understand nicotine effects and handling). You may be able to join if you’re generally healthy and regularly use e-cigarettes, but you’ll need to avoid certain medicines and nicotine products during the study.
San Francisco, CaliforniaAges 21–65 - NCT05972265Recruiting
Exercise for memory and thinking after childhood trauma
This study tests if exercise can help improve memory, attention, and thinking in adults aged 40–60 who experienced child abuse or neglect and have concerns about their cognitive function. You'll need to be a native English speaker, generally healthy, and not currently very active.
Austin, TexasAges 40–60 - NCT05973110Recruiting
Virtual reality training to improve thinking in psychosis
This trial tests whether a virtual reality program can help people living with psychosis improve thinking and daily functioning. It may help if your symptoms are currently stable and you can safely use the VR equipment.
Ottawa, OntarioAges 18–60 - NCT05968560Recruiting
Online therapy to help youth at risk for psychosis
This trial tests a telehealth (video/phone) version of cognitive behavioral therapy to help young people who are at risk for developing psychosis. It may help by teaching skills to reduce symptoms and improve coping, with support from a key family or close person.
New York, New YorkAges 14–25 - NCT05958017Recruiting
ReSET program to help stimulant use in HIV clinics
This study tests a care-support program called ReSET to improve adherence to treatment and reduce stimulant use for people living with HIV who are not currently in drug treatment. You may be offered support through HIV clinic care to help you stay on track, especially if you have access to a smartphone and stable housing.
Miami, FloridaAges 18–90 - NCT05950607Recruiting
Nursing home study to reduce unnecessary antibiotic use
This study looks at ways to lower how often antibiotics are used in nursing home residents with Alzheimer’s disease and other dementias. It aims to make antibiotic use more appropriate while monitoring resident outcomes.
Boston, MassachusettsAges 60–106 - NCT05967390Enrolling by invitation
Personalized brain-mapping test using a scalp-to-brain scan
This trial looks at whether a personalized brain “map” using imaging and scalp measurements can be measured and evaluated in people who can safely attend the testing. It may help researchers better understand how brain structure relates to performance, using scan-based measurements and related procedures.
Hong KongAges 60–95 - NCT05964010Recruiting
Parent-and-teen program for teen health visits
This trial offers a structured support program for teenagers and their primary caregiver during a primary care visit. It may help by testing an approach that connects youth and families with resources and support starting at the clinic visit.
New York, New YorkAges 12–17 - NCT05952674Recruiting
Vagus nerve stimulation for long-term depression symptoms
This trial studies whether a device that stimulates the vagus nerve (VNS) can help people with treatment-resistant depression or related mood disorders that have not improved despite multiple therapies. It may help by targeting mood symptoms when other treatments haven’t worked well.
Angers, FranceAges 18 years+ - NCT05950958Recruiting
Preventing ICU confusion with several supportive care steps
This trial tests whether a set of different care steps in the ICU can help prevent delirium, a sudden episode of confusion. It may help people who are at higher risk because they will likely need ICU care for more than a day.
SeoulAges 50 years+ - NCT05967819Recruiting
Study stress and exercise effects on missing periods
This study looks at how physical and stress load from exercise may affect hormone signals that help bring on regular menstrual periods in exercising women. You might benefit by learning more about your hormone and cycle patterns while being monitored through exercise, stress, and at-home measurements.
Colorado Springs, ColoradoAges 18–35 - NCT05973448Enrolling by invitation
Nightlight Falls Prevention for People With Dementia
This study tests a simple plan to help prevent falls in people who have dementia. You may be able to join if you live in a participating assisted living community and meet the safety and room rules.
Chapel Hill, North CarolinaAges 18 years+ - NCT05959434RecruitingPhase 2
Therapy program to reduce drinking relapse and PTSD symptoms
This Phase 2 study tests a combined therapy approach for people who have both alcohol use disorder and post-traumatic stress disorder (PTSD). It aims to help you process stressful memories and lower the chances of relapse back to heavy drinking.
Charleston, South CarolinaAges 18 years+ - NCT05949047Recruiting
Phone-based training for family caregivers of Alzheimer’s patients
This study tests a smartphone program that teaches skills to better manage emotions for people who provide unpaid care for someone with Alzheimer’s disease. It may help caregivers feel less overwhelmed and cope more effectively during daily stress.
Houston, TexasAges 18 years+ - NCT05957159RecruitingEarly Phase 1
Testing an alcohol brain imaging study based on opioid receptor balance
This early-phase study looks at how the brain’s opioid receptor balance may be different in people with alcohol use disorder (AUD), using brain scans and blood testing. It may help researchers understand why some people respond differently to alcohol and related treatments.
New Haven, ConnecticutAges 21–70 - NCT02914067Recruiting
Testing brain scan and computer measures in young brain tumor patients
This study looks at “brain biomarkers,” meaning brain signals measured on MRI and thinking/learning tests on a computer. It may help researchers understand how brain tumors affect the brain and track changes over time.
St Louis, MissouriAges 4–18
Common questions
- How many mental health clinical trials are recruiting?
- Clin2 is tracking 7,779 recruiting psychiatry studies from the U.S. registry right now, out of 12,461 we cover in this area in total.
- What does “Mental health” cover here?
- Depression, anxiety, and other mental-health and behavioral conditions. We group each study into mental health based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mental health trial near me?
- Use the search to filter mental health studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.