Psychiatry
Mental health clinical trials
Depression, anxiety, and other mental-health and behavioral conditions. We’re tracking 7,784 recruiting studies in this area right now.
By phase
- Not applicable6,423
- Phase 2495
- Phase 1249
- Phase 3240
- Phase 4214
- Phase 1/Phase 294
- Phase 2/Phase 369
Top conditions
- Anxiety388
- Depression382
- Alzheimer Disease338
- Autism Spectrum Disorder240
- Dementia228
- Mild Cognitive Impairment198
- Schizophrenia184
- Major Depressive Disorder173
- Insomnia159
- Cognitive Impairment150
- Alcohol Use Disorder145
- Opioid Use Disorder143
- Stress118
- PTSD104
- Mental Health99
- Autism94
- Mild Cognitive Impairment (MCI)89
- Suicidal Ideation89
Leading sponsors
- VA Office of Research and Development102
- Yale University87
- Massachusetts General Hospital79
- Stanford University69
- Assistance Publique - Hôpitaux de Paris64
- Johns Hopkins University62
- University of California, Los Angeles58
- University of Pennsylvania53
- Karolinska Institutet51
- The University of Hong Kong51
Where studies are running
- California520
- Massachusetts269
- New York254
- Texas209
- Maryland175
- Pennsylvania170
- Florida148
- Alabama119
- Arizona111
- Ohio104
Recruiting studies7,784 total
- NCT04432116Recruiting
Virtual reality training for schizophrenia and bipolar symptoms
This study looks at whether virtual reality and time-based training can improve symptoms for people with schizophrenia or bipolar disorder. You may do virtual-reality tasks as part of your care plan while the team tracks changes over time.
StrasbourgAges 18–60 - NCT04391816Recruiting
Study of how alcohol use changed during the COVID-19 pandemic
This study follows people over time to understand how the COVID-19 pandemic affected alcohol use and related health or behaviors. You may help by answering short surveys by phone or online on a regular schedule.
Bethesda, MarylandAges 18–100 - NCT04396873RecruitingPhase 1
PET brain scan study of inflammation markers in neurodegeneration
This Phase 1 study tests a PET scan to measure inflammation-related changes in the brain using a medication called ketoprofen. It may help researchers understand which people with certain brain diseases could benefit from treatments aimed at inflammation.
Bethesda, MarylandAges 18–99 - NCT04482660Enrolling by invitation
PET brain scan study of tau protein in ALFA volunteers
This study uses a special PET brain scan tracer to measure “tau” protein clumps in the brain. It’s meant to better understand brain changes in people who are already part of the ALFA research program, and may help researchers connect tau levels with memory and thinking.
Barcelona, BarcelonaAges 45 years+ - NCT04449068Recruiting
Tourette research using records from deep brain stimulation patients
This study is collecting information about people with severe Tourette syndrome who are not adequately helped by medication and may receive deep brain stimulation. It helps researchers understand outcomes and care patterns for this treatment over time using an observational database.
ParisAges 15 years+ - NCT04427241RecruitingPhase 4
Testing Cerebrolysin for prolonged brain injury after bleeding stroke
This study tests whether Cerebrolysin can improve recovery in people who remain in a vegetative or minimally conscious state more than 4 weeks after a bleeding stroke. It also tracks safety, to make sure the treatment is not causing harmful side effects.
SeoulAges 19–120 - NCT04421248RecruitingPhase 4
Testing blood or brain markers in kids with ADHD
This Phase 4 study checks whether certain markers change in the brain/body when children with ADHD take methylphenidate (a stimulant). It also compares these markers with healthy children to better understand ADHD.
Baltimore, MarylandAges 8–12 - NCT04480918Recruiting
Registry for people with depression or bipolar to receive psychiatry care
This is a patient registry that enrolls people being evaluated for treatment options from an Interventional Psychiatry Service. It helps track patients with depression, bipolar disorder, or treatment-resistant OCD who are suitable for these psychiatry treatments.
Iowa City, IowaAges 18–99 - NCT04446442Recruiting
Brain stimulation study for children with autism symptoms
This study tests a noninvasive brain stimulation approach (through the scalp) to see if it can help children with autism spectrum disorder. Families may be asked about the child’s development, communication level, and medical history to make sure the treatment is safe.
Dallas, TexasAges 4–17 - NCT04393259Recruiting
Pregnancy study for people with prior pregnancy loss
This study is for pregnant women who have previously experienced a stillbirth, the death of a baby shortly after birth, or a late pregnancy termination. The goal is to learn about care and support needs for these pregnancies and outcomes, which may help improve future guidance.
Manchester, Greater ManchesterAges 16–50 - NCT04445649Recruiting
Find factors to help people regain consciousness after brain injury
This study looks at what predicts recovery of consciousness after certain serious brain injuries, such as stroke or traumatic brain injury. It may help clinicians better identify which patients are more likely to wake up and guide early rehabilitation and care.
Hessisch OldendorfAges 18–85 - NCT04458545RecruitingPhase 1/Phase 2
Opioid vaccine study for adults with heroin or fentanyl use
This trial tests a vaccine made from parts designed to help the body respond to opioids (heroin or fentanyl). It is mainly for adults with moderate-to-severe opioid use disorder who are using opioids that match the study dosing needs and who are willing to do frequent visits over about a year.
Eatontown, New JerseyAges 18–59 - NCT04400617Recruiting
Improving sleep in assisted-living residents
This study looks at sleep quality in people living in assisted-living. It aims to see what changes (or routines) may improve sleep, especially in residents who are physically independent.
Calgary, AlbertaAges 50 years+ - NCT04379115Recruiting
Brain stimulation study for people with opioid addiction
This study tests a non-invasive brain stimulation approach to reduce opioid cravings in people who are actively using non-prescribed opioids while on stable methadone. It may help people feel less craving and improve recovery support.
Hinsdale, IllinoisAges 18–85 - NCT04467502Recruiting
Virtual reality therapy for gambling urges
This trial tests whether virtual reality exposure therapy can help people with gambling disorder by safely practicing facing gambling-related triggers. It may help you reduce urges and improve control, if you meet the study’s specific criteria.
AmiensAges 18 years+ - NCT04433455Recruiting
Brain and thinking health in hemodialysis patients
This study looks at how blood vessel problems in the brain and thinking (cognition) are related in people who are on long-term hemodialysis for kidney failure. By joining, you help doctors learn how to better protect brain health in dialysis patients.
Shanghai, Shanghai MunicipalityAges 50–85 - NCT04432883Recruiting
Brain stimulation to improve speech after stroke aphasia
This trial tests whether targeted mild brain stimulation (tDCS) can improve speech therapy results for people with long-lasting (chronic) aphasia after a stroke. It may help strengthen naming and communication when added to standard speech-language treatment.
Albuquerque, New MexicoAges 25–85 - NCT04478838RecruitingPhase 4
Alternate-day antipsychotic dosing for schizophrenia
This trial looks at whether taking an antipsychotic every other day can keep symptoms controlled in adults with schizophrenia or another psychotic disorder. It may help some people avoid daily dosing, but it requires specific medication stability and screening checks.
Toronto, OntarioAges 18 years+ - NCT01627301Recruiting
Study of stress-related body overactivity in people with PTSD
This study looks at how the body’s stress system works in veterans with PTSD compared with veterans without PTSD. You may be asked about blood pressure, lifestyle, and health conditions to see whether the study measures differences that could help future treatment.
Decatur, GeorgiaAges 18–65 - NCT04373317RecruitingPhase 4
Comparing two medicines for hallucinations in Parkinson's disease
This study compares two drugs, pimavanserin and quetiapine, to see which works better for hallucinations or delusions caused by Parkinson's disease. The goal is to help patients manage these symptoms more effectively.
Tucson, ArizonaAges 40 years+ - NCT04375033RecruitingPhase 4
Comparing Buprenorphine pill vs injection for opioid use disorder
This study compares two forms of a medication called buprenorphine (one is a pill you take under the tongue, the other is an injection) to see which works better for treating opioid use disorder. If you are eligible, you will receive one of these forms for a year and regular check-ups.
Tuscaloosa, AlabamaAges 18 years+ - NCT04323566Enrolling by invitationPhase 2
Rituximab for OCD or psychosis linked to immune inflammation
This trial tests rituximab (an immune system medicine) to see if it can reduce OCD symptoms and/or psychosis when there are signs the immune system may be involved. You may be considered if other standard psychiatric treatments have not helped enough and your illness seems relatively recent with possible inflammation clues.
UppsalaAges 18–55 - NCT04356274Enrolling by invitation
Improving access to addiction and mental health care at VA clinics
This study tests an approach to help VA clinics reach more Veterans with proven treatments for addiction and mental health conditions. It focuses on clinic-level processes (not individual medications) to increase how widely evidence-based care is delivered.
Palo Alto, CaliforniaAges 18 years+ - NCT04279158Recruiting
Attention training after stroke or for ADHD
This study tests an attention-focused training approach to help people improve how the brain inhibits or filters information. It may be relevant after certain stroke-related attention problems, and also for people with ADHD, or for healthy volunteers for comparison.
BronAges 8–75
Common questions
- How many mental health clinical trials are recruiting?
- Clin2 is tracking 7,784 recruiting psychiatry studies from the U.S. registry right now, out of 12,489 we cover in this area in total.
- What does “Mental health” cover here?
- Depression, anxiety, and other mental-health and behavioral conditions. We group each study into mental health based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mental health trial near me?
- Use the search to filter mental health studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.