Psychiatry
Mental health clinical trials
Depression, anxiety, and other mental-health and behavioral conditions. We’re tracking 7,784 recruiting studies in this area right now.
By phase
- Not applicable6,423
- Phase 2495
- Phase 1249
- Phase 3240
- Phase 4214
- Phase 1/Phase 294
- Phase 2/Phase 369
Top conditions
- Anxiety388
- Depression382
- Alzheimer Disease338
- Autism Spectrum Disorder240
- Dementia228
- Mild Cognitive Impairment198
- Schizophrenia184
- Major Depressive Disorder173
- Insomnia159
- Cognitive Impairment150
- Alcohol Use Disorder145
- Opioid Use Disorder143
- Stress118
- PTSD104
- Mental Health99
- Autism94
- Mild Cognitive Impairment (MCI)89
- Suicidal Ideation89
Leading sponsors
- VA Office of Research and Development102
- Yale University87
- Massachusetts General Hospital79
- Stanford University69
- Assistance Publique - Hôpitaux de Paris64
- Johns Hopkins University62
- University of California, Los Angeles58
- University of Pennsylvania53
- Karolinska Institutet51
- The University of Hong Kong51
Where studies are running
- California520
- Massachusetts269
- New York254
- Texas209
- Maryland175
- Pennsylvania170
- Florida148
- Alabama119
- Arizona111
- Ohio104
Recruiting studies7,784 total
- NCT04165746Recruiting
Early care program for very young children in foster systems
This study looks at how an early support program affects the development of infants who are newly entering institutional care or foster care in the São Paulo area. It may help families and caregivers support healthy growth during a critical first period.
São Paulo, São PauloAges Up to 2 years - NCT04159662Recruiting
Brain scans to study thinking in schizophrenia and depression
This study uses brain imaging to better understand how thinking works in people with schizophrenia or major depression. Your results may help researchers learn what brain patterns match different thinking and symptoms.
Ottawa, OntarioAges 18–60 - NCT04239079Recruiting
Study of immune-related changes in Parkinson’s and Alzheimer’s
This study looks for “autoimmune-like” (immune-system) features in brain-related diseases such as Parkinson’s and Alzheimer’s, using genetic testing and other assessments. Results may help researchers understand what drives these conditions and who might be more likely to have immune-related changes.
New York, New YorkAges 55–90 - NCT04161066RecruitingPhase 1
Psilocybin plus buprenorphine to help opioid use disorder symptoms
This Phase 1 study tests how adding psilocybin to a standard opioid treatment (buprenorphine-naloxone) affects recovery and symptoms in people with moderate-to-severe opioid use disorder. It may help researchers understand whether this combination is safe and beneficial alongside medication for opioid withdrawal and cravings.
Madison, WisconsinAges 21–65 - NCT04163081Recruiting
Help to quit smoking started from the emergency department
This study tests a program to help people who smoke quit, beginning when they are seen in the emergency department. It aims to see if starting nicotine-cessation support right away improves quitting over the next year.
Ottawa, OntarioAges 18 years+ - NCT04214561Enrolling by invitation
Studies how sleep measures relate to teeth grinding
This study looks at sleep testing results to understand what relates to sleep bruxism, which is teeth grinding or clenching during sleep. It may help researchers better understand the causes and patterns behind this condition.
WroclawAges 18–70 - NCT04237155Recruiting
French memory and attention task for schizophrenia or controls
This study tests how people with schizophrenia and healthy volunteers track sources of information using a French computer task. It may help researchers better understand memory and thinking differences that could guide future support and treatments.
BronAges 18–45 - NCT04174703Enrolling by invitation
Compassionate letter-writing to support eating disorder treatment
This study looks at whether writing compassionate letters can help people better prepare for a group eating disorder treatment program. It is specifically for adults with anorexia, bulimia, or binge eating disorder who are able to start the program.
Hamilton, OntarioAges 17 years+ - NCT04246437RecruitingPhase 1
Brain imaging study for autonomic failure with possible Parkinson disease
This Phase 1 study uses a special injected imaging tracer and an MRI scan to look at brain function in people with autonomic failure. It may help researchers understand what’s happening in conditions that can be related to Parkinson disease, multiple system atrophy, or dementia with Lewy bodies.
Nashville, TennesseeAges 18 years+ - NCT04197921Recruiting
Brain-focused ultrasound for opioid addiction-related substance use
This trial studies Exablate, a non-surgical brain treatment that aims to change activity in a specific brain area involved in cravings and substance use. It is meant for people in structured opioid or substance use treatment who are currently abstaining from opioids and other illicit drugs.
Tampa, FloridaAges 18–60 - NCT04248283Recruiting
Adjustable continence therapy for stress urine leakage
This trial tests an adjustable treatment to reduce stress urinary incontinence (urine leaking when you cough, sneeze, or exercise). It’s for women who still leak after trying other treatments and who may be able to have surgery, while excluding certain bladder problems and health risks.
Denver, ColoradoAges 22 years+ - NCT04200937Enrolling by invitation
Registry for men getting a penile implant
This registry collects information about men who are scheduled for a penile implant approved by Boston Scientific. It helps the doctors and study team understand outcomes over time and improve care for erectile function.
Los Angeles, CaliforniaAges 18 years+ - NCT03402919Recruiting
Brain and memory study for people with thinking changes
This study looks at memory and thinking changes using questionnaires, memory testing, and brain scans. It may help researchers better understand neurodegeneration and dementia and how these problems show up over time.
Calgary, AlbertaAges 50–90 - NCT04043442Enrolling by invitationPhase 2
Brain stimulation study for alcohol use with mild brain injury
This trial tests a type of brain stimulation to help with day-to-day functioning in people who have alcohol use disorder and a history of mild traumatic brain injury. It also uses brain and symptom testing to see who may benefit most and why.
Hines, IllinoisAges 22–65 - NCT04124029Recruiting
How head injuries affect brain health
This study looks at how mild or moderate head injuries (concussions) may relate to brain conditions like chronic traumatic encephalopathy (CTE) and Alzheimer's disease. By comparing people with and without head injuries, researchers hope to learn more about what causes brain changes over time.
Boston, MassachusettsAges 30–90 - NCT04113993RecruitingPhase 4
Bazedoxifene study in women with schizophrenia
This trial tests whether bazedoxifene can help women with schizophrenia who are stable on their current medicines. You may be asked to do questionnaires and thinking (cognitive) tests to see if symptoms or brain-related measures change.
Melbourne, VictoriaAges 18–65 - NCT04061148Recruiting
Near-infrared testing to assess depression
This study uses a near-infrared light test to measure things related to depression. It includes people without depression and people diagnosed with major depressive disorder receiving care at UCSF/SFVAMC, to see how well the test fits with depression status.
San Francisco, CaliforniaAges 18 years+ - NCT04066192RecruitingPhase 2
Brexpiprazole trial for alcohol use disorder in adults
This study tests whether brexpiprazole can help adults with alcohol use disorder. You must currently not be taking alcohol-focused treatment or alcohol medicines, and you’ll likely complete questionnaires and brain scans.
Aurora, ColoradoAges 21–65 - NCT04041154Recruiting
Study of how the brain senses effort cost
This study asks people to do tasks while the researchers measure brain activity, to understand how the brain represents the “cost” of effort. It may help improve understanding of effort-related problems in mental and neurological conditions.
Baltimore, MarylandAges 18–35 - NCT04060030RecruitingPhase 2
Leucovorin for young children with autism language difficulties
This Phase 2 study tests whether leucovorin (a vitamin-related medicine) can improve social communication and language in young children with autism. It also looks at safety and whether the results hold while the child stays on their usual therapies and routines.
Phoenix, ArizonaAges 2.5 years–5 years - NCT04120714Recruiting
tDCS brain stimulation for problematic internet gaming use
This trial tests whether a noninvasive brain stimulation method (tDCS) can help teens or adults reduce problematic internet gaming. It’s designed for people who meet diagnostic criteria for “pathological use of internet gaming.”
DijonAges 12 years+ - NCT04104659Enrolling by invitation
Tau PET scan study to map brain changes in Alzheimer’s
This study tests a PET scan “tracer” medicine called [18F]MK-6240 to see how tau protein changes show up in the brain. It may help researchers measure disease-related brain changes in people with normal thinking or mild dementia.
St Louis, MissouriAges 18 years+ - NCT04141202Recruiting
Exercise program during short inpatient treatment for substance use
This trial tests a structured exercise program for people receiving short-term inpatient treatment for substance use. It may help improve health and recovery support during your stay.
TrondheimAges 18 years+ - NCT04123314RecruitingEarly Phase 1
Psilocybin study for depression in mild memory or early Alzheimer’s
This early-phase study tests whether psilocybin (a psychedelic substance) can help with depression in people who have mild memory problems or early Alzheimer’s. The trial also closely monitors safety, thinking changes, mood, and blood pressure before and after dosing.
Baltimore, MarylandAges 18–85
Common questions
- How many mental health clinical trials are recruiting?
- Clin2 is tracking 7,784 recruiting psychiatry studies from the U.S. registry right now, out of 12,489 we cover in this area in total.
- What does “Mental health” cover here?
- Depression, anxiety, and other mental-health and behavioral conditions. We group each study into mental health based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mental health trial near me?
- Use the search to filter mental health studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.