Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 2,057 recruiting studies in this area right now.
By phase
- Not applicable1,634
- Phase 2148
- Phase 183
- Phase 381
- Phase 459
- Phase 1/Phase 236
- Phase 2/Phase 316
Top conditions
- Periodontitis108
- Nasopharyngeal Carcinoma80
- Periodontal Diseases57
- Dental Caries49
- Gingivitis35
- Oral Cancer35
- Head and Neck Cancer34
- Dental Implant30
- Sjogren's Syndrome29
- Gingival Recession27
- Periodontal Disease27
- Alveolar Bone Loss23
- Nasopharyngeal Carcinoma (NPC)23
- Peri-Implantitis23
- Tooth Loss22
- Oropharynx Cancer21
- Temporomandibular Disorders (TMD)21
- Trigeminal Neuralgia21
Leading sponsors
- Cairo University91
- Sun Yat-sen University52
- Ain Shams University30
- Mansoura University30
- Postgraduate Institute of Dental Sciences Rohtak24
- Al-Azhar University23
- Tanta University23
- University of Baghdad19
- Universidad Complutense de Madrid18
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California39
- Texas27
- Massachusetts22
- Ohio22
- Pennsylvania22
- New York20
- Maryland19
- Florida18
- Alabama16
- Michigan15
Recruiting studies2,057 total
- NCT06489093RecruitingEarly Phase 1
Silver agents for early cavities in children's baby teeth
This study checks if silver-containing agents can help heal early white spots (cavities) on baby teeth of children aged 3 to 8. It compares different silver treatments to see which works best for stopping or reversing these early cavities.
PlovdivAges 3–8 - NCT05729607Recruiting
Gum tissue repair around an implant using two material types
This trial compares two ways of adding gum (soft tissue) around a dental implant—using donor gum tissue versus a different graft material. If you have a healthy implant with some gum recession, this study may help find which approach works better for healing and gum coverage.
Boston, MassachusettsAges 18–99 - NCT07155343RecruitingEarly Phase 1
Comparing two types of glue for braces in teens and adults
This early-phase trial tests if a newer, faster-setting glue (bulk-fill composite) works as well as the standard glue for attaching braces. It's for people aged 13 to 40 who are starting or continuing fixed braces treatment.
Karachi, SindhAges 13–40 - NCT07077694Enrolling by invitation
AI study to find missed root canals in treated lower back teeth
This study uses artificial intelligence and 3D dental imaging to check if any root canals were missed during previous root canal treatment on lower back teeth. It may help find hidden problems and guide better treatment.
Cairo, Cairo GovernorateAges 18–50 - NCT07098325Recruiting
3d printed retainers for braces after treatment
This trial tests how your mouth reacts to a 3d printed retainer after braces. It may help you keep your teeth straight.
AsyutAges Any age - NCT07043998Recruiting
Comparing two ways to cement porcelain-fused-to-metal crowns
This study tests two different ways of using a special cement to attach porcelain-fused-to-metal crowns. It aims to see which curing method works best to keep your new crown strong and secure.
CairoAges 21 years+ - NCT07105995Recruiting
Chewing test with different foods for dental students
This trial studies how different foods affect jaw movement and tooth contact in healthy people. You may qualify if you are a dental student at Istanbul University with natural teeth and no jaw problems.
Istanbul, Süleymaniye FatihAges 18 years+ - NCT07496164Recruiting
Testing three new denture adhesives against no adhesive
This study tests whether three new denture adhesives help people who have a full upper denture (false teeth on the top) and some natural or false teeth on the bottom. You will try each adhesive and also a period with no adhesive to see how well your denture stays in place.
Indianapolis, IndianaAges 18 years+ - NCT07128589Recruiting
Testing a dental filling material for front teeth repair
This study tests a new flowable composite material that can be used to repair front teeth with class IV cavities or as veneers. The study looks at how well the material works and how satisfied patients are over time.
New York, New YorkAges 18–75 - NCT07410442Recruiting
Distal shoe safety guidelines for kids
This study looks at how safe and well-tolerated a dental device called a distal shoe is for children who need it. It will help create better care guidelines for kids getting this treatment.
Gainesville, FloridaAges 3–9 - NCT07124988Enrolling by invitation
Comparing Upper Jaw Reconstruction Methods
This trial compares different ways to rebuild the upper jaw after surgery for cancer, infection, or trauma. It may help find the best approach to improve function and appearance.
SohagAges Any age - NCT05664815RecruitingPhase 2
Amniotic membrane treatment for advanced jaw bone loss
This Phase 2 trial studies whether a human amniotic membrane dressing can help heal stage II maxillomandibular osteonecrosis of the jaw (MRONJ). It focuses on people who developed MRONJ after certain cancer-related bone treatments and who may need surgery and antibiotics.
BesançonAges 18 years+ - NCT06075017Recruiting
Zirconia vs. titanium implants and biofilm buildup
This trial compares how much biofilm (a sticky layer of bacteria) builds up on two types of dental implants – one made of zirconia (a white ceramic) and one made of titanium (a metal). It's for people getting a single implant to replace a missing tooth.
Madrid, MadridAges 18–99 - NCT07122128Recruiting
Saliva test for early oral cancer in people with OSMF
This trial studies whether a simple saliva test can help detect oral cancer early in people who have a condition called oral submucous fibrosis (OSMF), which raises the risk of oral cancer. Healthy volunteers and those with OSMF or proven oral cancer are needed.
Jāmshoro, SinchAges Any age - NCT06363721Recruiting
Testing an oil rinse for plaque and gum health
This study tests a special oil rinse called PerioPull™ to see if it improves dental health. You may be able to join if you have plaque buildup, bleeding gums, and no deep gum pockets.
Ellicott City, MarylandAges 18 years+ - NCT06711744Recruiting
Comparing dental implants after tooth extraction
This study compares different types of dental implants placed right after a tooth is removed. It may help people with a failing tooth who have healthy gums and surrounding teeth.
Rome, RMAges 18–99 - NCT06713733Recruiting
Steroid injection vs. pill for wisdom tooth recovery
This trial compares two treatments—a steroid placed under the gum and a pill—to reduce pain, swelling, and other problems after removing a lower wisdom tooth. It is for generally healthy patients who need that surgery and haven't taken anti-inflammatory drugs recently.
Dharān, KoshiAges 18 years+ - NCT07169305Recruiting
Study on filling placement depth and tooth health
This trial tests how the depth of a filling below the gumline affects the health of the tooth's nerve and surrounding gum tissue. It may help people with cavities that go below the gum to get better care.
Rohtak, HaryanaAges 18 years+ - NCT06722482Recruiting
Comparing bone grafts for front tooth implants
This trial compares two types of bone graft materials used when a front tooth is removed and replaced with a dental implant. It aims to see which works better for healing and long-term success.
Rochester, New YorkAges 18 years+ - NCT07113873Recruiting
Comparing two types of ultra-white dental veneers for appearance and patient comfort
This trial tests two different materials for dental veneers—ultra-translucent zirconia and lithium disilicate—to see which one patients prefer and how well they work. If you are between 18 and 50, have good oral health, and need veneers to fix gaps, slight color issues, or tooth shape, this study may be a good fit.
CairoAges 18–50 - NCT06018701RecruitingEarly Phase 1
Dental device secured with bone cement for missing teeth
This trial tests a special dental device that is cemented into the jawbone for people missing one or more teeth. It may be a good option if your jawbone is dense enough and you don't have serious other health issues.
Kathmandu, BagmatiAges 18–80 - NCT07562295Recruiting
How Smoking Affects Gum Health
This study compares gum and tooth health in young adults who smoke cigarettes, e-cigarettes, or hookah. Researchers want to understand how each type of smoking affects your mouth and gums differently.
Homs, Homs GovernorateAges 18–25 - NCT06721377Recruiting
Comparing denture attachments for implant-supported lower dentures
This trial tests different ways to attach a lower denture to dental implants. It aims to find which attachment type works best for people who need a stable, comfortable denture.
Cairo, Nasr City - CairoAges 65–69 - NCT05865028RecruitingPhase 2
Test drug APG-157 for abnormal mouth tissue
This Phase 2 trial studies whether APG-157 can safely improve abnormal cells in the mouth (dysplasia) or early cancer-like changes (carcinoma in situ). You may be eligible if you have a visible, biopsy-proven lesion and can take oral medication while meeting blood and health requirements.
Miami, FloridaAges 18 years+
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 2,057 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,953 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.