Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 1,957 recruiting studies in this area right now.
By phase
- Not applicable1,542
- Phase 2142
- Phase 384
- Phase 181
- Phase 460
- Phase 1/Phase 235
- Phase 2/Phase 313
Top conditions
- Periodontitis103
- Nasopharyngeal Carcinoma73
- Periodontal Diseases50
- Dental Caries45
- Head and Neck Cancer35
- Gingivitis33
- Oral Cancer31
- Periodontal Disease29
- Dental Implant28
- Gingival Recession25
- Alveolar Bone Loss24
- Nasopharyngeal Carcinoma (NPC)24
- Sjogren's Syndrome24
- Tooth Loss24
- Temporomandibular Disorders (TMD)22
- Oropharynx Cancer21
- Peri-Implantitis21
- Temporomandibular Joint Disorders20
Leading sponsors
- Cairo University77
- Sun Yat-sen University50
- Mansoura University25
- Ain Shams University24
- Postgraduate Institute of Dental Sciences Rohtak24
- Tanta University24
- Al-Azhar University23
- Universidad Complutense de Madrid16
- University of Baghdad16
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California44
- Texas26
- Maryland21
- Massachusetts21
- Florida20
- New York19
- Pennsylvania19
- Ohio18
- Alabama17
- Michigan15
Recruiting studies1,957 total
- NCT06611137RecruitingPhase 2
SBRT plus chemoimmunotherapy to save the voice box
This trial tests a new approach to treat advanced larynx or hypopharynx cancer without removing the voice box. First, you get targeted radiation (SBRT), then a combination of chemotherapy and an immunotherapy drug called Toripalimab, which helps your immune system fight the cancer.
Guangzhou, GuangdongAges 18–70 - NCT06614686RecruitingPhase 1
CAR-T therapy for advanced head and neck cancer
This study tests a new type of CAR-T cell therapy that targets a protein called Trop2 found on some head and neck cancer cells. It's for people who have tried standard treatments and need a new option.
ShanghaiAges 18–70 - NCT06463392Recruiting
Deep learning tool to diagnose post-radiation nasopharyngeal changes
This trial tests a new computer-based tool (deep learning) to help diagnose a condition called sbORN (suspected benign or recurrent nasopharyngeal carcinoma) after radiation therapy. It aims to see if the tool can accurately tell if a suspicious spot is a recurrence or something harmless.
Guangzhou, GuangdongAges 18 years+ - NCT06591884RecruitingPhase 1/Phase 2
Spray vs ointment for oral lichen planus
This trial tests a new spray version of the medication tacrolimus (enclosed in tiny particles) compared to a standard ointment for treating painful mouth sores caused by oral lichen planus. It aims to see if the spray works better and is easier to use.
Porto Alegre, Rio Grande do SulAges 18 years+ - NCT07740525Recruiting
Reducing anxiety in children during dental fillings
This trial tests whether using videos or having a parent present can help reduce anxiety in children during dental fillings. The goal is to make the dental visit less stressful for your child.
Islamabad, FederalAges 4–11 - NCT07737704RecruitingPhase 2/Phase 3
New bone graft for sinus lift before dental implants
This trial tests a new type of bone graft material for opening the upper-jaw sinus to make room for dental implants. It is for people with very little bone in the back of the upper jaw who need implants for missing teeth.
Ismailia, Ismailia GovernorateAges 18–65 - NCT07734987Recruiting
Root tip surgery accuracy with a 3D-printed guide
This trial tests whether using a custom 3D-printed guide helps make root-end surgery more accurate and improves healing. It may be right for you if you have an infected or damaged root tip that needs surgery.
Ho Chi Minh CityAges 16 years+ - NCT07740278Recruiting
3D-printed dentures for people without teeth
This study tests whether the way 3D-printed dentures are made affects how they fit. It aims to improve comfort and function for people who have no teeth and need a complete upper denture.
Tanta, Gharbia GovernorateAges 50–70 - NCT07736495RecruitingPhase 2/Phase 3
Alpha-lipoic acid for chemo mouth sores in colorectal cancer
This trial tests if a supplement called alpha-lipoic acid (ALA) can protect against painful mouth sores caused by chemotherapy (FOLFOX-6) in people with colorectal cancer. If you are starting FOLFOX-6 for the first time for colorectal cancer, this study may help reduce treatment side effects.
CairoAges 18 years+ - NCT07738185Recruiting
Massage after tongue-tie surgery in babies
This trial tests whether gentle mouth massages after tongue-tie surgery (frenotomy) can help prevent the tongue from re-attaching and improve feeding in babies under 1 year old.
Boynton Beach, FloridaAges Up to 1 year - NCT07740447Recruiting
Non-surgical gum treatment and its effect on body chemistry
This study looks at whether a standard non-surgical gum disease treatment changes certain chemicals in your blood or saliva. It may help show how treating gum disease can improve your overall health.
Catania, ItalyAges 18–70 - NCT07740265Recruiting
Scanning methods for jaw dentures on implants
This study compares different scanning techniques for making dentures that attach to dental implants in the lower jaw. It aims to find the most accurate method to fit dentures comfortably.
Tanta, Gharbia GovernorateAges 40–60 - NCT07739498Recruiting
Bite turbos with palate expander for teenagers
This trial tests whether adding small plastic bumps, called bite turbos, to a palate expander helps widen the upper jaw better than the expander alone in early teens. This may correct a crossbite, where upper teeth sit inside lower teeth when biting down.
Al MansurahAges 10–14 - NCT07739732Recruiting
Gum disease mouth fluid study
This study compares the chemicals in the fluid around teeth between people with gum disease and healthy people. The goal is to find changes that could help understand or detect gum disease.
Catania, ItalyAges 18–70 - NCT07732647Enrolling by invitation
Immediate tooth replacement with a temporary implant crown
This trial tests placing a temporary crown on a dental implant right after removing a front tooth. It may be an option if you need a front tooth replaced and have good overall health and oral hygiene.
Ann Arbor, MichiganAges 18 years+ - NCT07736222Recruiting
Does chewing affect artery stiffness in healthy adults?
This study looks at how your oral health and chewing habits might relate to your artery stiffness—a measure of heart health. Researchers will test participants' chewing ability and check their arteries using simple, non-invasive methods.
Innsbruck, TyrolAges 18 years+ - NCT07737743RecruitingPhase 2
Testing DDY391 for Sjögren's disease
This study tests an experimental drug called DDY391 for people with Sjögren's disease. The goal is to see if it can reduce symptoms and improve quality of life, and to check for side effects.
Clearwater, FloridaAges 18–100 - NCT06623851Recruiting
Digital vs. traditional dental molds for preschoolers
This study compares two ways of taking dental molds (digital vs. traditional) to see which one makes children feel less anxious and more comfortable. It is for young children who are cooperative and have never been to the dentist before.
AlexandriaAges 4–6 - NCT07730359Recruiting
Testing a treatment for white spots after braces
This trial tests a new gel called Epinamel to reverse white spots that form on teeth after braces are removed. If you recently had braces taken off and have white marks on your teeth, this study might help improve them.
LondonAges 12–60 - NCT07727200Recruiting
Tooth color and enamel loss in children with MIH
This study looks at how the color of white, yellow, or brown spots on children's first permanent molars (the back teeth that come in around age 6) relates to the breakdown of the enamel (the outer layer). It aims to help dentists better identify and treat this condition early.
Basel, Canton of Basel-CityAges 5–8 - NCT07726121Recruiting
Mapping the upper jaw artery using 3D X-ray scans
This study uses existing CBCT scans to map a small artery (the alveolar antral artery) in the upper jaw. It helps dentists and surgeons plan procedures to avoid bleeding.
KielceAges Any age - NCT07726511Recruiting
Hard gum chewing and facial shape changes
This study looks at how chewing a hard gum for 4 weeks might change the shape of your face and jaw muscles. It is for healthy adults aged 20–40 with no jaw problems or missing teeth.
Farmington, ConnecticutAges 20–40 - NCT07725913Recruiting
Gel for gum treatment after deep cleaning
This trial tests if a special gel placed in the gums after deep cleaning helps treat periodontitis (advanced gum disease). You may qualify if you have gum pockets of 5mm or deeper that bleed when probed.
Bologna, BOAges 18 years+ - NCT07725393Recruiting
Pomegranate gel for moderate to advanced gum disease
This study tests a gel made from pomegranate peel extract placed under the gums, along with standard deep-cleaning treatment, for people with moderate to advanced gum disease. It may help reduce gum inflammation and pocket depth naturally.
Cairo, Cairo GovernorateAges 30–60
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 1,957 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,729 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.