Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 2,058 recruiting studies in this area right now.
By phase
- Not applicable1,634
- Phase 2148
- Phase 183
- Phase 382
- Phase 459
- Phase 1/Phase 236
- Phase 2/Phase 316
Top conditions
- Periodontitis108
- Nasopharyngeal Carcinoma80
- Periodontal Diseases57
- Dental Caries49
- Gingivitis35
- Oral Cancer35
- Head and Neck Cancer34
- Dental Implant30
- Sjogren's Syndrome29
- Gingival Recession27
- Periodontal Disease27
- Nasopharyngeal Carcinoma (NPC)24
- Alveolar Bone Loss23
- Peri-Implantitis23
- Tooth Loss22
- Oropharynx Cancer21
- Temporomandibular Disorders (TMD)21
- Trigeminal Neuralgia21
Leading sponsors
- Cairo University91
- Sun Yat-sen University53
- Ain Shams University30
- Mansoura University30
- Postgraduate Institute of Dental Sciences Rohtak24
- Al-Azhar University23
- Tanta University23
- University of Baghdad19
- Universidad Complutense de Madrid18
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California40
- Texas27
- Massachusetts22
- Ohio22
- Pennsylvania22
- New York20
- Maryland19
- Florida18
- Alabama16
- Michigan15
Recruiting studies2,058 total
- NCT05541016RecruitingPhase 2
Personalized lower-dose radiation for HPV-related throat cancer
This Phase 2 study tests whether giving a less intense (de-escalated) radiation plan can work for certain people with HPV-related oropharyngeal throat cancer. It uses HPV blood testing and scans to help guide treatment, aiming to keep cancer control while reducing treatment side effects.
Scottsdale, ArizonaAges 18 years+ - NCT05553782RecruitingEarly Phase 1
IMD device study for certain head and neck cancers
This early-phase study tests a new small device (placed through the skin) plus standard surgery to study head and neck cancers. It may help researchers understand how the device works and gather safety information for people who need definitive surgery for a measurable tumor.
Boston, MassachusettsAges 18 years+ - NCT05562375Recruiting
Testing a device to detect early mouth pre-cancer changes
This study checks whether a handheld device (GOCCLES®) can spot early mouth “pre-cancer” changes by looking at suspicious areas in the mouth. If it works, it could help doctors find these problems earlier and guide next steps.
Alcorcón, MadridAges 18 years+ - NCT05575401Recruiting
Track surgery results in kids getting tonsil removal
This trial looks at how well a specific throat surgery technique works in children who are having their tonsils removed (with or without removing adenoids). It may help improve how doctors choose and perform surgery for safer, better recovery.
Murrieta, CaliforniaAges 3–17 - NCT05581680Recruiting
Facial movement study comparing people with and without facial weakness
This study uses special sensors (electrodes and small markers) to measure how facial muscles move. It compares people with peripheral facial palsy to people without facial problems to better understand facial movement changes.
Amiens, PicardieAges 18 years+ - NCT05582915Recruiting
Checking blood tests and scans to predict severe Bell’s palsy
This study looks for early “prognostic biomarkers” (measurable signs in blood/tissue or scans) to predict how severe Bell’s palsy will turn out. It may help doctors better choose the right treatment and follow-up for adults with severe facial nerve weakness.
MontpellierAges 18 years+ - NCT05587543RecruitingEarly Phase 1
Test of EBV CAR-T or TCR-T cells for nasopharyngeal cancer
This early-phase study tests personalized immune cells (EBV CAR-T or TCR-T) to treat nasopharyngeal cancer that has returned or spread. It aims to help the immune system find and attack the cancer after other treatments have not worked.
ShanghaiAges 18–75 - NCT05592314Recruiting
How dental implant shape affects gum and bone disease rates
This study looks at whether the way a dental implant is restored (the “prosthetic emergence profile,” or how it comes up through the gum) affects how often gum and tissue problems happen around implants. It may help clinicians choose restoration styles that lower the risk of peri-implant diseases.
Sant Cugat del Vallès, BarcelonaAges 18–80 - NCT05604391Recruiting
Free gum graft to help cover exposed tooth roots
This trial studies a procedure called a free gingival graft to cover exposed (receding) tooth roots and improve comfort and appearance. You might benefit if you have gum recession in the front lower teeth and meet the specific dental and health requirements.
KütahyaAges 18–99 - NCT05606562Recruiting
Free dental care during hospital treatment for drug abuse
This study offers free dental treatment to people who are staying in a hospital for drug abuse treatment. It aims to see how adding dental care can help while you’re getting help for substance use.
Narvik, NordlandAges 18 years+ - NCT05610878RecruitingPhase 1
Stem cell help to improve fat grafting results
This early-phase study tests whether “preconditioned” stem cells from fat tissue can improve the look of fat transferred during liposuction and grafting. If you qualify, you may receive stem cells along with fat grafting to see how well it works and how safe it is.
Lahore, Punjab ProvinceAges 18–50 - NCT05628922RecruitingPhase 2
Blood EBV DNA–guided therapy for advanced nasopharyngeal cancer
This trial tests a treatment approach for people with locally advanced nasopharyngeal cancer using their blood EBV DNA level (a cancer-related virus marker). It may help doctors choose and adjust therapy based on how much of this marker is in your blood after standard treatment.
Shanghai, Shanghai MunicipalityAges 18–70 - NCT05633511Recruiting
Tested ways to improve gum tissue coverage after grafting
This study compares different methods of adding soft tissue to help cover exposed or damaged roots in the gums. It may help if you need grafting for more than one area and can follow scheduled follow-up visits.
Boston, MassachusettsAges 18 years+ - NCT05635929Recruiting
Topical treatment to reduce mouth sores during or after radiation
This study tests a new cream/gel applied to the mouth to lower the chance of severe mouth sores in people receiving radiation for head and neck cancer. It also looks at how treatment affects quality of life using patient questionnaires.
Madrid, MadridAges 18 years+ - NCT05637619Recruiting
3D scan study of natural teeth and dental prosthesis wear
This study uses 3D scans to measure how teeth and dental replacements wear against each other over time. It may help improve how dentists design and fit dentures and full-mouth restorations.
LisbonAges 18 years+ - NCT05638269Recruiting
Study of gut bacteria in people with serious long-term illness
This study looks at the types of gut bacteria in people living in certain parts of China who have serious long-term (chronic) illnesses. The goal is to better understand how gut bacteria differ and may help doctors in the future tailor care.
Chaoyang, Beijing MunicipalityAges 18–75 - NCT05639972RecruitingPhase 1/Phase 2
HPV cancer trial using immune T cells made for you
This Phase 1/2 trial tests a one-time infusion of special immune T cells made to recognize your HPV16 tumor. It may help your body attack the cancer, while researchers closely monitor safety and early effectiveness.
New Brunswick, New JerseyAges 18 years+ - NCT05655247Recruiting
Comparing two gum treatments for multiple exposed tooth roots
This trial compares two types of gum surgery to cover exposed tooth roots when you have multiple adjacent gum recessions. It aims to find which approach works best for root coverage and long-term gum health.
TarantoAges Any age - NCT05656365Recruiting
Study of genes and immunity in PFAPA and other tonsil problems
This study looks at genetic markers and immune system patterns in people with PFAPA (periodic fevers with mouth sores and throat/neck gland symptoms) or similar tonsil problems. It may help researchers understand why these conditions happen and how they might be better diagnosed or treated.
Washington D.C., District of ColumbiaAges 1 month–99 years - NCT05664373Recruiting
Gum recession repair using tissue flap and graft
This trial studies a gum surgery technique to cover multiple areas where the gum has pulled back from the tooth root. It may help improve gum coverage and reduce sensitivity by restoring gum tissue where it is missing.
BelgradeAges 18–60 - NCT05674305RecruitingPhase 3
Tested radiation alone vs added chemotherapy for EBV-negative after treatment
This Phase 3 trial compares giving radiation alone versus giving radiation at the same time as chemotherapy for nasopharyngeal cancer. It focuses on people whose EBV test becomes undetectable after one cycle of chemotherapy, to see which approach works best and is safest.
Shanghai, Shanghai MunicipalityAges 18–70 - NCT05677243Recruiting
Observational study of radiosurgery for trigeminal neuralgia pain
This study follows people with trigeminal neuralgia to see how radiosurgery treatment affects their facial pain. It may help doctors better understand who benefits when medicines do not control the pain enough.
MonacoAges 18 years+ - NCT05683405Recruiting
Non-surgical treatment study for peri-implantitis
This trial looks at a non-surgical dental treatment approach for people who have peri-implantitis, an inflammation around a dental implant. It may help improve the health of the gum and supporting tissue around the implant without surgery.
Tromsø, TromsAges 18–85 - NCT05684510Recruiting
Clear aligners vs braces for mild overbite in adults
This trial compares clear plastic aligners with fixed braces to improve mild overbite (Class II) in adults who have not had orthodontics before. It may help you understand which option works better for your bite and alignment while also checking fit and dental health needs.
Hama, Hama GovernorateAges 15–20
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 2,058 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,961 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
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- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.