Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 1,962 recruiting studies in this area right now.
By phase
- Not applicable1,543
- Phase 2144
- Phase 385
- Phase 182
- Phase 460
- Phase 1/Phase 235
- Phase 2/Phase 313
Top conditions
- Periodontitis103
- Nasopharyngeal Carcinoma74
- Periodontal Diseases50
- Dental Caries46
- Gingivitis35
- Head and Neck Cancer35
- Oral Cancer32
- Periodontal Disease29
- Dental Implant28
- Gingival Recession25
- Alveolar Bone Loss24
- Nasopharyngeal Carcinoma (NPC)24
- Sjogren's Syndrome24
- Tooth Loss24
- Temporomandibular Disorders (TMD)22
- Oropharynx Cancer21
- Peri-Implantitis21
- Temporomandibular Joint Disorders20
Leading sponsors
- Cairo University77
- Sun Yat-sen University50
- Mansoura University25
- Ain Shams University24
- Postgraduate Institute of Dental Sciences Rohtak24
- Tanta University24
- Al-Azhar University23
- Universidad Complutense de Madrid16
- University of Baghdad16
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California44
- Texas26
- Florida21
- Maryland21
- Massachusetts21
- New York19
- Pennsylvania19
- Ohio18
- Alabama17
- Michigan15
Recruiting studies1,962 total
- NCT07306026Recruiting
Testing a toothbrush's bristles on plaque and gums
This trial compares how well different toothbrush bristles remove plaque and affect gum health. It may help find the best toothbrush design for everyday oral care.
Buffalo, New YorkAges 18–70 - NCT07303023RecruitingPhase 3
Personalized neck radiation to prevent cancer spread
This trial tests whether a personalized radiation plan for the neck can prevent cancer from spreading in people with nasopharyngeal carcinoma. It's for those whose cancer hasn't spread beyond the head and neck area.
Shanghai, Shanghai MunicipalityAges 18–70 - NCT06238076Recruiting
Universal surgical device for jaw reconstruction
This trial tests a universal surgical device for rebuilding the lower jaw using a bone flap from the leg. It aims to make the procedure more reliable and easier for patients needing reconstruction of the front part of the jaw.
ToulouseAges 18 years+ - NCT07293962RecruitingPhase 2
Liquid S-PRF for gum disease treatment
This study tests whether a special liquid made from your own blood (called liquid S-PRF) can improve gum health during deep cleaning for people with advanced gum disease. It lasts 3 months and may help reduce inflammation and promote healing without surgery.
Jenjarum, SelangorAges 18–65 - NCT07290621RecruitingPhase 2
Toripalimab with standard treatment for HPV-positive throat cancer
This study tests adding a new immunotherapy drug (toripalimab) to standard chemo for HPV-positive throat cancer. It aims to see if this combination works better than chemo alone for patients whose cancer has spread to nodes but not to other parts of the body.
Chicago, IllinoisAges 18 years+ - NCT07292870Recruiting
Biological treatments for deep gum bone defects
This trial tests whether biological agents can help heal deep gum bone defects that remain after standard non-surgical cleaning. It may be an option for people who still have deep pockets around their teeth and need a minimally invasive surgical procedure.
Leuven, Vlaams BrabantAges 18 years+ - NCT07294820Recruiting
Digital workflow for same-day implants
This trial tests a fully digital method for placing a single implant and attaching a temporary tooth right after extraction. It may help you avoid multiple visits and get a new tooth faster.
Turin, PiedmontAges 18 years+ - NCT07295197Recruiting
Oral signs for early eating disorder screening
This study looks at signs in your mouth that might help detect eating disorders early. Dentists will examine your teeth, gums, and oral tissues to see if they can spot clues that could lead to faster diagnosis and care.
BolognaAges 18–40 - NCT07288411Recruiting
Vagus nerve stimulation for temporomandibular joint disorders
This study tests if a gentle device that stimulates a nerve in your neck (the vagus nerve) can reduce jaw pain and improve how your jaw moves. It could offer a new, non-drug option for people with TMJ disorders.
Los Angeles, CaliforniaAges 18–50 - NCT07291336RecruitingPhase 4
Comparing two ways to place dental implants
This trial compares two methods for placing dental implants in the upper jaw: dynamic navigation (real-time guidance) versus static navigation (using a surgical guide). It aims to see which technique is more accurate for people missing one tooth between the right and left second premolars.
CairoAges 22–60 - NCT07288853Recruiting
Can a smartphone app help teens with braces keep cleaner teeth?
This trial tests whether a smartphone app with reminders can help teenagers with braces keep their teeth and gums cleaner. If you're getting braces and have a smartphone, you might be eligible.
Kuantan, PahangAges 12–18 - NCT07293013Recruiting
Olive oil mouthwash for mouth sores during cancer treatment
This study tests whether using an olive oil mouthwash can help prevent or reduce mouth sores caused by radiation and chemotherapy for head and neck cancer. If you are starting treatment, you may be able to join and receive the mouthwash to see if it helps keep your mouth healthier.
Chiayi City, Chia-Yi CityAges 20 years+ - NCT07290725Enrolling by invitation
Translating a dental tool for special needs patients
This study is testing a translation of a tool used by dentists for patients with special needs. Dentists who speak German, Spanish, or Portuguese as their first language will fill out the form twice to help make sure it works well in their language.
Vienna, State of ViennaAges Any age - NCT07296965Recruiting
Oral bacteria in carotid artery plaque study
This study looks at the bacteria living in your mouth and whether they are linked to plaque buildup in the carotid artery (the main artery in your neck). If you are already scheduled for surgery to remove that plaque, the researchers will take samples from your mouth and the plaque to compare them.
BudapestAges 18 years+ - NCT07289932Enrolling by invitation
Peptide vs fluoride varnish for white spots on teeth
This study compares a new peptide treatment to a standard fluoride varnish for reversing small white spots on teeth (early cavities) in teens and young adults. You’ll receive one treatment on one side of your mouth and the other treatment on the other side, and we’ll see which works better.
CairoAges 15–25 - NCT07293481Recruiting
Finding markers for gum disease diagnosis
This study looks for new markers in the body that could help diagnose gum disease. It's for adults with mild gum problems who haven't had recent dental treatment or antibiotics.
Shanghai, Shanghai MunicipalityAges 18–40 - NCT07296250Recruiting
Tracking cancer cells after chemoradiation for oral cancer
This trial studies whether detecting circulating tumor cells in the blood after chemoradiation can help predict outcomes for people with oral cancer that has spread to lymph nodes. It may help doctors better monitor the disease.
Taoyuan CityAges 1.5 years–90 years - NCT07290790Recruiting
Trimline Aligner Accuracy Study
This trial tests SureSmile clear aligners to see how accurately they fix common bite problems like crowding, spacing, and overbite. You may be able to join if you need mild to moderate orthodontic treatment.
Fresno, CaliforniaAges 18 years+ - NCT06882564RecruitingPhase 3
Resveratrol mouthwash for bad breath study
This trial tests whether a special mouthwash with resveratrol (a natural plant compound) can help reduce bad breath caused by gum-related bacteria. It might be a good option if you have bad breath from gingivitis (mild gum inflammation) and are a non-smoking dental student.
Baghdad, Bab Al-MoadhamAges 20–24 - NCT05979805Recruiting
Education programs to prevent cavities and gum problems during braces
This study compares two types of education programs to see which better prevents cavities and gum inflammation in people getting braces. Participants must be new to orthodontic treatment and have healthy teeth and gums at the start.
BogotáAges 13–28 - NCT07281456RecruitingPhase 2
Testing a new oral drug for Sjögren's disease safety
This study tests the safety of a daily pill called Tofacitinib for adults with mild-to-moderate Sjögren's disease. It aims to see if this drug helps manage symptoms when other treatments haven't worked well.
Bethesda, MarylandAges 18–75 - NCT07284797RecruitingPhase 1
Safety study for autoimmune disease and healthy volunteers
This trial is testing an experimental drug for safety in people with certain autoimmune diseases—like myositis, scleroderma, or Sjögren's disease—as well as in healthy volunteers. It aims to find out if the drug is safe enough to study further.
MelbourneAges 18–75 - NCT06884787Recruiting
New tooth-colored filling for front teeth: how well does it work?
This trial is testing a modern tooth-colored filling material for fixing cavities or gaps in front teeth. It looks at how well the filling performs and how satisfied patients are. You might be eligible if you need fillings in at least two front teeth and have generally healthy teeth and gums.
IrbidAges 18 years+ - NCT07279883Recruiting
Nerve block for pain after cleft palate surgery in children
This study looks back at the medical records of children who had cleft palate surgery in 2017 or 2018. It compares how long they stayed in the hospital and their pain needs after surgery, between those who got standard pain medicine alone and those who also got a nerve block to help with pain.
StockholmAges 3 months–15 years
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 1,962 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,756 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.