Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 2,058 recruiting studies in this area right now.
By phase
- Not applicable1,634
- Phase 2148
- Phase 183
- Phase 382
- Phase 459
- Phase 1/Phase 236
- Phase 2/Phase 316
Top conditions
- Periodontitis108
- Nasopharyngeal Carcinoma80
- Periodontal Diseases57
- Dental Caries49
- Gingivitis35
- Oral Cancer35
- Head and Neck Cancer34
- Dental Implant30
- Sjogren's Syndrome29
- Gingival Recession27
- Periodontal Disease27
- Nasopharyngeal Carcinoma (NPC)24
- Alveolar Bone Loss23
- Peri-Implantitis23
- Tooth Loss22
- Oropharynx Cancer21
- Temporomandibular Disorders (TMD)21
- Trigeminal Neuralgia21
Leading sponsors
- Cairo University91
- Sun Yat-sen University53
- Ain Shams University30
- Mansoura University30
- Postgraduate Institute of Dental Sciences Rohtak24
- Al-Azhar University23
- Tanta University23
- University of Baghdad19
- Universidad Complutense de Madrid18
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California40
- Texas27
- Massachusetts22
- Ohio22
- Pennsylvania22
- New York20
- Maryland19
- Florida18
- Alabama16
- Michigan15
Recruiting studies2,058 total
- NCT05686226RecruitingPhase 2
Trial tests immune cells targeting HPV-16 cancers
This Phase 2 trial tests an immune-cell treatment (E7 TCR T cells) designed to attack cancers caused by HPV type 16. It may help people whose HPV-16+ cancer has come back or not responded to standard treatment.
Bethesda, MarylandAges 18 years+ - NCT05688982Recruiting
Check oral health needs and local care resources in the ER
This study asks people in the emergency department (and their parents/guardians) about oral health needs and what local resources they can access. It aims to map gaps in dental and oral health support so future care can be better targeted.
Boston, MassachusettsAges 1 year+ - NCT05707819Recruiting
Sintilimab plus chemoradiotherapy for high-risk nasopharyngeal cancer
This trial tests whether adding sintilimab (an immune treatment) to standard chemoradiotherapy can improve outcomes for people with high-risk, locally advanced nasopharyngeal (throat) cancer. It may help your immune system work better against the cancer alongside radiation and chemotherapy.
Nanning, GuangxiAges 18–70 - NCT05710952Recruiting
Orthodontic braces study and how they affect jaw joints
This study looks at whether multi-attachment orthodontic treatment (either on the front or back of teeth) changes the temporomandibular joint, which is the jaw joint. The researchers will assess your jaw joint using a tool called Modjaw.
MontpellierAges 18 years+ - NCT05717985Recruiting
Gum tissue grafts using two modified surgical methods
This trial compares two ways of taking donor tissue from the roof of the mouth to rebuild gum/soft tissue. It may help people who need a gum tissue graft to improve the health and appearance of the oral area.
Kuala LumpurAges 18 years+ - NCT05717790Recruiting
Nimotuzumab with chemo and radiation for advanced nose cancer
This trial tests whether adding nimotuzumab (an anti-EGFR antibody) to standard chemotherapy and radiation can improve outcomes for people with advanced nasopharyngeal carcinoma. It may help the cancer respond better and control it more effectively after treatment.
Baise City, GuangxiAges 18–70 - NCT05719779Recruiting
Oral device trial for snoring and sleep apnea in throat cancer
This trial tests whether a custom mouth (mandibular advanced) device can reduce snoring and breathing pauses during sleep in people with oropharyngeal (throat) cancer. It also looks at how well you tolerate the device and whether it helps with sleep symptoms.
Montreal, QuebecAges 18–65 - NCT05721781Recruiting
Reducing infection risk after gum and tooth issues
This study looks at ways to lower the risk of infective endocarditis, a serious heart infection that can happen after certain bacteria enter the bloodstream from the mouth. You may be asked to pause routine dental cleanings for a period while they track dental health and infection risk.
Boston, MassachusettsAges 18 years+ - NCT05738096RecruitingEarly Phase 1
Testing nerve recordings to improve facial pain rhizotomy
This study looks at special nerve testing (nerve recordings) in adults who are scheduled for a procedure called percutaneous rhizotomy for facial pain. The goal is to see whether these recordings can help improve how the procedure works and affects pain.
Minneapolis, MinnesotaAges 18 years+ - NCT05740033Recruiting
Closing the radial forearm donor site after mouth surgery
This study looks at how best to close the skin area on the forearm after surgeons take tissue to rebuild part of the mouth. If you need a radial forearm tissue reconstruction, you may be asked about outcomes afterward using English questionnaires.
Vancouver, British ColumbiaAges 18 years+ - NCT05754190Recruiting
Smartphone study of mood and symptoms in people with pain
This study uses a smartphone app to track daily pain and mood changes over about 4 months. It’s meant to learn patterns that could help better understand how mood and pain affect each other.
Providence, Rhode IslandAges 18 years+ - NCT05757817Recruiting
New flap surgery for mouth or throat cancer reconstruction
This trial studies whether a new surgical reconstruction method can improve outcomes for people with oral cavity or oropharyngeal squamous cell carcinoma (a type of head and neck cancer). The goal is to rebuild the area using a tissue flap while reducing problems where the tissue is taken from.
MontpellierAges 18 years+ - NCT05759780Recruiting
Check how an eye probe measures tissue softness
This study uses a special eye/skin/gum imaging test to measure how tissues behave. It may help researchers improve noninvasive ways to understand eye and tissue health, and in some parts of the study, mild keratoconus.
Boston, MassachusettsAges 18–75 - NCT05761197Recruiting
Study of mouth yeast infection and a preventive treatment
This trial studies children ages 9–15 months and looks at oropharyngeal yeast infection in the mouth (often called “OPC”). It may help researchers understand how to prevent or manage this condition.
Philadelphia, PennsylvaniaAges 9 months–1.3 years - NCT05765162Recruiting
Research study on safer, more tailored anesthesia
This study looks at safer anesthesia—meaning medicines used during procedures—using a more personalized approach. It may help make anesthesia safer for adults having medical procedures.
Nykøbing FalsterAges 18–100 - NCT05767047RecruitingPhase 3
Apremilast study for children with mouth ulcers from Behçet’s
This trial studies whether apremilast can help reduce mouth ulcers in children who have Behçet’s disease or juvenile psoriatic arthritis. You may be considered if your child finished a main study and is under 18, and can safely continue treatment.
ThessalonikiAges 5–18 - NCT05772208RecruitingPhase 3
New treatment plan for nasopharyngeal cancer after EBV DNA stays detectable
This Phase 3 trial tests a stronger treatment approach for people with locally advanced nasopharyngeal cancer whose EBV “DNA” (a cancer-related virus signal in blood) does not go away after one cycle of chemotherapy. It may help improve outcomes by changing treatment based on how the cancer responds early.
Shanghai, Shanghai MunicipalityAges 18–70 - NCT05774483Recruiting
Check nodes in early mouth cancer using a biopsy or planned neck surgery
This trial studies two ways to check whether early oral cavity cancer has spread to nearby neck lymph nodes. It compares sentinel node biopsy versus limited elective neck dissection to see which approach is more useful for people with node-negative tongue or inner-cheek cancers.
Mumbai, MaharashtraAges 18–80 - NCT05774561Recruiting
Using blood tests to monitor HPV-related cancer treatment
This study checks whether “liquid biopsies” (blood tests that look for cancer-related signals) can help monitor how HPV-related cancers respond to treatment. It may help doctors spot changes earlier during care.
OlomoucAges 18–99 - NCT05775679Recruiting
CLEFT-Q survey study for people with cleft lip or palate
This study tests how consistently and clearly a questionnaire (CLEFT-Q) measures your symptoms and how well treatment helps. It may help researchers improve care for people who need a planned second surgery for the nose, lips, jaw, or speech.
Malmö, Skåne CountyAges 8–29 - NCT05786716RecruitingPhase 2/Phase 3
Trastuzumab plus pertuzumab for HER2-mutated cancers
This trial tests whether combining trastuzumab and pertuzumab can treat cancers that have HER2 amplification or an activating HER2 mutation. It looks at people ages 12 and older, and may include both children/teens and adults, using the study drug based on their HER2 test results.
BelfastAges 12 years+ - NCT05793151Recruiting
Guided care to start cancer treatment on time after surgery
This trial tests a navigation program (help from a care coordinator) versus usual care to help people start the recommended “next-step” treatments (like radiation, sometimes with chemo) on time after surgery. It’s for certain stages of squamous cell cancer in the head and neck area where late treatment could matter.
St Louis, MissouriAges 18 years+ - NCT05800574RecruitingPhase 2
Targeted neck radiation for p16-positive favorable throat cancer
This Phase 2 study tests whether a more precisely targeted radiation plan to the neck can work for people with p16-positive oropharynx cancer that is considered “favorable risk.” Doctors use special imaging to map where lymph nodes are likely involved, aiming to treat the right areas while avoiding unnecessary treatment.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05806398Recruiting
Sealant test for molars with enamel defects in children
This study tests whether a glass ionomer sealant can protect molars with molar-incisor hypomineralization (MIH), a type of enamel weakness, by sealing the biting surface. It may help reduce damage in affected teeth when children still have healthy surfaces that can be sealed.
TriesteAges 6–10
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 2,058 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,961 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.