Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 2,058 recruiting studies in this area right now.
By phase
- Not applicable1,634
- Phase 2148
- Phase 183
- Phase 382
- Phase 459
- Phase 1/Phase 236
- Phase 2/Phase 316
Top conditions
- Periodontitis108
- Nasopharyngeal Carcinoma80
- Periodontal Diseases57
- Dental Caries49
- Gingivitis35
- Oral Cancer35
- Head and Neck Cancer34
- Dental Implant30
- Sjogren's Syndrome29
- Gingival Recession27
- Periodontal Disease27
- Nasopharyngeal Carcinoma (NPC)24
- Alveolar Bone Loss23
- Peri-Implantitis23
- Tooth Loss22
- Oropharynx Cancer21
- Temporomandibular Disorders (TMD)21
- Trigeminal Neuralgia21
Leading sponsors
- Cairo University91
- Sun Yat-sen University53
- Ain Shams University30
- Mansoura University30
- Postgraduate Institute of Dental Sciences Rohtak24
- Al-Azhar University23
- Tanta University23
- University of Baghdad19
- Universidad Complutense de Madrid18
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California40
- Texas27
- Massachusetts22
- Ohio22
- Pennsylvania22
- New York20
- Maryland19
- Florida18
- Alabama16
- Michigan15
Recruiting studies2,058 total
- NCT06356272Recruiting
Oropharynx cancer biomarker study
This study looks at certain markers (called p16 and HPV) in tumor samples to better understand oropharynx cancer. It may help doctors learn more about the disease and guide future treatments.
Rochester, MinnesotaAges 18 years+ - NCT06357260Recruiting
Adding pregabalin to carbamazepine for trigeminal neuralgia
This trial tests whether adding pregabalin to your usual carbamazepine treatment can better control trigeminal neuralgia pain. It is for people with classic trigeminal neuralgia who want to see if a combination of medicines can help.
Rohtak, HaryanaAges 25–80 - NCT06357702Recruiting
Physical Self-Regulation vs Placebo for Chronic Jaw Pain
This study tests whether a physical self-regulation treatment (like relaxation or biofeedback) can help reduce chronic jaw muscle pain. It compares the treatment to a placebo (inactive) version to see if it works better.
Lexington, KentuckyAges 18 years+ - NCT06365151Recruiting
Jaw pain treatment in fibromyalgia
This study tests a gentle hands-on treatment (osteopathic manual therapy) for jaw pain or problems in people with fibromyalgia. The goal is to see if this approach can help ease jaw discomfort and improve function.
Cornellà de Llobregat, BarcelonaAges 18–75 - NCT06364982Recruiting
Distance Between Implants and Gum Disease Risk
This study looks at whether the spacing between dental implants can affect the risk of disease around them. If you have two or more implants next to each other that have been working for at least 3 years, this trial may help understand how to keep your implants healthy.
Sant Cugat del Vallès, BarcelonaAges 18 years+ - NCT06365281Recruiting
Cavity risk study for adults 35–44 years old
This study looks at how common cavities are and what factors might increase the risk of them in people ages 35–44. By joining, you'll help researchers learn more about oral health in this age group among Egyptians.
GizaAges 35–44 - NCT06379646Recruiting
YTS109 cell therapy for autoimmune disease
This study tests a new cell therapy (YTS109) for people with autoimmune diseases like lupus or Sjogren's syndrome that have not improved or keep coming back after standard treatments. It aims to see if the treatment can help control the disease.
Shanghai, Shanghai MunicipalityAges 18–65 - NCT06381505Recruiting
Retractor study for mouth and throat cancer surgery
This trial tests a new tool, called a retractor, that helps doctors see and reach tumors in the mouth, throat, or voice box during surgery. It's for people with suspected or confirmed cancer in these areas who are having a scope exam at Dartmouth Hitchcock Medical Center.
Lebanon, New HampshireAges 18 years+ - NCT06381713Recruiting
Speech therapy for children with cleft palate
This study compares two types of speech therapy for children with cleft palate. It looks at how well each type works and how much it costs, to help find the best way to improve your child's speech.
GhentAges 4–12 - NCT06383780RecruitingPhase 3
Tislelizumab plus chemo for nasopharyngeal cancer with bone spread
This trial tests a combination of the immunotherapy drug tislelizumab with chemotherapy for people whose nasopharyngeal cancer has spread to the bones. It may be an option if you have not had prior treatment for advanced disease.
Guangzhou, GuangdongAges 18 years+ - NCT06389201Recruiting
Hydroxychloroquine before radiation and chemo for NPC
This trial tests whether taking hydroxychloroquine (HCQ) before standard radiation and chemo can help treat advanced nasopharyngeal cancer. It is for patients who have not yet started any cancer therapy.
Nantong, JiangsuAges 20–70 - NCT06392711RecruitingPhase 1
Stem cell therapy for dry mouth not from radiation
This trial tests a new treatment using special cells (mesenchymal stromal cells) from your own bone marrow to help with dry mouth that is not caused by radiation. The goal is to see if it can increase saliva production and improve quality of life.
Madison, WisconsinAges 18–90 - NCT06394440Recruiting
Comparing two tooth-colored fillings for side cavities
This study compares two types of tooth-colored fillings for cavities on the side of teeth near the gum line. It aims to see if a newer, easier-to-place filling material works as well as the traditional one.
CairoAges 18–60 - NCT06401811Recruiting
Turkish swallowing questionnaire study for Sjögren's syndrome
This study tests a Turkish version of a swallowing questionnaire (EAT-10) to see if it is reliable and accurate for people with primary Sjögren's syndrome. Taking part could help doctors better understand and track swallowing problems in this condition.
AnkaraAges 18 years+ - NCT06408337RecruitingPhase 1/Phase 2
Biocleft for cleft palate repair in children
This trial tests a new treatment called BIOCLEFT, made from your child's own cheek cells, to help repair a complete cleft palate on one side. It aims to see if the treatment is safe and works better than standard surgery.
Granada, Spain/GranadaAges 10 months–1.2 years - NCT06409468Recruiting
New matrix for gum recession coverage
This trial tests a new material called NovoMatrix to cover exposed tooth roots caused by receding gums. It may help if you have gum recession and want to avoid taking tissue from your own palate.
BudapestAges 20–70 - NCT06410833RecruitingPhase 4
Combination therapy for resistant Sjögren's in children
This trial tests a combination of two medicines, rituximab then belimumab, for children and teens with Sjögren's syndrome that hasn't improved with other treatments. The goal is to see if this two-step approach can better control symptoms like joint pain, skin rashes, and blood problems.
Beijing, Beijing MunicipalityAges 5–18 - NCT06417502Recruiting
China pediatric rheumatic disease registry study
This study collects information from children with rheumatic and immune system diseases in China to better understand these conditions. By participating, you help researchers learn more about how to diagnose and treat these diseases.
Beijing, Beijing MunicipalityAges Up to 18 years - NCT06428188RecruitingPhase 1/Phase 2
CAR-T cells targeting BCMA/CD19 for autoimmune diseases
This trial tests a new treatment called CAR-T cells that target two proteins (BCMA and CD19) on immune cells. It is for people with certain autoimmune diseases that have not improved with standard treatments.
Beijing, Beijing MunicipalityAges 21–90 - NCT06428149Recruiting
Comparing gum surgery techniques for deep pockets
This study looks at three different ways to make cuts in the gums during surgery for deep pockets caused by gum disease. It aims to find which technique helps heal better and save more bone.
Murcia, MurciaAges 18–80 - NCT06435208Recruiting
Gum cleaning for mental health in teeth grinders with gum disease
This study tests whether a deep gum cleaning procedure (subgingival instrumentation) can reduce stress and improve mental health in people who grind their teeth and have gum disease. It aims to see if treating the gums can also help with psychological distress.
Rohtak, HaryanaAges 30–50 - NCT06438627RecruitingPhase 3
New triple therapy vs standard for advanced nasopharyngeal cancer
This trial tests a new combination of three drugs (TPC, apatinib, and camrelizumab) against the standard two-drug regimen (GP plus camrelizumab) for people with high-risk nasopharyngeal carcinoma that has spread to neck lymph nodes. The goal is to see if the three-drug combination works better and is safe.
Guangzhou, GuangdongAges 18–65 - NCT06444776Recruiting
Taste and saliva changes during radiotherapy for head & neck cancer
This study looks at how radiation therapy for head and neck cancer changes your sense of taste and saliva. It aims to better understand and manage these side effects.
Aarau, Canton of AargauAges 18 years+ - NCT06445088Recruiting
Testing a new EBV DNA test for nasopharyngeal cancer
This trial is testing a new way to diagnose nasopharyngeal cancer using a special test that looks at a change in the EBV virus DNA. It is for people who may have symptoms of this cancer or have tested positive for EBV, but have not yet been treated.
Fuzhou, FujianAges Any age
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 2,058 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,961 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.