Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 1,962 recruiting studies in this area right now.
By phase
- Not applicable1,543
- Phase 2144
- Phase 385
- Phase 182
- Phase 460
- Phase 1/Phase 235
- Phase 2/Phase 313
Top conditions
- Periodontitis103
- Nasopharyngeal Carcinoma74
- Periodontal Diseases50
- Dental Caries46
- Gingivitis35
- Head and Neck Cancer35
- Oral Cancer32
- Periodontal Disease29
- Dental Implant28
- Gingival Recession25
- Alveolar Bone Loss24
- Nasopharyngeal Carcinoma (NPC)24
- Sjogren's Syndrome24
- Tooth Loss24
- Temporomandibular Disorders (TMD)22
- Oropharynx Cancer21
- Peri-Implantitis21
- Temporomandibular Joint Disorders20
Leading sponsors
- Cairo University77
- Sun Yat-sen University50
- Mansoura University25
- Ain Shams University24
- Postgraduate Institute of Dental Sciences Rohtak24
- Tanta University24
- Al-Azhar University23
- Universidad Complutense de Madrid16
- University of Baghdad16
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California44
- Texas26
- Florida21
- Maryland21
- Massachusetts21
- New York19
- Pennsylvania19
- Ohio18
- Alabama17
- Michigan15
Recruiting studies1,962 total
- NCT07166224Recruiting
Home treatments for gum disease in older adults with memory issues
This trial tests two simple ways to improve gum health at home: using a special light-activated antibacterial rinse or using a powered toothbrush. It's for older adults who have gum disease and mild memory problems, and aims to see if these easy routines can help keep gums healthier.
Karlskrona, Blekinge CountyAges 60 years+ - NCT07166679Recruiting
Larger root canal tip for healing infection in back molars
This study tests whether making the tip of the root canal slightly larger during a single root canal treatment helps the infection heal better and reduces pain afterward. It is for people with a dead lower back molar that has an infection around the root tip.
RohtakAges 18–65 - NCT07171151Recruiting
Cyst fluid study for disease markers
This trial looks at fluid from cysts to find markers that might show disease. If you have a cyst and are not pregnant or breastfeeding, you may be able to join.
SanliurfaAges 12–80 - NCT07156227RecruitingPhase 1
Testing camonsertib with radiation for returning head and neck cancer
This study tests whether adding the drug camonsertib to radiation therapy can help people whose head and neck cancer has come back in a spot that was already treated with radiation. Camonsertib is an experimental drug that may help radiation work better.
Duarte, CaliforniaAges 18 years+ - NCT07156695Recruiting
Deep filling study for tooth decay and gum health
This trial tests a technique called deep marginal elevation for fixing deep cavities near the gumline. It aims to see if this method affects your gum health compared to a healthy tooth on the other side.
Tanta, El-GharbiaAges 18–60 - NCT07160660Enrolling by invitation
Comparing two types of partial denture anchors
This study looks at how patients feel about two ways to hold a removable partial denture in place: one uses small sticky attachments called 'extracoronal adhesive attachments' and the other uses clips called 'clasps'. It aims to see which patients prefer and how well each works over time.
Basel, BaselAges 18 years+ - NCT07158528Recruiting
Gum grafting study for multiple receding gums in upper jaw
This study compares two gum grafting techniques (CAF and TCAF) to see which one works better for treating multiple receding gums in the upper jaw. It may help if you have gum recession and want a treatment to cover the exposed roots.
Ghent, Oost-VlaanderenAges 18 years+ - NCT07155798Recruiting
Bamboo vs. plastic toothbrush for plaque removal in teens
This trial compares a bamboo toothbrush to a regular plastic toothbrush to see which one does a better job removing plaque. If you are a teenager in good health, you can help find out which brush is better for your teeth and the planet.
CairoAges 12–18 - NCT07158541Recruiting
Comparing Two Gum Treatments for Lower Front Recession
This study compares two techniques (TCAF and MTUN) for treating a single gum recession in the lower front part of the mouth. It will help determine which method works best for healing and appearance.
Ghent, Oost-VlaanderenAges 18 years+ - NCT07155343RecruitingEarly Phase 1
Comparing two types of glue for braces in teens and adults
This early-phase trial tests if a newer, faster-setting glue (bulk-fill composite) works as well as the standard glue for attaching braces. It's for people aged 13 to 40 who are starting or continuing fixed braces treatment.
Karachi, SindhAges 13–40 - NCT07157410Recruiting
Tooth-colored onlays for cavities below the gum line
This trial tests a tooth-colored filling (onlay) for back teeth with cavities that go below the gum line. It is designed for people whose tooth is weakened but still healthy enough to avoid more serious treatments like root canals.
Al Mansurah, Dakahlia GovernorateAges 20–50 - NCT06957652Recruiting
Surgery for advanced gum disease around dental implants
This study tests a surgical technique to repair bone damage around dental implants caused by severe gum disease (peri-implantitis). It is designed for people with specific types of bone defects and healthy gums elsewhere in the mouth.
Ankara, TurkeyAges 18–75 - NCT07153276RecruitingPhase 4
Laser vs estrogen cream for vaginal dryness in Sjögren's
This trial compares two treatments for vaginal dryness in women with Sjögren's disease: a CO2 laser procedure versus a topical estrogen cream called promestriene. The goal is to see which option works better to relieve dryness and discomfort.
São Paulo, São PauloAges 30–65 - NCT07154693Recruiting
Bone graft after tooth extraction to prepare for implant
This study tests a bone graft material (OsteoGen®) placed in the tooth socket after extraction to help the bone heal and get ready for a dental implant. It may be right for you if you need a single tooth pulled and plan to get an implant.
San Antonio, TexasAges 18–89 - NCT07146776Recruiting
Injectable PRF and bone graft for gum disease bone defects
This trial tests a treatment for deep gum disease pockets using a combination of your own blood components (injectable platelet-rich fibrin) and a bone graft material. It aims to help regenerate bone lost to periodontitis.
Istanbul, ÜsküdarAges 18–65 - NCT07146464Recruiting
Peptide vs calcium paste for early cavity spots
This trial tests whether a new peptide treatment or a calcium-phosphate paste works better at reversing early white-spot cavities on front teeth. If you're a young adult with early decay on your front teeth, you may be able to join.
Cairo, Cairo GovernorateAges 15–25 - NCT05970965Recruiting
Teeth and gum study in children with Down syndrome
This study looks at how gums and inflammation work in children with Down syndrome by collecting and analyzing biological samples. It may help researchers understand gum health differences and improve future care.
Ivry-sur-SeineAges 3–12 - NCT06958874Recruiting
Erythritol for gum pocket healing
This study tests if adding erythritol to standard gum treatment helps close deep gum pockets in people with advanced gum disease (periodontitis).
L’AquilaAges 35 years+ - NCT07136155Enrolling by invitation
Two ways to treat deep cavities in baby teeth
This study compares two ways to treat deep cavities in baby (primary) molars. One method places a special soothing medicine under a filling; the other uses a metal crown that covers the whole tooth. Both aim to keep the tooth healthy without needing a nerve treatment or extraction.
IrbidAges 4–9 - NCT07142629Enrolling by invitation
Cavity removal methods for MIH-affected molars
This trial compares two ways of removing tooth decay in children with a condition called MIH (which makes enamel weak and spotted). It tests whether selective or non-selective drilling works better for deep cavities, aiming to save the tooth and keep the nerve healthy.
IrbidAges 6–13 - NCT07137533Recruiting
Comparing two tooth replacement methods for lower jaw with PEEK framework
This study compares two ways to replace all missing teeth in the lower jaw using a special plastic framework called PEEK. One method uses four implants that support a removable overdenture, the other uses a fixed all-on-4 bridge. The goal is to see which lasts better over 4 years.
Shibīn al Kawm, MenoufiaAges 40–70 - NCT07140146Recruiting
Trehalose vs Glycine air-polishing for gum disease around implants
This trial compares two types of air-polishing powder (trehalose and glycine) to treat gum inflammation around dental implants. It aims to see which is better at cleaning the gum line without damaging implant surfaces.
Pavia, LombardyAges 18–70 - NCT07141459Recruiting
Laser disinfection for failed root canal treatment
This trial tests if using a special laser (810 nm diode) to disinfect the tooth after a second root canal treatment can reduce pain and inflammation. It aims to help patients whose previous root canal failed and who have a small infection around the tooth root.
CairoAges 20–40 - NCT07141758Recruiting
Saliva tests for recurrent mouth ulcers
This study looks at certain proteins in saliva to better understand recurrent aphthous stomatitis (common mouth ulcers). If you have frequent mouth ulcers, you might help researchers learn more about the condition.
Aydin, EfelerAges 18 years+
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 1,962 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,756 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.