Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 2,058 recruiting studies in this area right now.
By phase
- Not applicable1,634
- Phase 2148
- Phase 183
- Phase 382
- Phase 459
- Phase 1/Phase 236
- Phase 2/Phase 316
Top conditions
- Periodontitis108
- Nasopharyngeal Carcinoma80
- Periodontal Diseases57
- Dental Caries49
- Gingivitis35
- Oral Cancer35
- Head and Neck Cancer34
- Dental Implant30
- Sjogren's Syndrome29
- Gingival Recession27
- Periodontal Disease27
- Nasopharyngeal Carcinoma (NPC)24
- Alveolar Bone Loss23
- Peri-Implantitis23
- Tooth Loss22
- Oropharynx Cancer21
- Temporomandibular Disorders (TMD)21
- Trigeminal Neuralgia21
Leading sponsors
- Cairo University91
- Sun Yat-sen University53
- Ain Shams University30
- Mansoura University30
- Postgraduate Institute of Dental Sciences Rohtak24
- Al-Azhar University23
- Tanta University23
- University of Baghdad19
- Universidad Complutense de Madrid18
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California40
- Texas27
- Massachusetts22
- Ohio22
- Pennsylvania22
- New York20
- Maryland19
- Florida18
- Alabama16
- Michigan15
Recruiting studies2,058 total
- NCT06550050Recruiting
Study of Mouth Precancer and Cancer Features
This study looks at tissue and blood samples from people with mouth conditions that could become cancer or are already cancer. It aims to learn more about these conditions to improve diagnosis and treatment.
Houston, TexasAges 18 years+ - NCT06553677Recruiting
Comparing two gum repair surgeries for receding gums
This study compares two surgical techniques to cover exposed tooth roots caused by receding gums. The goal is to see which method works better and helps your gums heal.
CairoAges 18 years+ - NCT06553950Recruiting
Splint vs botox for jaw and neck pain
This trial compares a custom jaw splint with botox injections to see which better reduces neck muscle tension in people with jaw joint problems. It's for patients who have a displaced jaw disc that still clicks or pops and also have neck muscle spasms.
CairoAges 18–40 - NCT06554041Recruiting
How gum tissue reacts to different dental crown materials
This study compares how different dental crown materials affect your gums around dental implants. It may help you if you have several missing teeth and already have healed implants in good bone.
VilniusAges 18 years+ - NCT06554158Recruiting
Lowering radiation for low-risk HPV throat cancer patients
This trial tests whether giving less radiation after surgery is safe and effective for people with early-stage HPV-related throat cancer. It aims to reduce side effects while still controlling the cancer.
Washington D.C., District of ColumbiaAges 18 years+ - NCT06554366Recruiting
Comparing two cleaning systems for root canals on dead-nerve molars
This study compares two different cleaning methods (GentleWave and EdgePro) used during root canal treatment on lower back teeth where the nerve has died. The goal is to see which system removes more bacteria, which may lead to better healing.
Houston, TexasAges 18 years+ - NCT06555029Recruiting
Oral health help for older adults on Medicaid
This trial is testing an oral health program offered during routine primary care visits for older adults (55+) on Medicaid. It aims to see if adding dental care support to regular check-ups can improve health.
Cleveland, OhioAges 55 years+ - NCT06558955Recruiting
Preventing baby tooth decay with text support for new moms
This study tests a program that uses text messages and online support to help new moms prevent cavities in their baby's teeth. It provides tips and support from other parents to make dental care easier for your little one.
SingaporeAges 21 years+ - NCT06559605Recruiting
Comparing 3D Zirconia Barrier vs Titanium Mesh for Bone Growth
This study tests a new 3D-printed zirconia barrier to see if it helps grow bone better than a standard titanium mesh. It may be an option if you need more jawbone for dental implants.
CairoAges 20–70 - NCT06564987RecruitingPhase 1
Risk of nerve damage from numbing shots for dental work
This study looks at whether a common numbing shot for dental procedures can cause nerve damage. It may help dentists choose safer ways to numb your teeth.
Akron, OhioAges 18–55 - NCT06566508RecruitingPhase 2/Phase 3
Gotu kola gel for root canal infections
This study tests a natural gel made from asiaticoside (a compound from the Gotu kola plant) placed inside your root canal after cleaning. This gel may help reduce infection and inflammation better than standard medicines.
Al MansurahAges 20–60 - NCT06567535Recruiting
Nerve-sparing surgery for jaw cysts using a camera and navigation
This trial tests a new way to remove jaw cysts using a tiny camera and special guides, which may help protect the nerve in your jaw. It is for people with a tooth-related cyst at least 2 cm wide that is pushing on that nerve.
Guangzhou, GuangdongAges 18–75 - NCT06569329Recruiting
Extra cleaning for infected root canals
This study tests if extra cleaning steps after a standard root canal can remove more bacteria from an infected tooth. It is for adults with a dead nerve and an infection at the root tip in a single-rooted premolar that has never been treated before.
Iowa City, IowaAges 18–95 - NCT06571812Recruiting
Study of the TSX dental implant system (Xpresso)
This trial tests a new dental implant system (called TSX Xpresso) for replacing a single missing tooth, either right after pulling the tooth or after the gum has healed. It may be a good option if you need a dental implant and want to see how this system works.
Columbus, OhioAges 18 years+ - NCT06574477Recruiting
Mixed-reality tech for impacted canines
This trial tests whether a new mixed-reality technology helps guide an impacted canine tooth into the correct position. It may be a good option if you have a canine that is stuck high up in the roof of your mouth and you are already in braces to make room for it.
KrakowAges 10–20 - NCT06574802Recruiting
Laser and air polishing for gum disease treatment
This study tests if a special laser and air polishing can help treat gum disease. It may offer a gentler, more effective way to clean below the gum line compared to standard scaling.
Beijing, Beijing MunicipalityAges 35–65 - NCT06576063Recruiting
Light therapy for better oral hygiene in older adults
This study tests a special light therapy (called antibacterial photodynamic therapy) used with a device called Lumoral to improve oral hygiene in older adults. It may help reduce bacteria and plaque in people who can brush their teeth and follow the study routine.
Loviisa, UusimaaAges 65 years+ - NCT06576986Recruiting
Can a supplement prevent mouth sores during chemo?
This trial tests whether a special supplement (synbiotic) can prevent mouth sores caused by chemotherapy in people with colorectal cancer. It's for those starting treatment who live in or near Belo Horizonte, Brazil.
Belo Horizonte, Minas GeraisAges 18 years+ - NCT06576284Recruiting
Tracking custom dental implant performance over 3 years
This study follows people who already received a personalized dental implant designed by computer. Researchers want to see how the implant performs over 3 years, measuring things like how well it works and if any problems come up.
São PauloAges Any age - NCT06576622Recruiting
Periodontal disease, bacteria, and miscarriage
This study looks at whether gum disease and oral bacteria are linked to repeated pregnancy loss. If you have had multiple miscarriages, your gum health may play a role.
ToulouseAges Up to 18 years - NCT06576830RecruitingPhase 4
Pain relief study for kids having tonsil surgery
This study tests different ways to manage pain after tonsillectomy in children. The goal is to find better pain relief options.
Durham, North CarolinaAges 3–17 - NCT06580821Recruiting
Modified gum graft for lower front teeth
This trial tests a modified gum grafting technique to treat gum recession on lower front teeth. It may help if you have a small amount of recession and keep your teeth very clean.
Samborondón, GuayasAges 18–64 - NCT06582134Recruiting
Mindfulness for jaw pain in university students
This trial tests whether brief mindfulness exercises can help reduce jaw pain in university students. If you have had jaw pain for at least 3 months, you may be able to join.
Kuala Lumpur, Kuala LumpurAges 18–30 - NCT06587971Recruiting
Intensive gum treatment for aortic stenosis
This trial tests whether intensive gum disease treatment can improve health in people with aortic stenosis (a narrowed heart valve). If you have both gum disease and mild-to-moderate aortic stenosis, you may be able to join.
Beijing, Beijing MunicipalityAges 18 years+
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 2,058 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,961 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.