Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 1,962 recruiting studies in this area right now.
By phase
- Not applicable1,543
- Phase 2144
- Phase 385
- Phase 182
- Phase 460
- Phase 1/Phase 235
- Phase 2/Phase 313
Top conditions
- Periodontitis103
- Nasopharyngeal Carcinoma74
- Periodontal Diseases50
- Dental Caries46
- Gingivitis35
- Head and Neck Cancer35
- Oral Cancer32
- Periodontal Disease29
- Dental Implant28
- Gingival Recession25
- Alveolar Bone Loss24
- Nasopharyngeal Carcinoma (NPC)24
- Sjogren's Syndrome24
- Tooth Loss24
- Temporomandibular Disorders (TMD)22
- Oropharynx Cancer21
- Peri-Implantitis21
- Temporomandibular Joint Disorders20
Leading sponsors
- Cairo University77
- Sun Yat-sen University50
- Mansoura University25
- Ain Shams University24
- Postgraduate Institute of Dental Sciences Rohtak24
- Tanta University24
- Al-Azhar University23
- Universidad Complutense de Madrid16
- University of Baghdad16
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California44
- Texas26
- Florida21
- Maryland21
- Massachusetts21
- New York19
- Pennsylvania19
- Ohio18
- Alabama17
- Michigan15
Recruiting studies1,962 total
- NCT07083050Recruiting
Comparing collagen membrane to gum graft for multiple gum recessions
This trial compares a new collagen membrane (Fibroguide) to using your own gum tissue for covering multiple gum recessions. It aims to see if the membrane works just as well, so you might avoid a second surgical site in your mouth.
FlorenceAges 18–70 - NCT06977009Recruiting
Does tooth grinding relief help with post-dental pain?
This study tests whether reducing a tooth's contact with its opposite tooth before root canal treatment can lower pain after the procedure. It's for people with a dead nerve in a back molar that needs a crown.
Amman, Amman GovernorateAges 18–70 - NCT07077304Recruiting
Cardiac imaging study for inflammatory heart diseases
This study uses heart scans (MRI or nuclear imaging) to better understand inflammatory heart conditions. If you have a suspected inflammatory heart disease and are already scheduled for one of these scans, you may be able to join.
ParisAges 18 years+ - NCT07082972RecruitingPhase 4
Study of splint therapy and Botox for jaw muscle pain
This trial compares two treatments—a dental splint and Botox injections into the jaw muscle (masseter)—to see which one better relaxes head and neck muscles in people with myofascial pain syndrome. It may help you if you have facial pain related to muscle tension.
Istanbul, VeznecilerAges 18–55 - NCT07081230Recruiting
Albumin vs hyaluronic acid with growth factors for gum disease
This trial tests whether adding albumin or hyaluronic acid (both natural substances) to a special gum treatment helps heal gum pockets better. It is for people with moderate to advanced gum disease.
Al Mansurah, MansouraAges 25–45 - NCT07077122Recruiting
Comparing five gum disease treatments
This trial tests five different non-surgical gum treatments to see how they affect overall health. It may be a good fit for people with advanced gum disease who do not smoke heavily or take certain medications.
AthensAges Any age - NCT07078890Recruiting
Bone graft with implant removal for better reimplant success
This study tests whether adding a bone graft at the same time a failed dental implant is removed helps the new implant placed later in the same spot heal better. It may be a good option if you need a failed implant replaced and want to improve bone support for the new one.
Wuhan, HubeiAges 18–90 - NCT07082244Recruiting
Gum and bone shaping for dental implants
This study tests a procedure to improve the shape of the gum and bone around a dental implant in people with thin gums. It uses a special graft material to make the area thicker and more stable for a better-looking result.
Ann Arbor, MichiganAges 18 years+ - NCT07077694Enrolling by invitation
AI study to find missed root canals in treated lower back teeth
This study uses artificial intelligence and 3D dental imaging to check if any root canals were missed during previous root canal treatment on lower back teeth. It may help find hidden problems and guide better treatment.
Cairo, Cairo GovernorateAges 18–50 - NCT07077915Enrolling by invitation
New drilling method vs. standard for immediate dental implants
This trial tests a new drilling method called osseodensification (which makes the bone denser) versus the standard way of drilling for placing a dental implant right after pulling a tooth. It is for people who need a lower back molar removed and want an implant placed immediately.
BeirutAges 25–45 - NCT06330350Recruiting
Talking about family planning for genetic skin conditions
This study interviews people with inherited skin conditions (genodermatoses) who want to have children, and the doctors who care for them. The goal is to learn how to better support family planning decisions, like counseling about genetics and pregnancy risks.
Maastricht, LimburgAges Any age - NCT06980675Recruiting
Ozonized olive oil for gum disease treatment
This trial tests if a special ozonized olive oil gel can help treat deep gum pockets caused by periodontitis (advanced gum disease). If you have gum pockets that are 4 mm or deeper, this could be an option to reduce infection and improve healing.
Bari, BAAges 18 years+ - NCT06980870RecruitingPhase 2
Pain medicine before root canal for less discomfort
This study tests whether taking ibuprofen or dexamethasone before a root canal can help reduce pain afterward. It's for people with a painful, inflamed tooth nerve who haven't already taken pain medicine for it.
RawalpindiAges 18–50 - NCT05906810Recruiting
Treating gum inflammation around implants to improve blood vessel function
This study looks at whether non-surgical gum treatment around dental implants can improve early problems in blood vessel function. It includes people with implant gum disease, and also compares them with healthy people who do not have gum disease.
CataniaAges Any age - NCT06912711RecruitingPhase 2
Chemo before and after surgery for recurrent nasal cancer
This trial tests giving chemotherapy before and after surgery for people whose nasal cancer has come back. The goal is to see if this approach helps remove the cancer more effectively and prevents it from returning again.
Guangzhou, GuangdongAges 18–65 - NCT06965387Recruiting
Deep learning study for gummy smile analysis
This study uses artificial intelligence to analyze smiles and identify a gummy smile (excess gum showing when you smile). It may help researchers better understand and diagnose this condition.
Ankara, CankayaAges 12 years+ - NCT07068204Recruiting
Comparing two toothpastes to prevent cavities in healthy adults
This study tests whether a new 2% calcium hypophosphite toothpaste is better than standard fluoride toothpaste at preventing cavities. You may be able to join if you have healthy teeth and are willing to use an electric toothbrush and floss.
Bialystok, PolandAges 18–45 - NCT07070479RecruitingPhase 2
Combination treatment for PD-1 resistant nasopharyngeal cancer
This trial is testing a combination of drugs for people whose nasopharyngeal cancer has stopped responding to standard treatments like platinum chemotherapy and PD-1 inhibitors. It aims to find a new effective approach for advanced or recurrent disease.
Guangzhou, GuangdongAges 18–70 - NCT07069127Recruiting
Home treatment for tooth sensitivity in celiac disease
This study tests a special toothpaste-like treatment for adults with celiac disease who have sensitive teeth and enamel problems. You apply it at home, and it may help reduce tooth pain and protect your teeth.
Pavia, LombardyAges 18 years+ - NCT07067164Recruiting
Filling cavities in back teeth: A clinical trial comparing two materials
This trial compares a new type of filling material (high-viscosity glass ionomer) with a standard composite filling for cavities between back teeth. It tests which material works better over one year.
Cairo, Cairo GovernorateAges 18–45 - NCT07072143Recruiting
Study on children with rare tumors
This study is looking at children and teens with very rare tumors to learn more about these conditions and improve future care. It aims to gather information from patients treated at participating centers.
Padova, ItalyAges birth–18 years - NCT07065747Recruiting
Understanding inflammation in uveitis using advanced eye imaging
This study uses a special eye scan (OCT) to measure and classify inflammatory cells inside the eye. It aims to better understand different types of uveitis and improve diagnosis and treatment.
Portland, OregonAges 5–85 - NCT07070453Recruiting
Light-activated therapy for gum disease treatment
This study tests whether adding a light-activated therapy (photodynamic therapy) to standard deep-cleaning can improve gum disease treatment. It is for adults with periodontitis who have not had recent gum treatment or taken certain medications.
Almada, Monte Da CaparicaAges 18 years+ - NCT07069218Recruiting
Testing toothpaste with hydroxyapatite to strengthen tooth enamel
This study tests whether a toothpaste containing hydroxyapatite (a natural mineral) can help strengthen tooth enamel in children and teens. If your child has early signs of enamel weakness, this trial may help protect their teeth from further damage.
Pavia, LombardyAges 6–18
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 1,962 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,756 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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- Immune system & allergy
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- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.