Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 1,962 recruiting studies in this area right now.
By phase
- Not applicable1,543
- Phase 2144
- Phase 385
- Phase 182
- Phase 460
- Phase 1/Phase 235
- Phase 2/Phase 313
Top conditions
- Periodontitis103
- Nasopharyngeal Carcinoma74
- Periodontal Diseases50
- Dental Caries46
- Gingivitis35
- Head and Neck Cancer35
- Oral Cancer32
- Periodontal Disease29
- Dental Implant28
- Gingival Recession25
- Alveolar Bone Loss24
- Nasopharyngeal Carcinoma (NPC)24
- Sjogren's Syndrome24
- Tooth Loss24
- Temporomandibular Disorders (TMD)22
- Oropharynx Cancer21
- Peri-Implantitis21
- Temporomandibular Joint Disorders20
Leading sponsors
- Cairo University77
- Sun Yat-sen University50
- Mansoura University25
- Ain Shams University24
- Postgraduate Institute of Dental Sciences Rohtak24
- Tanta University24
- Al-Azhar University23
- Universidad Complutense de Madrid16
- University of Baghdad16
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California44
- Texas26
- Florida21
- Maryland21
- Massachusetts21
- New York19
- Pennsylvania19
- Ohio18
- Alabama17
- Michigan15
Recruiting studies1,962 total
- NCT07075276Recruiting
Comparing a new growth factor treatment to standard care for jaw joint pain
This study tests a new treatment for a common jaw joint problem called disc displacement. It compares a concentrated growth factor from your own blood to standard care to see which helps more with pain and jaw movement.
Damietta, New DamiettaAges 18–45 - NCT07067268RecruitingPhase 2
Tislelizumab and capecitabine for nasopharyngeal cancer with remaining EBV DNA
This trial tests a combination of two drugs, tislelizumab and capecitabine, for people with nasopharyngeal cancer who still have detectable EBV DNA in their blood after finishing radiation therapy. The goal is to see if this treatment can help clear the virus and improve outcomes.
Shanghai, ChinaAges 18 years+ - NCT07069881Recruiting
Comparing two dental cleaning methods for chronic root infection
This trial compares two ultrasonic cleaning methods (regular vs. passive) for treating a chronic tooth infection called chronic apical periodontitis. It aims to see which approach is more effective at clearing the infection and saving the tooth.
Guangzhou, GuangdongAges 18–59 - NCT07069140Recruiting
Lactoferrin mouthwash for gum health during pregnancy
This study tests if a daily lactoferrin mouthwash can improve gum health in pregnant women with gum disease, without needing antibiotics or other treatments. Researchers want to see if this natural protein helps keep gums healthier during the second trimester.
Pavia, LombardyAges 18–45 - NCT07069218Recruiting
Testing toothpaste with hydroxyapatite to strengthen tooth enamel
This study tests whether a toothpaste containing hydroxyapatite (a natural mineral) can help strengthen tooth enamel in children and teens. If your child has early signs of enamel weakness, this trial may help protect their teeth from further damage.
Pavia, LombardyAges 6–18 - NCT06749899RecruitingPhase 3
Immunotherapy with chemoradiation for advanced nasopharyngeal cancer
This trial tests a combination of a new immunotherapy (QL1706) plus standard chemoradiation for people with advanced nasopharyngeal cancer that hasn't spread to distant organs. The goal is to see if adding this drug helps control the cancer better than standard treatment alone.
Fuzhou, FujianAges 18–65 - NCT06321003Recruiting
Testing AI to detect early oral cancer with light scans
This trial uses a special light-based scanner (OCT) and artificial intelligence to help diagnose early signs of mouth cancer or precancer. It aims to see if this combination can make diagnosis easier and more accurate.
PalermoAges 18–99 - NCT06988098Recruiting
Comparing cleaning agents for tooth sealants in children
This study compares different cleaning agents used before placing tooth-colored sealants on the back teeth of children. The goal is to see which agent helps the sealants last longer and protect teeth better from cavities.
Tokat ProvinceAges 6–9 - NCT07058636Recruiting
Nerve block plus trigger point shots for neck pain relief
This study tests if adding a nerve block to standard trigger point injections provides better relief for people with chronic neck pain caused by myofascial pain syndrome.
AnkaraAges 18–65 - NCT07062523RecruitingPhase 1/Phase 2
FAPI PET scan for Sjögren's syndrome inflammation
This study uses a special PET scan (FAPI PET) to look at inflammation in people with Sjögren's syndrome. It helps doctors understand how active the disease is. You may join if you have Sjögren's syndrome or a solid tumor that needs this scan, and you are not on certain medications.
BeijingAges 18–80 - NCT07056998Enrolling by invitation
AI detects root canal quality, then retreats if needed
This trial tests whether artificial intelligence can spot problems in root canal treatments seen on special X-rays (CBCT) compared to regular X-rays. If the AI finds an issue, a retreatment is done.
Cairo, Cairo GovernorateAges 18–50 - NCT07056920Recruiting
Bone growth for lower jaw implants using a custom shell
This study tests whether a custom-made porous zirconia shell can help grow new bone in a narrow lower jaw so a dental implant can be placed. It might be a good option if you have a missing back tooth and need more jawbone for an implant.
Giza, Giza GovernorateAges 18 years+ - NCT07056959Recruiting
Collagen matrix for gum health around implants
This trial tests whether a collagen matrix can help improve the gum tissue around dental implants that have thin or insufficient gum width. It may help patients with narrow gum bands around their implants.
DubaiAges 21 years+ - NCT07063836Recruiting
Managing multiple adjacent tooth sockets
This trial tests a way to place dental implants right after removing several failing teeth at once in the front of the mouth. It may help if you need to replace two or more teeth that cannot be saved.
CairoAges 18–70 - NCT07059481Recruiting
Root canal sealers and oxidative stress study
This study is looking at how different types of root canal filling materials (sealers) affect oxidative stress markers in the body. It is for people with a single tooth that has a chronic infection at the root tip and needs a root canal.
Ordu, Ordu- AltınorduAges 18–45 - NCT07063212RecruitingPhase 2
Sacituzumab govitecan plus cetuximab for head and neck cancer
This trial tests a combination of two drugs—sacituzumab govitecan and cetuximab—for people with advanced head and neck cancer that has gotten worse after immunotherapy. The goal is to see if this new treatment can shrink or slow the cancer.
Basking Ridge, New JerseyAges 18 years+ - NCT07062757Enrolling by invitation
Massage and melatonin for jaw surgery recovery
This study tests whether combining gentle lymphatic drainage massage with melatonin can reduce pain and swelling after jaw surgery. If you are scheduled for jaw surgery for the first time and are otherwise healthy, you may be able to join.
Istanbul, FatihAges 16–55 - NCT07048418Recruiting
Nose job results in adults born with a cleft lip and palate
This trial asks adults who had a nose job as teens or children, after being born with a cleft lip and palate, to rate how they look and feel about their nose. Their answers will help doctors understand how these surgeries affect patients long-term.
MontpellierAges 18–30 - NCT07053969Recruiting
Does a protein gel thicken gum tissue around implants?
This study tests whether a protein-based gel (enamel matrix derivative) can make the gum tissue thicker during a second-stage implant procedure. It may help people getting dental implants achieve better healing and gum support.
San Antonio, TexasAges 18–18 - NCT07051057Enrolling by invitation
Oral health and diet of Sinai U students
This study looks at the oral hygiene and eating habits of physical therapy and pharmacy students at Sinai University. It aims to understand how these habits affect their health, which may help improve student wellness programs.
Ismailia, EgyptAges 16–25 - NCT07054008Recruiting
Gum Flap Surgery and Healing
This study looks at how gum surgery (flap surgery) affects healing. It aims to improve recovery for people with gum disease who need surgery.
San Antonio, TexasAges 18–18 - NCT07054177Recruiting
Saliva test for gum disease in pregnancy
This study looks at how pregnancy and gum disease might change the chemicals in your saliva. By comparing pregnant women and non-pregnant women, researchers hope to find a simple way to screen for gum problems during pregnancy.
Istanbul, FatihAges 18–40 - NCT07048171Recruiting
Bone graft and blood concentrate for tooth infection healing
This trial tests whether using a bone graft (allograft) together with your own blood concentrate (iPRF) and a collagen membrane helps heal the bone and gum around a tooth with a long-standing infection. It might be a good option if you have a tooth that keeps getting infected despite a root canal and has a deep pocket on the cheek side.
Rohtak, HaryanaAges 18 years+ - NCT07048028Recruiting
Chitosan rinse for root canals in premolars
This study tests a new natural mouth rinse (chitosan) during root canal treatment for lower premolar teeth. Researchers want to see if it helps clean the tooth better than standard treatment.
Ordu, AltınorduAges 18 years+
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 1,962 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,756 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.