Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 2,058 recruiting studies in this area right now.
By phase
- Not applicable1,634
- Phase 2148
- Phase 183
- Phase 382
- Phase 459
- Phase 1/Phase 236
- Phase 2/Phase 316
Top conditions
- Periodontitis108
- Nasopharyngeal Carcinoma80
- Periodontal Diseases57
- Dental Caries49
- Gingivitis35
- Oral Cancer35
- Head and Neck Cancer34
- Dental Implant30
- Sjogren's Syndrome29
- Gingival Recession27
- Periodontal Disease27
- Nasopharyngeal Carcinoma (NPC)24
- Alveolar Bone Loss23
- Peri-Implantitis23
- Tooth Loss22
- Oropharynx Cancer21
- Temporomandibular Disorders (TMD)21
- Trigeminal Neuralgia21
Leading sponsors
- Cairo University91
- Sun Yat-sen University53
- Ain Shams University30
- Mansoura University30
- Postgraduate Institute of Dental Sciences Rohtak24
- Al-Azhar University23
- Tanta University23
- University of Baghdad19
- Universidad Complutense de Madrid18
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California40
- Texas27
- Massachusetts22
- Ohio22
- Pennsylvania22
- New York20
- Maryland19
- Florida18
- Alabama16
- Michigan15
Recruiting studies2,058 total
- NCT06591884RecruitingPhase 1/Phase 2
Spray vs ointment for oral lichen planus
This trial tests a new spray version of the medication tacrolimus (enclosed in tiny particles) compared to a standard ointment for treating painful mouth sores caused by oral lichen planus. It aims to see if the spray works better and is easier to use.
Porto Alegre, Rio Grande do SulAges 18 years+ - NCT06592599RecruitingPhase 2
Drug combo for EBV-related nasopharyngeal cancer
This trial tests a combination of three drugs (gemcitabine, docetaxel, and toripalimab) as a first treatment for a type of nasopharyngeal cancer linked to the Epstein-Barr virus. The goal is to see if this combination helps shrink tumors before other treatments like radiation.
Palo Alto, CaliforniaAges 18 years+ - NCT06597669Recruiting
Comparing two treatments for cavities in baby molars
This clinical trial compares two methods for fixing cavities in baby molars: a traditional metal crown and a simpler technique that seals the crown over the cavity without removing much tooth. It aims to find which method works better in children.
Huế, Thừa Thiên Huế ProvinceAges 3–9 - NCT06599346Recruiting
MSC supernatant for skin and mouth sores in blood cancer patients
This trial tests whether a liquid made from stem cells (MSC supernatant) can help prevent or treat mouth, skin, and bladder sores that often happen after stem cell transplants, chemotherapy, or radiation therapy.
Chengdu, SichuanAges 18 years+ - NCT05573308Recruiting
Clear aligner study using remote monitoring and AI checks
This trial looks at clear braces (aligner) treatment for straightening teeth, using remote monitoring and computer-guided (AI) check-ins. It may help by making treatment progress easier to track and adjust.
Antioch, IllinoisAges 12–70 - NCT07673185Recruiting
Omega-3 and low-dose aspirin for gum disease in smokers
This trial tests whether taking omega-3 supplements with low-dose aspirin can improve gum health in smokers with advanced gum disease (stage III periodontitis). It aims to see if this combination safely reduces gum pocket depth and tissue damage.
CairoAges 30–50 - NCT07406360RecruitingPhase 3
Combined MMR and chickenpox vaccine booster for children
This study tests a combined vaccine that protects against measles, mumps, rubella, and chickenpox (varicella) in one shot. It's for healthy children who have already had their first dose of chickenpox and MMR vaccines, to see if this booster is safe and works well.
Birmingham, AlabamaAges 1.3 years–6 years - NCT06602375Recruiting
Physical therapy and exercise for jaw pain
This study tests if adding manual physical therapy and exercise to standard dental care helps active-duty service members with jaw pain (temporomandibular disorders). It aims to see if this combination works better than dental care alone.
Fort Sam Houston, TexasAges 18–55 - NCT06602518Recruiting
Airway changes after braces for deep overbite
This study looks at how fixing a deep overbite (where top teeth cover most of your bottom teeth) with braces may affect the size of your airway (the space in the back of your throat for breathing). It helps doctors understand if treatment can also help with breathing.
AlexandriaAges 12–16 - NCT06608563Recruiting
Dental sealant study for kids and molars
This study tests a special adhesive to help sealants stick better and prevent cavities on back teeth in children aged 6 to 12.
Dublin, DublinAges 6–12 - NCT06611137RecruitingPhase 2
SBRT plus chemoimmunotherapy to save the voice box
This trial tests a new approach to treat advanced larynx or hypopharynx cancer without removing the voice box. First, you get targeted radiation (SBRT), then a combination of chemotherapy and an immunotherapy drug called Toripalimab, which helps your immune system fight the cancer.
Guangzhou, GuangdongAges 18–70 - NCT06611150RecruitingPhase 1
Chemo and radiation for advanced nasopharyngeal cancer
This trial tests whether a specific chemotherapy drug (nab-paclitaxel) given along with targeted radiation therapy can help people with stage III or IVa nasopharyngeal cancer. The goal is to improve treatment outcomes while managing side effects.
Guangzhou, GuangdongAges 18–70 - NCT06614686RecruitingPhase 1
CAR-T therapy for advanced head and neck cancer
This study tests a new type of CAR-T cell therapy that targets a protein called Trop2 found on some head and neck cancer cells. It's for people who have tried standard treatments and need a new option.
ShanghaiAges 18–70 - NCT06620172Recruiting
Comparing two methods of nerve treatment for facial pain
This trial tests two image-guided procedures to treat severe facial pain from trigeminal neuralgia. It compares using a CT scan versus an X-ray video to guide a needle that heats the nerve to stop pain signals.
Zagazig, Sharqia ProvinceAges 18–60 - NCT06623266Recruiting
Observation vs. neck surgery for early mouth cancer
This study compares two approaches for early-stage mouth cancer: careful observation of the neck versus a preventive surgery to remove neck lymph nodes. The goal is to see which strategy works better to prevent cancer from spreading.
ShanghaiAges 18–75 - NCT06624241Recruiting
Curcumin gel plus deep cleaning for Stage III gum disease
This trial tests a new gel made from curcumin (a natural substance found in turmeric) combined with a standard deep cleaning treatment for Stage III gum disease. The goal is to see if the gel helps reduce gum inflammation and improve healing.
Chieti, CHAges 18–80 - NCT06627790RecruitingPhase 3
Herbal mouthwash for tooth sensitivity
This study tests a herbal mouthwash containing potassium nitrate against a potassium oxalate mouthwash to see which better reduces tooth sensitivity. If you have sensitive teeth, you may be eligible to try a new rinse that could help reduce pain.
Pune, MaharashtraAges 18–60 - NCT06627855Recruiting
Fascial stretch method for jaw pain relief
This study tests a hands-on technique called the fascial distortion model to see if it works better than a sham treatment for reducing jaw, face, or neck pain. It may help if you have had a jaw disorder for at least 3 months.
Merkez, Karabük ProvinceAges 18–64 - NCT06629038Recruiting
AI estimates jaw, neck, and shoulder movement
This study uses an artificial intelligence (AI) model to estimate how much you can move your jaw, neck, and shoulders. It aims to help doctors better measure movement problems in people with or without oral cancer.
TaipeiAges 20–65 - NCT06629597RecruitingPhase 3
Study of YL201 for advanced nasopharyngeal cancer
This trial tests a new drug, YL201, in people with nasopharyngeal cancer that has come back or spread. It may be an option if you have already tried a PD-(L)1 inhibitor and at least two chemotherapy treatments.
Guangzhou, GuangdongAges 18–75 - NCT06633627Recruiting
Brain response study for tooth sensitivity
This study looks at how your brain responds to tooth sensitivity. Researchers will test a simple air puff on your teeth and measure brain activity to better understand nerve signals from sensitive teeth.
SheffieldAges 18 years+ - NCT06636734RecruitingPhase 2
Lovastatin plus pembrolizumab for advanced head and neck cancer
This trial tests whether adding lovastatin (a cholesterol-lowering drug) to pembrolizumab (an immunotherapy) works better than pembrolizumab alone for head and neck cancer that has come back or spread. It's for people who haven't had immunotherapy before and aren't already on a statin.
Atlanta, GeorgiaAges 18 years+ - NCT06639009Recruiting
Laser treatment for better mouth opening in oral fibrosis
This study tests if a special laser therapy (photobiomodulation) helps people with oral submucous fibrosis open their mouths wider. It's for people who haven't had other treatments for this condition in the last three months.
New Delhi, National Capital Territory of DelhiAges 18–99 - NCT06641011Recruiting
Sealing molars with enamel spots: rinsing vs blotting
This study tests whether rinsing off or blotting dry a special silver fluoride liquid before placing a tooth sealant helps the sealant last longer on molars affected by a common condition called molar-incisor hypomineralization. The goal is to find the best way to protect these teeth from cavities.
AnkaraAges 6–14
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 2,058 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,961 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.