Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 1,962 recruiting studies in this area right now.
By phase
- Not applicable1,543
- Phase 2144
- Phase 385
- Phase 182
- Phase 460
- Phase 1/Phase 235
- Phase 2/Phase 313
Top conditions
- Periodontitis103
- Nasopharyngeal Carcinoma74
- Periodontal Diseases50
- Dental Caries46
- Gingivitis35
- Head and Neck Cancer35
- Oral Cancer32
- Periodontal Disease29
- Dental Implant28
- Gingival Recession25
- Alveolar Bone Loss24
- Nasopharyngeal Carcinoma (NPC)24
- Sjogren's Syndrome24
- Tooth Loss24
- Temporomandibular Disorders (TMD)22
- Oropharynx Cancer21
- Peri-Implantitis21
- Temporomandibular Joint Disorders20
Leading sponsors
- Cairo University77
- Sun Yat-sen University50
- Mansoura University25
- Ain Shams University24
- Postgraduate Institute of Dental Sciences Rohtak24
- Tanta University24
- Al-Azhar University23
- Universidad Complutense de Madrid16
- University of Baghdad16
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California44
- Texas26
- Florida21
- Maryland21
- Massachusetts21
- New York19
- Pennsylvania19
- Ohio18
- Alabama17
- Michigan15
Recruiting studies1,962 total
- NCT06943443Enrolling by invitation
Vitamin D and expander treatment for teens
This trial looks at whether vitamin D levels affect how well a special expander (MARPE) works to fix a narrow upper jaw in teens. If you are 15–18 and have a narrow upper jaw, you may be able to join.
Konya, MeramAges 16–18 - NCT06951178Enrolling by invitation
Long-term safety of a custom jaw joint implant
This study checks the long-term safety and how well a new jaw joint implant (for the TMJ) works. It follows patients who are already getting this implant to see how they do over time.
Copenhagen, Capital Region of DenmarkAges Any age - NCT06934291Recruiting
Comparing ultrasonic tools for deep gum cleaning
This trial tests two types of ultrasonic tools (piezoelectric vs magnetostrictive) for full-mouth deep gum cleaning in people with mild to moderate gum disease (periodontitis stages 1 and 2). It aims to see which tool works better for removing plaque and tartar.
Siena, SIAges 18–80 - NCT06934863Recruiting
Study of oral lichen planus and cancer risk
This study looks at people with oral lichen planus (a chronic mouth condition) to see how often it turns into mouth cancer. Researchers want to learn more about the condition and what might increase cancer risk.
RomaAges Any age - NCT06932848Recruiting
Curcumin gel for treating oral lichen planus
This trial tests if a curcumin nanogel can help heal painful sores from oral lichen planus compared to a standard corticosteroid gel. If you have this condition, you may be able to join.
BangkokAges 18 years+ - NCT06934317Enrolling by invitation
Bite force after root canal treatment vs. regenerative therapy
This trial compares how strongly you can bite down on a tooth that has had a root canal or a newer regenerative treatment. It is for people with a dead nerve inside a permanent tooth who are otherwise healthy.
IrbidAges 10–60 - NCT06932406Recruiting
Personality and self-help for jaw pain
This study tests whether a self-management program for jaw and face pain works differently in people with different personalities. You will learn techniques to manage your pain at home.
Valencia, ValenciaAges 18–65 - NCT06940050Recruiting
Gum graft study for lower jaw recessions
This study compares two gum grafting methods (one using a special collagen material plus soft tissue, the other using soft tissue alone) to treat multiple gum recessions on the lower jaw. It may help find a better way to cover exposed roots and improve gum health.
Ghent, Oost-VlaanderenAges 18 years+ - NCT06941727Recruiting
Mouth Opening and Jaw Muscle Elasticity in Oral Cancer
This study looks at how oral cancer treatment affects your ability to open your mouth and the elasticity of your jaw muscles. It may help researchers understand and prevent long-term jaw stiffness.
TaipeiAges 20–65 - NCT06923826RecruitingPhase 2
Study of sacituzumab govitecan for advanced salivary gland and thyroid cancers
This trial tests a drug called sacituzumab govitecan in people with advanced salivary gland cancer or thyroid cancer that has spread or cannot be removed. The goal is to see if the drug can help shrink or slow down the cancer.
SingaporeAges 21 years+ - NCT06926322Enrolling by invitation
Treating dead baby molars with special medicines
This study tests different medicines to treat dead (necrotic) baby molars in children. The goal is to safely clean the infection and save the tooth so it can stay until it falls out naturally.
CairoAges 4–8 - NCT06929676Enrolling by invitation
Tooth mobility after gum disease treatment and splinting
This trial tests how much tooth movement improves after deep cleaning and splinting (connecting loose teeth) in people with advanced gum disease. It may help if you have loose front teeth from gum disease.
Piracicaba, São PauloAges 18 years+ - NCT06912438Enrolling by invitation
Emotional release after dry needling for jaw and head pain
This study tests whether a dry needling technique (trigger point needling) can help release emotional tension and reduce pain from muscle knots in the head and neck. It may be a good option if you have jaw or headache pain related to muscle tightness.
Tel Aviv, IsraelAges 18 years+ - NCT06914596Recruiting
Pocket cleaning aid for gum disease after deep cleaning
This study tests a new device called Emanate Perio PODS that you use at home for 30 minutes twice a day after a deep cleaning procedure. It aims to help reduce gum pockets and improve gum health.
Fullerton, CaliforniaAges 30–75 - NCT06915454Recruiting
Better imaging during cancer surgery
This trial tests a high-resolution PET-CT scan done during surgery to help surgeons see exactly where the cancer ends. It may help make sure all cancer is removed while saving healthy tissue.
Nashville, TennesseeAges 18 years+ - NCT06920485Enrolling by invitation
Mouthwash after wisdom tooth surgery
This trial tests whether a mouthwash with hypochlorous acid can help healing after impacted wisdom tooth removal. It may reduce discomfort and speed recovery.
AnkaraAges 18–45 - NCT06914999RecruitingEarly Phase 1
Comparing a new scan to standard scan during head and neck cancer radiation
This trial is testing whether a newer type of PET/CT scan (F-18 NaF) can better detect blood vessel problems caused by radiation therapy than the standard scan (F-18 FDG) in people with head and neck cancer. If successful, it could lead to better ways to prevent and manage these complications.
Atlanta, GeorgiaAges 18 years+ - NCT06915038Recruiting
Measuring tumor DNA in blood for HPV-positive throat cancer
This study looks at a blood test that finds DNA from HPV-related throat tumors. It may help doctors decide on surgery and check if the cancer is completely removed.
Carmel, IndianaAges 18 years+ - NCT06806241Recruiting
Tranexamic Acid Rinse for Wisdom Tooth Removal
This trial tests rinsing the surgery area with a medicine called tranexamic acid to see if it helps reduce bleeding and swelling after wisdom tooth removal. If you need both of your lower wisdom teeth out, this study might help your recovery.
Istanbul, FatihAges 14–40 - NCT06902454Enrolling by invitation
Sinus lift with special drill and same-day implant placement
This trial tests a new way to lift the sinus floor using a special drill and a surgical guide, placing a dental implant at the same time. It may help people who need an implant in the upper jaw but don't have enough bone height.
TantaAges 18 years+ - NCT06900933Recruiting
Bone graft for upper jaw using jawbone blocks
This trial tests using a small piece of bone from your lower jaw to rebuild a narrow upper jaw so it can hold a dental implant. It compares using the bone alone versus covering it with a collagen membrane to see which works better.
CairoAges 20–40 - NCT06902623Recruiting
Less intense radiation for early HPV throat cancer
This study tries to see if less intense radiation can still work well for certain throat cancers linked to HPV. It is looking for people with early stage HPV-positive oropharynx cancer who may benefit from a lighter treatment plan.
Washington D.C., District of ColumbiaAges 18 years+ - NCT06904781Recruiting
Pulp treatment for baby teeth with severe toothache
This study compares two ways to treat severe tooth decay in baby molars: removing only the top part of the nerve (pulpotomy) versus removing all of the nerve (pulpectomy). It aims to see which method works better for saving the tooth and relieving pain.
IrbidAges 4–9 - NCT06891313Recruiting
One stage ridge splitting in the lower jaw
This trial tests two techniques for widening a narrow jawbone so dental implants can be placed, all in one surgery. It is for people who have lost at least one tooth and have a bone width between 3 and 5 mm.
CairoAges 20–48
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 1,962 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,756 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.