Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 2,053 recruiting studies in this area right now.
By phase
- Not applicable1,631
- Phase 2148
- Phase 183
- Phase 381
- Phase 458
- Phase 1/Phase 236
- Phase 2/Phase 316
Top conditions
- Periodontitis108
- Nasopharyngeal Carcinoma79
- Periodontal Diseases57
- Dental Caries49
- Gingivitis35
- Head and Neck Cancer35
- Oral Cancer35
- Dental Implant30
- Sjogren's Syndrome29
- Gingival Recession27
- Periodontal Disease27
- Alveolar Bone Loss23
- Nasopharyngeal Carcinoma (NPC)23
- Peri-Implantitis23
- Tooth Loss22
- Oropharynx Cancer21
- Temporomandibular Disorders (TMD)21
- Trigeminal Neuralgia21
Leading sponsors
- Cairo University91
- Sun Yat-sen University53
- Ain Shams University30
- Mansoura University30
- Postgraduate Institute of Dental Sciences Rohtak24
- Al-Azhar University23
- Tanta University23
- University of Baghdad19
- Universidad Complutense de Madrid18
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California40
- Texas27
- Massachusetts22
- Ohio22
- Pennsylvania22
- New York20
- Maryland19
- Florida18
- Alabama16
- Michigan15
Recruiting studies2,053 total
- NCT06801535Recruiting
3D-printed splint for burn scars on mouth
This trial tests a custom 3D-printed mouth splint to help people who have a tight, small mouth opening after a burn. It aims to see if the splint can improve how wide you can open your mouth.
Winston-Salem, North CarolinaAges 2–99 - NCT06801561Recruiting
Sealants and Laser to Prevent Cavities in MIH-Affected Molars
This trial tests whether a dental sealant or a special laser treatment can prevent cavities and breakdown in first permanent molars affected by MIH (a condition that makes enamel weak). Eligible children have a molar with MIH that hasn't yet broken down and has only minor cavities.
AlexandriaAges 6–9 - NCT06802835RecruitingPhase 1/Phase 2
EGFR antibody plus immunotherapy and chemo for advanced nasopharyngeal cancer
This trial tests a combination of an EGFR antibody, a PD-1 inhibitor, and chemotherapy for people with nasopharyngeal cancer that has returned or spread after initial treatment. The goal is to see if this new mix can help shrink tumors or slow the disease.
Guangzhou, GuangdongAges 18–75 - NCT06805448RecruitingPhase 1/Phase 2
Stem cell treatment for dry mouth in Sjögren's disease
This trial tests if injecting fat-derived stem cells into the salivary glands can help relieve dry mouth in people with Sjögren's disease. It aims to improve saliva flow and reduce discomfort.
CopenhagenAges 18 years+ - NCT06805617RecruitingPhase 2
Ivonescimab for advanced salivary gland cancer
This trial tests a new drug called Ivonescimab for people with advanced salivary gland cancer that has spread or cannot be removed surgically. The goal is to see if the drug can shrink tumors or slow cancer growth.
Boston, MassachusettsAges 18 years+ - NCT06806605Recruiting
3D computer planning for jaw surgery
This trial tests whether a full 3D computer-assisted approach helps better diagnose and correct jaw and facial deformities during orthognathic surgery. It may benefit patients who need surgery to realign their jaws.
Bologna, Emilia-RomagnaAges 18–60 - NCT06808373Recruiting
Hypnosis for gum disease treatment
This study tests whether hypnosis can help with gum disease treatment. It is for adults who have chronic gum disease but are otherwise healthy.
AfyonkarahisarAges 20–65 - NCT06811844RecruitingPhase 2
Shorter chemo plus immunotherapy for advanced nasopharyngeal cancer
This trial tests a shorter course of chemotherapy combined with an immunotherapy drug (camrelizumab) for people with advanced nasopharyngeal cancer that hasn't spread to distant organs. The goal is to see if this approach works well while reducing treatment side effects.
Xiamen, FujianAges 18–65 - NCT06813040Recruiting
TMS therapy for jaw and face pain
This trial tests if repetitive transcranial magnetic stimulation (a non-invasive brain stimulation technique) can reduce long-lasting jaw and face pain caused by temporomandibular disorders. It might help people who have had pain for over six months and rate their pain as high.
CoimbraAges 18 years+ - NCT06819033RecruitingPhase 4
Light therapy for canker sores in children
This study tests whether a special light treatment (photobiomodulation) can help reduce pain from canker sores (aphthous ulcers) in children. It may be a good option for kids who get painful mouth sores during dental visits.
Houston, TexasAges 5–17 - NCT06821243Recruiting
Finding markers in HPV-related throat cancer to guide treatment
This study looks for certain markers in people with HPV-related throat cancer that could help doctors choose the best treatment. If you are planning to have surgery for your throat cancer, you may be able to join.
Rome, RomeAges 18 years+ - NCT06826456Recruiting
Laser treatment to prevent cavities in children's molars
This study tests whether a special laser (Er,Cr:YSGG) can prevent cavities in the deep grooves of children's permanent back teeth. It is for children ages 6–12 who are calm during dental visits and have healthy, groove-filled molars without visible cavities.
AlexandriaAges 6–12 - NCT06828042RecruitingPhase 1/Phase 2
CAR-γδT cells for refractory autoimmune diseases
This trial tests a new type of immune cell therapy (CAR-γδT cells) that targets a protein called CD19 on your own B cells. It is for people with certain autoimmune diseases that have not gotten better with standard treatments. The goal is to see if this therapy can safely control the disease.
BeijingAges 18–80 - NCT06829147Recruiting
AI to diagnose lymph node spread in nasopharyngeal cancer
This trial tests whether a computer model can accurately detect if cancer has spread to lymph nodes in patients with nasopharyngeal carcinoma. It uses MRI and PET/CT scans taken before treatment to see if the AI can replace or supplement current methods.
Guangzhou, GuangdongAges Any age - NCT06830200Recruiting
Treating infected dental implants with a chitosan brush
This study tests a new treatment for infected dental implants using a small brush made of chitosan (a natural material from shellfish). It aims to clean the implant surface and help the infection heal.
AnkaraAges 18–65 - NCT06830148Recruiting
Tongue movement after tongue-tie release for better breastfeeding
This study tests whether gently moving the tongue after a tongue-tie release (frenotomy) helps babies breastfeed better. It's for babies under 3 months old who are having their tongue-tie cut with scissors and are breastfeeding at least some of the time.
Washington D.C., District of ColumbiaAges Up to 3 months - NCT06836882Recruiting
Testing cavity disinfectants for deep tooth decay pain
This study tests two cavity disinfectants to see which one better reduces pain and improves healing after removing deep decay from back teeth. It is for adults with deep cavities in their lower molars that are still alive (not needing a root canal).
HaryānaAges 18 years+ - NCT06839066RecruitingPhase 2
HLX43 for advanced nasopharyngeal cancer after prior treatments
This trial tests an investigational drug called HLX43 for people with nasopharyngeal cancer that has come back or spread, and who have already tried two or more prior treatments without success. The goal is to see if HLX43 can shrink tumors or slow the cancer's growth.
Fuzhou, FujianAges 18 years+ - NCT06842316Recruiting
Study on cannabis-like compounds for inflammatory arthritis
This trial tests whether plant-based compounds similar to cannabis (called phytocannabinoids) can help calm inflammation and improve immune function in people with certain types of arthritis or autoimmune diseases like lupus or Sjögren's disease. It aims to offer a new way to treat these conditions without the 'high' of marijuana.
OrléansAges 18 years+ - NCT06843018RecruitingPhase 2
Spray vs lozenge for sore throat from infection
This trial tests a new spray with anesthetic for sore throat caused by infections like pharyngitis. It compares the spray to a lozenge (Septolete Total) to see which works better and is safer.
Engel'sAges 18–75 - NCT06843525Recruiting
Bite force measurements for molar dental work
This trial measures how your bite force changes after getting a filling or root canal on a lower back tooth. It helps doctors understand if different dental treatments affect your ability to chew.
Newark, New JerseyAges 18–89 - NCT06843928Recruiting
Titanium brush for treating infected dental implants
This study tests whether using a special titanium brush during a deep cleaning helps treat infected dental implants (peri-implantitis) better than cleaning alone. It's for people who have had gum disease before and have at least one implant with ongoing infection and bone loss.
Barcelona, CataloniaAges 18 years+ - NCT06844448Recruiting
Factors affecting success of vital pulp therapy
This trial looks at how different risk factors affect the success of vital pulp therapy, a treatment that tries to keep the nerve of your tooth healthy after it's been opened during a dental procedure. If you have a tooth that still responds to cold and can be restored, you may be able to join.
BudapestAges 18 years+ - NCT06849908RecruitingPhase 2
Baricitinib for treating intestinal Behçet's disease
This trial tests baricitinib, an oral medication, for people with intestinal Behçet's disease that hasn't improved with standard treatments. It aims to see if baricitinib can reduce symptoms and help heal gut ulcers.
Beijing, Beijing MunicipalityAges 18–65
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 2,053 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,969 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.