Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,575 recruiting studies in this area right now.
By phase
- Not applicable2,950
- Phase 4240
- Phase 2131
- Phase 3102
- Phase 193
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University59
- Beijing Tiantan Hospital34
- Tanta University33
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University20
Where studies are running
- California151
- New York79
- Massachusetts65
- Florida64
- Texas51
- Illinois40
- North Carolina40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,575 total
- NCT05968313Recruiting
Brain scan study of pain feelings in teens who self-harm
This study uses brain activity during a task to understand how teens who self-harm react to pain and empathy. It may help researchers learn what brain differences are linked with non-suicidal self-injury and guide better support for teens.
Chengdu, SichuanAges 15–18 - NCT06361485RecruitingPhase 1
Umbilical cord injection for chronic low back pain
This study tests whether a special injection made from umbilical cord tissue is safe and can help with long-term low back pain. It is for adults who have not had recent back procedures or certain health problems.
Scottsdale, ArizonaAges 20 years+ - NCT06333353Recruiting
Can brain stimulation reduce endometriosis pain?
This study tests whether a gentle, non-invasive brain stimulation technique (repetitive transcranial magnetic stimulation, or rTMS) can reduce ongoing endometriosis-related pain. If you have persistent pelvic pain that hasn't improved with other treatments, this trial may offer a new option to explore.
Ottawa, OntarioAges 18–60 - NCT06372054Recruiting
Predicting health risks for Italian Air Force members
This study aims to develop smart risk models using your body's data (like proteins and genes) along with personal exposure readings. It will help predict health risks for Italian Air Force personnel. You will wear a monitor and give samples, then be followed over time.
MilanAges 26–38 - NCT06342570Recruiting
EEG changes during pain for laparoscopic surgery patients
This study measures brain wave changes in response to pain during laparoscopic surgery. It aims to improve how pain is monitored under anesthesia.
SeoulAges 19 years+ - NCT05458037Recruiting
Testing fast versus slow numbing during IUD or biopsy
This study compares two ways of applying a numbing tool (“tenaculum”) during an IUD insertion or an endometrial biopsy to see which one causes less pain. If you’re scheduled for one of these procedures, it may help improve how discomfort is managed.
Providence, Rhode IslandAges 18 years+ - NCT06319911Recruiting
Testing a new shoulder replacement implant system
This study tests a new shoulder implant system for people who need their first shoulder replacement due to arthritis or a shoulder deformity. It helps researchers see how well the implant works and if it improves shoulder function and pain.
San Francisco, CaliforniaAges 18 years+ - NCT06398353Recruiting
Acupuncture for frequent primary headaches
This study tests whether acupuncture can improve quality of life for people with frequent primary headaches (like migraines or tension headaches). If you have headaches more than twice a week, this trial may help you find relief.
Taoyuan, Select A StateAges 18 years+ - NCT05701046Recruiting
Front vs back surgery for a slipped lower-back vertebra
This trial compares two surgical approaches—operating from the front/side versus from the back—for a specific type of lower-back slip called lumbar isthmic spondylolisthesis. You may be eligible if you need surgery at a single level and have not had prior spine surgery, and if your back condition matches their exact limits.
Vancouver, British ColumbiaAges 18 years+ - NCT06084520Recruiting
Pain questionnaire study for opioid and non-opioid patients
This study tests two questionnaires for people with long-term pain. Researchers want to see if the tools work well for both those taking opioids and those who are not. Your answers can help improve pain care.
Uppsala, UpplandAges 18–75 - NCT02355457Recruiting
Blood marker study in new heart attack symptoms
This study looks at blood “biomarkers” (signals in blood tests) in people who arrive with symptoms that could be a heart attack. It may help doctors spot and manage acute heart problems sooner and more accurately.
HamburgAges 18 years+ - NCT06338865Recruiting
Lower pressure vs. standard pressure for laparoscopic gynecologic surgery
This trial compares using lower gas pressure during minimally invasive gynecologic surgery to the standard pressure. The goal is to see if lower pressure reduces pain and speeds recovery after surgery.
Los Angeles, CaliforniaAges 18 years+ - NCT06413277Recruiting
ECAP-controlled spinal cord stimulation for chronic pelvic pain
This trial tests a new type of spinal cord stimulator that uses closed-loop technology to treat chronic pelvic pain caused by a known injury. It may be an option if your pain is severe and hasn't responded to other treatments.
New York, New YorkAges 18 years+ - NCT07852767Recruiting
Spinal anaesthesia success after previous back surgery
This study looks at how well spinal anaesthesia (a numbing injection in the back) works for people who have had lumbar spine surgery in the past. It aims to see if previous back surgery affects the success of this type of anaesthesia, which could help doctors plan better care.
IstanbulAges 18 years+ - NCT07853300Enrolling by invitation
Virtual reality for comfort during colonoscopy
This study tests whether using virtual reality (a computer-generated 3D environment you can see and hear) during a colonoscopy can reduce pain, anxiety, and embarrassment. If it works, it could make the procedure more comfortable for people who have it without sedation.
Kocaeli, İzmitAges 18–65 - NCT07853170Recruiting
Comparing 3 vs 5-needle knee nerve blocks for arthritis pain
This study compares two ways of numbing the nerves around the knee to see which gives better pain relief and improves quality of life for people with knee osteoarthritis. It might help you decide if a nerve block is a good option for your knee pain.
Tanta, El-GharbiaAges 18 years+ - NCT07851233Enrolling by invitation
Patient education on sling use after shoulder surgery
This study looks at how different ways of teaching patients about sling use after shoulder surgery may affect their recovery. If you join, you may receive extra education materials to help you use your sling correctly.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06426251Recruiting
Light therapy for knee replacement recovery
This trial tests whether a special light therapy (photobiomodulation) can help reduce pain and speed healing after total knee replacement. If you're having knee replacement and don't have complications like infection or open wounds, you may be eligible.
HsinchuAges 20 years+ - NCT07844772Recruiting
Psoriasis treatment and nerve pain study
This study looks at how different psoriasis treatments affect nerve-related pain and sensitivity. It compares patients on biologic injections, standard pills, or creams to see if treatment type matters for pain and skin symptoms.
Istanbul, IstanbulAges 18 years+ - NCT07849244Enrolling by invitation
Sacroiliac joint fusion for mobility and pain relief
This study tests a surgical procedure to fuse the sacroiliac joint (the joint connecting your lower spine and pelvis) to reduce pain and improve mobility and function. It is for people with one-sided SI joint pain that has not improved with other treatments.
Post Falls, IdahoAges 21 years+ - NCT07845071RecruitingPhase 3
Cebranopadol for acute pain after surgery or injury
This study tests an investigational medication called cebranopadol to see if it safely and effectively relieves acute (short-term) pain after surgery or from a muscle or bone injury. It may offer a new option for people who need relief from moderate to severe pain.
Phoenix, ArizonaAges 18–75 - NCT07846722Recruiting
Comparing two medicines to reduce pain medicine use after laparoscopic hysterectomy
This study compares two drugs, esmolol and dexmedetomidine, to see which one better reduces the need for strong painkillers after laparoscopic hysterectomy. It may help you manage pain with fewer opioids.
AthensAges 20–70 - NCT07847788Recruiting
Using brain monitoring during gallbladder surgery
This study checks whether a special brain-monitoring device (entropy monitoring) can help anesthesiologists give just the right amount of anesthesia during gallbladder removal surgery. The goal is to see if this leads to using less anesthesia and a faster recovery after surgery.
IslamabadAges 18–60 - NCT07846163Recruiting
Pain assessment for chronic low back pain
This study looks at how the brain and nervous system process pain in people with long-lasting low back pain. It uses safe measurements inside a shielded room to compare chronic pain patients with healthy people, which may help improve pain treatments.
Thessaloniki, Central MacedoniaAges 18–45
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,575 recruiting pain medicine studies from the U.S. registry right now, out of 6,452 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.