Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,749 recruiting studies in this area right now.
By phase
- Not applicable3,095
- Phase 4251
- Phase 2145
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University96
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University31
- Mayo Clinic28
- Tanta University28
- Foundation University Islamabad26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California160
- New York81
- Massachusetts68
- Florida63
- Texas51
- Ohio47
- Maryland42
- Minnesota42
- North Carolina38
- Illinois37
Recruiting studies3,748 total
- NCT06672952Recruiting
Citrus compound for exercise, blood flow, and stress in overweight adults
This study looks at whether a natural citrus compound called glucosyl-hesperidin (CitraPeak) can boost your exercise performance, improve blood flow, reduce stress, and sharpen thinking. Researchers want to see if it works differently for people who are moderately overweight or mildly obese.
Saint Charles, MissouriAges 18–50 - NCT06611228Recruiting
Preventing disability in older hospital patients
This study tests if a program designed for older, frail hospital patients can prevent loss of ability to do daily tasks. It focuses on physical activity, mental engagement, and nutrition to help you stay independent.
Monza, LumbardyAges 70 years+ - NCT06500793RecruitingPhase 1
Study of oxycodone with nafamostat in healthy adults
This trial tests how a new combination of oxycodone and nafamostat works in the body. It is for healthy volunteers aged 18 to 55 to help understand the drug's safety and how it is processed.
Miami, FloridaAges 18–55 - NCT06365177Recruiting
Comparing sit-to-stand test in person vs. video call
This study compares how well a simple sit-to-stand test works when done in person versus through a video call. It helps doctors understand if a telehealth visit can accurately measure your leg strength and mobility.
BrestAges 65–110 - NCT05358535RecruitingPhase 3
Testing two common anesthesia options during endoscopy
This trial compares two IV anesthesia medicines (propofol and etomidate) during endoscopic procedures. It may help your care team choose the safest, most effective anesthesia approach for patients who need anesthesia for endoscopy.
Dallas, TexasAges 18 years+ - NCT07766200Recruiting
Pain types in people with long-term low back pain
This study looks at different types of chronic low back pain. It aims to understand how pain affects people differently, which might help improve future treatments.
Kütahya, TürkiyeAges 18–70 - NCT07489625RecruitingEarly Phase 1
Electroacupuncture and ear acupressure for cancer pain
This study tests whether adding electroacupuncture (a treatment using mild electric pulses on needles) and ear acupressure (pressing on specific points on the ear) to the pain medicine hydromorphone helps reduce cancer-related pain that isn't well managed by usual treatments.
XiningAges 18–80 - NCT07761689Recruiting
Kangaroo care for pain relief during newborn jaundice light therapy
This study tests whether holding your baby skin-to-skin (kangaroo care) during light therapy for jaundice can help reduce their pain and discomfort. It aims to see if this simple comfort measure is beneficial.
IstanbulAges 2 days–1 week - NCT04014829Recruiting
Study of pain processing after planned hysterectomy
This trial looks at how the nervous system and fear of pain may affect pain after a planned hysterectomy. If you qualify, you may be asked about pain levels and pain sensitivity to better understand who may have more pain recovery challenges.
SingaporeAges 21–80 - NCT06617494Recruiting
Study of pain control in chronic jaw pain
This study looks at how well the body's natural pain control system works in people with long-term jaw pain (TMD). It compares people with and without jaw pain to better understand why some have trouble turning off pain signals.
Minneapolis, MinnesotaAges 18–74 - NCT07378735Recruiting
Back to Life: early rehab after spinal fusion surgery
This trial tests an early rehabilitation program for people having lumbar spinal fusion surgery to see if it helps them get back to daily life faster. It may be a good option if you live in Copenhagen or Frederiksberg and have had low back pain for more than three months.
Glostrup MunicipalityAges 18 years+ - NCT07762170RecruitingPhase 4
Steroid injections for back and pelvic pain
This study is testing how well and how safely steroid injections work for different types of back pain. If you join, you'll receive the injection as part of your care and fill out surveys about your pain and ability to do daily activities before and after.
Thornhill, OntarioAges 18 years+ - NCT07761936RecruitingPhase 3
Safinamide for Parkinson's disease pain
This study tests whether safinamide, an add-on medication for Parkinson's disease, can reduce chronic pain in people who also experience motor fluctuations (times when symptoms return between doses). It aims to see if this treatment can improve pain and quality of life.
Verona, VenetoAges 18 years+ - NCT07202273Recruiting
One-time radiation treatment for painful bone metastases
This trial tests a single session of radiation therapy to relieve pain and improve stability in up to two bone spots where cancer has spread. The goal is to make treatment faster and more convenient for patients.
Salt Lake City, UtahAges 18 years+ - NCT07764354Recruiting
Patient education for sticking with home exercises
This study tests whether extra education helps people with chronic musculoskeletal conditions—like long-term back pain, knee arthritis, or partial rotator cuff tears—stick with their home exercise routines to feel better. If you have one of these conditions and are willing to follow a home exercise plan, this could help you manage pain.
Dammam, Eastern ProvinceAges Any age - NCT07763158Recruiting
Treatment for severe knee pain using artery embolization
This study tests a procedure that blocks tiny arteries in the knee to reduce pain from severe arthritis. It is for people who cannot have knee replacement surgery because of other health issues.
Jeddah, Mecca RegionAges 18 years+ - NCT07763132Recruiting
Virtual reality for needle pain in children
This study compares using virtual reality goggles, a numbing cream, or standard care to reduce pain and anxiety during blood draws in children aged 3 to 15. It aims to find which method works best to make the experience more comfortable.
Ústí nad Labem, Ústí nad Labem RegionAges 3–15 - NCT07763860Recruiting
Music during endoscopy procedures
This study tests whether listening to music during an endoscopy (a tube with a camera used to look inside your digestive tract) can make the procedure more comfortable and less stressful. Participants will wear headphones and listen to music while the procedure is done under sedation.
SidonAges 18 years+ - NCT06483659RecruitingPhase 2
Oxytocin for pain after minimally invasive hysterectomy
This study tests if giving oxytocin (a natural hormone) through an IV can help reduce pain after a minimally invasive hysterectomy. If you are having this surgery, you may be able to join.
Boston, MassachusettsAges 18–65 - NCT07423039Recruiting
Ear acupressure for anxiety and pain during breast cancer surgery
This study tests if pressing on specific points on the ear (acupressure) can help reduce anxiety and pain during breast cancer surgery. It compares acupressure plus standard care to standard care alone, and may be a drug-free way to help you feel calmer before and after your procedure.
StuttgartAges 18–99 - NCT06618820Enrolling by invitationPhase 3
Extended tranexamic acid after knee replacement
This trial tests whether taking tranexamic acid (a medicine that helps blood clot) for several days after knee replacement surgery reduces bleeding and improves recovery. It may help patients who have a standard knee replacement and are not on blood thinners.
Germantown, TennesseeAges 18 years+ - NCT07578324Recruiting
TENS to reduce pain during prostate biopsy
This study tests whether TENS (a gentle electrical stimulation applied to the skin) can help reduce pain when combined with numbing medicine during a prostate biopsy procedure. The goal is to see if this may make the biopsy more comfortable for patients.
Gdansk, Pomeranian VoivodeshipAges 40 years+ - NCT04094701Recruiting
Study of opioid needs after hip arthroscopy surgery
This study looks at how much pain medicine (opioids) people actually need after hip arthroscopy and what factors may affect it. It may help improve safer, more personalized pain control after surgery.
Chicago, IllinoisAges 18–80 - NCT07666646Recruiting
Nerve block comparison for lung function after gallbladder surgery
This trial compares two types of nerve blocks to see which one better preserves lung function after laparoscopic gallbladder removal. It may help patients recover breathing ability more quickly after surgery.
Kayseri, KocasinanAges 18–70
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,749 recruiting pain medicine studies from the U.S. registry right now, out of 6,757 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.