Clinical trials
Decompensated Heart Failure clinical trials
Below are recruiting decompensated heart failure clinical trials, each written for real people, not researchers. We’re tracking 162 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06272734Recruiting
Reprieve system study for hospitalized heart failure
This study tests a device (Reprieve System) to remove extra fluid more safely in heart failure patients while they are hospitalized. It may be a good option if you have fluid buildup and are not too sick from other conditions.
TbilisiAges 18 years+ - NCT05759806Recruiting
Testing a device to treat fluid overload in heart failure
This trial studies a device (the Nephronyx System) used in the hospital to treat worsening heart failure with fluid buildup, especially when diuretics (water pills) aren’t working well. It aims to check the device’s safety and whether it performs as expected to help patients get better.
HaifaAges 18 years+ - NCT03951467Recruiting
Health literacy support to help you follow medical advice
This study tests whether a communication tool matched to your health literacy level can improve how well people follow medical recommendations after an acute episode. It may help you understand your care plan and take the right next steps at home.
BronAges 18 years+ - NCT06081205Recruiting
Heart disease patients in intensive care study
This trial observes patients admitted to the cardiac intensive care unit with acute heart or blood vessel problems. It aims to learn more about their conditions and treatments.
Ioannina, EpirusAges Any age - NCT07643610Recruiting
Heart Failure Crisis Registry Study
This registry collects information from patients admitted to the hospital with cardiogenic shock—a serious condition where the heart cannot pump enough blood to the body. Doctors will gather data to better understand what happens to these patients and how to improve their care.
Basel, Canton of Basel-CityAges 18 years+ - NCT05525663Recruiting
Rehab for older adults after heart failure with strong pumping
This trial studies whether a physical rehabilitation program helps older adults recover and function better after a recent hospital stay for heart failure when the heart’s pumping strength is preserved. It may help you regain walking ability and daily independence after your episode.
Winston-Salem, North CarolinaAges 60 years+ - NCT07269717RecruitingPhase 2
Testing HRS-1893 for heart failure with preserved ejection fraction
This trial tests a new drug called HRS-1893 for people with heart failure with preserved ejection fraction (HFpEF). It aims to see if the drug can improve symptoms and quality of life.
Shanghai, Shanghai MunicipalityAges 40 years+ - NCT06754475Recruiting
Low volume arm HIIT for heart failure patients
This trial tests if short, high-intensity arm exercises can help people with stable heart failure. It looks at safety and improvements in daily function.
Mersin, MersinAges 18 years+ - NCT06803849Recruiting
Biomarkers and pregnancy history for heart failure prognosis
This study looks at whether certain substances in the blood and your history of pregnancy complications can help predict the course of heart failure with preserved ejection fraction (a type of heart failure where the heart pumps well but doesn't relax properly). It may help doctors better understand and manage this condition in older women.
MoscowAges 60–74 - NCT06820099RecruitingPhase 2
A drug for heart failure with obesity
This trial tests an oral drug called HRS-7535 for people with a certain type of heart failure (where the heart pumps normally but doesn't relax properly) and who also have obesity. It aims to see if the drug can improve symptoms and daily function.
Beijing, Beijing MunicipalityAges 18–80 - NCT07321509RecruitingPhase 4
Digoxin after a recent heart failure hospitalization
This trial tests whether digoxin, a heart medication, can help people who were recently hospitalized for heart failure with a weak heart pump. It aims to see if it improves symptoms and daily activity.
Buenos Aires, Buenos Aires F.D.Ages 18–120 - NCT07202000RecruitingPhase 2
Exercise and a drug to reduce inflammation for heart failure with preserved ejection fraction
This trial tests whether combining exercise with a medication that blocks a protein called activin can reduce inflammation, improve heart function, and help with thinking in people with heart failure with preserved ejection fraction (HFpEF).
Boston, MassachusettsAges 40 years+ - NCT07592494Recruiting
Arm Exercise Training for Heart Failure With Device
This study compares different types of arm exercises for people with heart failure who have a pacemaker or defibrillator implanted. The goal is to see which exercise approach best improves how well your arms function and help you stay active.
ÇorumAges 18 years+ - NCT06081049RecruitingPhase 2
Colchicine for heart failure with preserved pumping function
This trial is testing whether colchicine, a medication used for gout, can help people with a specific type of heart failure where the heart pumps normally but is stiff. If you have heart failure with preserved pumping and certain signs of inflammation, this study might be a good fit.
HellerupAges 40 years+ - NCT07465653RecruitingPhase 1
Study of HJB647 for heart failure with reduced pumping ability
This trial tests a new medicine, HJB647, in people with heart failure who have a weak heart pump. It aims to see if the drug is safe and well-tolerated. You may qualify if your heart's pumping ability is reduced and you are on a specific standard therapy.
Bradenton, FloridaAges 18–100 - NCT06862908RecruitingPhase 2
Study of IBI362 for heart failure with obesity
This study tests a new medicine called IBI362 for people with heart failure and obesity. The medicine may help improve symptoms and quality of life. You must have a specific type of heart failure (HFpEF or HFmrEF) and a BMI of 28 or higher.
Beijing, Beijing MunicipalityAges 18 years+ - NCT05371496Enrolling by invitationPhase 4
Semaglutide for heart failure patients with preserved pumping function
This Phase 2 trial studies whether semaglutide can improve heart function and related body/heart “metabolic” effects in people with heart failure with preserved ejection fraction. It may help you by improving the heart pressures that build up when you’re active and may reduce harmful strain on the body.
Rochester, MinnesotaAges 18 years+ - NCT05508035RecruitingPhase 3
Testing sacubitril/valsartan vs ramipril for heart failure
This trial compares two blood-pressure and heart-failure medicines: sacubitril/valsartan versus ramipril, to see which improves heart pumping and heart structure over time. It’s aimed at people with ischemic (blocked-artery) heart failure with mid-range ejection fraction and ongoing symptoms.
Krakow, Lesser Poland VoivodeshipAges 18 years+ - NCT06244953Recruiting
Heart failure support program with palliative care
This study tests whether a tailored program that includes palliative care (extra support for comfort and quality of life) can help people with advanced heart failure and their family caregivers. It aims to reduce hospital visits and improve well-being.
SingaporeAges 21–99 - NCT06377761Recruiting
Qishen granules for heart failure with preserved pumping function
This trial tests a Chinese herbal medicine called Qishen Granules for people with heart failure who still have a normal pumping ability (ejection fraction 50% or higher). It may help reduce symptoms and improve heart function.
Guangzhou, GuangdongAges 18–85 - NCT06706791RecruitingPhase 4
Empagliflozin for heart failure & diabetes: quality of life study
This trial tests whether a diabetes medicine called empagliflozin can improve the quality of life for people who have both chronic heart failure with a weak heart pump and type 2 diabetes. It compares the effects of adding empagliflozin to your current treatments.
Karachi, SindhAges 40–70 - NCT05583773RecruitingPhase 4
Herbal medicine for heart failure with lower pumping strength
This trial tests SHengXIaN-QuYu decoction (an herbal treatment) in people with symptomatic heart failure and reduced pumping function. It looks to see whether the herbal formula is safe and helpful for heart failure symptoms and heart function.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06447467Recruiting
Heart failure recovery in diabetics and non-diabetics
This study looks at how people with and without diabetes recover from acute heart failure (a sudden worsening). It aims to compare short-term outcomes in the hospital.
SohagAges 18 years+ - NCT07318103RecruitingPhase 2
Study of HRS-9057 for fluid retention in heart failure
This trial tests an investigational drug, HRS-9057, in people hospitalized with heart failure who still have fluid buildup despite taking standard diuretics. The goal is to see if HRS-9057 helps remove excess fluid better than current treatments.
Beijing, Beijing MunicipalityAges 18 years+
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Common questions
- Are there clinical trials for decompensated heart failure?
- Yes. Clin2 currently lists 162 recruiting decompensated heart failure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a decompensated heart failure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a decompensated heart failure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.