Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,838 recruiting studies in this area right now.
By phase
- Not applicable3,969
- Phase 2224
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 276
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis141
- Fibromyalgia102
- Osteoporosis87
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida80
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,838 total
- NCT05250375Recruiting
Study of mitochondrial muscle diseases over time
This natural history study follows children and adults with suspected or confirmed mitochondrial myopathy to better understand symptoms and how the condition changes. It may also include healthy participants to compare test results and improve future treatments.
Philadelphia, PennsylvaniaAges birth–100 years - NCT05251415Recruiting
Study of rare autoimmune diseases with blood and medical samples
This trial collects clinical and lab information (like blood and medical history) from people with rare autoimmune diseases, especially when symptoms are unusual. It aims to better understand what causes these illnesses and how newer treatments may help.
ToulouseAges 6–99 - NCT05254574RecruitingPhase 1
Acoustic therapy for ongoing joint pain from osteoarthritis
This Phase 1 study tests a sustained acoustic medicine device to help reduce pain from osteoarthritis (wear-and-tear arthritis) in joints like knees or hips. Because it’s early-stage research, you may be asked to follow strict rules about pain medicines and device use while the team monitors safety and comfort.
Tampa, FloridaAges 35–85 - NCT05264025RecruitingPhase 1/Phase 2
Fexofenadine for active rheumatoid arthritis
This Phase 1/2 study tests whether fexofenadine (an allergy medicine) can improve symptoms and inflammation in people with active rheumatoid arthritis. Participants may be assigned to different treatment groups, and the study looks at safety and early signs of benefit.
Banī SuwayfAges 18–60 - NCT05263596Recruiting
Testing ways to diagnose muscle loss in older adults
This study looks for the best ways to detect sarcopenia, which means age-related loss of muscle strength and mass, in older people in a hospital or care setting. It may help doctors spot muscle problems earlier so they can plan better care.
BaselAges 65 years+ - NCT05266976Recruiting
Exercise types and bone markers in healthy older veterans
This study compares different ways of exercising to see how they affect “bone-related” blood markers in older adults. It may help you and researchers understand which exercise patterns support healthy bones.
Aurora, ColoradoAges 60 years+ - NCT05273879Recruiting
Testing whether one-level fusion is needed after lumbar decompression
This trial compares outcomes after decompression surgery for one affected area in the lower back, with and without adding spinal fusion. It may help patients avoid unnecessary extra surgery—or ensure fusion is used when it’s needed.
Moscow, MoscowAges 45–75 - NCT05272488Recruiting
Manual therapy plus vagus nerve stimulation for jaw muscle pain
This trial tests whether combining hands-on jaw treatment with a vagus nerve stimulator can reduce jaw muscle pain and improve jaw movement. It may help people whose jaw pain has been present recently and who have not had recent physiotherapy.
Alcalá de Henares, MadridAges 18 years+ - NCT05276024Recruiting
iFuse implant plus SI joint fusion for low back pain
This study looks at a specific implant technique (iFuse Bedrock with iFuse-3D) during surgery to fuse the sacroiliac (SI) joint area and stabilize the low back/pelvis. It may help people with degenerative SI joint disease who have pain triggered by SI joint tests before surgery.
BordeauxAges 18 years+ - NCT05277818Recruiting
Follow-up study after certain lower-back disc surgery
This study collects health information after lower-back disc surgery to track outcomes over time. It may help improve how the surgery and devices are monitored in real-world patients.
ColmarAges 18 years+ - NCT05278520Recruiting
Study of hip arthritis types during hip replacement surgery
This study looks at differences inside the hip joint and in body cells when people have hip arthritis or rheumatoid arthritis and receive a hip replacement. Researchers hope this can improve understanding and future treatments for these conditions.
Turku, Southwest FinlandAges 18–74 - NCT05281757Recruiting
Follow-up safety check for Ennovate complex in adults
This study collects safety and imaging (radiology) follow-up information from people who used the Ennovate® Complex for a specific medical reason. It helps confirm the device works well and is safe in real-world use.
BrnoAges Any age - NCT05284006Recruiting
Non-invasive tests for Morquio A
This trial studies Morquio A (MPS IVA) using non-invasive ways to measure how the body is working, and to better understand why the condition happens. If you have Morquio A, this may help researchers learn more and improve care.
Wilmington, DelawareAges Any age - NCT05287867Recruiting
Study for painful degenerative disc disease treatment
This trial is testing a treatment approach for people with long-lasting, painful worn-out discs in the lower back (and sometimes leg pain). It looks for people who tried common non-surgical options without enough relief and who may be headed toward a lumbar procedure.
Broomfield, ColoradoAges 25–65 - NCT05290363Recruiting
Studying a blood signal in active spondyloarthritis
This study looks at how a body signal called IL-23 may drive inflammation in spondyloarthritis (including joints) using samples from your care. It may help researchers identify which body cells and targets are involved, and how treatments could work better for active disease.
CréteilAges 18 years+ - NCT05291819Recruiting
Imaging-guided vs standard treatment for psoriatic arthritis
This study compares two “treat-to-target” strategies for psoriatic arthritis. One strategy uses imaging to guide treatment changes, and the other uses standard clinic assessments, to see which approach controls symptoms more effectively.
ÅlesundAges 18 years+ - NCT05292339RecruitingPhase 4
Ketorolac shot for painful hand and arm tendon/joint problems
This trial studies whether a ketorolac injection can safely reduce pain and symptoms from certain shoulder, elbow, hand, or wrist tendon or joint conditions. It may help people who haven’t had surgery for the problem yet.
Atlanta, GeorgiaAges 18 years+ - NCT05299762Recruiting
INFUSE bone graft for lower back fusion: patient follow-up study
This study tracks patients who receive INFUSE bone graft during a specific type of lower back fusion surgery. It helps confirm how the device performs in real-world care and monitors safety and outcomes after surgery.
SeoulAges 18 years+ - NCT05300893Recruiting
Night splinting after a minimally invasive hand release
This trial checks whether wearing a night splint after a specific procedure for Dupuytren’s contracture helps keep your fingers straighter. It’s meant to reduce the chance of the hand contracting again during recovery.
Falun, Dalarna CountyAges 18 years+ - NCT05301959Recruiting
Electrolysis treatment for Achilles tendon pain
This trial studies whether percutaneous electrolysis can improve long-lasting Achilles tendon pain. It compares the treatment against a placebo and aims to reduce pain and symptoms in people with MRI-proven tendinopathy.
Buenos Aires, Buenos Aires F.D.Ages 18–65 - NCT05303285RecruitingPhase 4
Secukinumab for active ankylosing spondylitis in Chinese adults
This trial studies whether secukinumab (a targeted medicine given by injection) can reduce symptoms and disease activity in adults with active ankylosing spondylitis. You may be considered if other common anti-inflammatory medicines have not worked well enough or you could not take them.
Wuhan, HubeiAges 18–80 - NCT05302934Recruiting
Testing a knee-surgery app and sensor after knee replacement
This trial checks whether a data platform that uses a wearable sensor and a phone app works well for people getting a total knee replacement. It may help make follow-up care more organized and easier by capturing recovery information.
Konstanz, Baden-WurttembergAges 18 years+ - NCT05305066Recruiting
Study for people with rheumatoid arthritis who tried standard medicines
This trial studies an add-on treatment approach for rheumatoid arthritis (RA) in adults whose symptoms did not improve with standard “first-line” medicines. It may help people who still have active RA after trying certain disease-modifying drugs.
Montreal, QuebecAges 18 years+ - NCT05310799Recruiting
Personalized risk estimates for children with newly diagnosed JIA
This study looks at how best to estimate a child’s likely symptoms and treatment response in the first phase after a new JIA diagnosis. It may help families and clinicians make clearer, more personalized decisions about care.
Vancouver, British ColumbiaAges 1–18
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,838 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,965 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.