Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,610 recruiting studies in this area right now.
By phase
- Not applicable3,773
- Phase 2214
- Phase 4199
- Phase 1182
- Phase 3138
- Phase 1/Phase 270
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis173
- Rheumatoid Arthritis131
- Fibromyalgia104
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee65
- Shoulder Pain48
- Hip Osteoarthritis43
- Degenerative Disc Disease39
- Psoriatic Arthritis39
- Chronic Pain38
- Total Knee Arthroplasty38
- Systemic Lupus Erythematosus37
- Duchenne Muscular Dystrophy36
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital24
- Hacettepe University23
- Tanta University22
Where studies are running
- California206
- New York86
- Florida83
- Maryland76
- Arizona71
- Massachusetts71
- Texas66
- Alabama60
- Illinois50
- Pennsylvania47
Recruiting studies4,610 total
- NCT06621914Recruiting
Blood flow restriction training for military with leg injuries
This trial tests a low-weight exercise program using a special cuff on the leg (blood flow restriction) to see if it helps military personnel recover from leg injuries faster. It could be an option if pain is stopping you from doing normal rehab.
Loughborough, LeicestershireAges 18–55 - NCT06939530Recruiting
Comparing shoulder stretch treatments for frozen shoulder
This study compares two different amounts of fluid injected into the shoulder joint to treat frozen shoulder (adhesive capsulitis). The goal is to see which volume works better for pain and movement.
CórdobaAges 30–70 - NCT06940453Recruiting
A new cage for spinal fusion surgery
This trial is testing a new device called the CONDUIT cage for a type of back surgery called anterior lumbar interbody fusion (ALIF). The surgery helps treat degenerative disc disease in the lower back by fusing two vertebrae together using a cage to support the spine. The study will see how well this cage works in patients who are already scheduled for this surgery.
Dublin, LeinsterAges 18 years+ - NCT06941636RecruitingPhase 3
Botox for jaw muscle pain from TMD
This trial tests whether Botox injections can reduce jaw and face muscle pain in people with temporomandibular disorders (TMD). It is for those who have had moderate to severe pain for at least 3 months and have not received Botox recently.
StockholmAges 18–50 - NCT05971329Recruiting
Pilot study of bone graft for cervical disc wear and nerve symptoms
This trial tests a new bone graft product (ZetaFuse™) used during front-of-the-neck surgery to treat “wear and tear” in the cervical (neck) discs causing nerve problems. It may help relieve pain and nerve-related symptoms when other treatments haven’t worked.
Randwick, New South WalesAges 22–75 - NCT06503224Recruiting
Cell therapy for refractory autoimmune diseases
This trial tests a new type of cell therapy (SCAR02) that targets two proteins on immune cells to help calm down overactive autoimmune diseases like rheumatoid arthritis, lupus, Sjögren's syndrome, or systemic sclerosis. It may be an option if standard treatments haven't worked well enough.
Changsha, HunanAges 18 years+ - NCT06905691Recruiting
Eccentric training after ACL reconstruction
This study tests if a specific exercise (eccentric training) helps people recover better after ACL surgery. You may join if you are between 18 and 40 and are scheduled for this surgery.
Veranópolis, Rio Grande do SulAges 18–40 - NCT06934421Recruiting
A new approach for knee radiofrequency ablation
This trial tests a revised method for radiofrequency ablation to treat chronic knee pain from severe osteoarthritis (KL grade III or IV). It aims to see if the procedure can help patients who haven't gotten relief from standard treatments like physical therapy, painkillers, and steroid injections.
FaroAges 18 years+ - NCT06941584Recruiting
AIRE gene's role in autoimmune nerve diseases
This study looks at how the AIRE gene affects people with autoimmune nerve diseases like NMOSD, myasthenia gravis, and autoimmune encephalitis when they also have other autoimmune conditions. It may help researchers understand why some people get multiple autoimmune problems.
RomaAges 18 years+ - NCT06943053Recruiting
Waterproof bandage study for knee replacement recovery
This study compares two types of waterproof bandages used after total knee replacement surgery to see which one works better at keeping the wound dry and clean.
Pathum Thani, Khlong luangAges 55 years+ - NCT06943131Recruiting
Exercises for children with shoulder blade movement issues
This study tests two exercise programs—YWTL exercises and close kinetic chain exercises—for children with a shoulder blade movement problem. It aims to find which exercises help reduce pain and improve arm function.
Lahore, Punjab ProvinceAges 9–12 - NCT05660031Recruiting
Biceps treatment during rotator cuff repair
This study looks at how to treat the biceps tendon when someone is getting surgery for a rotator cuff tear. It may help improve outcomes after surgery and recovery, especially when there is also a supraspinatus tear.
Ann Arbor, MichiganAges 50–80 - NCT05924386Recruiting
Testing dental implants for jawbone change in full dentures
This study looks at how a specific implant connection (“OT bridge attachment system”) affects changes in the lower jawbone over time in people who have no teeth. You might benefit by getting a fixed All-on-Four style set of lower teeth, with close monitoring of your jawbone and fit.
CairoAges 40 years+ - NCT05756179RecruitingPhase 3
Diosmin and hesperidin for mild to moderate rheumatoid arthritis
This trial tests whether two natural plant-based medicines (diosmin and hesperidin) can reduce symptoms in people with mild to moderate rheumatoid arthritis. It compares treatment outcomes to standard care to see if these supplements help control the disease.
AlexandriaAges 19–65 - NCT07184450RecruitingPhase 1
CAR-T cell therapy for children with hard-to-treat rheumatic diseases
This trial tests a new treatment using your child's own immune cells, modified to target B cells and fight severe rheumatic diseases like juvenile dermatomyositis, arthritis, scleroderma, or Sjogren's syndrome. It's for children who haven't improved with standard treatments.
Hangzhou, ZhejiangAges 5 years+ - NCT07188012RecruitingEarly Phase 1
Gene therapy trial for Duchenne muscular dystrophy in young boys
This trial tests a new gene therapy called SPOT-03 to see if it can help the body make dystrophin, a protein that is missing in Duchenne muscular dystrophy (DMD). It is for boys ages 2 to under 8 who can still walk at least 10 meters.
Shanghai, Shanghai MunicipalityAges 2–7 - NCT07189819Recruiting
Closed-loop FES system for improving walking after stroke
This study tests a new electrical stimulation system that adapts in real time to help people who have had a stroke walk better. It may improve your step and make walking feel more natural.
Atlanta, GeorgiaAges 40–90 - NCT07189260Recruiting
Breathing exercises to prevent pneumonia after hip fracture
This trial tests whether simple breathing exercises before and after surgery can help prevent pneumonia in people with hip fractures. It is not a medication study—you'd use a small device to help you breathe deeply.
CopenhagenAges 18 years+ - NCT07188350Recruiting
Electrical muscle stimulation for patients on a breathing machine
This trial tests whether low-level electrical pulses to the leg muscles can help prevent weakness in patients who need a breathing tube (ventilator) for more than 48 hours. It aims to see if this treatment helps patients recover faster.
Porto Alegre, Rio Grande do SulAges 18 years+ - NCT07190339Recruiting
Nerve block for hip osteoarthritis pain
This trial tests whether blocking specific nerves in the hip and groin area can reduce pain from hip osteoarthritis when standard treatments like painkillers or physical therapy haven't worked.
AnkaraAges 18–75 - NCT07190820Enrolling by invitation
Comparing digital vs. traditional dental implant impressions
This study compares digital and traditional methods for taking dental impressions in people who have a full arch of implants supporting a permanent fixed bridge. It aims to see which method is more accurate.
ShanghaiAges 30–80 - NCT07191353RecruitingPhase 2
Bone strength study: weight training and a drug for bone health
This trial tests whether combining resistance training with the drug rapamycin can improve bone formation in postmenopausal women who have lower-than-normal bone density but not osteoporosis. It aims to find a new way to strengthen bones and prevent fractures.
Bispebjerg, Region SjællandAges 60–75 - NCT07193056Recruiting
CPH-MBD Cohort study for advanced kidney disease
This study is for people with advanced chronic kidney disease (CKD stages 4-5) whose kidneys are working at 29% or less. It aims to follow their health over time to better understand the condition.
HerlevAges 18 years+ - NCT07191743Recruiting
Functional Assessment in ICU Patients
This study observes how well adults in the intensive care unit (ICU) can function in daily activities, like moving and caring for themselves. It aims to understand recovery and may help improve care for future ICU patients.
Rio de Janeiro, Rio de JaneiroAges 18 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,610 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,529 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.