Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,838 recruiting studies in this area right now.
By phase
- Not applicable3,969
- Phase 2224
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 276
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis141
- Fibromyalgia102
- Osteoporosis87
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida80
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,838 total
- NCT05691868Recruiting
Long-term follow-up for a mobile-bearing ankle replacement
This study follows people who get a total ankle replacement using a specific implant, to check how it does over many years. You may be asked to return for regular visits so the team can see what works best and whether complications occur.
Santa Cruz de TenerifeAges 21 years+ - NCT05692778Recruiting
Care program for people with diabetes and foot problems
This trial is testing an improved care approach for people with diabetes who have foot complications, delivered through primary care. It may help by organizing care more effectively and supporting better diabetes and foot management.
GothenburgAges 18 years+ - NCT05697159Recruiting
7-tesla brain MRI to study how filgotinib eases RA pain
This trial uses a very high-strength brain MRI to understand how the RA medicine filgotinib may reduce pain. If you have active rheumatoid arthritis and can safely complete the scan, the study may help researchers better target pain relief in RA.
GlasgowAges 18–74 - NCT05700682Recruiting
MRI-guided artery blockage procedure for long-term joint pain
This study tests whether an MRI scan that looks at blood flow can help target a joint embolization procedure to reduce chronic shoulder, hip, or knee pain. It first uses MRI to find signs of increased blood flow, then may use the findings to guide treatment if you qualify.
Palo Alto, CaliforniaAges 25–80 - NCT05701059Recruiting
Tests different artificial discs for neck nerve and spinal cord problems
This trial compares two types of artificial disc implants used for certain neck problems. It may help people who have tried non-surgical treatments but still have ongoing nerve symptoms or spinal cord issues from a damaged disc in the neck.
Los Angeles, CaliforniaAges 18–60 - NCT05701254Recruiting
Study how type 1 diabetes affects fracture risk bones
This study compares bone structure in women with type 1 diabetes versus women without diabetes, to understand why fractures can happen more easily. You may need blood tests, scans, and a small bone biopsy (a surgical sample from your hip/thigh area).
Omaha, NebraskaAges 50 years+ - NCT05702476Recruiting
Non-invasive 3D scan study for Marfan face features
This study uses a non-invasive 3D scan to better measure facial features in people with Marfan syndrome. It may help researchers describe face differences more accurately, without needles or surgery.
San Donato Milanese, LombardyAges Any age - NCT05703958Recruiting
Long-term follow-up for a shoulder fracture plate
This study follows people who received a specific shoulder (proximal humerus) fracture plate system, to track how the implant performs over time. It helps doctors understand long-term safety and durability of the device after surgery.
New York, New YorkAges 21 years+ - NCT05704036RecruitingPhase 4
Estrogen use and bone health in women with cystic fibrosis
This observational study looks at how taking (or not taking) estrogen affects bone health in women with cystic fibrosis (CF). If you may have low estrogen, it also explores whether estrogen levels and symptoms relate to bone density over time.
Baltimore, MarylandAges birth–100 years - NCT05704257Recruiting
Fetal surgery study for complex gastroschisis safety
This trial tests whether a specialized fetal operation is safe and practical for babies with a serious form of gastroschisis (bowel outside the belly) and swollen bowel. You may be considered if the pregnancy is otherwise free of major related problems and the family is ready for follow-up after birth.
Houston, TexasAges 18 years+ - NCT05710952Recruiting
Orthodontic braces study and how they affect jaw joints
This study looks at whether multi-attachment orthodontic treatment (either on the front or back of teeth) changes the temporomandibular joint, which is the jaw joint. The researchers will assess your jaw joint using a tool called Modjaw.
MontpellierAges 18 years+ - NCT05713149Recruiting
Treating pressure sores with surgery and anti-bacterial medicines
This study looks at whether combining a surgical skin flap with anti-bacterial treatment can improve pressure sores that are complicated by bone infection (osteomyelitis). It targets adults who have nerve/movement problems that put them at high risk for these sores.
GarchesAges 18 years+ - NCT05715021Recruiting
First-Time Shoulder Dislocation Care Study
This study looks at treatment options for people who have had a first shoulder dislocation in the last 3 months. It may help find the best way to keep the shoulder from dislocating again and improve recovery.
Hamilton, OntarioAges 14–40 - NCT05717179Recruiting
Ultrasound-guided treatment choices for rheumatoid arthritis
This trial uses ultrasound to help decide how to adjust treatment in people with rheumatoid arthritis. It may help tailor therapy to keep the disease under better control using a treat-to-target approach.
Bruneck, BolzanoAges 18–84 - NCT05719935Recruiting
KinematX wrist replacement registry for people with wrist arthritis
This trial is a registry that follows people who get (or already had) a KinematX total wrist replacement. It collects health and recovery information to better understand outcomes for different wrist problems, like arthritis or certain bone alignment issues.
Loma Linda, CaliforniaAges 18–85 - NCT05724173Recruiting
Test of a brain-to-computer device for ALS hand paralysis
This study checks whether a brain-computer interface (a BrainGate2 system) is safe and workable for people with ALS. If you qualify, you may be asked to try the device and complete study tasks to help researchers learn how well it can support communication or control.
Stanford, CaliforniaAges 18–80 - NCT05725928Recruiting
Walking-support program for older hospitalized patients
This study tests whether extra help and guidance to walk while you’re in the hospital can improve health and recovery. It’s for older adults who can safely do some walking after being admitted for a medical problem.
Springfield, MassachusettsAges 65 years+ - NCT05726383RecruitingPhase 2
Mistletoe shots for lung-spread osteosarcoma after surgery
This trial tests Iscador P, a mistletoe-based immunotherapy given as skin injections, to help stop or control recurrent, resected osteosarcoma that has spread to the lungs. It’s for people who already had all visible lung metastases removed and are now trying to stay in remission.
Hackensack, New JerseyAges 8–30 - NCT05726591Recruiting
Robotic exoskeleton study to improve walking in children
This study looks at how safely using a pediatric robotic exoskeleton over the long term can improve how children walk. It’s for children ages 3–17 who have certain movement or spine-related conditions and who can meet walking and joint-movement requirements.
Bethesda, MarylandAges 3–17 - NCT05732870Recruiting
Study looks for blood and gene signals that affect bone health
This study collects information and samples around the time of certain bone or joint surgeries (like joint replacement or fracture repair) to learn what factors help or harm bone healing. The results may help find better targets to improve long-term bone health and recovery.
London, Greater LondonAges 18–110 - NCT05734651Recruiting
Study of PROMIS stem in hip replacement patients
This study looks at people who had a hip replacement (total hip arthroplasty) using the PROMIS stem. The goal is to evaluate how this specific hip part performs in real-world use.
Sankt Johann in Tirol, TyrolAges 18 years+ - NCT05738824Recruiting
Study how inflammatory muscle diseases naturally change over time
This study follows people with suspected or confirmed inflammatory muscle disease (and sometimes healthy adults) to better understand how the condition progresses and what changes over time. It may help researchers identify patterns that could guide future treatments.
Bethesda, MarylandAges 2–120 - NCT05741112Recruiting
Long COVID wearable study to track symptoms and help daily management
This study uses a wearable device to track symptoms and patterns in people with Long COVID, ME/CFS, and/or POTS. The goal is to see how wearable feedback and tracking tools may help you manage your symptoms.
La Jolla, CaliforniaAges 18 years+ - NCT05742776Recruiting
Ultrasound and sleep quality check in carpal tunnel
This trial studies whether ultrasound exam findings match how well you sleep if you have carpal tunnel syndrome. It may help doctors better understand which ultrasound results go along with worse sleep and symptoms.
Afyonkarahisar, Afyonkarahi̇sarAges 20–80
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,838 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,965 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.