Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,610 recruiting studies in this area right now.
By phase
- Not applicable3,773
- Phase 2214
- Phase 4199
- Phase 1182
- Phase 3138
- Phase 1/Phase 270
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis173
- Rheumatoid Arthritis131
- Fibromyalgia104
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee65
- Shoulder Pain48
- Hip Osteoarthritis43
- Degenerative Disc Disease39
- Psoriatic Arthritis39
- Chronic Pain38
- Total Knee Arthroplasty38
- Systemic Lupus Erythematosus37
- Duchenne Muscular Dystrophy36
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital24
- Hacettepe University23
- Tanta University22
Where studies are running
- California206
- New York86
- Florida83
- Maryland76
- Arizona71
- Massachusetts71
- Texas66
- Alabama60
- Illinois50
- Pennsylvania47
Recruiting studies4,610 total
- NCT06787417RecruitingPhase 4
Knee alignment study for total knee replacement
This study compares two different surgical techniques for total knee replacement to see which one leads to better knee movement and function. If you need a knee replacement due to arthritis, this trial may help find the best approach for your surgery.
Hamilton, OntarioAges 18 years+ - NCT06693479Recruiting
Using a feedback device to help manage shoulder pain at work
This study tests whether a feedback device can help people with work-related shoulder pain manage their symptoms. You may qualify if you have shoulder pain from rotator cuff issues, arthritis, or rheumatoid arthritis and work full-time.
Québec, QuebecAges 18 years+ - NCT06962046Recruiting
Can virtual reality improve knee replacement surgery results?
This trial tests if using virtual reality (VR) during knee replacement surgery can help improve your recovery. You wear a VR headset during the procedure to relax and distract you, which may lead to better outcomes.
BelfastAges 18–100 - NCT06877078Recruiting
Podcast for constipation before surgery
This study tests if listening to a podcast about preventing constipation before surgery can help people who are having back, shoulder, knee, or hip surgery. If you are scheduled for one of these surgeries, you may be able to take part.
SilkeborgAges 18 years+ - NCT07126262RecruitingPhase 2
Vosoritide for growth in infants with hypochondroplasia
This study tests a daily injection called vosoritide to see if it helps children with hypochondroplasia grow taller. It is for babies and toddlers up to 35 months old who are shorter than average for their age.
Phoenix, ArizonaAges birth–3 years - NCT07127042RecruitingPhase 2
Testing a drug to reduce bleeding during knee replacement
This trial tests an experimental drug called BT-114143 to see if it reduces bleeding during and after total knee replacement surgery. It may be a good option for people with osteoarthritis who are having their first knee replacement.
Chengdu, Si'ChuanAges 18–70 - NCT07127978Recruiting
Study of Givinostat in people with Duchenne muscular dystrophy
This study is for people with Duchenne muscular dystrophy (DMD) who are taking Givinostat, a daily oral medicine. Researchers will look at real-world data to see how the medicine works in everyday life, including lab results and how it's being used.
Little Rock, ArkansasAges 6 years+ - NCT07133633RecruitingPhase 2
Tulisokibart for X-ray confirmed axial spondyloarthritis
This study tests a new medicine called Tulisokibart for people with a type of inflammatory arthritis that affects the spine and pelvic joints, specifically when X-rays show changes. The goal is to see if it can reduce symptoms like pain and stiffness.
Chandler, ArizonaAges 18–80 - NCT07134257Recruiting
Smart crutch tips for leg fracture recovery
This study tests a special crutch tip that helps guide how much weight you put on your leg after shinbone surgery. It may help you recover more safely by giving you feedback on your weight-bearing.
Kyiv, Kyiv OblastAges 18–80 - NCT07134010Recruiting
Sugar-water injections for frozen shoulder
This study tests a treatment called perineural injection therapy, where a sugar-water solution (dextrose) is injected around the nerves in your shoulder. It may help reduce pain and improve movement in people with frozen shoulder that hasn't improved with other treatments.
Kuala Selangor, SelangorAges 18 years+ - NCT07128043Enrolling by invitation
Cassava wax baths for trigger finger pain and function
This study tests whether warm baths made from cassava (tapioca) wax can reduce pain, improve hand function, and help with the catching or locking feeling in people with trigger finger. If you have trigger finger and no other major hand problems, this treatment may offer a gentle, non-surgical option.
Chiang Rai, Tha SutAges 40–70 - NCT07130552Recruiting
Comparing two pain relief methods after knee replacement
This study tests two different nerve-block techniques to see which provides better pain control after total knee replacement surgery. The goal is to help you recover more comfortably.
KaramanAges 18–85 - NCT07131787Recruiting
Blood flow restriction training after Achilles tendon repair
This study tests whether adding blood flow restriction training to standard rehab helps your Achilles tendon and calf muscle heal better after surgery. You would do exercises with a special cuff that gently limits blood flow to your leg.
Ghent, East-FlandersAges 18 years+ - NCT07134244Recruiting
Predicting cartilage damage and pain after knee injury or early arthritis
This study uses computer models and MRI scans to predict how knee cartilage and pain may change over time in people with early osteoarthritis or a recent ACL tear. It aims to find better ways to manage these conditions and prevent long-term damage.
Aalborg, North DenmarkAges 18–70 - NCT07127380Recruiting
Comparing two types of spine surgery for disc-related low back pain
This study compares two different surgery methods (Mini-TLIF and MIDLIF) for treating low back pain caused by worn-out discs in the lower back. The goal is to see which one offers better recovery, fewer complications, and lower costs.
Lodz, Łódź VoivodeshipAges 18 years+ - NCT07127250Recruiting
Can walking sticks help people with spine imbalance walk more?
This study tests whether using walking sticks can help people with a forward-leaning spine (sagittal imbalance) walk more and feel better. If you are 50 or older, have trouble walking due to this spine condition, and don't already use walking sticks, you may be able to join.
ParisAges 50 years+ - NCT07132333Recruiting
Personalized inflammation study for chronic conditions
This study uses advanced testing to understand inflammation in people with certain chronic inflammatory diseases, such as psoriasis, psoriatic arthritis, other types of arthritis, or inflammatory bowel disease. The goal is to tailor treatment to your specific needs.
TübingenAges 18 years+ - NCT07125963Recruiting
Custom vs. standard jaw positioning for jaw surgery
This study compares two ways of positioning your jaw during surgery to correct jaw alignment. The goal is to see if using a custom-made guide based on your own CT scans leads to better results than the standard method.
Istanbul, BağcılarAges 18 years+ - NCT07126431Recruiting
Study of hard-to-treat rheumatoid arthritis
This study is observing people with a hard-to-treat form of rheumatoid arthritis (RA). Researchers want to understand what treatments and outcomes are like for people whose RA doesn't get better with standard medications like methotrexate.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07129096Enrolling by invitation
Digital relaxation training for jaw pain
This study tests if a digital relaxation program can help reduce jaw pain caused by temporomandibular disorders (TMD). It may be a good option if you have jaw muscle or joint pain and want to try a non-drug approach.
OuluAges Any age - NCT07132736Recruiting
Underwater vs. regular exercise for quality of life and muscle power
This trial compares exercising underwater to doing regular aerobic exercise on land. It aims to see which type of exercise better improves muscle strength, energy levels, and overall quality of life in people with excess weight.
AmmanAges 18–50 - NCT07132762Recruiting
Shock wave therapy for chronic low back pain
This study tests whether adding a special sound wave therapy (called ESWT) to standard care (like exercise and education) can reduce pain and improve daily function in people with long-term low back pain. It is designed for people whose back pain does not have a specific known cause.
DenizliAges 18–65 - NCT07128602Recruiting
Brain stimulation to help quadriceps after ACL surgery
This study tests whether a gentle, non-invasive brain stimulation can improve thigh muscle function in women recovering from ACL reconstruction. If you are between 2 and 6 months post-surgery, you may be able to join.
Glenside, PennsylvaniaAges 18–35 - NCT07129954Recruiting
Fear of Falling in Muscular Dystrophy Trial
This trial tests a treatment to help people with certain types of muscular dystrophy who are afraid of falling. It aims to improve confidence and walking safety.
Verona, veronaAges 16–65
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,610 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,529 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.