Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,838 recruiting studies in this area right now.
By phase
- Not applicable3,969
- Phase 2224
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 276
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis141
- Fibromyalgia102
- Osteoporosis87
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida80
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,838 total
- NCT05746533Recruiting
Hip surgery outcomes study
This trial looks at how well hip-preserving surgery works for people who need hip surgery. It may help your care team understand what outcomes to expect after this type of operation.
New Haven, ConnecticutAges 12 years+ - NCT05752396Recruiting
Study of Pain Patterns Over Time in Kids
This study follows kids who have a specific type of chronic pain (headaches, stomach pain, or muscle/joint pain) to better understand how pain changes over time. It also checks whether certain factors are linked to those pain patterns.
Cincinnati, OhioAges 10–19 - NCT05754190Recruiting
Smartphone study of mood and symptoms in people with pain
This study uses a smartphone app to track daily pain and mood changes over about 4 months. It’s meant to learn patterns that could help better understand how mood and pain affect each other.
Providence, Rhode IslandAges 18 years+ - NCT05754710Recruiting
Kids taking Xeljanz for juvenile arthritis study
This study is collecting real-world information about how Xeljanz (tofacitinib) is used and how well it works in children with juvenile idiopathic arthritis. It may help improve how the medicine is used safely in everyday care.
SeoulAges 2–17 - NCT05756179RecruitingPhase 3
Diosmin and hesperidin for mild to moderate rheumatoid arthritis
This trial tests whether two natural plant-based medicines (diosmin and hesperidin) can reduce symptoms in people with mild to moderate rheumatoid arthritis. It compares treatment outcomes to standard care to see if these supplements help control the disease.
AlexandriaAges 19–65 - NCT05760898Recruiting
Helping control blood pressure in people with rheumatoid arthritis
This study aims to improve blood pressure control in adults who have both uncontrolled high blood pressure and rheumatoid arthritis. It may help by testing ways to better coordinate care between primary care and rheumatology.
Durham, North CarolinaAges 18 years+ - NCT05761015RecruitingPhase 4
Test of an NSAID to help osteoarthritis pain when walking
This trial studies whether taking an anti-inflammatory pain medicine (an NSAID) can reduce hip or knee osteoarthritis pain during walking. It may help people who have had walking pain for at least 3 months and don’t already take NSAIDs.
Clermont-FerrandAges 50–70 - NCT05761314Recruiting
Study treatments for cancers in people with RASopathy
This study looks at people who have a RASopathy—a genetic condition—and also have solid tumors (tumor growths not in blood). To join, your RASopathy must be confirmed by genetic testing, not only by symptoms.
RomaAges Any age - NCT05764733RecruitingPhase 4
How bone exercise, alendronate, and diet affect bone strength
This trial studies whether doing a structured bone-focused exercise program, taking alendronate (a medication that slows bone loss), and making a calorie-reducing diet can improve bone strength in people with low bone density. It also compares different combinations to see what helps most and is safest for you.
Aurora, ColoradoAges 60 years+ - NCT05765071Recruiting
Botulinum injections for lower leg exertional muscle pressure pain
This trial studies whether injecting botulinum (a medicine that relaxes overactive muscles) into the lower leg can reduce pain and pressure during exercise in people with a confirmed condition called chronic exertional compartment syndrome. It may help by lowering the muscle compartment pressure that builds up after activity.
Calgary, AlbertaAges 18–50 - NCT05767047RecruitingPhase 3
Apremilast study for children with mouth ulcers from Behçet’s
This trial studies whether apremilast can help reduce mouth ulcers in children who have Behçet’s disease or juvenile psoriatic arthritis. You may be considered if your child finished a main study and is under 18, and can safely continue treatment.
ThessalonikiAges 5–18 - NCT05767762Recruiting
Tests whether leg muscle patterns predict treatment outcome in clubfoot
This study looks at how certain leg muscles move to see if that can predict how well an Achilles tenotomy (a small procedure to release tight tendon) works for children with idiopathic clubfoot. It may help doctors choose the best timing and approach for treatment.
NiceAges birth–1 year - NCT05773482Recruiting
Breathing and attention training for fibromyalgia pain
This study tests whether breathing and attention exercises can change how your body controls pain in people with fibromyalgia. It may help you learn non-medication ways to influence pain signals and improve comfort.
Gainesville, FloridaAges 18–70 - NCT05775523Recruiting
Safety follow-up study for children using lonapegsomatropin
This study tracks the safety of lonapegsomatropin in children being treated for growth hormone deficiency (GHD). It’s meant to check for side effects and make sure the medicine continues to be safe in real-world use.
Phoenix, ArizonaAges 1–18 - NCT05778006Recruiting
Registry for people with ME/CFS
This study is a registry, meaning it collects information from people who have ME/CFS. It helps researchers better understand ME/CFS and may guide future studies that could improve care.
Munich, BavariaAges birth+ - NCT05779670Recruiting
Check if home exercises work after leg bone tumor surgery
This trial looks at whether a personalized home exercise plan helps people recover after surgery to rebuild a lower leg for a bone tumor. It may help by improving exercise adherence using support for at-home care during treatment.
BolognaAges 12–90 - NCT05781763Recruiting
High-intensity exercise for spondyloarthritis pain and stiffness
This study tests whether a structured, high-intensity exercise program can improve symptoms in people with axial spondyloarthritis. It compares the exercise approach against another group to see if it helps function and well-being.
Halmstad, Halland CountyAges 18–67 - NCT05782335Recruiting
Study immune cell changes with Orencia in rheumatoid arthritis
This trial studies how Orencia (abatacept) affects your immune system’s T and B cells in people with rheumatoid arthritis. It may help researchers better understand who responds to Orencia and what immune changes happen over time.
New York, New YorkAges 18 years+ - NCT05785884Recruiting
Diet program to help knee osteoarthritis pain
This trial studies whether different diet approaches can reduce knee pain in people with knee osteoarthritis who have certain eating patterns. It may help by changing diet-related factors that can affect inflammation and pain.
Birmingham, AlabamaAges 40–75 - NCT05786235Recruiting
Pregnant people with or without antiphospholipid antibodies
This study is looking at pregnancy outcomes in people who are pregnant and either have antiphospholipid antibody syndrome (APS) or do not have APS but do have prior full-term pregnancies. It may help doctors understand risks and how to manage pregnancies in these groups.
MilanAges 18–45 - NCT05787808Recruiting
Preventive treatment for people with early bone loss
This trial studies a preventive treatment for people over 55 who have early bone thinning (called osteopenia). If you qualify, it may help reduce the risk of getting osteoporosis and related fractures.
Skjetten, AkershusAges 55–85 - NCT05790031Recruiting
Night brace with smart padding for teenage scoliosis
This trial tests an intelligent nighttime brace with sensors and smart padding to help teens with early scoliosis straighten or stop it from worsening. You may be asked to wear the brace at night and complete tests to track curve changes and comfort.
Hong KongAges 10–13 - NCT05790356Recruiting
Fecal transplant to treat rheumatoid arthritis symptoms
This study tests whether transferring stool from a screened healthy donor into the gut can improve rheumatoid arthritis (RA) in people whose RA is in remission or low activity. It’s mainly trying to change the gut bacteria to reduce RA symptoms or flare-ups.
London, OntarioAges 18 years+ - NCT05796908Recruiting
Prosthesis surgery for unstable elbow joint injuries
This study tests a new implant (prosthesis) for people with a painful, unstable proximal radial/ulna joint in the elbow. It may help restore stability and motion if you are a good surgical candidate and can follow a long recovery and follow-up plan.
Carmel, IndianaAges 18–85
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,838 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,965 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.