Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,610 recruiting studies in this area right now.
By phase
- Not applicable3,773
- Phase 2214
- Phase 4199
- Phase 1182
- Phase 3138
- Phase 1/Phase 270
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis173
- Rheumatoid Arthritis131
- Fibromyalgia104
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee65
- Shoulder Pain48
- Hip Osteoarthritis43
- Degenerative Disc Disease39
- Psoriatic Arthritis39
- Chronic Pain38
- Total Knee Arthroplasty38
- Systemic Lupus Erythematosus37
- Duchenne Muscular Dystrophy36
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital24
- Hacettepe University23
- Tanta University22
Where studies are running
- California206
- New York86
- Florida83
- Maryland76
- Arizona71
- Massachusetts71
- Texas66
- Alabama60
- Illinois50
- Pennsylvania47
Recruiting studies4,610 total
- NCT06910696Enrolling by invitation
Comparing two nerve blocks for lumbar disc surgery pain
This trial tests two types of nerve blocks to see which one works better for pain control after lumbar disc surgery. It may help reduce pain and the need for strong pain medicines after your operation.
ZagazigAges 21–64 - NCT06911437Enrolling by invitation
Knee pain relief with Chinese formula and massage
This study tests if combining a Chinese herbal formula called Xiaoyu Zhitong with a gentle drainage massage can reduce knee pain and swelling. It may help people whose knee symptoms are worse in cold, damp weather.
BeijingAges 25–70 - NCT06905288Recruiting
Secukinumab for Ankylosing Spondylitis in Biologic-Free Patients
This study is looking at how well secukinumab works for people with ankylosing spondylitis in Korea who have never taken a biologic or JAK inhibitor before. It aims to understand if the drug helps control symptoms over a short period of time.
Jinju, Gyeongsangnam-doAges 18–40 - NCT06910033Enrolling by invitation
Long-term safety of porous titanium implants for facial and skull repair
This study checks how safe and effective custom-made porous titanium implants are over time for people who had surgery to rebuild parts of the face or skull. It helps confirm that these implants work well long-term.
CopenhagenAges Any age - NCT03245801Recruiting
Juvenile arthritis registry for newly diagnosed children
This study collects information about children with juvenile idiopathic arthritis (JIA) soon after diagnosis. The information helps researchers understand how the condition and treatments change over time, and it may guide future care.
Calgary, AlbertaAges Up to 18 years - NCT04677907Recruiting
Testing a metal knee implant feature in osteoarthritis surgery
This trial studies a specific type of knee replacement and how well it works after surgery for people with knee osteoarthritis. It may help doctors understand which implant approach leads to better outcomes and recovery.
Glasgow, ScotlandAges 18 years+ - NCT06370312Recruiting
Biomarkers for thumb osteoarthritis surgery
This study looks at joint fluid and tissue samples from people with thumb base osteoarthritis who are already scheduled for a surgery called trapeziectomy. The goal is to find markers that might help better understand the disease and improve treatment.
Malmö, Skåne CountyAges 25 years+ - NCT06907901Recruiting
Testing a measurement tool for rounded upper back
This study is testing how reliable a measurement tool (called PHAS) is for people with postural hyperkyphosis—a condition where the upper back is overly rounded. It may help researchers understand if this tool works well for people like you.
Istanbul, IstanbulAges 8–65 - NCT06902805RecruitingPhase 2/Phase 3
Testing botox injections and splints for thumb arthritis pain
This study tests if botox injections into the thumb joint, along with a custom splint, can reduce pain from thumb base arthritis. It may be an option if you have persistent pain and have not had recent thumb surgery or certain other treatments.
Paris, Île-de-France RegionAges 18 years+ - NCT06903975RecruitingPhase 4
Botox for a more feminine neck appearance
This trial tests Botox injections into the neck muscles to create a more feminine neck contour. It may be an option if you're looking for a non-surgical way to soften or slim the look of your neck.
Newton, MassachusettsAges 18–65 - NCT06900933Recruiting
Bone graft for upper jaw using jawbone blocks
This trial tests using a small piece of bone from your lower jaw to rebuild a narrow upper jaw so it can hold a dental implant. It compares using the bone alone versus covering it with a collagen membrane to see which works better.
CairoAges 20–40 - NCT06902285RecruitingPhase 4
Magnesium supplement for better sleep after joint replacement
This study tests whether taking magnesium L-threonate can improve sleep quality after total knee or hip replacement surgery. It may help you sleep better during recovery.
Miami, FloridaAges 18 years+ - NCT06904326Recruiting
Stability check for spine surgery
This trial checks if a specific imaging test before lumbar spine surgery can help predict how stable your spine is after the procedure. It focuses on people having one or two levels of decompression using a special technique called UBE.
MontpellierAges 50 years+ - NCT06906874RecruitingPhase 2
Activated charcoal for kidney disease patients on dialysis
This trial tests if taking activated charcoal by mouth can help people with advanced kidney disease who are already on dialysis. It may improve how the body handles certain waste products and reduce the need for other medicines.
Al Mansurah, Please SelectAges 18 years+ - NCT06906419Enrolling by invitation
Knee surgery study for chronic kneecap dislocations
This study looks at how well a specific knee surgery (arthroscopic trochleoplasty) works over time for people who have had repeated kneecap dislocations. If you had this surgery between 2015 and 2023, your results could help doctors understand how to better treat this condition.
DrammenAges 18 years+ - NCT06906549RecruitingPhase 4
Testing a lower dose of rituximab every 6 months for rheumatoid arthritis
This study tests whether a lower dose (200 mg) of rituximab given every 6 months is effective for maintaining control of rheumatoid arthritis. It is for people who are already on rituximab maintenance therapy and have low to moderate disease activity.
StrasbourgAges 18 years+ - NCT06906094Enrolling by invitation
Preventing arthritis after meniscus tear surgery
This trial tests a new approach to prevent arthritis after surgery to remove part of a torn meniscus. It looks at whether a treatment can stop the knee from wearing down after the operation.
Milan, MilanoAges 19 years+ - NCT06907849Enrolling by invitationPhase 2
Imaging amyloid in spinal stenosis and carpal tunnel
This trial tests a special scan that uses a radioactive tracer to look for amyloid protein deposits in people who have had surgery for lumbar spinal stenosis (narrowing of the spine in the lower back) or carpal tunnel syndrome. The goal is to see if the scan can detect these deposits, which may be linked to ongoing orthopedic issues.
Knoxville, TennesseeAges 60 years+ - NCT06903767Enrolling by invitation
Automated vs manual tool study for hip replacement
This trial tests whether an automated surgical tool is better than a manual one for putting in hip replacement parts. If you are having a planned first-time hip replacement and are over 18, you might be able to join.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06908213Recruiting
Enhanced recovery after surgery for teen scoliosis
This trial tests a special program to help teens recover faster after scoliosis surgery. It focuses on better pain control, shorter hospital stays, and getting back to normal activities sooner.
AmiensAges 11–17 - NCT06902714RecruitingPhase 3
Tranexamic acid for shoulder replacement recovery
This study tests whether taking an oral medicine called tranexamic acid (TXA) before and after shoulder replacement surgery can reduce bleeding and improve recovery. It is for adults scheduled for a total shoulder replacement who are generally healthy.
Birmingham, AlabamaAges 18–79 - NCT06906939RecruitingEarly Phase 1
Brain stimulation and tai chi for knee arthritis and depression
This pilot study tests if combining brain stimulation (rTMS) with Tai Chi can help knee arthritis pain and improve depression. It compares these two treatments to see which works better for people with both pain and low mood.
Los Angeles, CaliforniaAges 50–95 - NCT06907914Recruiting
Special exercises for hyperkyphosis in children
This study tests whether special exercises (Schroth and scapular muscle activation) can improve posture and reduce the curve in children with a rounded upper back (hyperkyphosis). It may help if you are a young person with a moderate curve and no other spinal issues.
Istanbul, IstanbulAges 7–18 - NCT06910228Enrolling by invitation
Brain oxygen changes during spine surgery position shifts
This study measures how your child's brain oxygen levels change when they are repositioned during spine surgery. It may help make surgeries safer for teens and young adults.
Columbus, OhioAges 10–21
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,610 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,529 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.