Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,843 recruiting studies in this area right now.
By phase
- Not applicable3,974
- Phase 2225
- Phase 4197
- Phase 1190
- Phase 3149
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis140
- Fibromyalgia102
- Osteoporosis86
- Osteoarthritis74
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University111
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad33
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida82
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois55
- Pennsylvania50
Recruiting studies4,843 total
- NCT07489937Recruiting
Arm exercise effects on the shoulder tendon
This study compares how two different arm exercises affect the shoulder tendon (supraspinatus) in people with and without shoulder pain. It may help find better ways to exercise without causing injury.
Gainesville, FloridaAges 18–45 - NCT07490041RecruitingEarly Phase 1
CAR-NK cell therapy for refractory childhood rheumatic diseases
This trial is testing a new type of cell therapy (CAR-NK cells) that targets two markers on immune cells (CD19 and BCMA) to treat severe forms of childhood rheumatic diseases. It aims to see if this treatment is safe and can help when other medicines have failed.
Hangzhou, ZhejiangAges 5 years+ - NCT07490522Recruiting
Remote monitoring for gout in primary care
This study tests whether a smartphone app can help your doctor monitor your gout and adjust your urate-lowering medication. It is a feasibility study, meaning it checks if the approach works well for patients.
OsloAges 18 years+ - NCT07491016Recruiting
Telitacicept plus baricitinib for hard-to-treat rheumatoid arthritis
This study tests a combination of two drugs (telitacicept and baricitinib) for people with stubborn rheumatoid arthritis that hasn't improved with other treatments. The goal is to see if this combination is safe and effective in reducing joint pain and inflammation.
Hangzhou, ZhejiangAges 18–85 - NCT07491315Recruiting
Do ME/CFS patients react differently to exercise?
This study looks at whether people with ME/CFS have a different reaction to exercise compared to people with heart conditions who also feel tired. It involves filling out online questionnaires and may help doctors better understand ME/CFS.
MarseilleAges 18 years+ - NCT07491939Recruiting
Living Well with Arthritis: A Palliative Care Study
This study explores how palliative and supportive care can help people with arthritis feel better and live well. You can join even if you are not currently receiving palliative care.
Bath, WiltshireAges 18 years+ - NCT07493096Recruiting
Intensive therapy program for children with brain-based conditions
This trial tests an intensive therapy program designed to help children with brain-based conditions like cerebral palsy or autism improve their skills in movement, thinking, and daily activities. The program runs for 2 weeks with daily sessions, and researchers will check for changes in your child's abilities.
The Woodlands, TexasAges 4–12 - NCT07493213Recruiting
Ultrasound-guided shoulder injections for frozen shoulder
This study tests whether ultrasound-guided injections into the shoulder can improve pain and movement in people with frozen shoulder. It may help if you have had shoulder pain for at least 3 months and other treatments haven't worked well.
Konya, SelçukluAges 18–75 - NCT07493226Recruiting
NSAIDs for Frozen Shoulder Pain Study
This study tests different types of nonsteroidal anti-inflammatory drugs (NSAIDs) to see which works best for people with frozen shoulder. It may help you if you have ongoing shoulder pain and stiffness without other shoulder injuries.
Konya, SelçukluAges 18–75 - NCT07494162Recruiting
Acupuncture for chronic low back pain with muscle knots
This trial tests if acupuncture can help chronic low back pain by looking at changes in muscle metabolism and blood flow. It compares real acupuncture with a sham (fake) procedure to see if there is a true benefit.
Sacramento, CaliforniaAges 18 years+ - NCT07495306Recruiting
Measuring nerve changes after frozen shoulder surgery
This study checks how shoulder nerves change after a surgery called capsular release for frozen shoulder. It may help doctors understand recovery better.
Istanbul, IstanbulAges 21–70 - NCT07498491Recruiting
Weighted blanket study for adults with ongoing pain
This study tests whether using a weighted blanket (10–25 pounds) while sleeping can help adults with chronic pain. If you join, you'll use the blanket every night for about 5 weeks and complete simple online questionnaires.
Portland, OregonAges 18 years+ - NCT07499362RecruitingPhase 2
Study of Pimicotinib for Japanese Patients with TGCT
This trial tests a new drug called pimicotinib for people in Japan with tenosynovial giant cell tumor (TGCT) that cannot be removed by surgery. It aims to see if the drug can help with pain and stiffness caused by the tumor.
ChūōkuAges 18 years+ - NCT07500883Recruiting
Adding body awareness therapy to scoliosis exercises for teens
This trial tests whether adding Basic Body Awareness Therapy (a gentle movement practice that helps you notice how your body feels and moves) to standard scoliosis exercises can improve posture and reduce discomfort in teenagers with scoliosis.
Ankara, AnkaraAges 10–17 - NCT07501013Recruiting
Shoulder and knee surgery outcomes study
This study looks at how well different types of shoulder and knee surgeries work for sports injuries. It aims to help improve future care by following patients' recovery after common procedures like fixing torn cartilage or repairing ligaments.
Hangzhou, ZhejiangAges 8–80 - NCT07501429RecruitingPhase 1
Shockwave therapy for arm spasticity after spinal cord injury
This trial tests whether shockwave therapy can reduce muscle tightness in the elbow and wrist caused by spinal cord injury. It may help make daily tasks like dressing or bathing easier.
West Orange, New JerseyAges 18 years+ - NCT07502989Recruiting
Study of Muscle Health Using Electrical Impedance Myography
This study uses a simple electrical test (EIM) and an MRI scan to check muscle health in people with muscle diseases. It may help researchers learn how to measure muscle changes without a biopsy.
Boston, MassachusettsAges 18–89 - NCT07503327Recruiting
Remote rehab for ankylosing spondylitis
This trial tests whether doing physical therapy exercises at home using a smartphone app can help people with ankylosing spondylitis feel better and move more easily.
ElâzığAges 16–65 - NCT07504146Recruiting
The Orienting study: imaging in CPPD, gout, and OA
This study looks at imaging findings (ultrasound and X-rays) in people with CPPD, gout, or osteoarthritis. It aims to help doctors better identify these conditions early.
Milan, MilanoAges 18 years+ - NCT07505342Recruiting
Remote study for myotonic dystrophy type 1
This study tests whether remote assessments can track myotonic dystrophy type 1 (DM1) and looks at genetic factors. It aims to find better ways to monitor the disease from home.
Rochester, New YorkAges 18–88 - NCT07507175Recruiting
Calf muscle release for women with knee arthritis
This trial tests whether releasing tight calf muscles can help women with knee osteoarthritis feel less pain. It focuses on women who have moderate knee arthritis and a tight spot in their calf muscle.
Giza, Giza GovernorateAges 45–55 - NCT07507734Recruiting
Splint and exercise therapy for jaw joint pain
This trial tests whether a custom mouth splint combined with jaw exercises can reduce pain in the jaw joint (TMJ). It may help people who have had jaw joint pain for at least 3 months.
Istanbul, TuzlaAges 18–65 - NCT07508033RecruitingPhase 1/Phase 2
Stem cell exosomes vs platelet-rich fibrin for socket healing
This trial tests whether stem cell exosomes (tiny healing particles from stem cells) work better than platelet-rich fibrin (a blood-derived clot) to help a tooth socket heal after extraction. It may help if you need a single front or premolar tooth removed and are generally healthy.
Tanta, Gharbia GovernorateAges 20–45 - NCT07508410Recruiting
Mulligan vs Myofascial Release for Neck-Related Headaches
This study compares two hands-on therapy techniques—Mulligan mobilization and myofascial release—to see which works better for headaches that start from the neck. If you have neck pain on one side and headaches that get worse with movement, this trial may help you find relief.
KonyaAges 18–65
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,843 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,987 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.