Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,845 recruiting studies in this area right now.
By phase
- Not applicable3,977
- Phase 2225
- Phase 4197
- Phase 1190
- Phase 3148
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis140
- Fibromyalgia102
- Osteoporosis86
- Osteoarthritis73
- Osteoarthritis, Knee71
- Rheumatoid Arthritis (RA)66
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Chronic Pain37
- Total Knee Arthroplasty37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University111
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad33
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California210
- New York94
- Florida82
- Massachusetts77
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois55
- Pennsylvania50
Recruiting studies4,845 total
- NCT05368064Enrolling by invitation
Study of cleidocranial dysplasia care from symptoms and genetics
This study looks at cleidocranial dysplasia (CCD) using a person’s symptoms and/or genetic findings to better understand what needs care and support. It may help teams improve how CCD is recognized and managed over time.
Baltimore, MarylandAges Any age - NCT05352139Enrolling by invitation
TenJet treatment for chronic tendon pain
This trial studies a device (TenJet hydroresection) used to treat long-lasting tendon pain by targeting damaged tendon tissue. It may help people whose tendon pain has not improved after several months of non-surgical care.
Redwood City, CaliforniaAges 18–70 - NCT05308927Enrolling by invitation
Registry for children with Noonan syndrome on growth hormone
This trial is a real-world registry that collects information about children with Noonan syndrome who are treated with Norditropin (a growth hormone). It helps researchers understand how these children do over time in routine care.
AngersAges Any age - NCT05266339Enrolling by invitation
Testing mirror training after rotator cuff repair
This trial looks at whether mirror-based arm exercises (“cross-education”) help recovery after arthroscopic rotator cuff surgery. It may help improve shoulder movement and function by training the other arm to support rehab.
Istanbul, BakırkoyAges 35–65 - NCT05183503Enrolling by invitation
Study of pain, stress, anxiety, and depression in jaw disorder
This study looks at how chronic jaw pain from temporomandibular disorder (TMD) relates to stress, anxiety, and depression in adults. Your results may help researchers better understand what affects symptoms and how people respond to care.
WroclawAges 18–80 - NCT05145010Enrolling by invitationPhase 2
Infigratinib follow-up for children with achondroplasia
This trial studies how well infigratinib works and remains safe for children with achondroplasia. It includes children who already took infigratinib in a prior QED study, and some who are starting treatment for the first time.
Oakland, CaliforniaAges 3–18 - NCT05116137Enrolling by invitation
Exercise therapy to build muscle after glioblastoma
This trial studies whether a resistance (strength-building) exercise program can help survivors of glioblastoma keep or increase their muscle mass. If you are able to safely exercise, it may support recovery and overall strength after treatment.
Halifax, Nova ScotiaAges 18 years+ - NCT05110833Enrolling by invitation
Study dosing effects during monitored neck or chest spine surgery
This trial studies whether different medication dosing during monitored neck or upper chest spine surgery leads to better outcomes. You might help doctors figure out the most effective dosing approach for this type of surgery.
Minneapolis, MinnesotaAges 18 years+ - NCT05066711Enrolling by invitation
Study of a neck surgery implant for adults
This trial looks at using a specific implant system during planned front-of-the-neck surgery (C2 to C7) for common neck problems like disc degeneration, injury, or spinal narrowing. It may help doctors compare outcomes with this particular hardware and surgical approach.
Naperville, IllinoisAges 18 years+ - NCT05033457Enrolling by invitation
Compare two treatments for lumbar spinal canal narrowing
This trial compares two approaches (UBE and PETD) for relieving nerve pressure caused by a single-level problem in the lower spine. It may help reduce pain and nerve symptoms by treating the narrowed spinal canal or disc-related compression.
Taiyuan, ShanxiAges Any age - NCT05011942Enrolling by invitation
Study of Irrisept during low-back fusion surgery
This study looks at whether using Irrisept (an antiseptic placed during surgery) can help during primary low-back fusion operations. It is mainly aimed at people having their first low-back fusion for up to three levels.
Kansas City, KansasAges 18–85 - NCT04899895Enrolling by invitation
Rheumatology sample study for people starting new treatment
This study collects blood or other samples from people with rheumatology (joint/autoimmune) conditions. It looks at changes around the time you start a specific new medicine, which may help researchers understand how treatments work.
Waltham, MassachusettsAges 18 years+ - NCT04840017Enrolling by invitation
Rehab program for balance and walking in flexible flatfeet
This trial tests whether a rehabilitation exercise program can improve balance and walking in children who have flexible flatfeet. The goal is to see if targeted rehab improves posture, stability, and gait (how your child walks).
GdanskAges 7–12 - NCT04816773Enrolling by invitation
Long-term follow-up for specific knee replacement parts
This study follows people for up to 10 years after a knee replacement done with specific manufacturer parts. It helps the company and doctors understand how well these knee implants work and whether they cause any long-term problems.
Fremont, CaliforniaAges 21 years+ - NCT04770571Enrolling by invitation
Study of posterior neck and upper-back spine fixation systems
This trial studies specific surgical hardware used to stabilize the back of the neck and upper back during spine surgery. It may help surgeons compare outcomes for people needing fixation for trauma, instability, failed prior fusion, tumors, or certain degenerative conditions.
Orange, CaliforniaAges 18 years+ - NCT04735081Enrolling by invitation
Bed rest vs early getting up for spine bone infection
This study compares standard prolonged bed rest with starting to get up earlier in people with an infection of the spine bones and discs. It aims to see which approach is safer and leads to better recovery.
Ages 18 years+ - NCT04732507Enrolling by invitationPhase 2
Trigger point injections: test fewer needlings for pain relief
This Phase 2 study tests whether doing a smaller number of needle “treatments” during trigger point injections works as well for myofascial pain. If you’ve tried safer treatments without success (or can’t do physical therapy), you may be eligible to help answer the best treatment approach.
Tucson, ArizonaAges 18 years+ - NCT04689854Enrolling by invitation
Cervical spine surgery implant study for neck disc problems
This trial studies specific neck (cervical) spine implants used during surgery for degenerative disc disease or neck instability, along with a particular kind of bone grafting and supporting hardware. It may help patients by testing whether these devices and the planned fusion approach work safely and effectively in real-world surgery.
Orange, CaliforniaAges 18 years+ - NCT04684901Enrolling by invitation
AlloWrap to reduce inflammation during cervical spine fusion surgery
This trial tests whether AlloWrap® can lower inflammation during anterior cervical fusion surgery (ACDF). It may help improve healing and recovery by reducing the body’s inflammatory response after surgery.
San Diego, CaliforniaAges 18 years+ - NCT04651673Enrolling by invitation
Knee brace program for adults with knee osteoarthritis pain
This trial looks at using a prescribed knee brace to help relieve knee pain and symptoms from knee osteoarthritis. You may be able to join if your knee braces are being provided through participating clinics and you can consent and complete study questionnaires.
Hässleholm, Skåne CountyAges 18–100 - NCT04505020Enrolling by invitation
3D-printed planning to help hip preservation surgery
This study tests whether using 3D-printed models from scans can help plan hip preservation surgery for people with a specific hip shape problem (cam-type femoroacetabular impingement). It may help surgeons plan more precisely, though you would only be eligible if your hip damage and other health factors fit specific limits.
Halifax, Nova ScotiaAges 18 years+ - NCT04504721Enrolling by invitation
Light therapy for fibromyalgia using blue-enriched white light
This study tests whether a specific type of light (blue-enriched white light) can reduce symptoms of fibromyalgia. It may help people feel better by changing how the body responds to light.
TaipeiAges 20–64 - NCT04418830Enrolling by invitation
Study of a spine cage implant for degenerative back problems
This trial studies how well specific lumbar (lower back) implant “cages” help fuse vertebrae in people with degenerative disc disease, spinal slippage, narrowing, curvature, or forward-bending deformity. It may help by testing an approach to improve stability and reduce symptoms after surgery.
La Jolla, CaliforniaAges 18 years+ - NCT04364295Enrolling by invitation
Patients who used SeaSpine products join a global registry
This registry collects information from people who have been treated with at least one SeaSpine product and had standard imaging and symptom surveys before and after surgery. It helps doctors understand outcomes over time and can support future improvements in care.
Durango, ColoradoAges Any age
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,845 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 8,007 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.