Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,832 recruiting studies in this area right now.
By phase
- Not applicable3,967
- Phase 2222
- Phase 4195
- Phase 1191
- Phase 3151
- Phase 1/Phase 273
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis141
- Fibromyalgia102
- Osteoporosis88
- Osteoarthritis74
- Osteoarthritis, Knee73
- Rheumatoid Arthritis (RA)64
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Chronic Pain38
- Degenerative Disc Disease38
- Total Knee Arthroplasty38
- Musculoskeletal Pain36
- Pain34
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California208
- New York94
- Florida80
- Arizona76
- Massachusetts76
- Maryland73
- Texas64
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,832 total
- NCT05218785Recruiting
Botulinum toxin for calf tightness and long-term heel pain
This trial tests whether injections of botulinum toxin A can loosen a tight calf muscle and improve long-lasting plantar fasciitis (heel/foot pain). It’s for people whose symptoms have lasted at least a year and who haven’t improved enough with physical therapy.
Oslo, OsloAges 18–75 - NCT05183971Recruiting
Testing balance changes in older people with neck spinal cord wear
This trial studies how changes in balance and body sensing (proprioception) show up in people with age-related neck spinal cord problems. It may help researchers understand symptoms and how best to evaluate or manage degenerative cervical myelopathy.
Hong Kong, Hong KongAges 50 years+ - NCT05000723Recruiting
Follow-up for hip joint infection after joint replacement
This study checks what happens over the long term for people who had an infection around a replaced (prosthetic) hip. It mainly helps doctors understand recovery and long-term outcomes after treatment.
LeuvenAges 18 years+ - NCT04805164Recruiting
Gentamicin bone paste to treat stubborn long-bone bone infection
This study tests a bone filler/paste called Cerament-G that releases the antibiotic gentamicin directly at the infected bone site. It aims to improve treatment of chronic bone infection (chronic osteomyelitis) in long bones after surgery.
AmiensAges 18–80 - NCT05495399Recruiting
Radiation after limited spine surgery for spine metastases
This study tests whether radiation given after limited surgery helps control cancer that has spread to a small area of the spine. It may help reduce tumor growth in the treated spine area and improve local control after operation.
TaipeiAges 20 years+ - NCT04824040Enrolling by invitation
Study of immune, muscle, and genetic features in LGMD 2B
This study looks at immune function, muscle appearance, and genetic information in people with limb-girdle muscular dystrophy type 2B. It may help researchers understand the condition better, which can support future treatments.
MoscowAges 18–85 - NCT05054335Recruiting
Testing personalized walking models for pelvic sarcoma surgery rehab
This study uses personalized computer models and movement measurements (often with MRI) to improve how surgery and physical rehab plans are tailored after pelvic sarcoma surgery. It aims to better understand walking and movement patterns so rehabilitation can be more effective.
Houston, TexasAges 18 years+ - NCT04730700Recruiting
Radiofrequency treatment test for facet back pain
This study compares a nerve procedure (radiofrequency “neurotomy” using an expandable electrode) to non-procedure medical care for long-lasting low back pain from facet joints. It aims to see whether the procedure helps more safely than conservative treatment.
Kansas City, KansasAges 18 years+ - NCT04989751Enrolling by invitation
Study of gene patterns in limb-girdle muscle weakness
This study looks at how specific gene changes relate to the pattern of muscle weakness in people with limb-girdle muscular dystrophy (LGMD). It may help doctors better understand the condition and improve future care.
ShanghaiAges 10 years+ - NCT04954690Recruiting
Exercise program after kidney transplant for older adults
This trial tests a structured, coached exercise program for people who recently received a living-donor kidney and are coming from dialysis. It may help improve strength and daily function after transplant, especially if starting fitness is difficult.
San Francisco, CaliforniaAges 50 years+ - NCT04851509Recruiting
Testing a special screw-locking nail for hip fractures
This trial studies a specific way of fixing certain hip (upper thigh) fractures using a metal nail with locking screws. It may help improve how well fractures heal and how stable the repair is.
New Westminster, British ColumbiaAges 18 years+ - NCT05358574Recruiting
Shoulder implant follow-up study after a salvage bipolar surgery
This study looks at how safe and well a specific shoulder implant (“bipolar system”) works after it’s used as a backup plan during surgery. You may join if you needed this implant because the usual reverse shoulder attachment couldn’t be done during the operation.
HamburgAges 18 years+ - NCT04728282Recruiting
RTSA surgery with or without repairing the subscapularis
This study compares two surgical approaches for RTSA (reverse shoulder replacement): doing a tendon repair on the front of the shoulder or not. It may help show which approach leads to better recovery and shoulder function for people who need their first RTSA.
Winnipeg, ManitobaAges 18 years+ - NCT04934839Recruiting
Gait study comparing prosthetic walking types in adults
This study compares how people walk using an osseointegrated prosthesis (a prosthesis connected to the bone) versus a traditional socket prosthesis. It may help researchers understand which option works better for walking balance, comfort, and function.
Milan, MIAges 18 years+ - NCT05134142Recruiting
Quality of life after hemipelvectomy for pelvic tumors
This study looks at how people with pelvic tumors feel and function after a hemipelvectomy (surgery removing part of the hip/pelvis). It aims to better understand recovery and day-to-day quality of life after this operation.
Houston, TexasAges Any age - NCT04720846Recruiting
Physical therapy for hip and groin pain without arthritis
This trial studies a categorized physical therapy approach for people with hip impingement and hip/groin pain that is not caused by arthritis. It may help by testing whether a structured PT plan improves pain and function for the right type of hip problem.
New York, New YorkAges 18–60 - NCT05175300Recruiting
Vitamin E hip implant for young, active hip replacements
This study tests a hip replacement implant that uses Vitamin E–doped material to see how well it works for young, active adults. It’s meant for people who need a total hip replacement, and compares outcomes over follow-up visits.
LyonAges 18–65 - NCT04716803Recruiting
BMAC injection for severe knee osteoarthritis before knee surgery
This trial studies injecting “bone marrow aspirate concentrate” (BMAC) into the knee to help relieve pain from severe knee osteoarthritis. It’s for people who have strong signs of advanced arthritis on X-ray and still have ongoing pain despite usual treatments, before a planned knee procedure.
La Jolla, CaliforniaAges 45–75 - NCT06785792Recruiting
AI posture study for young adults
This trial tests an artificial intelligence app that helps improve posture in young adults aged 18-39. It aims to see if the app can make a difference in how you stand and move.
Izmir, Karabağlar/İzmirAges 18–39 - NCT05108948Recruiting
Study factors linked to better quality of life after spine surgery
This study looks at what helps adults with spinal deformity have a better quality of life one year after surgery. It may help doctors understand which patients benefit most and how to improve follow-up care.
BrugesAges 18 years+ - NCT05053646Recruiting
Check if a marrow venting procedure helps meniscus stitches heal
This study tests whether adding a “marrow venting” step during arthroscopic surgery can improve healing of stitched meniscus tears. It may help people whose meniscus tears are repairable with sutures, but eligibility is limited by tear type and overall health.
LuganoAges 16–50 - NCT04642456Recruiting
Balance and walking strength testing for spinal deformity adults
This study checks balance and leg strength using simple walking and movement tests. It focuses on adults with spinal deformity and compares them to people without deformity, to better measure how well you function.
Leuven, Vlaams-BrabantAges 18–79 - NCT04949087Recruiting
Shoulder arthritis injection study for ongoing pain relief
This trial looks at how well medicine given directly into the shoulder joint reduces pain from primary shoulder osteoarthritis. If you have ongoing shoulder pain confirmed by X-ray, you may be eligible to receive an in-joint injection and be followed for response.
Chicago, IllinoisAges 18 years+ - NCT04629391Recruiting
Reverse vs standard shoulder replacement for arthritis
This study compares two types of shoulder replacement surgery for people with arthritis and an intact rotator cuff. The goal is to see which operation works better and is more reliable for your type of shoulder problem.
MeyrinAges 65–85
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,832 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,923 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.