Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,832 recruiting studies in this area right now.
By phase
- Not applicable3,967
- Phase 2222
- Phase 4195
- Phase 1191
- Phase 3151
- Phase 1/Phase 273
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis141
- Fibromyalgia102
- Osteoporosis88
- Osteoarthritis74
- Osteoarthritis, Knee73
- Rheumatoid Arthritis (RA)64
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Chronic Pain38
- Degenerative Disc Disease38
- Total Knee Arthroplasty38
- Musculoskeletal Pain36
- Pain34
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California208
- New York94
- Florida80
- Arizona76
- Massachusetts76
- Maryland73
- Texas64
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,832 total
- NCT05070078Recruiting
Assessing recovery after lumbar disc surgery using SANE
This study uses a simple recovery questionnaire called SANE to understand how people do after lumbar discectomy (surgery to relieve a slipped or herniated disc). It may help the care team measure recovery in a clearer, more consistent way.
Windsor, OntarioAges 18 years+ - NCT04802603Recruiting
Focused spine radiation for limited spread to the spine
This trial tests a stronger, carefully measured form of radiation aimed at a small number of spots where cancer has spread to the spine. It may help control pain and tumor growth while protecting the spinal cord.
Miami, FloridaAges 18 years+ - NCT04715139Recruiting
Testing safety of specific foot and ankle implants
This study follows people who get certain Arthrex foot and ankle implants to check how safely they heal and work over time. It may help your care team by adding long-term information about these devices.
Sacramento, CaliforniaAges 2 years+ - NCT04822558Recruiting
3D foot scan after reconstructive ankle and foot surgery
This trial tests whether a detailed 3D foot model (made from measurements/scans) can better predict outcomes after certain reconstructive ankle and foot surgeries. You may be able to join if you’re already scheduled for one of these surgeries and can meet walking and measurement requirements.
Leuven, Vlaams-BrabantAges 18 years+ - NCT05294029Recruiting
Study of movement and aging in adults with neuromotor disability
This study looks at how neuro-related movement problems change as people age. It may help improve care plans for adults with neuromotor disabilities by learning what happens over time.
GarchesAges 18 years+ - NCT04725422Recruiting
Registry for children with nonbacterial bone inflammation
This study collects medical information (and imaging results) from children and teens with nonbacterial bone inflammation. It may help doctors better understand how this condition looks on scans and how it’s diagnosed, especially to rule out infection or cancer.
Seattle, WashingtonAges Up to 21 years - NCT05047133RecruitingPhase 2/Phase 3
Early TXA treatment for adult hip fracture surgery
This study tests whether giving a blood-clot-reducing medicine (TXA) early after an adult hip fracture helps reduce bleeding and related problems around surgery. It may help some patients getting operative fixation by improving safety during recovery.
Grand Blanc, MichiganAges 18 years+ - NCT04692714Recruiting
Cemented vs cement-free robotic knee replacement surgery
This trial compares two ways surgeons can attach a knee replacement using robotic-assisted surgery: with cement or without cement. It may help improve how well the new knee lasts and how patients recover after a first-time knee replacement.
LyonAges 50–80 - NCT04805437Recruiting
Brace treatment for early idiopathic scoliosis in kids
This study tests whether wearing a scoliosis brace can stop or slow curve worsening in children who are still growing. It is meant for kids with a moderate, idiopathic (not caused by another condition) curve.
LinköpingAges 9–17 - NCT05044767Recruiting
Hip replacement study using specific implant brands
This study checks how safe and how well specific hip replacement implants work after hip replacement surgery. You might be eligible if your surgeon plans to use an ATF Implants and/or Lapé Médical prosthesis and you don’t have certain health issues that can make surgery riskier.
BordeauxAges Any age - NCT04924205Recruiting
Smart knee brace rehab versus usual physical therapy
This trial compares recovery after primary knee replacement using a smart knee brace and app versus standard outpatient physical therapy. It may help you understand which rehab approach leads to better comfort and mobility during recovery.
Iowa City, IowaAges 18–100 - NCT04752761Recruiting
Digital tracking after knee replacement for people with severe knee arthritis
This study checks whether using digital tools (like a phone app or tablet) can better track patient-reported outcomes after knee replacement, compared with usual outpatient follow-up. It may help improve how symptoms and recovery are monitored, which can guide care.
Bologna, ItaliaAges 18–78 - NCT04704947RecruitingPhase 3
Beta blockers and fracture risk in osteoporosis
This study tests whether using beta blocker blood pressure medicines affects the risk of fractures in people with osteoporosis. It may help doctors understand which medication choices lower fracture risk.
TantaAges 50 years+ - NCT04858217Recruiting
Testing blood and joint fluid tests for hip or knee infection
This trial checks how accurate certain blood tests and joint-fluid (synovial) tests are at identifying infections around hip or knee replacements. It also looks at whether these tests are worth the cost, to help doctors choose the best next step.
BolognaAges 18 years+ - NCT04095637Recruiting
Compare two types of partial knee replacement surgeries
This study compares two implant types used for a partial knee replacement (only the inside/medial part) for people with “wear-and-tear” arthritis in that compartment. It looks to see which option leads to better outcomes after surgery and follow-up.
LondonAges 40–80 - NCT04761549Recruiting
3D planning study for scoliosis surgery decisions
This study looks at how 3D measurements and biomechanical (how the spine moves/loads) information can help guide decisions for adolescent idiopathic scoliosis surgery. It may help your team plan treatment more accurately when you’re scheduled for tethering or selective fusion.
Leuven, Vlaams-BrabantAges 10 years+ - NCT05569161Recruiting
Testing a shoulder replacement called Embrace for 2 years
This study looks at how safe an Embrace reverse shoulder replacement is over two years and what results you can expect on imaging scans. You may qualify if you’re an adult with a shoulder problem that can be treated with this specific type of replacement and have recent CT or MRI scans.
MadridAges 18 years+ - NCT05862246Recruiting
Kids with foot or leg pain and normal leg function
This trial looks at children who have tightness, foot pain, and/or leg pain, as seen in a pediatric orthopedic clinic. The goal is to study this problem in children who otherwise seem healthy and do not have signs of a different underlying foot or medical condition.
TrondheimAges 4–16 - NCT04098146Recruiting
Registry for jawbone reconstruction after jaw cancer and jaw bone death
This study collects real-world information from people undergoing jaw reconstruction after their jaw bone was damaged (from cancer and certain medicines). It may help improve future treatment planning by tracking surgical choices and outcomes.
Jacksonville, FloridaAges 18 years+ - NCT05412615Recruiting
Meniscal graft surgery for wrist arthritis
This trial studies whether using a donor meniscus (meniscal allograft) during wrist replacement surgery can help people with painful wrist osteoarthritis. It’s mainly for certain types of arthritis changes in the wrist (SLAC or SNAC) and specific age ranges.
Englewood, ColoradoAges 30–80 - NCT04226339Recruiting
Test walking analysis after knee replacement, different alignment methods
This study compares two ways of aligning the knee during a total knee replacement and checks how people walk afterward using a walking test. It may help doctors choose the alignment method that best supports safer, smoother walking.
LyonAges 55–80 - NCT04454203RecruitingPhase 4
Local anesthetic catheter to reduce tourniquet-related blood pressure spikes
This Phase 4 trial tests whether a local anesthetic catheter placed near a nerve and artery can prevent high blood pressure caused by a tourniquet during total ankle replacement surgery. If it works, it may make recovery safer and more comfortable for some patients.
Durham, North CarolinaAges 18–75 - NCT05589701Recruiting
Compare two radiation plans for painful spinal cancer spread
This study compares two different radiation approaches—SBRT and CRT—for people with painful cancer that has spread to the spine. It may help determine which plan controls pain and tumor growth while limiting side effects to nearby organs.
Toronto, OntarioAges 18–100 - NCT03752034Recruiting
Muscle fragments after rotator cuff surgery to improve shoulder function
This study looks at whether using “muscle fiber fragments” during/after rotator cuff repair can help your shoulder work better. It targets people with a small tear in one shoulder who can follow the post-surgery follow-up plan.
Winston-Salem, North CarolinaAges 40–80
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,832 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,923 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.