Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,832 recruiting studies in this area right now.
By phase
- Not applicable3,967
- Phase 2222
- Phase 4195
- Phase 1191
- Phase 3151
- Phase 1/Phase 273
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis184
- Rheumatoid Arthritis141
- Fibromyalgia102
- Osteoporosis88
- Osteoarthritis74
- Osteoarthritis, Knee73
- Rheumatoid Arthritis (RA)64
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Chronic Pain38
- Degenerative Disc Disease38
- Total Knee Arthroplasty38
- Musculoskeletal Pain36
- Pain34
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California208
- New York94
- Florida80
- Arizona76
- Massachusetts76
- Maryland73
- Texas64
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,832 total
- NCT03935295RecruitingPhase 4
Dysport with a brace for teens with specific scoliosis curves
This trial studies whether adding Dysport (a botulinum toxin shot) to standard bracing can improve scoliosis in teens. It’s mainly for certain curve patterns and requires careful brace follow-through.
Baltimore, MarylandAges 10–16 - NCT04571918Recruiting
Arthroscopic repair using a biodegradable spacer for severe shoulder tears
This study looks at an arthroscopic procedure (a minimally invasive surgery) that includes cleaning the tear and placing a biodegradable spacer to treat painful, severe rotator cuff tears. It may help reduce pain and improve shoulder function in people who have tried non-surgical treatments but still have symptoms.
ArendalAges 60–85 - NCT04381663Enrolling by invitation
Tracking symptoms in degenerative neck spine narrowing
This study follows adults with degenerative narrowing in the neck spine to see how symptoms and function change over time. It may help doctors better understand which patients improve or worsen, and why.
BaselAges 18 years+ - NCT04270617Recruiting
Yoga practice for long-term back pain
This study looks at whether regular yoga helps people with chronic (long-lasting) back pain. If you can safely take part in yoga sessions and your pain has lasted at least 3 months, you may be able to enroll.
New York, New YorkAges 18 years+ - NCT03968614Recruiting
Needling plus exercises for Achilles tendon pain
This trial studies whether electrical “deep needling” (a clinician inserts very thin needles and uses electricity) added to stretching and exercises can reduce Achilles tendon pain. It’s mainly for people with Achilles tendinopathy that started at least 3 months ago.
Columbia, South CarolinaAges 18 years+ - NCT04086368Recruiting
Testing treatment planning for hip bone rotation in teens
This study looks at teens with hip (and sometimes knee) pain and a specific pattern of hip bone rotation seen on X-rays. It aims to test an approach (the “FDR” trail) that may improve how the hip’s rotation is treated.
OsloAges 10–18 - NCT07147543RecruitingPhase 4
Study of a powered exercise device for walking problems
This trial tests if a motorized leg exercise machine can help improve walking and balance in adults with gait disorders. It may be suitable for people who have difficulty walking but can stand with or without help.
Yongin-si, Gyeonggi-do, South KoreaAges 19 years+ - NCT04312880Enrolling by invitationPhase 4
Tranexamic acid during elective back surgery to reduce bleeding
This trial studies whether giving tranexamic acid (a medicine that helps reduce bleeding) during planned lower-back decompression surgery can lower blood loss or related complications. It compares patients who receive the infusion during surgery to those who meet study procedures and safety requirements.
Albany, New YorkAges 18–80 - NCT04104412RecruitingPhase 1
Stem cell injection study for long-lasting disc back pain
This Phase 1 study tests the safety and early effectiveness of an umbilical cord stem cell injection for people with persistent lumbar (lower back) disc-related pain that has not improved with standard care. If you qualify, it may offer a new treatment option, while researchers closely monitor side effects and pain changes.
Beijing, Beijing MunicipalityAges 18 years+ - NCT05861609Recruiting
Tapering pain meds for nerve pain after spinal cord stimulation
This study helps people with persistent nerve pain in the low back or legs who are planned to start spinal cord stimulation (SCS). It tests a careful plan to reduce (taper) opioid pain medicines using specific replacement medicines, while monitoring safety and pain control.
JetteAges 18 years+ - NCT04123431Recruiting
Study of an hip cup implant used in planned hip replacements
This trial studies a specific hip replacement hip “cup” implant used during planned total hip replacement surgery. It may help confirm how well this implant performs in real-world patients who are getting surgery for non-traumatic reasons.
WorthingAges 18 years+ - NCT04228419Recruiting
Shoulder replacement approach comparison for advanced shoulder arthritis
This trial compares two ways of doing shoulder arthroplasty (shoulder replacement) for people with advanced shoulder arthritis who have not improved with non-surgical treatments. It may help determine which approach works better for pain and function.
Edmonton, AlbertaAges 65 years+ - NCT04030650Recruiting
Study of walking expectations on slopes and stairs after limb amputation
This study looks at how people with a leg amputation think about and perform walking on stairs and up/down slopes. It may help researchers understand what supports safer, more confident mobility.
DijonAges 18 years+ - NCT03513731Recruiting
Regenerative fat cell injection for facet joint arthritis pain
This trial tests whether injecting regenerative cells made from your body’s fat can reduce pain from facet joint osteoarthritis in the low back. It focuses on people whose pain has lasted months and did not improve with standard care, after a positive diagnostic injection test.
Deerfield Beach, FloridaAges 18–75 - NCT05869812RecruitingPhase 2
HMB supplement study to help recovery after surgery
This trial tests whether taking an HMB supplement after surgery can help improve muscle size and function during recovery. It may be helpful if you are a female athlete planning rehab at a specific physical therapy clinic.
Overland Park, KansasAges 18–45 - NCT03711175Enrolling by invitation
Repairing a shoulder tendon after reverse shoulder replacement
This study looks at whether repairing a specific shoulder tendon (the subscapularis) improves outcomes after reverse shoulder replacement. You may be eligible if you’re getting a reverse shoulder implant because of severe arthritis and your tendon is strong enough to repair on MRI.
St Louis, MissouriAges 21 years+ - NCT03292601Recruiting
Brace monitoring for teens with scoliosis
This trial studies a way to monitor how well a scoliosis brace is being used in teenagers. It may help improve brace treatment for adolescents with a common type of spinal curve (adolescent idiopathic scoliosis).
New York, New YorkAges 8–17 - NCT05127005Recruiting
Compare thumb arthritis surgery versus placebo surgery
This study compares a real thumb basal joint surgery (trapeziectomy) with a sham/placebo operation to see which option helps pain and daily function better. It is for people with thumb arthritis who have tried non-surgical treatments but still have significant thumb pain.
HelsinkiAges 45 years+ - NCT01344200RecruitingPhase 2
Celecoxib drug study in children on leukemia treatment
This trial studies how celecoxib moves through a child’s body and how much reaches the fluid around the brain and spinal cord. It’s for children (age 2–12) who are in the maintenance phase of certain blood cancers, to better understand dosing and safety.
Ottawa, OntarioAges 2–12 - NCT01193647Enrolling by invitation
Study genetics that may raise rotator cuff injury risk
This study looks at genetic (inherited) factors that may make some people more likely to develop rotator cuff tears. You may be able to join if you’ve had a shoulder MRI for pain or you’re a close family member of someone with a documented tear.
Salt Lake City, UtahAges 18 years+ - NCT02333825Enrolling by invitation
Study of first-time kneecap dislocation in youth
This study focuses on children and teens (25 or younger) who have had only one kneecap (patella) dislocation episode. It’s testing an approach for stabilizing the knee, aiming to help prevent future instability and improve outcomes for first-time dislocators.
Ages 8–25 - NCT05231343Recruiting
Dual small-plate vs single plate for broken collarbones
This trial compares two surgical plate methods to fix a broken collarbone in the middle part (midshaft). The goal is to see which method works better for healing and function after an acute, fully displaced fracture.
Toronto, OntarioAges 18–65 - NCT05625282Recruiting
Surgery for a floating toe with or without a bone cut
This trial studies how best to repair a “floating toe” using a specific foot surgery approach. It compares whether the repair should be done alone or combined with another bone procedure (a Weil osteotomy).
BarcelonaAges 18 years+ - NCT01898416RecruitingPhase 2
5-ALA by mouth to reduce regrowth of desmoid tumors
This Phase 2 trial tests whether taking a medicine called 5-ALA by mouth after treatment can lower how often desmoid tumors come back in the same area. If you have a desmoid tumor that can be removed and you meet safety criteria, this study may help determine whether 5-ALA is effective and safe for you.
Tel Aviv, IsraelAges 18 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,832 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,923 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.