Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,611 recruiting studies in this area right now.
By phase
- Not applicable3,768
- Phase 2217
- Phase 4200
- Phase 1182
- Phase 3139
- Phase 1/Phase 271
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis172
- Rheumatoid Arthritis132
- Fibromyalgia105
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee64
- Shoulder Pain48
- Hip Osteoarthritis43
- Psoriatic Arthritis40
- Degenerative Disc Disease39
- Chronic Pain38
- Total Knee Arthroplasty38
- Duchenne Muscular Dystrophy37
- Systemic Lupus Erythematosus37
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital25
- Hacettepe University23
- Tanta University22
Where studies are running
- California207
- New York87
- Florida82
- Maryland76
- Arizona72
- Massachusetts71
- Texas67
- Alabama59
- Illinois51
- Pennsylvania48
Recruiting studies4,611 total
- NCT07734311RecruitingPhase 3
Testing a weight-loss injection for knee arthritis pain
This study tests whether an experimental weight-loss injection can reduce knee pain in people who are obese and have knee osteoarthritis. It may help if you have been unable to lose weight through diet and exercise and have moderate knee pain.
Wuhan, HubeiAges 18–75 - NCT07737743RecruitingPhase 2
Testing DDY391 for Sjögren's disease
This study tests an experimental drug called DDY391 for people with Sjögren's disease. The goal is to see if it can reduce symptoms and improve quality of life, and to check for side effects.
Clearwater, FloridaAges 18–100 - NCT04601363Recruiting
Personalized spine registry for people with spinal hardware
This registry follows people who recently had spinal surgery where custom (patient-specific) spine hardware (like rods) was placed. It collects consent and health questionnaires to learn how these implants affect patients over time.
Aurora, ColoradoAges 10–85 - NCT06628336Recruiting
Study of HARMONY Evolution hip replacement implants
This study looks at how well HARMONY Evolution implants and tools work for people getting a total hip replacement. It will help doctors understand if the implants are safe and effective over time.
BesançonAges 18–99 - NCT05291819Recruiting
Imaging-guided vs standard treatment for psoriatic arthritis
This study compares two “treat-to-target” strategies for psoriatic arthritis. One strategy uses imaging to guide treatment changes, and the other uses standard clinic assessments, to see which approach controls symptoms more effectively.
ÅlesundAges 18 years+ - NCT04137835Recruiting
Noninvasive motion testing for arm and leg function
This study tests how well your upper and lower body moves using non-invasive methods (no procedures or surgery). It’s likely best for healthy adults who can follow instructions and want to help researchers measure movement and function.
Aurora, ColoradoAges 18–65 - NCT04728542Recruiting
Observational study comparing two osteoporosis treatment approaches
This is an observational study, meaning researchers watch what happens in real life rather than assigning a treatment by chance. It compares outcomes between people using ORIGIN® and VANGUARD® PS, to better understand how these approaches perform.
MainzAges 18 years+ - NCT06366815Recruiting
A study of Duchenne muscular dystrophy in boys who no longer walk
This study is for boys with Duchenne muscular dystrophy who can no longer walk. It aims to describe how the condition changes over time once walking is lost, without testing any new treatments.
Bosisio Parini, LcAges 8–35 - NCT06627998Recruiting
Bone health study for thyroid cancer patients
This study checks how common bone problems are in people with thyroid cancer. It uses a chest x-ray done before surgery to look at the spine's shape.
MilanAges 18 years+ - NCT07727174Recruiting
Chondroitin supplement for joint health in young men
This trial tests a food supplement containing chondroitin sulfate to see how it affects joint cells. It may help you understand how to support joint health.
Clermont-Ferrand, Cedex 1Ages 18–35 - NCT07726082Recruiting
A group program to help with long-term fatigue
This study tests a new way to help people with long-term fatigue that gets in the way of daily life. It uses a group program that focuses on making small, helpful choices to feel better.
BaselAges 18–65 - NCT07724977Recruiting
Comparing two arm exercises for shoulder stability in bowlers
This trial compares two sets of exercises to see which better helps bowlers with shoulder instability. If you are a male bowler aged 16 to 25 with at least 2 years of experience and no recent shoulder injuries, this study may be right for you.
Lahore, Punjab ProvinceAges 16–25 - NCT07731035Recruiting
Balance and foot exercises for ankle instability
This study tests if combining core stability training with foot exercises helps people with chronic ankle instability. It compares these exercises to either core training alone or no treatment to see which works best.
Al MansurahAges 18–44 - NCT07726797Recruiting
Pelvic control training vs core stability for low back pain
This trial compares two types of exercises — pelvic control training with a pressure sensor versus core stability training — to see which one works better for relieving low back pain. It may help if you are a young adult with no other health issues affecting your back or balance.
Lahore, Punjab ProvinceAges 18–30 - NCT07727434Recruiting
Stress and Anxiety in People Having Biopsy for Bone or Soft Tissue Cancer
This study looks at how stress and anxiety levels change in people who are about to have a biopsy for a possible bone or soft tissue tumor. The goal is to better understand the emotional impact of waiting for results and starting treatment.
IstanbulAges 18 years+ - NCT07727551Recruiting
Nerve block before knee replacement for better recovery
This trial tests if a nerve block given a few weeks before knee replacement surgery can improve pain and function after the operation. It is designed for people who have certain risk factors that might make recovery harder.
BrusselsAges 18–60 - NCT07723742Recruiting
Nutrition education before knee or shoulder surgery
This trial tests whether learning about nutrition before your knee or shoulder arthroscopy helps you recover better after surgery. You'll receive educational materials to help you eat well during your recovery.
Birmingham, AlabamaAges 10 years+ - NCT07730723RecruitingPhase 2/Phase 3
Nicorandil for moderate to severe rheumatoid arthritis
This study tests whether a heart medication called nicorandil can help reduce arthritis symptoms when added to your current treatment. It is for people with moderate to severe rheumatoid arthritis who have been stable on their current treatments.
Cairo, AbbasiaAges 18 years+ - NCT07725822RecruitingPhase 4
Cream for psoriasis affecting skin and nails
This study tests a new prescription cream called roflumilast to see if it helps with both skin plaques and nail psoriasis. If you join, you'll apply the cream to affected areas and be monitored to see how well it works and if it's safe.
Dallas, TexasAges Any age - NCT07726030Recruiting
Exercises for chronic rotator cuff pain in overhead athletes
This trial compares two types of exercises to see which better reduces chronic shoulder pain in male athletes who play overhead sports. If you have ongoing rotator cuff tendinopathy and are an active overhead athlete, this study may help find the best exercise approach for you.
Faisalābad, Punjab ProvinceAges 17–35 - NCT07731737Recruiting
Biofeedback vs foam roller for knee osteoarthritis
This trial compares two non-surgical therapies—pressure biofeedback and foam rolling—to see which better reduces pain, improves muscle function, and boosts quality of life in people with early-stage knee osteoarthritis.
LahoreAges 45–65 - NCT07729930Recruiting
Creatine supplement study for healthy middle-aged women
This study is testing a creatine supplement (a substance that may help with energy and muscle function) in healthy middle-aged women. You may join if you are between 35 and 65, a non-smoker, and have a certain activity level.
LoughboroughAges 35–65 - NCT07724470Recruiting
Stretching techniques for neck and arm pain
This study tests two types of stretching to see which one works better for neck pain that spreads into the arm. If you have had this pain for more than a month, this trial might help find a way to move better and feel less pain.
Lahore, Punjab ProvinceAges 30–60 - NCT07724691Recruiting
Comparing two shoulder therapies for frozen shoulder
This study compares two types of gentle shoulder movements (mobilizations) to treat frozen shoulder. The goal is to reduce pain and help you move your arm more easily.
Lahore, Punjab ProvinceAges 30–50
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,611 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,492 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.