Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,841 recruiting studies in this area right now.
By phase
- Not applicable3,975
- Phase 2223
- Phase 4196
- Phase 1191
- Phase 3149
- Phase 1/Phase 274
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis185
- Rheumatoid Arthritis142
- Fibromyalgia102
- Osteoporosis88
- Osteoarthritis74
- Osteoarthritis, Knee72
- Rheumatoid Arthritis (RA)64
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Chronic Pain38
- Degenerative Disc Disease38
- Total Knee Arthroplasty38
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California210
- New York94
- Florida80
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,841 total
- NCT06517043Recruiting
Balance training for older adults with slow walking
This study looks at how older adults learn and keep balance skills. It tests a training program to help people who walk slowly and have balance problems. The goal is to improve walking and reduce fall risk.
Gainesville, FloridaAges 65–95 - NCT06473298Recruiting
Light tracking therapy for kids with one-sided muscle tightness
This study tests a special light-tracking activity to help children with spastic hemiplegia (tightness on one side) improve their movement. It's for kids ages 4–7 who can walk and have mild muscle tightness.
CairoAges 4–7 - NCT06208267Recruiting
Tranexamic acid for pain and bleeding after hip or knee replacement
This study tests whether a medicine called tranexamic acid (TXA) can reduce pain, improve movement, and lessen bleeding after hip or knee replacement surgery. It is for adults having their first joint replacement at St. Mary's Hospital.
Montreal, QuebecAges 18 years+ - NCT07006545Enrolling by invitation
Getting back to activity after knee replacement
This study looks at how well people can return to daily activities and exercise after total knee replacement surgery. It may help find better ways to guide recovery.
Munich, BavariaAges 18 years+ - NCT06523426Recruiting
Outpatient spine surgery for adults over 75
This trial tests a minimally invasive spine surgery (endoscopic decompression) done as an outpatient procedure in people 75 and older. It aims to see if this approach is safe and effective for treating a single-level lumbar spine problem.
BordeauxAges 75 years+ - NCT06534853Recruiting
Stretching study for low back pain relief
This study compares two stretching techniques for a condition called quadratus lumborum syndrome, which causes low back or hip pain. Researchers want to see which type of muscle stretch works better to relieve pain and improve movement.
Rawalpindi, Punjab ProvinceAges 18–35 - NCT06204315RecruitingPhase 2
Spine radiosurgery for spinal cord compression
This trial tests a precise radiation technique for people whose spinal tumors are very close to the spinal cord or nerves. It aims to safely give higher radiation doses while limiting damage to the cord.
Houston, TexasAges 18 years+ - NCT06202443Recruiting
Physical therapy timing after neck surgery
This study looks at whether starting physical therapy soon after ACDF neck surgery helps people recover better. It compares early physical therapy to standard care.
Honolulu, HawaiiAges 18–75 - NCT03713528Enrolling by invitationPhase 4
Antibiotic placed in bone to help save an infected knee implant
This trial tests whether putting antibiotics directly inside the bone during surgery can improve outcomes for an infected knee prosthesis when the implant is being kept. It may help more people avoid needing full implant removal and replacement.
San Francisco, CaliforniaAges 18 years+ - NCT03661645Enrolling by invitationPhase 4
Steroid dose taper after orthopedic surgery
This trial tests whether a planned, gradually stopping steroid medicine (methylprednisolone) after certain orthopedic surgeries helps with recovery or symptoms. It compares a post-surgery steroid taper to other routine care and focuses on safety and outcomes after surgery.
Atlanta, GeorgiaAges 18–95 - NCT06481865Recruiting
Walking after pelvic ring fracture surgery
This study looks at how well people can put weight on their legs after surgery for a pelvic ring fracture. It will track your recovery by checking your X-rays and CT scans to see how the bone heals and how you manage standing and walking.
GrenobleAges 18–100 - NCT06475391Recruiting
L-arginine supplement for exercise performance
This study tests whether taking L-arginine (a natural amino acid supplement) can improve your performance during short, intense exercise like sprinting or weightlifting. If you are a healthy, active adult, you may be able to join.
Winnipeg, ManitobaAges 18–39 - NCT06489106Enrolling by invitation
Spinal stimulation to improve hand function in kids with spinal cord injury
This study tests a noninvasive spinal stimulation device to help children with spinal cord injury regain hand strength and control. It may improve grip and daily activities.
Louisville, KentuckyAges 7–12 - NCT07447219Recruiting
Ergonomics program for dental workers
This study tests an ergonomics program designed to reduce muscle and bone pain in dental healthcare workers. If you are a practicing dental professional, this program may help you prevent work-related injuries.
Serdang, SelangorAges 25–65 - NCT06517680Recruiting
Tight Control for Shoulder Tendon Pain
This study tests whether a strict, well-monitored treatment plan works better for recent-onset rotator cuff tendinopathy (pain from the tendons around your shoulder). It aims to see if controlling treatment closely can help you recover faster.
AngersAges 18–65 - NCT06162858Recruiting
Study on arm motion after reverse shoulder replacement
This study looks at how well people can move their arms during daily activities after having a reverse shoulder replacement. It may help find ways to improve recovery and function.
GhentAges 60 years+ - NCT06506968Recruiting
Ergonomics study for heart lab staff
This study looks at how ergonomics (the way your body moves and feels at work) affect staff in the heart catheterization lab. You might join if you work there and are willing to wear special sensors to track your movements.
Boston, MassachusettsAges 21 years+ - NCT05849961Recruiting
Follow-up study for an Exactech hip replacement
This study checks how people do after receiving a specific brand of hip replacement (Exactech Hip System). It looks at safety and outcomes using either new follow-up, past medical records, or both, to better understand how the device performs over time.
Tulsa, OklahomaAges 18 years+ - NCT06424249Recruiting
Virtual reality vs. standard rehab for balance after below-knee amputation
This study compares virtual reality exercises to standard physical therapy for improving balance in people with one leg amputated below the knee. It may help you regain better balance and confidence in walking.
Le Grau-du-RoiAges 18–80 - NCT06536803Recruiting
Strength training with or without stretching for plantar fasciitis
This study tests whether adding specific stretches for the plantar fascia to high-load strength training helps male athletes with plantar fasciitis feel better. It compares strength training alone to strength training plus targeted stretching.
Mirpur MatheloAges 20–35 - NCT06520306Enrolling by invitation
Ropivacaine with methylene blue for hip surgery pain
This trial tests if adding different amounts of methylene blue to a standard numbing medicine (ropivacaine) can improve pain relief, thinking ability, and hip movement after hip replacement surgery.
TaizhouAges 60–85 - NCT07569549Recruiting
Thumb Base Surgery: Joint Replacement vs. Removal Comparison
This study compares two surgical approaches for thumb base arthritis: replacing the damaged joint with an implant or removing the problematic bone. Researchers want to see which approach works better for pain relief and hand function.
ÖrebroAges 40–80 - NCT04507412RecruitingPhase 4
IV steroid before shoulder surgery to reduce inflammation
This trial studies whether giving dexamethasone through a vein (an anti-inflammatory steroid) around the time of total shoulder replacement surgery improves outcomes. It may help lower inflammation and related discomfort, but you must meet specific health and medication safety criteria to join.
LuganoAges 58–85 - NCT06430164Recruiting
Brain and walking study for healthy adults
This study looks at how the brain controls walking in healthy people. You will walk on a treadmill while we measure your brain activity and leg muscles. It helps us understand normal walking so we can better help people with walking problems.
Atlanta, GeorgiaAges 18–65
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,841 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,937 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.