Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,611 recruiting studies in this area right now.
By phase
- Not applicable3,768
- Phase 2217
- Phase 4200
- Phase 1182
- Phase 3139
- Phase 1/Phase 271
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis172
- Rheumatoid Arthritis132
- Fibromyalgia105
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee64
- Shoulder Pain48
- Hip Osteoarthritis43
- Psoriatic Arthritis40
- Degenerative Disc Disease39
- Chronic Pain38
- Total Knee Arthroplasty38
- Duchenne Muscular Dystrophy37
- Systemic Lupus Erythematosus37
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital25
- Hacettepe University23
- Tanta University22
Where studies are running
- California207
- New York87
- Florida82
- Maryland76
- Arizona72
- Massachusetts71
- Texas67
- Alabama59
- Illinois51
- Pennsylvania48
Recruiting studies4,611 total
- NCT07538830Recruiting
Probiotic supplement for muscle strength in older adults
This study tests whether a specific probiotic (a beneficial bacteria called Lactiplantibacillus plantarum) can help improve muscle strength and physical function in adults aged 50–84. The probiotic may work by improving gut health, which could support muscle health.
BusanAges 50–85 - NCT07542184Recruiting
Nanochon Chondrograft Knee Cartilage Repair Study
This early-stage study tests a new implant designed to repair damaged knee cartilage. Researchers will evaluate whether this treatment is safe and feasible for people with knee cartilage damage.
Panama City, Provincia de PanamáAges 22–60 - NCT07539194Recruiting
Hyaluronic acid injection for wear-and-tear knee cartilage tears
This trial tests a single injection of hyaluronic acid (a lubricating fluid) into the knee to relieve pain from degenerative meniscus tears—the kind caused by age and wear, not injury. The goal is to see if it safely reduces pain and improves how well your knee works.
Milan, MIAges 35–75 - NCT07542314RecruitingPhase 4
Gene therapy for Duchenne muscular dystrophy
This study is checking how safe and effective ELEVIDYS, a gene therapy for Duchenne muscular dystrophy, is when used in everyday clinics. It will help doctors understand more about the treatment's real-world effects and provide care for those who receive it.
Houston, TexasAges 4 years+ - NCT07535034RecruitingPhase 2
Testing Dotinurad for Gout in People Who Can't Take Other Medications
This trial tests a new drug called dotinurad for gout patients whose standard medications either don't work or cause side effects. Dotinurad works differently by helping your body get rid of uric acid (the substance that causes gout attacks), and the study will see if it safely lowers uric acid levels.
Birmingham, AlabamaAges 18–75 - NCT06674980Recruiting
Testing placenta-based wound treatment for diabetic and venous leg ulcers
This trial tests if adding a special placenta-based wound covering to standard care helps heal diabetic foot ulcers and venous leg ulcers faster. It's for people with wounds that haven't healed after standard treatment for at least 4 weeks.
Metairie, LouisianaAges 18 years+ - NCT06732687Recruiting
Exercise program to prevent injuries in school boys
This trial tests if a combination of bodyweight and jumping exercises can help prevent muscle and bone injuries in school-aged boys. It could be a good fit if your child is between 8 and 12 years old, has a normal weight, and hasn't had a recent injury.
Rawalpindi, Punjab ProvinceAges 8–12 - NCT07537153Recruiting
Blocking Blood Vessels to Reduce Knee Arthritis Pain
This trial tests a procedure called genicular artery embolization, which blocks small blood vessels around the knee to reduce pain from moderate arthritis. It may help people whose knee pain hasn't improved with medications.
Chicago, IllinoisAges 40–80 - NCT07536529Recruiting
Oxidative Stress in Autoimmune Joint Diseases
This study looks at a type of cellular damage called oxidative stress in people with autoimmune joint diseases like rheumatoid arthritis, psoriatic arthritis, or ankylosing spondylitis. Researchers want to understand how this damage relates to your disease and may help develop better treatments.
Larissa, ThessalyAges 18 years+ - NCT07536672Enrolling by invitation
Understanding Pain and Sexual Health in Chronic Pain
This study helps develop a questionnaire (survey) that measures how chronic pain affects sexual health and relationships. If you have long-term pain and a stable relationship, your feedback could help doctors better understand and support patients like you.
Kütahya, KütahyaAges 18 years+ - NCT07538323Recruiting
Wrist Strengthening Exercise Program After Fracture
This trial compares a structured wrist strengthening exercise program (WISE) to standard care advice for people recovering from a broken wrist (distal radius fracture). The goal is to see if guided exercises help reduce pain and improve how well your wrist works.
Aarhus NAges 50 years+ - NCT07535372Recruiting
Gene therapy study for babies with fused skull bones
This study tests a new treatment called ASO (antisense oligonucleotide) therapy on tissue samples from babies with syndromic craniosynostosis—a condition where skull bones fuse too early due to specific genetic changes. Researchers hope this approach could eventually help prevent or reduce the severity of this condition.
RomeAges Up to 5 years - NCT07538024Recruiting
Reduced-dose radiation for spine cancer spread
This trial tests whether lower radiation doses work well for treating cancer that has spread to the spine. If you have a few spine tumors that are stable or causing symptoms, this study might help doctors find safer, faster treatment options.
Negrar, VeronaAges 18 years+ - NCT07542470Enrolling by invitationPhase 4
Cold and compression therapy after spinal surgery
This study compares a new cold and compression device (NICE1) to standard care after spinal surgery to see if it reduces pain and swelling. If you're having spine surgery, this trial tests whether keeping the area cold and compressed helps you recover better.
Sarasota, FloridaAges 18 years+ - NCT07536399RecruitingPhase 3
Bone Marrow Treatment for Jaw Joint Pain Relief
This study tests whether injecting your own bone marrow cells into your jaw joint during a minimally invasive procedure can reduce pain and improve jaw function better than arthroscopy alone. It's for people with significant jaw pain that hasn't improved with conservative treatments like NSAIDs, physical therapy, and bite splints.
New York, New YorkAges 18–75 - NCT07537036Recruiting
Pain Relief Methods for Hip Replacement Surgery
This trial compares two nerve-blocking techniques to reduce pain after hip replacement surgery. Both methods use numbing medication around specific areas near your hip to help you feel more comfortable after the operation.
Tanta, El-GharbiaAges 18 years+ - NCT06748651RecruitingPhase 1
Allocetra injection for jaw joint arthritis
This study tests a new injection called Allocetra directly into the jaw joint to treat pain and inflammation in temporomandibular joint osteoarthritis. Eligible participants must have MRI-confirmed inflammation and meet basic health requirements.
Ramat GanAges 18–60 - NCT06750601Recruiting
Using rehab data for research on physical disabilities
This study collects information from people receiving rehabilitation care. The data may be used to improve treatments for physical disabilities and chronic diseases.
GroningenAges Any age - NCT04848870Recruiting
Check dental and gum health in Sjögren’s disease
This study looks at dental and gum (periodontal) health in adults with Sjögren’s syndrome. It may help researchers understand how Sjögren’s affects the mouth and how patients can be supported better.
Ivry-sur-Seine, Île-de-France RegionAges 18 years+ - NCT06751160Recruiting
Dry needling vs. soft tissue massage for tight hamstrings
This study compares two treatments—dry needling and soft tissue massage—to see which works better for relieving tight hamstring muscles in people with low back pain.
Lahore, Punjab ProvinceAges 20–40 - NCT05334862Recruiting
8-plate surgery study for pediatric knock-knees after correction
This trial looks at children who have had surgery to correct knock-knees (genu varum) and may still have a remaining twist or shape problem. It tests a specific growth-modifying technique (an 8-plate hemi epiphysiodesis) to help improve bone alignment as the child grows.
Asyut, Asyut GovernorateAges 2.5 years–12 years - NCT06320262Recruiting
Wet cupping (Hijama) for fibromyalgia pain
This trial tests whether wet cupping (Hijama) can help reduce pain in women with fibromyalgia. It is for women who have had moderate to severe pain and have not taken certain pain medications in the past year.
CairoAges 18–55 - NCT07532226Recruiting
Tracking how long patients stay on guselkumab for psoriatic arthritis
This study follows people with psoriatic arthritis (joint pain and swelling linked to psoriasis) who are starting a newer medication called guselkumab. Researchers want to learn how long patients continue taking this medicine and how well it works for them.
LilleAges 18 years+ - NCT07533955RecruitingPhase 1
Testing JADE201 drug in rheumatoid arthritis patients
This early-stage study tests a new drug called JADE201 in people with rheumatoid arthritis (RA). Researchers want to see if it is safe and how the body handles it, which could lead to better RA treatments.
Chisinau, MoldovaAges 18–70
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,611 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,492 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.