Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,611 recruiting studies in this area right now.
By phase
- Not applicable3,768
- Phase 2217
- Phase 4200
- Phase 1182
- Phase 3139
- Phase 1/Phase 271
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis172
- Rheumatoid Arthritis132
- Fibromyalgia105
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee64
- Shoulder Pain48
- Hip Osteoarthritis43
- Psoriatic Arthritis40
- Degenerative Disc Disease39
- Chronic Pain38
- Total Knee Arthroplasty38
- Duchenne Muscular Dystrophy37
- Systemic Lupus Erythematosus37
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital25
- Hacettepe University23
- Tanta University22
Where studies are running
- California207
- New York87
- Florida82
- Maryland76
- Arizona72
- Massachusetts71
- Texas67
- Alabama59
- Illinois51
- Pennsylvania48
Recruiting studies4,611 total
- NCT04843865Recruiting
Chinese herbal add-on for joint pain from letrozole
This trial studies whether Chinese herbs, used alongside letrozole, can reduce ongoing joint and muscle pain or stiffness in postmenopausal women with hormone-receptor positive breast cancer. It’s mainly for people whose pain started or worsened after beginning letrozole and who have completed cancer treatments.
Bukit Bintang, Kuala LumpurAges 18 years+ - NCT07528092Recruiting
Pinning methods for broken metatarsal bones in the foot
This trial compares two surgical techniques for fixing broken bones in the middle of the foot (metatarsals). If your fracture couldn't stay in place with a cast alone, this study tests which pinning method works better for healing and foot function.
SohagAges 18–65 - NCT07526831Recruiting
Pain Relief Methods for Knee Surgery: Two Nerve Block Approaches
This study compares two ways of numbing nerves around the knee during surgery to see which method reduces pain better after the operation. Both methods use safe, well-established pain-relief techniques.
Kayseri, TalasAges 18 years+ - NCT07529392Recruiting
Ear nerve stimulation plus rehabilitation for chronic back pain
This trial tests a non-surgical treatment that stimulates a nerve in your ear while you do rehabilitation exercises to reduce chronic back pain. It may help if you've had pain for more than 6 months and pain medications aren't working well enough.
Baden, Lower AustriaAges 30–65 - NCT07525453Recruiting
Exercise Programs to Improve Balance in Older Adults
This study tests three different exercise programs designed to help older adults improve their balance and reduce fall risk. You'll participate in one of the programs and have your balance tested before and after to see which approach works best.
Istanbul, AtaşehirAges 65 years+ - NCT07526051Recruiting
Stretching techniques for lower back pain and muscle tightness
This study compares two stretching methods to help relieve lower back pain caused by muscle imbalances. You'll be tested to confirm the pattern of muscle tightness, then receive one of two types of stretching therapy to see which works better for your pain.
Islamabad, Punjab ProvinceAges 25–50 - NCT07525557Recruiting
Understanding Fear and Disability in Long-Term Neck Pain
This study explores how fear of movement, pain, and daily difficulties relate to each other in people with chronic neck pain lasting 3+ months. Understanding these connections may help improve future treatment approaches.
Samsun, SamsunAges 18 years+ - NCT07531537Recruiting
Breathing exercises versus neck muscle training for neck pain
This study compares two types of exercises—breathing exercises and deep neck muscle training—to see which works better for people with long-term neck pain. You'll do one type of exercise program to help relieve your pain and improve function.
ZagazigAges 18–35 - NCT07526129Recruiting
Ridge Preservation After Back Tooth Extraction
This study looks at whether a procedure called ridge preservation, done after removing upper back teeth, helps prevent the need for sinus bone grafting later. Researchers will compare patients who had this procedure with those who didn't, using 10 years of X-ray records.
Beirut, BeirutAges 18 years+ - NCT07526337Recruiting
Digital Planning for Sinus Lift Dental Implants
This study examines how computer planning improves dental implant surgery when bone needs to be built up in the upper back jaw. Researchers will assess whether digital planning helps predict better outcomes for patients getting sinus lift procedures.
Beirut, BeirutAges 18 years+ - NCT07528144Recruiting
Exoskeleton vs. Lead Apron for Surgeon Protection During Aortic Repair
This study compares a new exoskeleton device (a wearable support system) to standard lead aprons for protecting surgeons from radiation during endovascular aortic repair procedures—a minimally invasive surgery to fix problems in the main artery in the abdomen. The trial tests whether the exoskeleton provides better protection and comfort.
Szczecin, West Pomeranian VoivodeshipAges 35 years+ - NCT07525921Recruiting
Dry Needling for Calf Pain in Amateur Football Players
This study tests whether dry needling—inserting thin needles into tight muscle knots in the calf—can reduce pain and improve running speed and performance in young football players. Researchers want to see if this treatment helps athletes play better and feel less discomfort.
Islamabad, Punjab ProvinceAges 18–25 - NCT07526493RecruitingPhase 1
QH103 Cell Therapy for Resistant Autoimmune Nerve and Brain Diseases
This Phase 1 trial tests whether QH103 cell injections can help patients with serious autoimmune diseases affecting nerves and the brain (like MS, NMOSD, myasthenia gravis, and others) that haven't responded well to standard treatments. The goal is to evaluate safety and whether the treatment helps reduce symptoms.
Wuhan, HubeiAges 18–75 - NCT07525895Enrolling by invitation
Nerve Stretching for Lower Leg Pain Relief
This study tests whether gentle stretching exercises targeting the sciatic nerve (a major nerve in your leg) can help reduce leg pain and improve how your body perceives pain. Researchers will compare this treatment to standard care to see if it works.
Istanbul, AtaşehirAges 18–30 - NCT07529093Recruiting
Mobilization and Movement Training for Sacroiliac Joint Pain
This trial tests whether a combination of hands-on joint mobilization techniques and specific movement control exercises can reduce pain and improve function in people with sacroiliac joint dysfunction (pain in the lower back/buttock area where the spine connects to the pelvis). You would receive these treatments over several weeks and be measured on pain relief, movement, walking, and daily activities.
Lahore, Punjab ProvinceAges 45–64 - NCT07529197Recruiting
Study of Immunoadsorption Treatment for Post-Infectious ME/CFS
This study observes how a blood-cleaning treatment called immunoadsorption works in patients with ME/CFS (severe fatigue condition) who have specific immune markers. Researchers will track whether this treatment helps reduce symptoms and improve daily functioning.
Berlin, State of BerlinAges 18–65 - NCT07526350RecruitingEarly Phase 1
MTS109 for Hard-to-Treat Autoimmune Diseases
This early-stage trial tests a new treatment called MTS109 for autoimmune diseases (like lupus, muscle inflammation, scleroderma, vasculitis, or Sjögren's syndrome) that haven't responded well to standard medications. The goal is to see if MTS109 can help control disease that keeps flaring or getting worse despite current treatments.
Shanghai, Shanghai MunicipalityAges 18–65 - NCT07526038Recruiting
Physical therapy for postpartum pelvic joint pain
This study tests whether a hands-on movement technique combined with core exercises helps postpartum mothers with sacroiliac joint pain (a pain in the lower back/buttock area). The research compares this combined approach to see if it reduces pain and improves function.
Islamabad, Punjab ProvinceAges 20–40 - NCT07528248Recruiting
Posture exercises for upper back and neck pain
This study compares two types of gentle posture-correction exercises for people with upper cross syndrome—a condition where your shoulders round forward and your neck posture shifts. The trial tests which approach works better to reduce pain and improve how you stand and move.
Okāra, Punjab ProvinceAges 20–45 - NCT07532785Recruiting
Water and Land Exercise Before Knee Replacement Surgery
This trial tests whether a 6-week program combining weekly water-based exercise and three times weekly land-based training can help reduce knee pain and improve strength before total knee replacement surgery. The program aims to help you recover better after your operation.
London, EnglandAges 18 years+ - NCT07533188Recruiting
Robotic Knee Replacement Surgery Alignment Techniques Study
This study compares two different ways surgeons can align and position a robotic knee replacement to see which gives better results. You'll be randomly assigned to one approach and tracked over time to measure pain, function, and satisfaction.
SingaporeAges 18 years+ - NCT07532070Recruiting
Exercise and Therapy for Chronic Pain and Sleep Problems
This study tests whether exercise, talk therapy for sleep problems, or both together can help people with long-term back, hip, or knee pain who also struggle with sleep. You'll attend video appointments and try one of these approaches for several weeks.
San Antonio, NevadaAges 18 years+ - NCT07525063Enrolling by invitation
Brain Stimulation for Fibromyalgia Pain Relief
This study tests whether a non-invasive brain stimulation technique (called TMS) can help reduce pain and improve mood in women with fibromyalgia. Researchers will use MRI scans and brain stimulation to understand how pain and reward circuits in the brain work.
Durham, North CarolinaAges 18 years+ - NCT07531498Recruiting
Muscle aging study for childhood cancer survivors
This study looks at muscle health and aging in adults who had childhood cancer. Researchers want to see how muscle mass and strength change over time and what factors (like past treatments) might affect this.
Memphis, TennesseeAges 18 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,611 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,492 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.