Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,610 recruiting studies in this area right now.
By phase
- Not applicable3,771
- Phase 2215
- Phase 4199
- Phase 1182
- Phase 3139
- Phase 1/Phase 270
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis171
- Rheumatoid Arthritis131
- Fibromyalgia105
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee65
- Shoulder Pain48
- Hip Osteoarthritis43
- Psoriatic Arthritis40
- Degenerative Disc Disease39
- Chronic Pain38
- Total Knee Arthroplasty38
- Systemic Lupus Erythematosus37
- Duchenne Muscular Dystrophy36
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University66
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital25
- Hacettepe University23
- Tanta University22
Where studies are running
- California207
- New York87
- Florida82
- Maryland76
- Arizona72
- Massachusetts71
- Texas66
- Alabama60
- Illinois51
- Pennsylvania48
Recruiting studies4,610 total
- NCT06775197RecruitingPhase 4
Partial meniscus replacement with Spongioflex sponge
This trial tests a sponge-like implant (Spongioflex) to replace part of a torn meniscus in the knee. It may help people with pain on the inner or outer side of the knee who have enough healthy rim left to hold the implant.
Greven, North Rhine-WestphaliaAges 18–60 - NCT06776562Recruiting
Corrective exercises for knee collapse in young women
This study tests whether specific corrective exercises can improve how your knees move when you squat or walk, focusing on women who have knee collapse (dynamic knee valgus) but no pain. If you qualify, you would attend supervised exercise sessions designed to strengthen and align your knees properly.
IstanbulAges 18–25 - NCT06075004Recruiting
Hip pain relief study comparing two injection methods
This trial tests two ways to give pain medicine around the hip joint during surgery to see which provides better pain relief. It may help patients experience less pain after hip replacement.
Santiago, Santiago MetropolitanAges 18–80 - NCT06082739Recruiting
Exercise for kyphosis (curved upper back)
This study tests whether a specific exercise program can help reduce the forward rounding of the upper back (kyphosis) in people with postural or Scheuermann's kyphosis. It's for patients 8 and older who have a significant curve, and it also includes their parents or guardians.
Los Angeles, CaliforniaAges 8 years+ - NCT06189495RecruitingPhase 2
Study of Genakumab for lung scarring from connective tissue disease
This study tests a new injected medication (Genakumab) for people with connective tissue disease-related lung scarring. It aims to see if it helps stabilize or improve lung function safely.
Beijing, Beijing MunicipalityAges 18–75 - NCT06676189Recruiting
Comparing two types of plastic knee implants for replacement
This study compares two different types of plastic knee implants (polyethylene) used in total knee replacement surgery. The goal is to see which one works best for patients with knee arthritis.
Clermont-FerrandAges 18–90 - NCT06771427Recruiting
Exosomes for Sjogren's and Dry Eye
This study looks at tiny particles called exosomes in tears to find new ways to diagnose or treat Sjogren's syndrome and dry eye disease. It may help people with these conditions by learning more about what causes them.
Taipei, TaiwanAges 20–75 - NCT07478822RecruitingPhase 3
Botulinum toxin study for arm spasticity after stroke
This study tests a new botulinum toxin injection (YY001) for adults whose arm muscles are tight or stiff after a stroke. It looks at whether repeated treatments help with daily activities like washing and dressing.
BeijingAges 18–75 - NCT07477860RecruitingPhase 1
Achilles tendon pain treatment trial
This trial tests a minimally invasive treatment for chronic Achilles tendon pain that hasn't improved with at least 3 months of rest, therapy, or other non-surgical care. It aims to help people who want to avoid surgery.
Libertyville, IllinoisAges 25–80 - NCT07473154RecruitingPhase 1/Phase 2
Calming an overactive immune system with special cells
This trial tests a new type of cell therapy made from a patient's own white blood cells (called lymphocytes) that are designed to help control the immune system. The goal is to reduce inflammation and symptoms in people with hard-to-treat rheumatoid arthritis or a severe form of scleroderma (dcSSc).
DüsseldorfAges 18 years+ - NCT07472010Recruiting
Jaw Stretching with Slow Breathing for Calmness
This study tests whether doing a simple jaw-stretching exercise along with a slow breathing pattern (breathe in for 4 seconds, hold for 4, breathe out for 8) can help calm your body's 'fight or flight' system. It is designed for healthy students who want to try relaxation techniques.
Konya, KonyaAges 18–30 - NCT07472088Recruiting
Knee pain study using weight-bearing CT scans
This trial uses a special CT scan taken while you stand to see how the shape of your knee joint relates to your knee pain. It may help researchers better understand knee arthritis and front-of-knee pain.
Kansas City, KansasAges 18 years+ - NCT07478861Enrolling by invitation
Vibration training for seniors with knee arthritis and obesity
This study tests whether whole-body vibration training can help older adults who have both severe knee arthritis and obesity. It aims to improve strength, mobility, and quality of life.
Banī SuwayfAges 60–75 - NCT07478289RecruitingPhase 2
Radiation boost for painful spinal metastases
This trial tests a higher dose of radiation (a boost) to painful spots in the spine where cancer has spread. The goal is to see if it can better relieve pain and improve function.
Toronto, OntarioAges 18 years+ - NCT07473414Recruiting
Knee tissue study for early osteoarthritis treatment
This trial studies knee tissue to find better ways to diagnose early osteoarthritis. It may help people who need a knee injection for pain relief.
NantesAges 18 years+ - NCT07473232Recruiting
Comparing platelet-rich plasma and cytokine-rich serum injections for knee osteoarthritis
This trial compares two types of injections (PRP and ACS) to see which one works better for knee osteoarthritis. It may help people with knee pain who have not had these injections recently.
Pamukkale, DenizliAges 40–80 - NCT07478367Recruiting
Muscle weakness in hospitalized patients outside the ICU
This study looks at muscle weakness that can develop when you are in the hospital for an acute illness but not in the intensive care unit (ICU). It aims to understand how common this weakness is and what factors might be involved.
RozzanoAges Any age - NCT07473141Recruiting
Measuring walking problems with wearable sensors
This trial uses small wearable sensors to measure how you walk while you are in the hospital. It can help doctors better understand and treat walking difficulties.
Milan, ItalyAges 18–80 - NCT07472400Recruiting
Hip surgery recovery study for young adults with hip impingement
This study follows people before and after hip arthroscopy to treat femoroacetabular impingement (a condition where the hip bones pinch together). It measures strength, mobility, and daily function to see how recovery progresses over 6 months.
Sart Tilman, LiègeAges 18–40 - NCT07473713RecruitingPhase 1
Veverimer for bone loss in adults with osteopenia
This study tests whether a medication called veverimer can help reduce bone loss in adults with osteopenia (early bone thinning) by lowering the acid load from their diet. Participants must be 50 or older, eat a typical Western diet, and have low bone density but not full osteoporosis.
Boston, MassachusettsAges 50 years+ - NCT07474571Recruiting
Study of aging bones and joints using advanced scans
This trial uses scans like X-rays, CT, or MRI to study how bones and joints age. It aims to understand aging-related problems and may help develop better ways to detect or treat them.
BeijingAges 18 years+ - NCT07476976Enrolling by invitation
Joint hypermobility, body awareness, and quality of life study
This study looks at how flexible joints (joint hypermobility) affect body awareness and quality of life. The goal is to learn more about these connections and suggest helpful exercises or treatments.
KaunasAges 1.7 years–8.3 years - NCT07477873Enrolling by invitation
Emotions and jaw surgery recovery study
This study looks at how patients feel emotionally and physically before and after jaw surgery. It uses special software and questionnaires to track emotions, and checks the jaw joint and muscles after surgery. The goal is to see how these relate to recovery in patients having planned jaw surgery.
Kaunas, KaunoAges 18 years+ - NCT07477847Enrolling by invitation
Custom exercise for back pain, posture, and quality of life
This study tests a personalized exercise program to see if it reduces back pain, improves posture (kyphosis angle), and boosts quality of life. It may help if you have nonspecific back pain and haven't been exercising regularly.
IstanbulAges 18–45
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,610 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,508 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.