Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,837 recruiting studies in this area right now.
By phase
- Not applicable3,970
- Phase 2223
- Phase 4196
- Phase 1191
- Phase 3149
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis185
- Rheumatoid Arthritis142
- Fibromyalgia102
- Osteoporosis88
- Osteoarthritis74
- Osteoarthritis, Knee72
- Rheumatoid Arthritis (RA)65
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Total Knee Arthroplasty38
- Chronic Pain37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida80
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,837 total
- NCT05863741Recruiting
Knee surgery planning using a 3D next-step guidance system
This trial studies whether a NextAR system’s planning and gait (walking) analysis can improve how knee replacement surgery is done and how you walk afterward. It’s for adults with severe knee osteoarthritis who are eligible for total knee replacement.
FremantleAges 18 years+ - NCT06942689RecruitingPhase 4
Finding the best dose of numbing medicine for knee surgery pain
This trial tests different amounts of a long-lasting numbing medicine (liposomal bupivacaine) injected near the nerve in your thigh to see which volume works best for controlling pain after knee surgery. If you qualify, you may receive better pain relief and need fewer opioids.
Nanjing, JiangsuAges 18–85 - NCT05978024Recruiting
Predicting how sarcoma responds and side effects from limb radiotherapy
This study collects information to predict how soft tissue sarcoma in an arm or leg will respond to radiotherapy and what side effects may happen. It may help doctors improve planning and follow-up for people like you.
CambridgeAges 16 years+ - NCT06953375Recruiting
Electrical stimulation for faster recovery after knee replacement
This study tests if adding a gentle electrical stimulation (called NMES) to standard physical therapy helps people recover strength faster after knee replacement surgery. It is for patients who go to specific UCHealth or Intermountain Health therapy clinics after their first total knee replacement.
Aurora, ColoradoAges 18 years+ - NCT07434505Recruiting
Comparing two bone graft sites for foot surgery
This trial compares two ways to collect bone graft material for foot and ankle surgeries. It uses a special tool to take graft from either the shin bone or the hip to see which works better for healing.
Jacksonville, FloridaAges 18–70 - NCT06814808Enrolling by invitation
Comparing three treatments for chronic neck pain
This study compares three different treatments for chronic neck pain caused by trigger points (tender knots in muscles). It aims to find which approach works best for pain relief and improved function.
Istanbul, ZeytinburnuAges 18–65 - NCT07300592Recruiting
Balance test for healthy older adults
This study is testing a new tool to measure balance in older adults who are still active and independent. It aims to help identify early balance problems before they lead to falls.
Kaohsiung City, Kaohsiung CityAges 60–80 - NCT07245615Recruiting
Vibration therapy for neck dystonia
This study tests whether a gentle vibration device placed on the neck can improve head posture in people with cervical dystonia (neck muscle spasms). The goal is to find the best vibration strength to help reduce symptoms.
Minneapolis, MinnesotaAges 30 years+ - NCT06944730Recruiting
Trunk muscle training for better movement and balance in low back pain
This study tests whether trunk muscle training can improve the quality of your movements and balance if you have chronic low back pain. It is designed for people with moderate pain and no other major health issues.
Hong KongAges 18–55 - NCT06943053Recruiting
Waterproof bandage study for knee replacement recovery
This study compares two types of waterproof bandages used after total knee replacement surgery to see which one works better at keeping the wound dry and clean.
Pathum Thani, Khlong luangAges 55 years+ - NCT06937931RecruitingPhase 2
Study of IPN10200 for neck muscle spasms in adults
This trial tests a new botulinum toxin medication (IPN10200) for adults with cervical dystonia, a condition that causes painful muscle spasms in the neck and shoulders. It aims to see if the treatment is safe and effective in reducing symptoms.
Tucson, ArizonaAges 18–80 - NCT06940063Recruiting
Music therapy for chronic low back pain
This trial tests whether an active music-based program can help reduce chronic low back pain. It is for adults aged 18 to 65 whose pain has lasted at least 3 months and has been present on most days.
Denton, TexasAges 18–65 - NCT07248501Recruiting
Bulgarian exercises for leg function in children
This study tests a type of exercise called Bulgarian exercises to see if they help improve leg function in children. If your child can walk and follow instructions, they may be able to join.
Lahore, Punjab ProvinceAges 8–18 - NCT07248748Recruiting
Alexander technique for upper cross syndrome in teens
This study tests whether the Alexander Technique, a method that helps improve posture and reduce muscle tension, can help teenagers with upper cross syndrome (a common posture problem where the shoulders round forward and the head juts out). It may help them feel better and move more easily during school and daily activities.
Lahore, Punjab ProvinceAges 13–16 - NCT06937710Recruiting
Return to sport after hip arthroscopy
This trial studies how the hip moves and works after hip arthroscopy (a keyhole surgery to fix a torn labrum). It aims to help athletes like you return to sport safely.
MérignacAges 18–50 - NCT06843174RecruitingPhase 4
Methadone for pain during and after spine surgery
This trial tests if giving a single dose of methadone right before and during spine surgery can help manage pain better. If it works, you might need fewer other pain medicines after surgery.
Toronto, OntarioAges 18–65 - NCT06717568Recruiting
Using 3D camera to check scoliosis in teens
This trial tests a 3D depth camera to measure spinal curves in teens with scoliosis. It may help avoid repeated X-rays while tracking your curve.
Hangzhou, ZhejiangAges 10–18 - NCT06933953Recruiting
French foot health questionnaire study
This study tests a French version of a foot health questionnaire. It aims to make sure the questions are clear and accurate for people receiving foot care.
AlençonAges 18 years+ - NCT07568015Recruiting
Nerve-targeted treatment for lateral hip pain
This study tests an experimental treatment that targets nerves around the hip to relieve pain on the outside of the hip. It may help people who have tried other treatments without enough relief.
Sun City, ArizonaAges 22–80 - NCT07745218Recruiting
Testing a new companion therapy for LAMA2 muscular dystrophy
This study looks at a new protein that might help people with LAMA2-related muscular dystrophy. It uses stored samples to see if the protein could be a useful addition to future treatments.
MilanAges Any age - NCT06931067Recruiting
Exercise program to prevent falls in older adults
This study tests an exercise program called OTAGO, combined with motivational interviewing, to help older adults at high risk for falling improve their balance and strength. If you are 60 or older, have had a fall or worry about falling, and have some difficulty walking or moving around, this trial may be a good fit for you.
Portland, OregonAges 60–120 - NCT06928948Enrolling by invitation
Medium-term results of LPS thigh bone replacement
This study looks at how well the LPS™ system works for replacing the lower part of the thigh bone. It aims to find out the medium-term results for people who had this surgery.
BrestAges Any age - NCT07744542Enrolling by invitation
Physical therapy for shoulder arthritis pain
This study tests if a specific physical therapy program can help people with shoulder arthritis (wear-and-tear in the shoulder joint) feel better and move more easily without surgery. It may help you if you have this type of arthritis and have not tried physical therapy recently.
Buffalo, New YorkAges 18 years+ - NCT06343714RecruitingPhase 1
Testing a new drug for knee osteoarthritis pain
This study tests a new antibody drug (FB1003) for people with knee osteoarthritis pain. It will check if the drug is safe and helps reduce pain. You may be eligible if you have moderate to severe knee pain and are willing to temporarily stop your usual pain medications.
Brisbane, QueenslandAges 18–75
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,837 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,953 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.