Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,610 recruiting studies in this area right now.
By phase
- Not applicable3,771
- Phase 2215
- Phase 4199
- Phase 1182
- Phase 3139
- Phase 1/Phase 270
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis171
- Rheumatoid Arthritis131
- Fibromyalgia105
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee65
- Shoulder Pain48
- Hip Osteoarthritis43
- Psoriatic Arthritis40
- Degenerative Disc Disease39
- Chronic Pain38
- Total Knee Arthroplasty38
- Systemic Lupus Erythematosus37
- Duchenne Muscular Dystrophy36
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University66
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital25
- Hacettepe University23
- Tanta University22
Where studies are running
- California207
- New York87
- Florida82
- Maryland76
- Arizona72
- Massachusetts71
- Texas66
- Alabama60
- Illinois51
- Pennsylvania48
Recruiting studies4,610 total
- NCT07472088Recruiting
Knee pain study using weight-bearing CT scans
This trial uses a special CT scan taken while you stand to see how the shape of your knee joint relates to your knee pain. It may help researchers better understand knee arthritis and front-of-knee pain.
Kansas City, KansasAges 18 years+ - NCT07473713RecruitingPhase 1
Veverimer for bone loss in adults with osteopenia
This study tests whether a medication called veverimer can help reduce bone loss in adults with osteopenia (early bone thinning) by lowering the acid load from their diet. Participants must be 50 or older, eat a typical Western diet, and have low bone density but not full osteoporosis.
Boston, MassachusettsAges 50 years+ - NCT07478172Recruiting
Electrical muscle stimulation exercise for neuromuscular disease
This study tests whether whole-body electrical muscle stimulation (using small electrodes on the skin) can help adults with certain neuromuscular diseases exercise and improve muscle strength. It may be an option if you can stand for about 15 minutes at a time and have some muscle strength left.
Columbia, MissouriAges 18 years+ - NCT07478224Recruiting
Blood flow restriction training for osteogenesis imperfecta type I
This study tests whether a special type of strength training, called blood flow restriction training, can improve muscle, bone, and quality of life in adults with osteogenesis imperfecta type I.
GhentAges 18–65 - NCT07473414Recruiting
Knee tissue study for early osteoarthritis treatment
This trial studies knee tissue to find better ways to diagnose early osteoarthritis. It may help people who need a knee injection for pain relief.
NantesAges 18 years+ - NCT06781554Recruiting
Collagen device for thumb arthritis
This trial tests a new collagen-based medical device injected into the thumb joint to treat thumb base arthritis (rhizarthrosis). It aims to see if it safely reduces pain and improves hand function without surgery.
Milan, MIAges 18–75 - NCT05540938RecruitingPhase 4
Testing WangBi granules for rheumatoid arthritis along with standard care
This trial studies whether WangBi granules help control rheumatoid arthritis symptoms when used by people already taking stable methotrexate and tofacitinib. It’s mainly for people with mild-to-moderate disease activity and specific diagnostic features.
BeijingAges 18–75 - NCT06432543Recruiting
Wear particle study in revision hip replacement
This study looks at tiny plastic particles that wear off from artificial hip joints over time. Researchers will study these particles from tissue taken during revision hip replacement surgery to understand how they affect the body.
Rochester, MinnesotaAges 20 years+ - NCT06769191RecruitingEarly Phase 1
CD7 car-t, stem cell transplant, and kidney transplant for SIOD
This trial tests a sequence of treatments for SIOD (a genetic condition causing immune and kidney problems). First, you receive CD7 car-t cells, then a stem cell transplant from a family donor, followed by a kidney transplant from the same donor. The goal is to see if this approach is safe and can help your body accept the new kidney.
Hangzhou, ZhejiangAges Any age - NCT06778343Recruiting
Biomarkers study for inflammatory rheumatic diseases
This study is looking for people with ankylosing spondylitis, rheumatoid arthritis, or lupus to help find biomarkers that may make diagnosis easier. If you have one of these conditions and haven't tried biologic therapies, you may be able to join.
LisbonAges 18–65 - NCT06075979Recruiting
Microbes and spine health: a surgical study
This study looks at whether certain microbes (tiny living things) are linked to spine problems like herniated discs or narrow spinal canals. It involves people who need spine surgery, and the findings might help explain why some spines wear out faster.
Jinan, ShandongAges 18–85 - NCT04814082Recruiting
Compare two knee implant types for walking and function
This study compares two designs of knee replacement implants to see how they affect walking, function, and outcomes after surgery. You may be randomly assigned to one of the implant types used for your specific, approved knee replacement.
Baltimore, MarylandAges 18–75 - NCT04729686RecruitingPhase 4
Nerve block during hip replacement for less postoperative pain
This trial tests whether a specific nerve block given during planned hip replacement surgery can reduce pain afterward. It may help you use less opioid pain medicine, but you must meet certain safety and medication criteria.
Baltimore, MarylandAges 18–80 - NCT06688227Recruiting
Core Stability Training for Cricket Fast Bowlers
This study is testing whether core stability exercises can help cricket fast bowlers prevent back pain. It compares doing core exercises on their own versus combining them with regular training.
Lahore, Punjab ProvinceAges 18–28 - NCT06434441Recruiting
Skull vs hip bone graft for upper jaw
This trial compares two ways to rebuild a narrow upper jaw bone: using a bone block from your skull (calvarial) versus one from your hip (iliac crest). It may help if you need more bone for future dental implants.
CairoAges 20–55 - NCT06688279Recruiting
Plyometric exercises for female fast bowlers
This trial tests plyometric exercises (jumping and explosive moves) to see if they can improve strength and performance for female fast bowlers in cricket. If you are a healthy, active bowler between 19 and 28, you may be able to join.
Lahore, Punjab ProvinceAges 19–28 - NCT06688214Recruiting
Kinesiology taping and shoulder exercises for shoulder pain
This trial tests if kinesiology taping (a special type of tape applied to the shoulder) plus exercises that strengthen the shoulder blades works better than just exercises alone for people with shoulder impingement syndrome (a common cause of shoulder pain). You may qualify if you have had pain on the front or side of your shoulder for at least 3 months and have certain positive tests from a physical therapist.
Lahore, Punjab ProvinceAges 18–55 - NCT05290363Recruiting
Studying a blood signal in active spondyloarthritis
This study looks at how a body signal called IL-23 may drive inflammation in spondyloarthritis (including joints) using samples from your care. It may help researchers identify which body cells and targets are involved, and how treatments could work better for active disease.
CréteilAges 18 years+ - NCT07470359RecruitingPhase 2
ACL surgery with and without platelet-rich plasma injection
This study compares standard ACL knee reconstruction using a peroneus longus tendon graft to the same procedure plus an injection of platelet-rich plasma (a concentrated portion of your blood that may help healing). It aims to see if adding the plasma improves knee function after surgery.
Lahore, Punjab ProvinceAges 18–50 - NCT06645899Recruiting
Italian database for parathyroid conditions
This study is creating a database of people with hypoparathyroidism or pseudohypoparathyroidism in Italy. It may help researchers learn more about these conditions and improve future care.
AlessandriaAges Any age - NCT07470021Recruiting
Numbing injection for pain relief after ankle surgery
This study tests whether a numbing injection around the ankle nerves before surgery can reduce pain and help you recover faster after ankle arthroscopy. It is for people having this keyhole surgery and staying in the hospital for a short time.
Hangzhou, ZhejiangAges 18–65 - NCT07465991Recruiting
Online insomnia therapy for fibromyalgia and activity
This study tests if an online therapy program for insomnia (using cognitive behavioral therapy, or CBT) can help people with fibromyalgia sleep better and be more physically active. If you have fibromyalgia and trouble sleeping, this treatment may improve your pain and daily function.
OxfordAges 18 years+ - NCT07466823Recruiting
Spasticity Patterns and Quality of Life in MS
This study looks at patterns of muscle stiffness (spasticity) in people with multiple sclerosis and how these patterns affect daily life and well-being. It aims to better understand the link between spasticity and quality of life.
IstanbulAges 18 years+ - NCT07468734Recruiting
Shock wave vs. physical therapy for knee arthritis
This study compares two treatments for chronic knee osteoarthritis: shock wave therapy and traditional physical therapy. The goal is to see which one helps reduce pain and improve function better.
CairoAges 40 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,610 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,508 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.