Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,610 recruiting studies in this area right now.
By phase
- Not applicable3,771
- Phase 2215
- Phase 4199
- Phase 1182
- Phase 3139
- Phase 1/Phase 270
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis171
- Rheumatoid Arthritis131
- Fibromyalgia105
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee65
- Shoulder Pain48
- Hip Osteoarthritis43
- Psoriatic Arthritis40
- Degenerative Disc Disease39
- Chronic Pain38
- Total Knee Arthroplasty38
- Systemic Lupus Erythematosus37
- Duchenne Muscular Dystrophy36
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University66
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital25
- Hacettepe University23
- Tanta University22
Where studies are running
- California207
- New York87
- Florida82
- Maryland76
- Arizona72
- Massachusetts71
- Texas66
- Alabama60
- Illinois51
- Pennsylvania48
Recruiting studies4,610 total
- NCT05759039Recruiting
Surgery choice for recurrent kneecap instability
This trial looks at whether transferring the tibial tubercle (a surgical repositioning of the kneecap tracking attachment) is a better option for people who have repeated kneecap slipping. It may help reduce symptoms and improve kneecap stability, depending on your specific knee anatomy.
Canmore, AlbertaAges 13–30 - NCT05972876Recruiting
Blood-flow restriction rehab after ACL surgery
This trial looks at how well your ACL graft (the repaired tissue) heals after ACL reconstruction when you use a specific rehab method called blood-flow restriction training. It may help your care team understand whether this rehab approach leads to better healing and function.
Sittard, LimburgAges 18–65 - NCT06431867Recruiting
Managing osteoporosis in older women
This study tests a new way for primary care doctors to help older women manage osteoporosis. It aims to find better strategies for treatment and follow-up in the community.
Bradford, West YorkshireAges 70 years+ - NCT06781060Recruiting
Nerve stimulation for sciatic nerve injury in children
This trial tests if electrical nerve stimulation can help children aged 3 to 19 who have nerve damage in the leg caused by an injection. The goal is to improve nerve healing and leg function.
Multan, Punjab ProvinceAges 3–19 - NCT07439575Recruiting
Wound closure methods in hip and knee replacement
This study compares different ways of closing the wound after hip or knee replacement surgery. It looks at which methods heal best with fewer problems.
Istanbul, IstanbulAges 30 years+ - NCT07435129RecruitingPhase 2
Study of apitegromab for people with FSHD
This study tests whether a drug called apitegromab can help improve muscle function in people with facioscapulohumeral muscular dystrophy (FSHD). It is for adults aged 18-60 who have mild to moderate symptoms and can walk or run 10 meters in 5 seconds or less.
Austin, TexasAges 18–60 - NCT07435571RecruitingPhase 2
Treatment of thumb arthritis with a umbilical cord membrane
This trial tests a special membrane made from donated umbilical cord tissue that is placed into the thumb joint to help with pain and function. It aims to be an alternative to surgery for people with early-stage thumb arthritis who haven't gotten better with other treatments.
LyonAges 18–75 - NCT07443826RecruitingPhase 1/Phase 2
Gene therapy for age-related muscle loss and heart health
This trial tests a gene therapy that may help rebuild muscle and improve blood vessel growth in people ages 35 to 75. It's designed for those with stable health conditions and no history of cancer, heart disease, blood clots, or diabetes.
Coxen Hole, Bay IslandsAges 35–75 - NCT07441876RecruitingPhase 2/Phase 3
Comparing a new drug to vosoritide for children with achondroplasia
This trial tests a new medicine, BMN 333, against an existing one (vosoritide) to see if it helps children with achondroplasia grow. It's for kids who haven't used these treatments before.
Oakland, CaliforniaAges 2–17 - NCT06806605Recruiting
3D computer planning for jaw surgery
This trial tests whether a full 3D computer-assisted approach helps better diagnose and correct jaw and facial deformities during orthognathic surgery. It may benefit patients who need surgery to realign their jaws.
Bologna, Emilia-RomagnaAges 18–60 - NCT07436143Recruiting
Posture and quality of life in Duchenne muscular dystrophy
This study looks at how different body positions affect daily life and well-being in children with Duchenne muscular dystrophy. It may help find ways to improve comfort and function.
Lahore, Punjab ProvinceAges 5–9 - NCT07435207Enrolling by invitation
Blood clot risk study in CRPS patients
This study looks at factors that might increase the risk of blood clots in people with CRPS (Complex Regional Pain Syndrome). It aims to help doctors better understand and manage these risks.
Pavia, PaviaAges 18 years+ - NCT07438652Recruiting
Mediterranean vs paleo diet for rheumatoid arthritis
This 12-week study compares two diets (Mediterranean and paleo) to see which one better helps rheumatoid arthritis symptoms, muscle health, and quality of life. It is for adults aged 40 to 60 who have been diagnosed with rheumatoid arthritis.
Cairo, Al-ManialAges 40–60 - NCT07439679Recruiting
Anxiety Before Double Jaw Surgery and Your Recovery
This trial studies how anxiety before double jaw surgery affects your body during surgery and your recovery (pain, swelling, and ability to open your mouth). Researchers will use a simple anxiety questionnaire to see if feeling anxious changes your surgical experience.
IstanbulAges 18 years+ - NCT07440862Recruiting
Pelvic floor exercises and belt for pubic pain in pregnancy
This trial tests if pelvic floor exercises and a support belt work better than either alone for symphysis pubis dysfunction, a condition that causes pain in the front of the pelvis during pregnancy.
Daska KalanAges 25–40 - NCT07437924Enrolling by invitation
Bruxism and pelvic floor health in young women
This study looks at whether teeth grinding (bruxism) is linked to pelvic floor muscle function in young women. If you are 18–30 and either grind your teeth or do not, you may help researchers understand this connection.
KonyaAges 18–30 - NCT07442812Recruiting
Dexamethasone: pill vs. IV for knee replacement recovery
This trial compares two ways of giving dexamethasone (a strong anti-inflammatory) for people having knee replacement surgery. One group gets a pill and the other gets an IV. The goal is to see which method works better for pain, swelling, and recovery.
Istanbul, IstanbulAges 50–80 - NCT07440849Recruiting
Core stability and pelvic exercises for sacroiliac joint pain
This study tests whether core stability and pelvic clock exercises can reduce pain in women with sacroiliac joint dysfunction after childbirth. It may help you if you are a new mom with significant lower back or pelvic pain.
Sargodha, Punjab ProvinceAges 25–35 - NCT07435259Recruiting
Treating jaw bone problems around dental implants: keep or remove?
This study compares two ways to treat a jaw bone problem caused by medications (called MRONJ) when it happens around a dental implant. One option is to keep the implant and treat the bone, the other is to remove the implant. The goal is to see which approach leads to better healing.
Seoul, SeoulAges 20 years+ - NCT07442773Recruiting
Support for partners and family caregivers of frail RA patients
This trial tests a support program for people who care for a loved one with rheumatoid arthritis. The program aims to reduce the burden on caregivers and help them feel more supported.
Glostrup Municipality, Capital RegionAges 18 years+ - NCT07443956Recruiting
Biologic and anti-obesity drug combo for psoriatic arthritis
This study tests whether adding a weight-loss medication (tirzepatide) to a biologic (ixekizumab) helps people with psoriatic arthritis and overweight or obesity. You will need to have biopsies of joint tissue and fat to see how the treatment affects inflammation.
Birmingham, EnglandAges 18–75 - NCT07440615Recruiting
Leg muscle and heart performance in active adults
This study looks at how leg muscle size relates to heart and muscle performance in healthy men and women. It aims to understand normal differences between sexes.
EskişehirAges 18–30 - NCT07438522Recruiting
Hand strength exercises for female badminton players
This trial tests two types of hand strengthening exercises (isometric and isotonic) in female competitive badminton players. It aims to see which approach better improves hand and grip performance, which can help with racquet control and power.
Lahore, Punjab ProvinceAges 18–30 - NCT05806021RecruitingPhase 4
Tested different cortisone doses for knee osteoarthritis pain
This trial compares different doses of injected cortisone (triamcinolone) directly into the knee to see which dose helps knee osteoarthritis pain most. You may be enrolled in a group receiving a 5 mg, 10 mg, or 40 mg dose if you meet the study’s knee and health requirements.
Montreal, QuebecAges 50 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,610 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,508 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.