Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,610 recruiting studies in this area right now.
By phase
- Not applicable3,771
- Phase 2215
- Phase 4199
- Phase 1182
- Phase 3139
- Phase 1/Phase 270
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis171
- Rheumatoid Arthritis131
- Fibromyalgia105
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee65
- Shoulder Pain48
- Hip Osteoarthritis43
- Psoriatic Arthritis40
- Degenerative Disc Disease39
- Chronic Pain38
- Total Knee Arthroplasty38
- Systemic Lupus Erythematosus37
- Duchenne Muscular Dystrophy36
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University66
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital25
- Hacettepe University23
- Tanta University22
Where studies are running
- California207
- New York87
- Florida82
- Maryland76
- Arizona72
- Massachusetts71
- Texas66
- Alabama60
- Illinois51
- Pennsylvania48
Recruiting studies4,610 total
- NCT07449442Recruiting
Pain relief study after knee replacement surgery
This trial tests a special injection around the knee to improve pain control after knee replacement surgery. It may help reduce the need for strong pain medicines.
PoznanAges 65–100 - NCT07448857Recruiting
Scapula movement and muscle activity in upper string players with neck pain
This study looks at how the shoulder blade moves and muscles work in violin and viola players who have neck pain. It may help understand why neck pain happens and how to treat it better.
Taipei, TaiwanAges 18 years+ - NCT07449468Recruiting
Nerve block to prevent confusion after hip replacement
This trial tests whether a nerve block (PENG block) can reduce confusion (delirium) after hip replacement surgery in older adults. It is for people 75+ scheduled for a first-time hip replacement under spinal anesthesia.
PoznanAges 75–100 - NCT07446517Recruiting
Laser therapy for knee or heel pain in young athletes
This study tests if low-level laser therapy can help teenagers with Osgood-Schlatter knee pain or Sever heel pain. It aims to reduce pain from sports, so you can keep playing.
Gdansk, PomeranianAges 10–17 - NCT07453498Recruiting
Nerve block for pain after hip replacement
This study tests if a specific nerve block (the psoas sheath block) helps reduce pain after hip replacement surgery. If you are having a hip replacement, you may be able to join and get this extra pain relief.
GalwayAges 18 years+ - NCT07449806Recruiting
Comparing two bone graft materials for front tooth implants
This trial looks at two different types of bone graft material used when placing a dental implant right after removing a front tooth. It aims to see which one better maintains the thickness of the bone on the lip side of the implant.
AlexandriaAges Any age - NCT07449403Recruiting
Pain after hip replacement: testing a nerve block
This study tests a special numbing injection (called a PENG block) given around the hip joint to see how well it controls pain after hip replacement surgery. If you are having a hip replacement under spinal anesthesia and are in generally good health, this study may help find better ways to manage your post-surgery pain.
PoznanAges 65–100 - NCT07445516Recruiting
Bite adjustment for TMD: long-term follow-up
This trial follows up with people who previously had a dental bite adjustment (occlusal equilibration) for TMD (jaw or face muscle/joint pain). It compares their long-term results with a group that received a 'sham' (fake) procedure.
Santiago de Compostela, A CoruñaAges 18–85 - NCT07447193Recruiting
Pain perception by gender in adults with scoliosis
This study looks at how men and women with scoliosis experience pain differently. It involves questionnaires and simple movement tests to understand pain patterns.
BakuAges 18–45 - NCT07448883Recruiting
How well a Turkish scale measures spinal cord compression
This study tests a Turkish translation of a spinal cord function scale (mJOA) in people with degenerative cervical myelopathy. It helps doctors and patients better understand and track symptoms.
Buca, İzmirAges 18 years+ - NCT07451210Recruiting
Blood flow restriction therapy after ankle ligament surgery
This study tests whether a special blood flow restriction device used during physical therapy helps people recover better after ankle ligament repair. You would do physical therapy as usual, but with a cuff on your upper leg that gently limits blood flow during exercises, which may help strengthen muscles more quickly.
Lubbock, TexasAges 18–65 - NCT07447219Recruiting
Ergonomics program for dental workers
This study tests an ergonomics program designed to reduce muscle and bone pain in dental healthcare workers. If you are a practicing dental professional, this program may help you prevent work-related injuries.
Serdang, SelangorAges 25–65 - NCT07449078Recruiting
Cognitive functional therapy for chronic ankle sprain
This trial tests a type of talk therapy that teaches you new ways to move and think about your ankle. It may help people who have ongoing pain or instability from an old sprain.
Istanbul, AtaşehirAges 18–65 - NCT07447934Recruiting
Vibration therapy for leg muscle stiffness
This trial tests if gentle vibrations can reduce muscle stiffness (spasticity) in the lower leg after a neurologic condition like stroke or brain injury. You may join if you've had spasticity for at least 6 months and can stand with or without help.
New York, New YorkAges 18–85 - NCT07445035Recruiting
Robotic leg brace to help walking while on a breathing machine
This study tests whether walking with a robotic leg brace (exoskeleton) can help people who are on a breathing machine get better faster. It is for adults in the intensive care unit who can sit, stand with help, and have no major leg or heart problems.
New Taipei CityAges 45–65 - NCT07450781Enrolling by invitation
How saline temperature and local anesthetics affect shoulder pain after gallbladder surgery
This trial tests whether warming the saline used during surgery or adding a numbing medicine can reduce shoulder pain after laparoscopic gallbladder removal. It also checks how these affect inflammation markers in the blood.
AlexandriaAges 18–65 - NCT07448584Recruiting
Study of shoulder repair with Lok™ suture anchors
This trial tests how well Lok™ suture anchors work for repairing certain shoulder problems like rotator cuff tears, shoulder instability, or partial tears. It is for people whose MRI confirms the injury and who haven't had prior shoulder surgery on that side.
Valence, Auvergne-Rhône-AlpesAges 18 years+ - NCT05202678Recruiting
Check a new therapy for osteoporosis-related hip bone loss
This trial studies AGN1 LOEP, a treatment being tested to improve bone strength in people with osteoporosis-related bone loss in the hip. If you qualify, you would be followed over time with clinic visits and testing to see how the treatment affects your bone health.
Sint-Niklaas, AntwerpenAges Any age - NCT06802419Recruiting
Comparing two types of knee nerve blocks for pain relief after knee surgery
This study compares two types of nerve blocks—one that numbs the front of the thigh and one that adds extra numbing behind the knee—to see which provides better pain relief after arthroscopic knee surgery (like ACL or PCL repair). The goal is to help patients have less pain and recover more comfortably.
CairoAges 21–65 - NCT06805942Recruiting
Embolization for heel pain from plantar fasciitis
This study tests a minimally invasive procedure called embolization to reduce heel pain caused by plantar fasciitis. It blocks tiny blood vessels in the painful area, which may relieve pain and help you walk more comfortably.
Falls Church, VirginiaAges 22–100 - NCT06766448Recruiting
Physical therapy for frozen shoulder
This trial tests if a special rehabilitation program helps people with frozen shoulder (adhesive capsulitis). It aims to improve shoulder movement and reduce pain.
RabatAges 18 years+ - NCT06805448RecruitingPhase 1/Phase 2
Stem cell treatment for dry mouth in Sjögren's disease
This trial tests if injecting fat-derived stem cells into the salivary glands can help relieve dry mouth in people with Sjögren's disease. It aims to improve saliva flow and reduce discomfort.
CopenhagenAges 18 years+ - NCT06805188Recruiting
Acupuncture for knee osteoarthritis
This study tests whether acupuncture can reduce pain and improve function for people with knee osteoarthritis. If you have had persistent knee pain and meet the age and health requirements, this treatment may offer relief without surgery or strong medications.
Nanchang, JiangxiAges 18–70 - NCT06804265Recruiting
Better bacteria testing for joint implant infections
This study is testing a new, advanced lab test that can quickly identify exactly which bacteria are causing a joint implant infection. The goal is to help doctors choose the right antibiotics and improve treatment success.
BolognaAges 18 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,610 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,508 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.