Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,837 recruiting studies in this area right now.
By phase
- Not applicable3,970
- Phase 2223
- Phase 4196
- Phase 1191
- Phase 3149
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis185
- Rheumatoid Arthritis142
- Fibromyalgia102
- Osteoporosis88
- Osteoarthritis74
- Osteoarthritis, Knee72
- Rheumatoid Arthritis (RA)65
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Total Knee Arthroplasty38
- Chronic Pain37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida80
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,837 total
- NCT07709416Recruiting
Testing toludesvenlafaxine for long-lasting low back pain
This study tests an experimental medication called toludesvenlafaxine to see if it can help people with long-lasting low back pain that has no clear cause. If you have moderate to severe lower back pain for more than 3 months and haven't taken antidepressants before, this may be an option for you to explore.
BeijingAges 18–75 - NCT06628336Recruiting
Study of HARMONY Evolution hip replacement implants
This study looks at how well HARMONY Evolution implants and tools work for people getting a total hip replacement. It will help doctors understand if the implants are safe and effective over time.
BesançonAges 18–99 - NCT06644222Recruiting
Physical therapy exercises for smartphone-related shoulder problems
This study tests if two types of physical therapy exercises can improve shoulder posture in young women who have rounded shoulders from using smartphones. It aims to find which treatment works better.
Al Majma'ah, AlriyadhAges 18–25 - NCT06527235RecruitingPhase 3
Steroid injection for knee pain with ultrasound guidance
This trial tests whether a steroid injection guided by ultrasound can reduce knee pain caused by a degenerative meniscus tear. It may help if you have ongoing knee pain that hasn't improved with pain relievers.
ToulouseAges 18 years+ - NCT07270341Recruiting
Checking brain oxygen during shoulder surgeries in sitting position
This trial monitors brain oxygen levels during shoulder surgeries done in a beach chair (semi-sitting) position under general anesthesia. It helps doctors understand how well the brain gets oxygen during these surgeries.
AntalyaAges 18 years+ - NCT06634147Recruiting
Exercise program to prevent decline in hospitalized older adults
This study is testing a gentle exercise program for older adults (75+) while they are in the hospital. The goal is to see if it helps prevent loss of strength, memory, or thinking skills.
Pamplona, NavarreAges 75 years+ - NCT05943197Recruiting
Microbiology-focused choice of joint prosthetic material
This trial focuses on using lab testing (microbiology) to help choose the best material for a prosthetic used in orthopedic treatment. If you need a prosthetic, this could help doctors select a material more tailored to your situation.
SamaraAges 1 month–1 month - NCT07216339Recruiting
Can a game make the walking test more fun for kids?
This study tests if adding game-like features to a standard 6-minute walking test makes it more engaging for children with muscle or nerve disorders. It may help kids stay motivated and perform better during the test.
Lexington, KentuckyAges 6–12 - NCT07366099Recruiting
Special PET scan for tumor-induced osteomalacia
This trial tests a new PET/CT scan (using a tracer called Al18F-NOTA-LM3) to better find tumors causing TIO, a condition that leads to bone softening and weakness. It may help doctors diagnose and treat TIO more accurately.
Beijing, Beijing MunicipalityAges 18–80 - NCT06626490Recruiting
Follow-up study of the Prevision hip stem
This study follows patients who got a Prevision hip stem during revision hip surgery to see how well different versions of the stem perform. The goal is to help doctors choose the best options for you.
HanoverAges 18 years+ - NCT06383962Recruiting
Synergy Disc cervical disc replacement outcomes study
This trial is for people who are getting or have already received a Synergy Disc implant to replace a damaged disc in the neck. It follows patients over time to see how well the disc performs in relieving nerve pain or spinal cord compression.
BirminghamAges 21 years+ - NCT07371390Recruiting
Minimal sedation for knee replacement surgery
This trial tests whether less sedation during knee replacement surgery can improve recovery. It may help you if you are having your first total knee replacement and can have spinal anesthesia.
Rochester, MinnesotaAges 18 years+ - NCT06617806Recruiting
Preventing falls in very old, active adults
This trial tests if advanced practice nurses can help prevent falls in robust adults aged 80 and older. It may help you stay independent and avoid injuries.
Nantes, Loire-AtlantiqueAges 80 years+ - NCT06612372Recruiting
60-Day Bed Rest Study for Knee Joint Health
This trial studies how 60 days of bed rest with the head tilted down affects the cartilage and function of your knee. It may help understand changes that happen during long periods without weight bearing, like in spaceflight.
BeijingAges 25–50 - NCT06616896Recruiting
Vibration exercise for knee osteoarthritis
This study tests whether a special vibrating exercise program can improve knee pain and function in people with knee osteoarthritis. It compares this new rehab approach to standard exercise.
TaipeiAges 50–80 - NCT06820190Recruiting
Numbing injection for pain after scoliosis fusion surgery
This trial is testing a new type of numbing injection near the spine to see how well it controls pain after scoliosis surgery. If you are having a posterior spinal fusion for idiopathic scoliosis, you may be able to join and receive the injection plus patient-controlled pain medicine.
Tanta, El-GharbiaAges 18 years+ - NCT06891378Recruiting
Home rehab app for patients after shoulder replacement surgery
This trial tests a digital rehab program you can do at home after reverse total shoulder replacement. The goal is to see if an app-based exercise plan helps you recover safely and effectively.
Seoul, Irwon-ro 81Ages 50 years+ - NCT07375914Recruiting
New approach for managing acute low back pain in the ER
This trial tests a comprehensive program that looks at your physical, mental, and social needs to treat sudden low back pain in the emergency room. It may help you get better care and avoid long-term pain.
ParisAges 18–55 - NCT06611748Recruiting
Hand function restoration after spinal cord injury
This trial tests a device to help people with cervical spinal cord injury improve hand function. It's for those with certain levels of paralysis and some residual arm strength.
Cleveland, OhioAges 18 years+ - NCT06574919Recruiting
Study of inherited muscle diseases in children
This study looks at children with inherited muscle diseases (not Duchenne muscular dystrophy) to understand their symptoms and muscle function better. It may help doctors identify what type of muscle disease a child has and how it affects them day-to-day.
SohagAges 2–18 - NCT06608745Recruiting
Computer-assisted vs standard knee replacement study
This trial compares a computer-assisted technique to the standard method for total knee replacement. It aims to see if the computer-assisted approach leads to better clinical and functional outcomes.
BolognaAges 45 years+ - NCT06605482Recruiting
Early Fixation for Upper Arm Fractures in Older Adults
This trial tests if early surgery helps older patients heal from a broken upper arm bone (the humerus). It may lead to better recovery and less pain.
New Westminster, British ColumbiaAges 65 years+ - NCT06603051Recruiting
Freezing a nerve before ACL surgery to cut opioid use
This study looks at freezing a nerve before ACL surgery to help reduce the amount of strong pain medicine you need afterward. If you're having ACL reconstruction with your own tendon and haven't been using opioids regularly, you may be able to join.
Burlington, New JerseyAges 14 years+ - NCT06599697RecruitingPhase 2
IVIG for anti-HMGCR muscle disease
This trial tests if IVIG (intravenous immunoglobulin, a donated blood product that helps the immune system) can improve muscle strength and reduce damage in people with anti-HMGCR immune-mediated necrotizing myopathy (a rare muscle disease where the immune system attacks muscle cells). It may help you if your muscle weakness is not too severe and you haven't tried IVIG before.
Birmingham, AlabamaAges 16 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,837 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,953 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.