Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,610 recruiting studies in this area right now.
By phase
- Not applicable3,771
- Phase 2215
- Phase 4199
- Phase 1182
- Phase 3139
- Phase 1/Phase 270
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis171
- Rheumatoid Arthritis131
- Fibromyalgia105
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee65
- Shoulder Pain48
- Hip Osteoarthritis43
- Psoriatic Arthritis40
- Degenerative Disc Disease39
- Chronic Pain38
- Total Knee Arthroplasty38
- Systemic Lupus Erythematosus37
- Duchenne Muscular Dystrophy36
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University66
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital25
- Hacettepe University23
- Tanta University22
Where studies are running
- California207
- New York87
- Florida82
- Maryland76
- Arizona72
- Massachusetts71
- Texas66
- Alabama60
- Illinois51
- Pennsylvania48
Recruiting studies4,610 total
- NCT06040827Recruiting
Study of a knee implant extension for knee replacement
This trial is for adults having their first knee replacement surgery. It tests a special part (tibial extension) of a common knee implant system. Researchers will follow participants over time to see how well it works.
Fayetteville, ArkansasAges 18 years+ - NCT06707909RecruitingPhase 4
Vitamin K2 gel for bone healing after tooth extraction
This study tests if applying a vitamin K2 gel directly into the tooth socket after extraction can help rebuild healthy bone faster. It is for people who need to have a single-rooted lower tooth removed.
Cairo, Cairo GovernorateAges 18–80 - NCT06809231Recruiting
Long-term follow-up of CartiONE for knee cartilage repair
This study follows people who had CartiONE treatment for a knee cartilage lesion more than 6 months ago. Researchers want to see how well the treatment works and how safe it is over 1 to 13 years.
Ghent, Oost-VlaanderenAges 18 years+ - NCT06343688Recruiting
How ankle braces affect motor skills in CP
This study tests how wearing special ankle braces (called DAFOs) right away affects movement and balance in children with spastic diplegic cerebral palsy. It aims to see if the braces make it easier to walk and stand.
BoluAges 4–15 - NCT06715085RecruitingPhase 4
PRGF injections for chronic low back pain
This trial tests whether injections of a blood-based treatment called PRGF can help people with long-term low back pain caused by worn discs. It is for those who haven't gotten relief from standard treatments like medication.
Vitoria-Gasteiz, AlavaAges 18 years+ - NCT07426965Recruiting
Ultrasound findings and pain in stroke patients with shoulder pain
This study uses ultrasound to look at the shoulder on the side affected by stroke and see how it relates to pain. It may help understand why shoulder pain happens after a stroke.
AnkaraAges 18–75 - NCT07429240RecruitingPhase 1/Phase 2
Gene editing trial for Duchenne muscular dystrophy (ages 2-7)
This trial tests a new gene editing treatment called PBGENE-DMD for boys with Duchenne muscular dystrophy (DMD) whose genetic mutation falls within a specific range of the dystrophin gene (exons 45-55). The goal is to see if it is safe and can help improve muscle function.
Little Rock, ArkansasAges 2–7 - NCT07433335RecruitingPhase 1
First study of sr-878 for rheumatoid arthritis safety
This study tests a new investigational drug called SR-878 for people with rheumatoid arthritis. It aims to see if the drug is safe and tolerable. You may join if you are between 18 and 60, have RA for at least 3 months, and take a stable dose of methotrexate.
TbilisiAges 18–60 - NCT07434115RecruitingEarly Phase 1
Orthobiologics for muscle, bone, and joint problems
This study tests treatments using your body's own healing cells or proteins (called orthobiologics) for muscle, bone, and joint problems. It collects information through digital questionnaires on WhatsApp to see how these treatments work in real life.
Bento Gonçalves, Rio Grande do SulAges 18 years+ - NCT05831345RecruitingPhase 3
Methadone during surgery to prevent post-surgery pain
This Phase 3 trial tests whether giving methadone during hip or knee replacement surgery can reduce pain after surgery. It may help some people use less rescue pain medicine afterward, but it also has safety checks for kidney, liver, heart, and opioid-related risks.
BrusselsAges 18–80 - NCT07433322Recruiting
Preserving gum and bone after back tooth removal
This study tests a procedure to preserve the bone and gum after removing upper back teeth, which may help prepare the area for future dental implants.
Richmond, VirginiaAges 18 years+ - NCT07428070Recruiting
Exercise program for rotator cuff shoulder pain
This trial tests if a specially designed exercise program can reduce shoulder pain related to the rotator cuff. It may help if you've had shoulder pain for more than three months.
IstanbulAges 18–75 - NCT07433686Recruiting
Saskatoon Berry Juice for Muscle Recovery
This trial tests whether Saskatoon berry juice helps muscles recover after exercise. It involves healthy adults aged 18–35 who can exercise safely.
Saskatoon, SaskatchewanAges 18–35 - NCT07431632Recruiting
Nerve freezing vs. epidural for pain after pectus excavatum repair
This study compares two ways to manage pain after pectus excavatum surgery: freezing the nerves during surgery (cryoanalgesia) versus an epidural block. The goal is to see which method provides better pain relief with fewer side effects.
São Paulo, São PauloAges 13 years+ - NCT07425652Recruiting
Physiotherapy methods for fibromyalgia pain
This study tests different physiotherapy techniques to help women with fibromyalgia manage pain and improve daily function. It compares several hands-on therapies to find the most effective approach.
AnkaraAges 18–65 - NCT07429188Recruiting
Study of upper-limb assistive device users
This study looks at how well upper-limb assistive devices (like robotic arms) work for people who use them and for their caregivers. You and your caregiver can help by sharing your experiences in video interviews.
PerpignanAges 18 years+ - NCT07426991Recruiting
Multiple sclerosis, thinking, sleep, and tiredness study
This study looks at how multiple sclerosis (MS) affects your thinking, sleep, and tiredness. It compares people with MS who have at least mild fatigue to people without MS who also have sleep problems, to understand these issues better.
DüsseldorfAges 18–79 - NCT07434011Recruiting
Smartphone exercise program for knee osteoarthritis
This study tests if an artificial intelligence-powered smartphone app can help people with knee osteoarthritis do exercises at home that reduce pain and improve function.
Madrid, MadridAges 45 years+ - NCT07435116Enrolling by invitation
Duchenne Muscular Dystrophy and Upper Limb Muscle Stiffness Study
This study looks at how Duchenne Muscular Dystrophy (DMD) affects the stiffness of muscles in the upper limbs (arms and shoulders). The goal is to better understand muscle changes and help improve care.
Gaziantep, GaziantepAges 5–18 - NCT07428928Recruiting
Play-based hand therapy for cerebral palsy children
This trial tests whether playful hand and nerve exercises can improve grip strength and hand use in children with cerebral palsy. It may help children who have trouble with fine motor tasks.
Lahore, Punjab ProvinceAges 6–12 - NCT07426549Recruiting
Knee Exercises With Blood Flow Restriction for Osteoarthritis
This study compares two types of knee exercises (closed chain and open chain) with a special blood flow restriction technique to see which helps reduce pain and improve function in people with mild to moderate knee osteoarthritis.
RawalpindiAges 45–75 - NCT07429955Recruiting
Study on muscle and recovery after hip surgery in older adults
This trial looks at how muscle health affects your ability to get back to normal activities after hip replacement surgery for a broken hip or severe arthritis. By using MRI scans and other tests, researchers hope to understand if having less muscle makes recovery harder.
MontpellierAges 75 years+ - NCT07427368Recruiting
Shockwave vs Ozone Injection for Tennis Elbow
This study compares two treatments for tennis elbow (lateral epicondylitis) that hasn't gotten better with simple care: one uses sound waves (ESWT) and the other uses a small injection of ozone gas. The goal is to see which works better for pain and function.
AnkaraAges 18–65 - NCT07429916RecruitingEarly Phase 1
Ketamine for shoulder pain after weight loss surgery
This trial tests if a single dose of ketamine, given during surgery, can reduce common shoulder pain after laparoscopic gastric sleeve surgery. If you are having this weight-loss procedure and meet the weight and health criteria, this study may help improve your recovery.
IrbidAges 18–60
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,610 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,508 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.