Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,837 recruiting studies in this area right now.
By phase
- Not applicable3,970
- Phase 2223
- Phase 4196
- Phase 1191
- Phase 3149
- Phase 1/Phase 275
- Phase 2/Phase 333
Top conditions
- Knee Osteoarthritis185
- Rheumatoid Arthritis142
- Fibromyalgia102
- Osteoporosis88
- Osteoarthritis74
- Osteoarthritis, Knee72
- Rheumatoid Arthritis (RA)65
- Shoulder Pain50
- Psoriatic Arthritis47
- Hip Osteoarthritis41
- Systemic Lupus Erythematosus41
- Duchenne Muscular Dystrophy39
- Degenerative Disc Disease38
- Total Knee Arthroplasty38
- Chronic Pain37
- Musculoskeletal Pain36
- Pain35
- Dermatomyositis31
Leading sponsors
- Riphah International University110
- Cairo University72
- Istituto Ortopedico Rizzoli71
- Assistance Publique - Hôpitaux de Paris37
- Foundation University Islamabad34
- Mayo Clinic29
- Massachusetts General Hospital27
- National Taiwan University Hospital25
- Chinese University of Hong Kong22
- Hacettepe University22
Where studies are running
- California211
- New York94
- Florida80
- Massachusetts76
- Arizona75
- Maryland73
- Texas65
- Alabama57
- Illinois54
- Pennsylvania50
Recruiting studies4,837 total
- NCT03193476Recruiting
XLH patient registry for people with X-linked hypophosphatemia
This registry collects information about people diagnosed with X-linked hypophosphatemia (XLH). It helps researchers better understand the condition and may support future studies by tracking patients over time.
BrusselsAges Any age - NCT03231644Recruiting
Registry for fibrous dysplasia and related conditions
This is a patient registry that collects health information from people with fibrous dysplasia, McCune-Albright syndrome, or Mazabraud’s syndrome. It helps researchers understand these conditions better and may support future studies.
Bethesda, MarylandAges Any age - NCT03248284Recruiting
Study of inflammation in Achilles tendons in psoriatic arthritis
This trial studies people with psoriatic arthritis who have painful Achilles tendon insertion with signs of inflammation on ultrasound. It may help researchers better understand what drives tendon inflammation and how it can be treated.
OdenseAges 18–70 - NCT03245801Recruiting
Juvenile arthritis registry for newly diagnosed children
This study collects information about children with juvenile idiopathic arthritis (JIA) soon after diagnosis. The information helps researchers understand how the condition and treatments change over time, and it may guide future care.
Calgary, AlbertaAges Up to 18 years - NCT03276923Recruiting
Pregnancy registry for women with autoimmune disease
This study is a pregnancy and health registry for women with autoimmune (immune system) conditions who are trying to become pregnant or are already pregnant. It helps researchers better understand pregnancy outcomes and health needs in autoimmune disease.
Durham, North CarolinaAges Any age - NCT03297775Recruiting
Studying rheumatoid arthritis treatment risks for lung scarring
This trial is for people with rheumatoid arthritis (RA) who are at risk for developing interstitial lung disease, which is scarring in the lungs. It aims to better understand why this happens and how to help prevent or manage it.
Aurora, ColoradoAges 45–90 - NCT03304730Recruiting
Tracking pain patterns after low back joint injections
This study follows adults with long-lasting low back pain to learn what predicts who improves after a specific type of back joint injection. It mainly helps doctors understand which factors relate to better or worse outcomes over time.
São Paulo, São PauloAges 18 years+ - NCT03333200Recruiting
Study of genetic brain diseases over time
This trial follows people with genetic neurodegenerative (brain-wasting) disorders over time to better understand how the condition changes. The goal is to learn patterns that could help future treatments or care plans.
Pittsburgh, PennsylvaniaAges Any age - NCT03373968RecruitingPhase 2/Phase 3
Long-term study of givinostat safety in Duchenne muscular dystrophy
This trial looks at how safely givinostat works over a longer time in people with Duchenne muscular dystrophy (DMD). It mainly checks long-term side effects and tolerability, especially in a specific subgroup of muscle fat levels.
Sacramento, CaliforniaAges 7 years+ - NCT03374215Recruiting
Study hormone causes of high blood pressure in Black adults
This study looks at the body’s hormone signals to understand what causes primary aldosteronism (a condition that can lead to high blood pressure). By comparing clinical results and lab data, researchers hope to improve how the condition is diagnosed and managed, especially in Black participants.
Bethesda, MarylandAges 7–70 - NCT03383081RecruitingPhase 2
Stem cell injection for moderate knee osteoarthritis pain
This Phase 2 study tests whether injected umbilical-cord stem cells can improve safety and reduce symptoms in people with moderate knee osteoarthritis. It focuses on people with significant knee pain who have not gotten enough relief from standard, non-procedure treatments.
Changsha, HunanAges Up to 70 years - NCT03386981Recruiting
Study of bone health patterns in healthy adult athletes
This study looks at what bone “profiles” look like in healthy adult athletes. It may help researchers better understand how normal bone health varies in people who are physically active.
MilanAges 18 years+ - NCT03414502RecruitingPhase 3
Predictors of Response to DMARDs in Rheumatoid Arthritis
This trial studies rheumatoid arthritis (RA) patients starting or adjusting DMARD medicines and looks for signs that predict who responds best. It may help doctors choose more effective treatment sooner.
Omaha, NebraskaAges 19 years+ - NCT03425812Recruiting
NSAID medicines to prevent flares in spondyloarthritis after remission
This trial tests whether taking nonsteroidal anti-inflammatory drugs (NSAIDs) helps people with axial spondyloarthritis stay in remission and avoid future flare-ups. It’s meant to see if NSAIDs can reduce the chance of symptoms returning and keep disease activity low over time.
Xiamen, FujianAges 18 years+ - NCT03439228Recruiting
Testing brace use after low back fusion surgery
This pilot study looks at whether wearing a brace helps after single-level low back fusion surgery. You may be offered screening if you’re healing from a specific type of fusion and don’t have certain risk factors.
Hamilton, OntarioAges 18–80 - NCT03442465Recruiting
Study of healing and function after bone reconstruction surgery
This study looks at how well people heal and how well they can move and use the repaired bone after reconstructive surgery for bone tumors. It may help doctors understand what recovery looks like and what could improve function over time.
Basking Ridge, New JerseyAges 4 years+ - NCT03456778Recruiting
Ultrasound test of tendon stiffness in leg pain
This study uses an ultrasound method to measure tendon stiffness (how “firm” the tendon feels) in people with leg tendon pain or with leg pain but no tendon involvement. It may help researchers better understand tendon problems and how to detect them early using ultrasound.
Atlanta, GeorgiaAges 18–65 - NCT03461237Recruiting
Study of care after osteoporotic hip fractures
This study looks at people with osteoporotic hip fractures (breaks in the femur near the hip) and evaluates their care and outcomes. It may help improve how hip fractures are treated in people whose bones are weaker due to osteoporosis.
Beijing, Beijing MunicipalityAges 50–95 - NCT03473912Recruiting
Rheumatoid disease biobank study for adults
This study asks adults with a rheumatoid condition to join a biobank, which is a safe place to store health information and biological samples for future research. It may help researchers better understand rheumatoid conditions and develop better treatments.
Kfar SabaAges 18–120 - NCT03481010Recruiting
Periacetabular hip surgery with MRI-guided planning
This study compares periacetabular osteotomy alone versus adding arthroscopy (a camera procedure inside the hip) to address cartilage/labrum problems in the hip’s center compartment. It aims to see which approach better improves symptoms and recovery for people with hip instability due to acetabular dysplasia.
Chicago, IllinoisAges 16–50 - NCT03491761RecruitingPhase 2
PRP injection versus hyaluronic acid shots for knee arthritis
This trial tests whether a platelet-rich plasma (PRP) shot works better than a standard hyaluronic acid (“gel”) injection to reduce knee osteoarthritis pain. It may help people with ongoing knee pain choose the treatment that relieves symptoms more effectively.
Skokie, IllinoisAges 18–75 - NCT03494374Recruiting
Foot brace and exercise for flat feet
This trial looks at whether using a foot brace (an orthosis) plus exercises can improve symptoms from flat feet. It may help by changing how your foot and heel work when you stand or walk.
Seongnam-si, Bundang-guAges 3–10 - NCT03519269Recruiting
Robotic versus standard knee replacement for severe knee arthritis
This study compares a robotic-assisted knee replacement to a standard (non-robotic) knee replacement. It may help people with severe knee arthritis learn which approach improves pain and knee function after surgery.
New York, New YorkAges 40–85 - NCT03582917RecruitingPhase 2
Vitamin D during rehabilitation for teen scoliosis
This study looks at whether vitamin D affects recovery during rehab for teens with idiopathic scoliosis (a sideways spine curve without a known cause). It may help the rehab process by improving vitamin D–related factors in growing teens.
AsvestochóriAges 10–18
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,837 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,953 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.