Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,610 recruiting studies in this area right now.
By phase
- Not applicable3,773
- Phase 2214
- Phase 4199
- Phase 1182
- Phase 3138
- Phase 1/Phase 270
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis173
- Rheumatoid Arthritis131
- Fibromyalgia104
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee65
- Shoulder Pain48
- Hip Osteoarthritis43
- Degenerative Disc Disease39
- Psoriatic Arthritis39
- Chronic Pain38
- Total Knee Arthroplasty38
- Systemic Lupus Erythematosus37
- Duchenne Muscular Dystrophy36
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital24
- Hacettepe University23
- Tanta University22
Where studies are running
- California206
- New York86
- Florida83
- Maryland76
- Arizona71
- Massachusetts71
- Texas66
- Alabama60
- Illinois50
- Pennsylvania47
Recruiting studies4,610 total
- NCT07289893Recruiting
Kettlebell training for shoulder pain in athletes
This trial tests whether kettlebell training can help people with long-lasting shoulder pain caused by rotator cuff tendon problems or small tears. You would do kettlebell exercises and see if your pain and strength improve.
AnkaraAges 18–35 - NCT07288983Recruiting
Pain blocks after hip surgery: testing three approaches
This trial compares three different numbing injections (nerve blocks) to see which provides the best pain relief after hip replacement surgery. It may help older adults with moderate health status who are having hip surgery.
PoznanAges 65–100 - NCT07292168RecruitingPhase 1/Phase 2
Study of a new antibody for advanced tumors with FGFR1 protein
This trial tests an experimental antibody, OM-RCA-01, in people with advanced solid tumors that have high levels of a protein called FGFR1. It aims to see if the drug is safe and effective for those who have already tried other treatments.
Kazan'Ages 18 years+ - NCT07289737Recruiting
Comparing two spine surgeries for a slipped backbone
This study compares two types of spine surgery for a common condition where a lower back bone slips forward. It aims to see which surgery works better to relieve pain and improve function.
Yiwu, ZhejiangAges 50–90 - NCT07293767Recruiting
Silymarin vs Hesperidin/Diosmin for Fibromyalgia Pain
This trial tests two natural supplements—silymarin (milk thistle) and a combination of hesperidin and diosmin (citrus compounds)—to see if they help reduce fibromyalgia pain. It is for people whose pain persists despite current treatments.
CairoAges 18–60 - NCT07294131RecruitingPhase 2
Preventing muscle loss in hospitalized older adults
This trial tests a special exercise approach using blood-flow restriction and a video game to help older adults in the hospital keep their muscle strength. The goal is to find a safe way for bedridden patients to exercise and recover better.
AntwerpAges 65 years+ - NCT07291388Recruiting
Retrolaminar block for lumbar fusion with multimodal pain control
This study tests whether adding a retrolaminar block (a type of back injection) to standard pain medicines helps reduce pain after lumbar spine fusion surgery. It may help you recover with less need for strong painkillers.
Santiago, Santiago MetropolitanAges 18–75 - NCT07294014Recruiting
Foot Arch Study in Women With Lipedema
This study looks at the arch of the foot and how the foot works in women with lipedema, a condition where fat builds up unevenly, usually in the legs. Participants will have their existing foot X-rays reviewed to compare foot structure between those with and without lipedema.
IstanbulAges 18–65 - NCT07294417Recruiting
Bone cement screws vs. special screws for weak spine bones
This study compares two types of screws used to fix spine fractures or instability in people with brittle bones (osteoporosis). One type uses bone cement to strengthen the screw, and the other uses a special hollow screw. The goal is to see which method works better for reducing pain and stabilizing the spine.
Kafr ash Shaykh, KafrelsheikhAges 18 years+ - NCT07296471Recruiting
Vitamin D and Bone Health Study
This study is looking at how vitamin D levels relate to bone health and overall health markers in people with and without osteoporosis. It aims to find better ways to understand and treat bone loss.
Yichang, HubeiAges 18 years+ - NCT07294196Recruiting
Needle therapy for chronic foot pain in adults
This trial tests a new treatment for chronic plantar fasciitis (heel pain) using very thin needles that deliver a mild electrical current to the muscles and fascia. It may help people who have had heel pain for at least 6 weeks and haven't tried other treatments.
Sivas, MerkezAges 18–70 - NCT07295457Recruiting
Exercise to prevent pain from hormone therapy in breast cancer
This trial tests whether starting a gentle exercise program early can help prevent or reduce joint and muscle pain caused by aromatase inhibitors (a common breast cancer medicine). It is for women with hormone-sensitive breast cancer who are not yet experiencing severe pain from their treatment.
LyonAges 18–75 - NCT07288684Recruiting
Virtual chiropractor rehab after back fracture
This study tests a virtual, at-home rehab program led by a chiropractor for people over 50 who have had a recent back fracture. The goal is to help you recover strength and mobility through live video sessions, without needing to travel.
Waterloo, OntarioAges 50 years+ - NCT07289620Recruiting
Nerve block boosters for kids' leg surgery
This study tests whether adding dexamethasone, dexmedetomidine, or both to a numbing shot (nerve block) provides better pain relief after leg surgery in children. The goal is to find which combination works best to keep your child comfortable with fewer side effects.
PoznanAges 3–12 - NCT07290660Recruiting
Motor imagery and exercise for shoulder pain
This study tests whether combining mental movement training with targeted exercises can reduce shoulder pain caused by impingement syndrome. It aims to improve your shoulder function without surgery.
IstanbulAges 25–65 - NCT07289412Recruiting
Meniscus repair study with or without ligament surgery
This study looks at how well meniscus repairs (using the all-inside technique) work over time, both when done alone and when combined with ligament reconstruction. It may help you understand the success of this surgery for your knee.
BolognaAges 12–65 - NCT07288411Recruiting
Vagus nerve stimulation for temporomandibular joint disorders
This study tests if a gentle device that stimulates a nerve in your neck (the vagus nerve) can reduce jaw pain and improve how your jaw moves. It could offer a new, non-drug option for people with TMJ disorders.
Los Angeles, CaliforniaAges 18–50 - NCT07291128Recruiting
VOJTA therapy for children with ataxic cerebral palsy
This trial tests a special movement therapy called VOJTA technique to help improve balance and coordination in children with ataxic cerebral palsy. It may offer a gentle way to help your child move better.
Lahore, Punjab ProvinceAges 2–6 - NCT07290296Recruiting
Comparing muscle release and taping for knee pain
This trial compares two treatments for kneecap pain that has lasted at least 3 months: a muscle release technique and kinesio taping. The goal is to see which one helps reduce pain from daily activities like climbing stairs, running, or sitting for long periods.
CairoAges 18–30 - NCT07293871Recruiting
Ultrasound treatment for rheumatoid arthritis
This trial tests whether ultrasound waves applied to the spleen can reduce inflammation in adults with rheumatoid arthritis. It is for people with moderate to severe disease who have not tried many biologic medications.
Colleyville, TexasAges 18 years+ - NCT07295847RecruitingPhase 1
Study of AZD0120 for autoimmune diseases
This trial tests if a new medication, AZD0120, is safe for people with autoimmune diseases. It aims to help patients by targeting the immune system.
Tucson, ArizonaAges 18–75 - NCT07295509RecruitingPhase 2/Phase 3
Testing picankibart for active psoriatic arthritis
This trial tests a new drug called picankibart to see if it helps people with active psoriatic arthritis who haven't gotten enough relief from standard treatments like NSAIDs or non-biologic DMARDs. It may be an option if you have at least 3 tender and 3 swollen joints and active or past plaque psoriasis.
Hangzhou, ZhejiangAges 18–75 - NCT07290036RecruitingPhase 1
Testing different ways to give bimekizumab for psoriatic arthritis or axial spondyloarthritis
This study looks at whether giving bimekizumab in different ways is safe and how it moves through the body over time. It is for adults with active psoriatic arthritis or axial spondyloarthritis who may benefit from bimekizumab treatment.
Peoria, ArizonaAges 18 years+ - NCT03716128Recruiting
Testing bone hormone changes in people with kidney problems
This study checks how kidney disease affects bone health by measuring hormones like PTH and related blood markers. It may help doctors better diagnose bone problems that can occur with poor kidney function.
HerlevAges 18 years+
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,610 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,529 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.