Rheumatology & orthopedics
Bones, joints & muscles clinical trials
Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We’re tracking 4,610 recruiting studies in this area right now.
By phase
- Not applicable3,773
- Phase 2214
- Phase 4199
- Phase 1182
- Phase 3138
- Phase 1/Phase 270
- Phase 2/Phase 334
Top conditions
- Knee Osteoarthritis173
- Rheumatoid Arthritis131
- Fibromyalgia104
- Osteoporosis82
- Osteoarthritis71
- Rheumatoid Arthritis (RA)68
- Osteoarthritis, Knee65
- Shoulder Pain48
- Hip Osteoarthritis43
- Degenerative Disc Disease39
- Psoriatic Arthritis39
- Chronic Pain38
- Total Knee Arthroplasty38
- Systemic Lupus Erythematosus37
- Duchenne Muscular Dystrophy36
- Musculoskeletal Pain35
- Osteoarthritis (OA) of the Knee32
- Pain32
Leading sponsors
- Riphah International University85
- Istituto Ortopedico Rizzoli69
- Cairo University65
- Assistance Publique - Hôpitaux de Paris36
- Foundation University Islamabad31
- Mayo Clinic28
- Massachusetts General Hospital25
- National Taiwan University Hospital24
- Hacettepe University23
- Tanta University22
Where studies are running
- California206
- New York86
- Florida83
- Maryland76
- Arizona71
- Massachusetts71
- Texas66
- Alabama60
- Illinois50
- Pennsylvania47
Recruiting studies4,610 total
- NCT06796309Recruiting
Testing a rural health app for seniors and shoulder pain
This study tests a digital tool (called TRAK) to improve healthcare quality and access in rural areas. It is for healthcare workers or patients who are seniors or have long-term shoulder pain.
MadridAges 18 years+ - NCT06915935Recruiting
Osteoporosis study in older adults in Shandong
This trial is a study to understand how common osteoporosis is in people aged 65 and older living in Shandong province. By joining, you help researchers learn more about bone health in older adults.
Jinan, ShandongAges 65 years+ - NCT07217405RecruitingPhase 4
Radiation or steroid shot for hand osteoarthritis pain
This trial compares low-dose radiation therapy to a corticosteroid injection to see which works better for hand osteoarthritis pain. It's for people 50 and older with moderate to severe hand OA who have significant pain when using their hand.
Rochester, MinnesotaAges 50 years+ - NCT07217626RecruitingPhase 4
Nerve blocks before leg fracture surgery in older adults
This trial tests whether giving a nerve block (medicine to numb the leg) before surgery helps older adults recover better from a broken leg bone. If you are 50 or older and need surgery for a specific type of leg fracture, you may be eligible.
Baltimore, MarylandAges 50 years+ - NCT07212699Recruiting
Knee osteoarthritis app-based outcome score study
This trial uses a smartphone app to track symptoms in people with knee osteoarthritis or a knee replacement. The goal is to develop a better way to measure how patients are doing.
Munich, BavariaAges 18 years+ - NCT07219498Recruiting
Probiotics for muscle soreness after exercise
This trial tests whether taking a probiotic supplement for 5 weeks can reduce muscle soreness after exercise. If you exercise regularly and are generally healthy, you may be able to join.
Minneapolis, MinnesotaAges 18–30 - NCT07215104Recruiting
Spinal cord stimulation for chronic low back pain
This trial tests a special type of spinal cord stimulation (called BurstDR) in people with chronic low back pain. If you already have a spinal cord stimulator and it helps your pain, researchers want to see if adding muscle stimulation can provide even more relief.
Charleston, West VirginiaAges 18 years+ - NCT07213622Enrolling by invitation
Smart glasses for numbing nerve block during knee replacement
This study tests if using smart glasses (like high-tech glasses that show a video) can help doctors give a more accurate numbing injection (nerve block) to the saphenous nerve for knee replacement surgery. The goal is to improve pain control after surgery.
Cleveland, OhioAges 18 years+ - NCT07217821Recruiting
Music and imagery for chronic pain
This study tests a step-by-step approach using music and guided imagery to help people with long-term muscle or joint pain. It's done from home using a device, so you don't need to travel.
Indianapolis, IndianaAges 18 years+ - NCT07217782Recruiting
Pain in Juvenile Arthritis Study
This study looks at pain in kids with juvenile arthritis compared to healthy kids. It may help researchers understand pain better and improve future treatments.
St Louis, MissouriAges 9–17 - NCT07218133Recruiting
Ear Stimulation to Reduce Pain After Spine Surgery
This trial tests whether a gentle electrical stimulation delivered through the ear can reduce inflammation and pain after major spinal fusion surgery. If you are having a long spinal fusion, you might be able to join.
St Louis, MissouriAges 18 years+ - NCT07216300Enrolling by invitation
Osteopathic treatment for baseball pitchers
This trial tests if osteopathic manipulation of the shoulder and hip can improve pitching performance in college baseball players. It may help you throw better and prevent injuries.
Hattiesburg, MississippiAges 18–102 - NCT07218757Recruiting
Trial of emotional awareness therapy for veterans with chronic pain
This study tests if a type of therapy that helps you understand and express emotions related to pain (called Emotional Awareness and Expression Therapy) can reduce chronic pain in veterans. It is designed for veterans who have had muscle or joint pain for at least 3 months and rate their pain as moderate or greater.
Los Angeles, CaliforniaAges 18 years+ - NCT07219888Enrolling by invitationPhase 4
Comparing suzetrigine and oxycodone for knee replacement pain
This study compares a new pain medicine called suzetrigine with a commonly used opioid, oxycodone, for pain after a knee replacement. The goal is to see which works better and has fewer side effects.
Louisville, KentuckyAges 21–89 - NCT07217873RecruitingPhase 2/Phase 3
IV iron for teens with scoliosis and low iron
This trial tests whether giving intravenous (IV) iron before spine surgery helps teens with scoliosis who have low iron stores. The goal is to see if it can reduce the need for blood transfusions during surgery.
New York, New YorkAges 10–19 - NCT07215611Recruiting
Financial stress after sarcoma surgery study
This study looks at financial problems patients may have after surgery for bone or soft tissue sarcoma. It aims to understand how treatment costs affect patients and help find ways to support them.
Houston, TexasAges Any age - NCT07212777Recruiting
Custom vs standard knee surgery for knee alignment
This study compares a custom 3D-printed surgical guide to the standard technique for a knee realignment surgery called high tibial osteotomy. It is for people with knee arthritis on the inner side of the knee who have not improved with other treatments.
Málaga, MálagaAges 18–70 - NCT07215845Recruiting
Healing spinal bone stress with MRI monitoring
This study uses MRI scans to see how well a spinal stress injury (called a pars defect) heals over time. It might help if you are a young person with low back pain from a specific type of bone stress in the lower spine.
Columbia, MissouriAges 12–30 - NCT07212829Recruiting
Brain stimulation during exercise for chronic pain
This trial tests whether adding gentle brain stimulation (tDCS) to exercise can help people with chronic widespread pain (like fibromyalgia). It aims to see if this combination reduces pain better than exercise alone.
JetteAges 18–70 - NCT07217964Enrolling by invitation
Study of natural protein for spinal fusion surgery
This trial is testing a natural protein material used during spinal fusion surgery to treat lower back pain caused by worn-out discs. It may help patients who haven't gotten better with other treatments and need surgery on up to four levels of the lower spine.
New York, New YorkAges 18 years+ - NCT07216339Recruiting
Can a game make the walking test more fun for kids?
This study tests if adding game-like features to a standard 6-minute walking test makes it more engaging for children with muscle or nerve disorders. It may help kids stay motivated and perform better during the test.
Lexington, KentuckyAges 6–12 - NCT06916676Recruiting
Laser therapy for knee osteoarthritis pain
This study tests a type of laser treatment called HILT to see if it can help reduce knee pain from osteoarthritis. You would attend 3 sessions each week for 4 weeks.
CairoAges 18–65 - NCT06915896Recruiting
Chronic back or neck pain: predicting therapy outcomes
This study looks at people with long-term low back or neck pain who are waiting for physical therapy. It aims to find what factors predict how well they will do with different treatment paths.
Florence, FIAges 18 years+ - NCT04064307Recruiting
Register people with myotubular or centronuclear myopathy
This study sets up a patient registry for people diagnosed with myotubular myopathy or centronuclear myopathy. Your information can help researchers better understand these conditions and plan future studies or treatments.
Newcastle upon Tyne, Tyne and WearAges Any age
Common questions
- How many bones, joints & muscles clinical trials are recruiting?
- Clin2 is tracking 4,610 recruiting rheumatology & orthopedics studies from the U.S. registry right now, out of 7,529 we cover in this area in total.
- What does “Bones, joints & muscles” cover here?
- Arthritis, osteoporosis, and other conditions of the bones, joints, and muscles. We group each study into bones, joints & muscles based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a bones, joints & muscles trial near me?
- Use the search to filter bones, joints & muscles studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.