Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,425 recruiting studies in this area right now.
By phase
- Not applicable9,762
- Phase 2784
- Phase 1574
- Phase 3535
- Phase 4342
- Phase 1/Phase 2305
- Phase 2/Phase 3123
Top conditions
- Stroke845
- Parkinson Disease426
- Multiple Sclerosis343
- Alzheimer Disease341
- Dementia226
- Ischemic Stroke200
- Epilepsy197
- Obstructive Sleep Apnea155
- Spinal Cord Injuries154
- Insomnia153
- Sarcopenia149
- Traumatic Brain Injury149
- Acute Ischemic Stroke139
- Cerebral Palsy131
- Mild Cognitive Impairment129
- Pain Management114
- Migraine112
- Amyotrophic Lateral Sclerosis108
Leading sponsors
- Beijing Tiantan Hospital133
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic99
- Xuanwu Hospital, Beijing94
- VA Office of Research and Development93
- Hospices Civils de Lyon79
- Johns Hopkins University70
- National Taiwan University Hospital70
- University of Minnesota64
Where studies are running
- California678
- Massachusetts300
- New York292
- Florida275
- Texas267
- Maryland245
- Arizona213
- Alabama211
- Illinois189
- Pennsylvania178
Recruiting studies12,423 total
- NCT04521881RecruitingPhase 3
Testing an antifibrinolytic for mild head injury in older adults
This study tests whether an anti-bleeding medicine (given to reduce unwanted clot breakdown) can improve outcomes after a mild head injury in people 50 and older. It is looking for patients who arrive quickly after injury and have certain symptoms like brief loss of consciousness, confusion, or nausea.
London, LondonAges 50 years+ - NCT04523909Recruiting
Testing spinal fluid inflammation changes after aortic surgery
This study tracks inflammation-related lab markers in spinal fluid taken through a temporary drain during and after thoracic aortic surgery. It may help doctors understand what inflammatory changes happen around surgery and how they relate to recovery.
NijmegenAges 18 years+ - NCT04524338Recruiting
At-home brain stimulation study for dementia
This study looks at using a home device that delivers a mild electrical current to the brain (“tDCS”) over time in people with Alzheimer’s disease or other dementias. It aims to learn whether this approach is safe and potentially helpful for symptoms.
Montreal, QuebecAges 50–100 - NCT04524637Recruiting
Testing a clotting test in recent traumatic brain injury
This trial tests whether a special blood clotting test called thromboelastography can help assess clotting problems after a head injury. It may help doctors better understand bleeding risk and related complications early after trauma.
ShanghaiAges 18–80 - NCT04525144RecruitingPhase 2
Test EGb 761 for mild memory loss with brain blood vessel disease
This trial studies EGb 761 to see if it can improve symptoms in people with mild cognitive impairment (early memory/thinking changes) who also have signs of brain blood vessel disease. It may help by targeting the brain changes seen on scans.
SingaporeAges 45–85 - NCT04528355Recruiting
Study of hospital data after stem cell transplant for non-cancer illness
This study collects medical information from people with certain non-cancer conditions who receive a stem cell transplant. It may help doctors better understand transplant outcomes and care, since the study focuses on data collection rather than adding new treatment.
Pittsburgh, PennsylvaniaAges 2 months–60 years - NCT04530734Recruiting
Measuring lorazepam levels in adults with catatonia
This trial looks at adults with catatonia (a serious condition that affects movement and speech) and measures blood levels of lorazepam. It may help doctors better understand how the medicine behaves in the body for people receiving treatment.
LilleAges 18 years+ - NCT04532047RecruitingPhase 1
Fetal enzyme therapy trial for certain inherited storage disorders
This Phase 1 trial tests an enzyme replacement treatment given to a developing baby before birth for specific inherited “lysosomal storage” diseases. The goal is to see if the treatment is safe and can improve outcomes for babies diagnosed in pregnancy.
San Francisco, CaliforniaAges 18–50 - NCT04532606RecruitingPhase 4
Remimazolam to improve outcomes after bladder tumor surgery
This trial tests whether the anesthesia medicine remimazolam can improve recovery and longer-term outcomes after surgery for early-stage bladder cancer. If you are having a bladder tumor procedure through the urethra, this study may help doctors understand whether this anesthesia choice matters for prognosis.
Beijing, Beijing MunicipalityAges 50–90 - NCT04535349Recruiting
Imaging heart uptake of bone tracer in ATTR amyloidosis
This study uses special imaging tracers to see how much they build up in the heart in people with cardiac transthyretin (ATTR) amyloidosis. It may help researchers better measure disease activity and understand who benefits from treatments like tafamidis.
CaenAges 18–100 - NCT04534777Recruiting
Tests ways to predict recovery after brain injury
This study looks at different ways to predict how people with severe disorders of consciousness might recover after a brain injury. It may help doctors better estimate prognosis and improve care planning.
ParisAges 18–80 - NCT04535843Recruiting
Precision testing study for myasthenia gravis in China
This study follows people with suspected or confirmed myasthenia gravis (a condition that causes muscle weakness that gets worse with use). It uses several specialized nerve and antibody tests to make a more precise diagnosis and tracks you over time to see how well these methods work.
Shanghai, Shanghai MunicipalityAges birth–90 years - NCT04537403RecruitingPhase 1
PET scan study of artery inflammation marker in plaque
This Phase 1 study tests whether a special PET scan can detect a specific inflammation signal (CCR2) in atherosclerosis—fatty plaque buildup in blood vessels. It may help future doctors better see which plaques are more inflamed and potentially more dangerous.
St Louis, MissouriAges 18–89 - NCT04541082RecruitingPhase 1
Oral ONC206 for recurrent brain and spinal tumors
This early-phase study tests an oral medicine called ONC206 in adults with recurrent, rare brain or spinal cord tumors. The goal is to find a safe dose and look for signs the treatment can shrink or control the cancer.
Bethesda, MarylandAges 18 years+ - NCT04540068Recruiting
Predicting whether a sciatica procedure will work
This study looks for ways to predict how well a specific sciatica procedure (TEI) will help. If you have one-sided nerve pain from the low back, the trial may help personalize treatment so you’re less likely to go through ineffective care.
HaarlemAges 18 years+ - NCT04543253Recruiting
Recovery study after Cushing surgery for cortisol excess
This study looks at how people recover after surgery to treat Cushing syndrome and mild cortisol overproduction. It may help doctors understand what recovery looks like and how treatment affects cortisol levels and symptoms.
Rochester, MinnesotaAges 18 years+ - NCT04545606Recruiting
Helping kids with autism sleep better by treating insomnia
This study looks for the best way to improve sleep in children with autism who have ongoing insomnia. You and your child will complete sleep tracking and participate in an insomnia treatment plan to reduce trouble falling asleep, staying asleep, or waking too early.
Columbia, MissouriAges 6–12 - NCT04550728RecruitingPhase 1/Phase 2
Robot training plus electrical stimulation after stroke
This trial tests a “hybrid” rehab program that combines robot-assisted walking practice with electrical stimulation to help movement after stroke. It may help people improve walking and leg function at home as they work with a caregiver.
Baltimore, MarylandAges 18–85 - NCT04550377RecruitingPhase 2
Cannabidiol for PTSD, including PTSD after mild head injury
This Phase 2 study tests whether cannabidiol (CBD) can reduce PTSD symptoms, including in people who also had a mild traumatic brain injury (TBI). It’s meant to see if CBD is helpful and safe for PTSD symptoms over the study period.
New York, New YorkAges 18–70 - NCT04556227Recruiting
Exercise and memory training after ICU delirium
This study tests whether combining gentle cycling while lying down with tablet-based memory exercises can improve recovery after ICU delirium. It may help people regain thinking and comfort after a hospital stay.
Kansas City, MissouriAges 45–64 - NCT04557618Recruiting
Ear nerve stimulation after a brain bleed
This trial studies whether stimulating a nerve near the ear (auricular VNS) can help after a spontaneous subarachnoid hemorrhage, a type of bleeding around the brain. If you qualify, you may receive the ear stimulation as an added treatment while doctors monitor your recovery.
St Louis, MissouriAges 18 years+ - NCT04558541Recruiting
Speech and grammar training study for kids with language disorder
This study looks at how children with developmental language disorder understand and produce parts of speech, especially verb endings and grammar patterns. It may help researchers develop better ways to support communication in kids who struggle with language.
Tucson, ArizonaAges 4–8 - NCT04557293Recruiting
Testing how thinking decisions affect CPAP use
This trial studies whether a person’s decision-making skills affect how well they use CPAP, a common treatment for sleep apnea. It may help you and your care team improve CPAP adherence so therapy is more effective.
PaviaAges 18–80 - NCT04559243Recruiting
Left atrial appendage closure to prevent stroke in AF
This study tests whether closing a heart pocket called the left atrial appendage can lower future stroke or other clot-related events in people with atrial fibrillation. It’s mainly for people who have had a prior clot-related event or are at higher risk but may not be good candidates for long-term blood thinners.
Jinan, ShandongAges 18 years+
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,425 recruiting neurology studies from the U.S. registry right now, out of 19,436 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.