Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,425 recruiting studies in this area right now.
By phase
- Not applicable9,762
- Phase 2784
- Phase 1574
- Phase 3535
- Phase 4342
- Phase 1/Phase 2305
- Phase 2/Phase 3123
Top conditions
- Stroke845
- Parkinson Disease426
- Multiple Sclerosis343
- Alzheimer Disease341
- Dementia226
- Ischemic Stroke200
- Epilepsy197
- Obstructive Sleep Apnea155
- Spinal Cord Injuries154
- Insomnia153
- Sarcopenia149
- Traumatic Brain Injury149
- Acute Ischemic Stroke139
- Cerebral Palsy131
- Mild Cognitive Impairment129
- Pain Management114
- Migraine112
- Amyotrophic Lateral Sclerosis108
Leading sponsors
- Beijing Tiantan Hospital133
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic99
- Xuanwu Hospital, Beijing94
- VA Office of Research and Development93
- Hospices Civils de Lyon79
- Johns Hopkins University70
- National Taiwan University Hospital70
- University of Minnesota64
Where studies are running
- California678
- Massachusetts300
- New York292
- Florida275
- Texas267
- Maryland245
- Arizona213
- Alabama211
- Illinois189
- Pennsylvania178
Recruiting studies12,423 total
- NCT04868994Recruiting
MRI study to help diagnose amyotrophic lateral sclerosis (ALS)
This trial uses a special MRI scan to help diagnose ALS by looking at signs in both nerve pathways. If you’re being evaluated for ALS, it may help doctors confirm the diagnosis sooner and more accurately.
ToulouseAges 18–99 - NCT04872543RecruitingPhase 2
Study drug for nerve tumor caused by PRC2 loss
This Phase 2 trial studies ASTX727 in people with malignant peripheral nerve sheath tumors (MPNST) that have a specific genetic change (“PRC2 loss”). It aims to shrink or control advanced tumors that have not responded to at least one standard treatment, by testing how well the drug works and is tolerated.
Basking Ridge, New JerseyAges 16 years+ - NCT04873583RecruitingPhase 3
High-dose steroids for children after a one-sided stroke
This trial tests whether high-dose steroids given soon after a stroke can improve outcomes for children. It is aimed at children whose stroke is caused by a one-sided blood-vessel problem seen on brain scans.
Randwick, New South WalesAges 6 months–17 years - NCT04873492Recruiting
Study how genes and blood signals relate to MS outcomes
This study looks at genetic information and blood test signals to understand why some people with early MS develop a worse outcome. It may help doctors predict who is at higher risk and better understand disease mechanisms.
Nantes, Loire-AtlantiqueAges 18 years+ - NCT04874454Recruiting
Checks choking risk from a throat ultrasound after stroke
This study looks at whether using an ultrasound on the throat (laryngeal ultrasound) could cause choking in people who have had a recent stroke. If you recently had an acute stroke, they may test the safety of this monitoring approach for you.
Taipei, None SelectedAges 20 years+ - NCT04875936Recruiting
Neurofeedback therapy to improve reading after recent stroke
This trial studies whether a brain-training approach called neurofeedback can improve reading skills after a stroke that happened recently. It may help if you have clear reading and comprehension problems following a left-side stroke.
West Orange, New JerseyAges 18–80 - NCT04876339Recruiting
Sound-based training to improve walking after brain illness
This study tests whether using special sounds (sonification) during gait training can improve walking for people with stroke, Parkinson’s disease, or multiple sclerosis. It may help your walking speed, stamina (fatigue), and overall walking pattern.
PaviaAges Up to 80 years - NCT04877444RecruitingEarly Phase 1
Exercise program to improve arm recovery after stroke
This early-stage trial tests a special exercise approach meant to “prime” the brain and improve arm movement after a stroke. You may be eligible if you’re 6+ months out from a one-sided stroke and can safely do an exercise test.
Charleston, South CarolinaAges 50–90 - NCT04879862Recruiting
Study of walking and bladder recovery after recent spinal injury
This study looks at how leg movement and bladder function change after an acute spinal cord injury. It’s meant for adults who recently injured their spine and cannot stand or move their leg joints on their own.
West Orange, New JerseyAges 18–65 - NCT04882904Recruiting
Tracking movement in people with ALS and healthy volunteers
This study continuously measures activity and movement in people with ALS and in control participants. It aims to better understand how muscle disease changes day-to-day function, which may help improve future monitoring or care.
Liège, LiègeAges 18 years+ - NCT04880356Recruiting
Study of very rare inherited brain diseases over time
This study follows adults over time who have a very rare inherited brain disease, or whose illness seems like it may run in families. The goal is to better understand these conditions and how they progress.
Milan, MilanoAges 18 years+ - NCT04881318Recruiting
Compression garments for POTS symptoms at home
This study tests whether wearing waist-high compression garments in everyday life can reduce symptoms for people with POTS. You’ll take part over a 4-day period and compare different days with a washout period in between.
Calgary, AlbertaAges 18–60 - NCT04881682RecruitingPhase 2
Testing blood-cleansing vs immunoglobulin for CIDP
This Phase 2 study compares a blood-cleansing treatment (immunoadsorption) with standard immune-boosting treatment (intravenous immunoglobulins) for chronic inflammatory demyelinating polyneuropathy (CIDP). It may help people whose steroid treatment did not work well, or who cannot take steroids.
Ulm, Baden-WurttembergAges 18 years+ - NCT04883411Recruiting
First-in-human test of new cervical spine plate and cage
This study tests a new implanted metal plate and cage to treat problems in the neck caused by worn spinal discs and nerve or spinal cord compression. It is aimed at people whose symptoms have not improved with non-surgical care for at least 6 weeks (or who have worsening nerve/spinal cord symptoms).
Union, New JerseyAges 22–79 - NCT04883463Recruiting
Brain and spinal stimulation to improve breathing after SCI
This trial tests a neuromodulation treatment to improve breathing in people living with a cervical spinal cord injury who have significant breathing problems. If you qualify, you would have regular weekly testing over many months to see whether breathing and breathing support needs improve.
Los Angeles, CaliforniaAges 18–75 - NCT04885179Recruiting
Study of SPLIS genetics and patient experiences
This observational study and patient registry collects information from people diagnosed with SPLIS due to specific changes in the SGPL1 gene, including children and newborns. It helps researchers understand the condition better and may improve future care and research planning.
San Francisco, CaliforniaAges Any age - NCT04885374Recruiting
ALS patient registry for people using traditional Chinese medicine
This trial is a registry that collects information from adults with ALS who are using traditional Chinese medicine. It may help researchers better understand ALS and how traditional treatments are used alongside standard care.
BeijingAges 18 years+ - NCT04886245Recruiting
Eye-tracking study of face attention in facial paralysis
This pilot study uses an eye-tracking camera to measure where people look when viewing faces. It compares attention patterns in adults with facial paralysis to healthy adults, which may help improve understanding and support for people affected.
AmiensAges 18 years+ - NCT04886895Recruiting
Motor training program for infants with cerebral palsy risk
This study tests a motor (movement) training program for very young infants at higher risk for cerebral palsy or who show early signs of it. The goal is to see whether training improves early movement and development during the first months of life.
Cincinnati, OhioAges 3 months–8 months - NCT04896281Recruiting
Phenylalanine-free diet study for ICU adults with high phenylalanine
This study tests whether a phenylalanine-free diet is helpful for ICU patients with high phenylalanine levels in the blood. It aims to see if changing diet in critically ill adults can improve outcomes during their ICU stay.
KeelungAges 20 years+ - NCT04896775Recruiting
Online program to improve sleep for dementia caregivers
This trial tests a web-based program (NiteCAPP) to help people who care for someone with dementia sleep better. It targets caregivers with ongoing insomnia, and aims to improve sleep and daytime functioning.
Tampa, FloridaAges 18 years+ - NCT04897334Recruiting
Brain stimulation plus rehab to improve thinking after stroke
This study tests whether a noninvasive brain stimulation treatment, combined with rehabilitation, can improve thinking and other “neurocognition” problems after a recent stroke. It may help people whose thinking has been affected by stroke within the past month.
Philadelphia, PennsylvaniaAges 18–90 - NCT04897321RecruitingPhase 1
CAR T therapy for children with B7-H3 solid tumors
This early-phase study tests a lab-made immune therapy (CAR T cells) made from your own cells to treat children’s solid tumors that have a specific marker called B7-H3. It is designed for kids whose cancer has come back or did not respond to standard treatment, aiming to shrink tumors and keep the therapy safe.
Memphis, TennesseeAges Up to 21 years - NCT04897347Recruiting
Robotic sitting and reaching training for children with cerebral palsy
This trial tests a robotic therapy that helps children with cerebral palsy practice sitting balance and reaching safely. It may improve how well your child can control posture and move during functional tasks.
New York, New YorkAges 6–17
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,425 recruiting neurology studies from the U.S. registry right now, out of 19,436 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.