Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,425 recruiting studies in this area right now.
By phase
- Not applicable9,762
- Phase 2784
- Phase 1574
- Phase 3535
- Phase 4342
- Phase 1/Phase 2305
- Phase 2/Phase 3123
Top conditions
- Stroke845
- Parkinson Disease426
- Multiple Sclerosis343
- Alzheimer Disease341
- Dementia226
- Ischemic Stroke200
- Epilepsy197
- Obstructive Sleep Apnea155
- Spinal Cord Injuries154
- Insomnia153
- Sarcopenia149
- Traumatic Brain Injury149
- Acute Ischemic Stroke139
- Cerebral Palsy131
- Mild Cognitive Impairment129
- Pain Management114
- Migraine112
- Amyotrophic Lateral Sclerosis108
Leading sponsors
- Beijing Tiantan Hospital133
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic99
- Xuanwu Hospital, Beijing94
- VA Office of Research and Development93
- Hospices Civils de Lyon79
- Johns Hopkins University70
- National Taiwan University Hospital70
- University of Minnesota64
Where studies are running
- California678
- Massachusetts300
- New York292
- Florida275
- Texas267
- Maryland245
- Arizona213
- Alabama211
- Illinois189
- Pennsylvania178
Recruiting studies12,423 total
- NCT05301543Recruiting
Program to improve long-term insomnia symptoms
This study tests a behavioral (non-medication) program to help people with chronic insomnia sleep better. It may help if you regularly use sleep medications but still struggle with staying asleep or falling asleep.
Philadelphia, PennsylvaniaAges 55–85 - NCT05302271RecruitingPhase 1
Testing gene therapy for Friedreich’s ataxia heart disease
This Phase 1 trial tests an AAV gene therapy that aims to improve heart problems caused by Friedreich’s ataxia. You may be eligible if you have genetically confirmed Friedreich’s ataxia with measurable heart weakening but still enough heart function to safely receive treatment.
New York, New YorkAges 12–50 - NCT05302999RecruitingPhase 4
Early gabapentin for recovery after spinal cord injury
This trial studies whether starting gabapentin within 5 days after a traumatic spinal cord injury is safe and helpful for early recovery. It will mainly look at feasibility—whether patients can take the medicine and whether it affects early neurologic progress.
Cleveland, OhioAges 18 years+ - NCT05303649Recruiting
Theta burst brain stimulation for language problems after stroke
This study tests whether a type of brain stimulation guided by a brain scan (MRI) can improve speech and language (“aphasia”) after a stroke. It may help people who have trouble producing speech but can still understand others’ words.
Warsaw, Masovian VoivodeshipAges 18–75 - NCT05303987RecruitingPhase 2
Dexmedetomidine or propofol for sleep endoscopy in children
This Phase 2 study compares two medicines used to help children sleep during a procedure called drug-induced sleep endoscopy. It’s for children with obstructive sleep apnea who are being evaluated before adenotonsillectomy, to help surgeons understand the cause of the blockage and potentially improve treatment planning.
Ann Arbor, MichiganAges 3–11 - NCT05305430Recruiting
Synergy cervical disc data study after neck surgery
This study collects real-world information about people who get the Synergy cervical disc implant after neck surgery for nerve or spinal cord pressure. It may help doctors understand how well the implant works in everyday care and what outcomes to expect.
Windsor, VictoriaAges 21 years+ - NCT05306834Recruiting
Study to slow memory decline by targeting hidden small brain vessel disease
This trial looks at how to slow cognitive decline and early dementia in people with a specific kind of “silent” blood vessel damage in the brain seen on scans. It may help identify whether targeting this hidden condition can protect thinking and memory over time.
BordeauxAges 60–88 - NCT05306899RecruitingPhase 3
IV ketamine for chronic daily headaches
This trial tests whether an IV dose of ketamine can reduce chronic daily headaches and is safe for people with this condition. It may help by lowering headache frequency and severity, but it also has several medicine and health-related safety checks.
Toronto, OntarioAges 18–75 - NCT05307146Recruiting
Brain activity study during treatment for epilepsy
This study measures brain activity in people with epilepsy while doctors place temporary electrodes inside the brain. It may help researchers better understand seizures and how to improve treatment.
LeuvenAges 18–90 - NCT05307055Recruiting
Testing brain effects after low-frequency stimulation in Parkinson’s
This study looks at how Parkinson’s disease symptoms and brain thinking (neurocognitive function) may change after low-frequency stimulation from an implanted brain device. It may help researchers understand whether this specific stimulation pattern could improve thinking or brain-related symptoms.
Los Angeles, CaliforniaAges 18 years+ - NCT05307367Recruiting
Study exercise and body muscle changes in advanced lung cancer
This study looks at why cancer can cause loss of muscle in people with advanced non–small cell lung cancer, and whether exercise can improve or explain those muscle changes. You may be asked to do physical testing and answer questionnaires while receiving standard palliative cancer treatment.
Copenhagen, DKAges 18–100 - NCT05307640Recruiting
Support for caregivers after moderate to severe brain injury
This study tests a caregiver-focused program to improve well-being for people caring for someone who recently had a moderate to severe traumatic brain injury. It may help caregivers feel better and cope more effectively during the early recovery period.
Cincinnati, OhioAges 18 years+ - NCT05309473Recruiting
Sounds during restricted sleep after being sleep deprived
This study tests whether playing certain sounds during a period of limited sleep can affect how your body responds after you’ve been kept awake. It’s designed for healthy adults and checks safety and how well you can follow the study instructions.
Silver Spring, MarylandAges 18–39 - NCT05312424RecruitingPhase 1/Phase 2
Testing an annatto-based treatment for statin muscle pain
This early-stage trial tests whether an annatto-derived product (called GG) can help people who develop new muscle pain after starting or increasing a statin. If you recently noticed statin-related muscle aches, this study may see whether the treatment improves symptoms and safety.
Lubbock, TexasAges 40 years+ - NCT05312983Recruiting
Testing new hearing tests to better diagnose age-related hearing loss
This study is developing a set of hearing tests to more precisely identify age-related hearing loss. It may help you (or the study team) better understand what type of hearing problem you have and how to guide next steps.
ParisAges 18 years+ - NCT05313191Recruiting
Proton therapy for tumors after prior radiation
This study looks at whether a type of proton beam treatment can be given safely and effectively to tumors that have already been treated with radiation before. It may help people whose tumors came back or persisted after earlier radiation, using a specific proton method called pencil beam scanning.
New York, New YorkAges 18 years+ - NCT05313308Recruiting
Survey of midazolam use in non-convulsive seizure emergencies
This trial is a survey about how midazolam is used in people with non-convulsive status epilepticus, especially when it’s given outside a medical facility and when an extra dose is needed. It may help doctors better understand real-world treatment patterns and safety.
TokyoAges Any age - NCT05315167RecruitingPhase 1/Phase 2
Study drug PRJ1-3024 for advanced solid tumors
This trial tests how safe PRJ1-3024 is and how the body handles it, and it also looks for early signs that it can shrink advanced solid tumors. It may help people whose cancer can’t be treated with standard options.
Zhengzhou, HenanAges 18 years+ - NCT05315895Recruiting
Study of people with “dampness” signs in Chinese medicine
This is an observational study that looks at a Chinese-medicine pattern called “dampness” by collecting health and biological information from volunteers. It may help researchers better understand what this pattern looks like and how it relates to people’s health.
Guangzhou, GuangdongAges 35–79 - NCT05315752Recruiting
Body fat changes after CPAP-treated sleep apnea improves
This study looks at how bariatric (weight-loss) surgery may change body fat and body shape in people with severe obstructive sleep apnea who use CPAP. It aims to understand what may improve when sleep apnea is better controlled after surgery.
BrusselsAges 18–99 - NCT05317390Recruiting
Tests an AI tool to diagnose isolated dystonia
This trial checks whether an AI (software) called DystoniaNet can accurately identify isolated dystonia using information from your evaluation, and compares its results to standard diagnosis. If you have focal, segmental, or generalized dystonia, this study may help improve faster and more accurate diagnosis in the future.
Boston, MassachusettsAges Any age - NCT05317234Recruiting
Genetic testing study for children with cerebral palsy
This study looks for genetic reasons that may contribute to cerebral palsy. It may help families understand potential causes, especially when a specific genetic change is found.
BronAges 2–15 - NCT05317832RecruitingPhase 2
Smartphone program to increase daily movement after spinal cord injury
This Phase 2 study tests whether a smartphone and smartwatch plan can help people with spinal cord injury be more physically active. It may help you build safer, more consistent movement if you’re already ready to be active and can use your arms.
Philadelphia, PennsylvaniaAges 18–75 - NCT05318417Recruiting
Cochlear implant study for one-sided deafness
This study checks whether cochlear implantation is safe and effective for people who have very poor hearing in one ear (single-sided deafness) while the other ear hears normally or nearly normally. You may be enrolled if you meet specific hearing test and health/surgery readiness requirements.
Palo Alto, CaliforniaAges 5 years+
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,425 recruiting neurology studies from the U.S. registry right now, out of 19,436 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.