Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,425 recruiting studies in this area right now.
By phase
- Not applicable9,762
- Phase 2784
- Phase 1574
- Phase 3535
- Phase 4342
- Phase 1/Phase 2305
- Phase 2/Phase 3123
Top conditions
- Stroke845
- Parkinson Disease426
- Multiple Sclerosis343
- Alzheimer Disease341
- Dementia226
- Ischemic Stroke200
- Epilepsy197
- Obstructive Sleep Apnea155
- Spinal Cord Injuries154
- Insomnia153
- Sarcopenia149
- Traumatic Brain Injury149
- Acute Ischemic Stroke139
- Cerebral Palsy131
- Mild Cognitive Impairment129
- Pain Management114
- Migraine112
- Amyotrophic Lateral Sclerosis108
Leading sponsors
- Beijing Tiantan Hospital133
- Riphah International University125
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic99
- Xuanwu Hospital, Beijing94
- VA Office of Research and Development93
- Hospices Civils de Lyon79
- Johns Hopkins University70
- National Taiwan University Hospital70
- University of Minnesota64
Where studies are running
- California678
- Massachusetts300
- New York292
- Florida275
- Texas267
- Maryland245
- Arizona213
- Alabama211
- Illinois189
- Pennsylvania178
Recruiting studies12,423 total
- NCT05708807Recruiting
Follow-up study of recovery after first-time stroke in Gothenburg
This study tracks how people recover after their first-ever stroke (either blocked artery stroke or bleeding in the brain). It may help doctors better understand recovery patterns and what support could work best over time.
GothenburgAges 18 years+ - NCT05709314RecruitingPhase 2
AMDX-2011P for cerebral amyloid angiopathy (CAA
This Phase 2 study tests AMDX-2011P to see if it can help people with cerebral amyloid angiopathy (CAA), a condition where abnormal protein affects blood vessels in the brain. You may be able to join if you have confirmed or likely CAA and a recent brain MRI showing changes from CAA.
Phoenix, ArizonaAges 18 years+ - NCT05710692RecruitingPhase 2/Phase 3
Study drug PRX-102 for Fabry disease in Japanese patients
This trial tests whether PRX-102 is safe and effective for treating Fabry disease in Japanese participants. It also measures how the drug moves through the body and affects body systems, to see if it helps your symptoms and organ function.
Chikushino-shi, FukuokaAges 13–70 - NCT05710549Recruiting
Brain study of autobiographical memory using brain stimulation
This study looks at how the brain supports remembering your own past experiences. It tests brain mechanisms using brain scanning (MRI) and noninvasive brain stimulation to see how these memory processes work.
Geneva, Canton of GenevaAges 18–85 - NCT05710809Recruiting
Exercise and health check study for older colorectal cancer patients
This trial looks at sarcopenia (loss of muscle strength/size) and vertigo (feeling dizzy or off-balance) in older adults with colorectal cancer. It tests whether a structured, exercise-based approach can help these issues alongside cancer care.
CopenhagenAges 65 years+ - NCT05710991Recruiting
Brief therapy for sleep trouble in early pregnancy
This trial compares two short approaches to help with insomnia (sleep difficulties) during early pregnancy: brief cognitive behavioral therapy or sleep hygiene tips. It may help improve how well you sleep without using new or changing medications.
Hamilton, OntarioAges 18–45 - NCT05711888Recruiting
Alzheimer brain study using a memory and recognition task
This study uses a computer task to test thinking and recognition skills in people with or without Alzheimer’s disease. It also includes checking Alzheimer-related biomarkers to help researchers understand how the task connects to the disease.
Beşiktaş, IstanbulAges Any age - NCT05713877RecruitingPhase 2
Melatonin to treat confusion in ICU patients
This Phase 2 trial tests whether melatonin can reduce delirium, a sudden confusion that can happen in the ICU. If you qualify, you may be given melatonin to see if it improves alertness and comfort during an expected longer ICU stay.
Montreal, QuebecAges 18 years+ - NCT05713630RecruitingPhase 3
Tranexamic acid for symptomatic subdural blood clots
This trial studies whether tranexamic acid (a medicine that helps slow blood breakdown) can improve outcomes for people with symptomatic subdural hematoma—blood collecting between the brain and its outer covering. You may be able to join if you’re older, have bleeding seen on CT, symptoms linked to the bleed, and meet several safety and timing rules.
Toronto, OntarioAges 45 years+ - NCT05713890Recruiting
Home VR training for right arm function in MS
This study tests whether doing a virtual-reality–based training program at home can improve movement and daily use of the right arm and hand in people with multiple sclerosis. It may help reduce hand limitations by practicing targeted movement skills using an easy remote setup.
Milan, MilanAges 18–65 - NCT05714917Recruiting
Studying recovery after nerve damage from NOS use
This study looks at how neurological symptoms (like numbness, weakness, unsteadiness, or walking problems) recover after damage caused by NOS use. It may help researchers understand what recovery looks like and what support or treatments could work best.
BirminghamAges 16–40 - NCT05715710Recruiting
MRI and brain vein pattern study for memory and thinking problems
This study looks at whether certain deep brain veins seen on MRI are linked to thinking and memory problems in people with small-vessel brain disease. It compares brain scan findings with cognitive (thinking) testing to better understand what may drive cognitive dysfunction.
Zigong, SichuanAges 50–85 - NCT05716321Recruiting
Study of pain and function after limb amputation surgery
This study looks at pain and day-to-day functioning after someone has a limb removed due to surgery. The results may help doctors better understand what to expect and how to improve comfort and mobility after amputation.
Hershey, PennsylvaniaAges 18–89 - NCT05716048RecruitingPhase 1
Rehab program study for adults with lasting brain injury symptoms
This Phase 1 trial tests a combined rehabilitation program to improve function in people living with moderate-to-severe traumatic brain injury (TBI) for at least a year. It may help people who still have new problems with learning and memory and who are not very physically active.
West Orange, New JerseyAges 18–65 - NCT05716100RecruitingPhase 3
Study drug for focal epilepsy that isn’t controlled on current meds
This trial tests XEN1101 compared with a placebo (inactive pill) in people with focal-onset seizures that haven’t been fully controlled despite trying at least two anti-seizure medicines. If you qualify, you may help researchers see whether the study drug reduces seizure frequency and improves control.
Little Rock, ArkansasAges 18 years+ - NCT05717712RecruitingPhase 1
Study virus treatment for newly diagnosed DIPG in children
This Phase 1 trial tests a type of cancer-fighting virus given directly into the tumor for children with newly diagnosed diffuse intrinsic pontine glioma (DIPG). The goal is to see if it can be delivered safely and to learn how the body responds to it.
Beijing, Beijing MunicipalityAges 1–18 - NCT05717699RecruitingPhase 1
Trial of a virus treatment for DIPG in children
This Phase 1 trial tests a lab-made cancer virus (Ad-TD-nsIL12) in children with DIPG whose tumor keeps growing after standard treatment. It mainly focuses on safety and how the treatment works, and it may help shrink or control the tumor by stimulating the immune system.
Beijing, Beijing MunicipalityAges 1–18 - NCT05718622Recruiting
EECP for people with stable first stroke and blocked artery
This study looks at whether EECP (a non-surgical therapy that helps blood flow) improves outcomes in people who recently had their first ischemic stroke and have a narrowed or blocked artery. It also aims to predict who may benefit most based on health data.
Xi'an, ShaanxiAges 18–80 - NCT05718440Recruiting
Checking risk factors for urinary and related issues
This study looks at why some adults with spinal dysraphism develop problems with bladder, bowel, and/or sexual function. It gathers information during a one-day visit to help doctors better understand risk factors.
ParisAges 18 years+ - NCT05719844Recruiting
Computer tests to assess concussion recovery in young rugby players
This study checks whether a set of computer-based attention and thinking tests can help manage concussion (a brain injury) in young rugby players. It compares players who had a concussion with similarly aged players who haven’t had one.
Clermont-FerrandAges 11–25 - NCT05719779Recruiting
Oral device trial for snoring and sleep apnea in throat cancer
This trial tests whether a custom mouth (mandibular advanced) device can reduce snoring and breathing pauses during sleep in people with oropharyngeal (throat) cancer. It also looks at how well you tolerate the device and whether it helps with sleep symptoms.
Montreal, QuebecAges 18–65 - NCT05719935Recruiting
KinematX wrist replacement registry for people with wrist arthritis
This trial is a registry that follows people who get (or already had) a KinematX total wrist replacement. It collects health and recovery information to better understand outcomes for different wrist problems, like arthritis or certain bone alignment issues.
Loma Linda, CaliforniaAges 18–85 - NCT05721027RecruitingPhase 4
Ibuprofen alone or with a steroid for new sciatica pain
This trial compares ibuprofen alone versus ibuprofen plus dexamethasone (a steroid) for short-term relief of acute nerve-related low back pain that shoots into the buttock or leg. It aims to see which approach reduces pain and improves function after an emergency visit.
The Bronx, New YorkAges 18–70 - NCT05721911Recruiting
Study using brain-cell tests to better understand Parkinson’s risk
This study collects blood and related samples to create a “biobank” and uses lab tests to study genetic risk in Parkinson’s disease and idiopathic REM sleep behavior disorder (RBD). It may help researchers understand why symptoms develop and improve future prevention or treatment approaches.
Milan, ItalyAges 18 years+
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,425 recruiting neurology studies from the U.S. registry right now, out of 19,436 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.