Neurology
Brain & nervous system clinical trials
Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We’re tracking 12,516 recruiting studies in this area right now.
By phase
- Not applicable9,855
- Phase 2786
- Phase 1573
- Phase 3533
- Phase 4344
- Phase 1/Phase 2305
- Phase 2/Phase 3120
Top conditions
- Stroke852
- Parkinson Disease423
- Alzheimer Disease341
- Multiple Sclerosis340
- Dementia230
- Ischemic Stroke202
- Epilepsy197
- Insomnia156
- Obstructive Sleep Apnea156
- Traumatic Brain Injury156
- Spinal Cord Injuries152
- Sarcopenia151
- Acute Ischemic Stroke141
- Cerebral Palsy129
- Mild Cognitive Impairment128
- Migraine112
- Pain Management112
- Amyotrophic Lateral Sclerosis106
Leading sponsors
- Beijing Tiantan Hospital134
- Riphah International University127
- Assistance Publique - Hôpitaux de Paris112
- Mayo Clinic98
- Xuanwu Hospital, Beijing94
- VA Office of Research and Development92
- Hospices Civils de Lyon80
- Johns Hopkins University71
- National Taiwan University Hospital71
- University of Minnesota65
Where studies are running
- California678
- Massachusetts307
- New York295
- Florida274
- Texas271
- Maryland245
- Alabama214
- Arizona209
- Illinois193
- Pennsylvania177
Recruiting studies12,514 total
- NCT05746104Enrolling by invitationPhase 1
Testing a glowing dye to find nervous system tumor tissue
This early (Phase 1) study tests whether a glowing dye called indocyanine green helps surgeons better see nervous system tumor tissue during an operation, with the goal of lowering the chance of tumor coming back locally. It’s for adults whose tumor is expected to be removable and at risk for local recurrence.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05745129Enrolling by invitation
AI tool for personalized care decisions in spine problems
This trial looks at using an artificial intelligence (AI) tool to help guide care choices for people with spine problems. It may help doctors assess whether you need surgery or a different approach, especially when disc herniation isn’t the main issue.
Oslo, NorgeAges 18–80 - NCT05718570Enrolling by invitation
Long-term follow-up for adults taking Sogroya for growth hormone deficiency
This study follows adults with growth hormone deficiency who start (or have started) Sogroya to learn about its long-term safety. It does not change your treatment—it mainly checks for side effects and health outcomes over time.
Phoenix, ArizonaAges 18 years+ - NCT05715957Enrolling by invitation
Follow-up study for women who carry a DMD gene change
This study follows women who have a confirmed DMD gene mutation (a genetic change related to Duchenne/Becker muscular dystrophy) to learn more about health and muscle-related measurements. Depending on the part of the study, you may be asked to take part in MRI or other assessments.
CopenhagenAges 18 years+ - NCT05706220Enrolling by invitation
Eye tests to measure visual speed in multiple sclerosis
This study tests how fast and how accurately your eyes process visual information and how eye movements look in people with multiple sclerosis. It may help researchers understand vision-related effects of MS using objective eye measurements.
Valladolid, ValladolidAges 18–80 - NCT05705128Enrolling by invitationPhase 2/Phase 3
Dexmedetomidine to help pain after shoulder surgery
This trial studies whether dexmedetomidine can reduce pain after elective shoulder arthroscopy surgery done under general anesthesia. If you’re eligible, it may help improve postoperative comfort and reduce the need for additional pain treatment.
AsyutAges 18–60 - NCT05704309Enrolling by invitation
Study of diabetes prevention participants using brain scans
This study looks at how people who previously took part in a diabetes prevention program are doing over time, including brain health using MRI scans for some participants. It may help researchers understand who is at higher risk for memory and thinking problems and why.
Phoenix, ArizonaAges Any age - NCT05685160Enrolling by invitation
Foot ultrasound and MRI study for forefoot pain
This study uses imaging (an exam plus ultrasound and MRI) to help understand causes of pain between the toes, such as a small pad inflammation or nerve irritation (Morton’s neuroma). It may help researchers better match imaging findings to the likely cause of your symptoms.
CopenhagenAges 18 years+ - NCT05682248Enrolling by invitation
Testing a brain assessment and stimulation system for unconsciousness
This trial studies a device and plan to assess brain function and deliver an intervention in people who are in a coma, minimally conscious state, or unresponsive arousal state after brain injury, stroke, or lack of oxygen. If you qualify, it may help doctors understand and potentially improve brain function over time.
BeijingAges 14–80 - NCT05616910Enrolling by invitationPhase 2
Inhaled nitric oxide for microvascular problems after brain injury
This Phase 2 study tests whether inhaled nitric oxide can improve tiny blood-flow problems in the brain after traumatic brain injury. If you qualify, you may receive inhaled nitric oxide and be monitored for safety and recovery.
Philadelphia, PennsylvaniaAges 18–75 - NCT05614531Enrolling by invitationPhase 1/Phase 2
Safety and benefit study of EXG001-307 for baby spinal muscular atrophy
This Phase 1/2 study tests whether EXG001-307 is safe and may improve health in babies with spinal muscular atrophy (SMA) type 1. It mainly looks at safety first, and whether the treatment can help the body work better over time.
Shanghai, Shanghai MunicipalityAges 1 day–6 months - NCT05606991Enrolling by invitation
Testing how CPAP affects brain waste clearance during sleep
This study looks at how stopping CPAP for 14 nights affects “brain waste clearance,” a process your brain uses to clear byproducts during sleep. It is testing whether using CPAP versus stopping it changes this brain cleanup in adults with severe obstructive sleep apnea (OSA).
Macquarie Park, New South WalesAges 35–65 - NCT05598775Enrolling by invitation
Long-term safety follow-up for CTX0E03 after PISCES III
This study checks how safe CTX0E03 is over the long term in people who already received it in a previous PISCES III trial. It may help confirm long-term safety information for future patients, and you may contribute valuable follow-up data.
Morgantown, West VirginiaAges 35–75 - NCT05594992Enrolling by invitationPhase 3
Study extension of JR-141 for long-term Hunter syndrome safety
This is a follow-up study for people who already took JR-141 in an earlier trial for Hunter syndrome (MPS II). It checks how well the treatment works over the long term and monitors long-term safety.
Oakland, CaliforniaAges Any age - NCT05573542Enrolling by invitation
Study early Parkinson signs in people with IBS
This study looks for early clues of Parkinson’s disease in people who have IBS (irritable bowel syndrome), and compares them with people without IBS. The goal is to understand whether gut symptoms or test results can help spot Parkinson’s earlier.
ÖrebroAges 18–85 - NCT05554692Enrolling by invitation
Study how aging and cochlear implants affect speech timing
This study looks at how the brain processes the timing of sounds and speech in people with cochlear implants and in people with typical hearing. It may help researchers understand what changes with age and how implant hearing works in the real world.
College Park, MarylandAges 18–85 - NCT05544721Enrolling by invitationPhase 4
Nerve-block pain study for thoracic outlet surgery
This trial tests whether a targeted numbing injection near the back helps reduce pain or improve comfort for people having first rib removal surgery for thoracic outlet syndrome. It’s a Phase 4 study, meaning it builds on earlier use of this pain-control approach to see how well it works in routine care.
Jacksonville, FloridaAges 18 years+ - NCT05542628Enrolling by invitation
Baseline concussion testing for football players
This study sets up “starting point” measurements for concussion-related tests in football. It enrolls players who currently do not have a suspected or confirmed concussion, so researchers can compare future test results if a concussion is suspected later.
ZurichAges 18 years+ - NCT05530863Enrolling by invitation
Relaxation methods for insomnia during pregnancy
This study tests relaxation-based approaches to help pregnant people who have trouble falling asleep or waking up during the night. If you meet the sleep and pregnancy timing needs, the goal is to see whether the approach can improve sleep.
Philadelphia, PennsylvaniaAges 18–55 - NCT05527041Enrolling by invitation
Portable eye test device for mild concussion after injury
This study tests a portable device that uses eye checks to assess people with a mild concussion after a head or body impact. It may help find concussion-related changes in settings like deployment or far-forward locations.
West Point, New YorkAges 17–35 - NCT05504902Enrolling by invitation
Device training for advanced Parkinson’s using touch feedback
This study tests whether coordinated touch (vibrotactile) training can improve symptoms in people with Parkinson’s. You may be asked to use a special device and attend virtual check-ins, with some visits requiring stopping Parkinson’s meds for short periods.
Stanford, CaliforniaAges 18 years+ - NCT05495321Enrolling by invitationPhase 3
Interleukin-2 for active dermatomyositis
This Phase 3 study tests whether interleukin-2 can better control “active” dermatomyositis, an inflammatory muscle and skin disease. Participants will be monitored to see if treatment improves disease activity and symptoms.
Beijing, Beijing MunicipalityAges 18–75 - NCT05477004Enrolling by invitation
Study of ketamine infusions for ongoing chronic pain
This study is observing people with chronic pain who are getting ketamine infusions at Stanford. You may help by completing email surveys about how you feel, which can help the team understand the treatment’s impact.
Stanford, CaliforniaAges 18 years+ - NCT05457998Enrolling by invitation
Study of Alzheimer’s brain markers using memory testing
This trial looks for signs of Alzheimer’s disease in the brain by using memory and thinking tests, and related study procedures. It may help researchers find better ways to identify Alzheimer’s-related changes earlier.
Providence, Rhode IslandAges 50–80
Common questions
- How many brain & nervous system clinical trials are recruiting?
- Clin2 is tracking 12,516 recruiting neurology studies from the U.S. registry right now, out of 20,061 we cover in this area in total.
- What does “Brain & nervous system” cover here?
- Conditions of the brain, spinal cord, and nerves — including stroke, dementia, and movement disorders. We group each study into brain & nervous system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a brain & nervous system trial near me?
- Use the search to filter brain & nervous system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.