Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,599 recruiting studies in this area right now.
By phase
- Not applicable4,683
- Phase 21,187
- Phase 1568
- Phase 3457
- Phase 1/Phase 2366
- Phase 4228
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer478
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona189
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,599 total
- NCT07481422RecruitingPhase 1/Phase 2
Fecal transplant capsules for irritable bowel syndrome
This trial tests whether taking capsules containing freeze-dried healthy donor stool can improve symptoms of irritable bowel syndrome (IBS) that haven't gotten better with usual treatments. It aims to see if this approach is safe and helpful for people with moderate to severe IBS.
RijekaAges 18–65 - NCT07482969Recruiting
GERD symptoms in Czech children study
This study asks children ages 8-9 and 12-13 about symptoms of gastroesophageal reflux disease (GERD), a condition where stomach acid flows back into the throat. It aims to understand how common these symptoms are.
PragueAges 8–13 - NCT07484607Recruiting
Study on infections and treatments in cystic fibrosis exacerbations
This study looks at how lung infections and inflammation affect people with cystic fibrosis during severe flare-ups. It aims to understand which antibiotics work best and why, so your care team can choose the right treatment for you.
CardiffAges 16 years+ - NCT07487168RecruitingPhase 1
PIPAC with mitomycin for peritoneal cancer
This trial tests a new way to deliver chemotherapy directly into the abdomen (called PIPAC) for people with cancer spread to the lining of the belly. It uses the drug mitomycin and is for patients who cannot have standard surgery or heated chemotherapy.
Tampa, FloridaAges 18 years+ - NCT07488078RecruitingPhase 1
IV fluids for recovery after gallbladder surgery
This trial compares giving more or less IV fluids during gallbladder removal surgery to see which helps patients recover faster. It may help you heal better after your operation.
Lahore, Punjab ProvinceAges 18–60 - NCT07486518Recruiting
Stomach precancer study with advanced endoscopy
This study uses high-definition endoscopy to look at early changes in the stomach lining that might lead to cancer. It aims to better understand these changes in people having a routine upper endoscopy for stomach-related symptoms.
Hyderabad, TelanganaAges 40 years+ - NCT07488013Recruiting
Early Regular Diet vs Clear Fluids After Colon Surgery
This study compares starting a regular diet soon after colon surgery versus a traditional clear-liquid diet. It aims to see which helps your bowel connection heal better and get you home sooner.
CairoAges 18–60 - NCT07487623Recruiting
Nutritional supplement for liver protection in hepatitis C
This trial tests whether a special nutritional supplement can protect the liver in people with chronic hepatitis C. If you have mild to moderate liver damage and meet the criteria, you may be able to join.
Guadalajara, JaliscoAges 18–69 - NCT07480785Recruiting
Nerve stimulation plus 3 anti-nausea drugs for surgery nausea
This trial tests whether combining a gentle electrical nerve stimulation technique (called TEAS) with three standard anti-nausea medicines can better prevent nausea and vomiting after laparoscopic surgery in women at high risk. If you qualify, you would receive the stimulation plus the medicines, or the medicines alone, to see which works best.
Hangzhou, ZhejiangAges 18–65 - NCT07487480Recruiting
Guselkumab for Crohn's after ustekinumab
This study looks at whether guselkumab, a different biologic medicine, can help people with Crohn's disease who have already tried ustekinumab but it didn't work well or caused side effects. It aims to see if switching to guselkumab is safe and effective.
Hangzhou, ZhejiangAges 18–75 - NCT07488312Enrolling by invitationPhase 1
Leucine-restricted diet for gastric cancer patients
This trial tests if a diet low in leucine (an amino acid) can help treat gastric cancer before surgery. It aims to see if it's safe and effective for patients who are preparing for tumor removal.
Jinan, ShandongAges 18–70 - NCT07483658Recruiting
Salvage pelvic radiotherapy: 20 vs 25 sessions for recurring prostate cancer
This trial compares two schedules of pelvic radiotherapy for men whose prostate cancer has returned after surgery. Both schedules aim to control the cancer with fewer visits for one of them.
Gatineau, QuebecAges 18 years+ - NCT07484724RecruitingPhase 2
JS212 combination therapy for advanced esophageal cancer
This trial tests a new combination of drugs (JS212 plus another medicine) for people with advanced esophageal squamous cell carcinoma who have not had prior treatment. It aims to see if the combination is safe and effective.
Beijing, Beijing MunicipalityAges 18–75 - NCT07488299Recruiting
Study of acid-reducing drug in pancreatic necrosis drainage
This trial tests whether giving a type of acid-reducing drug (called a PPI) affects the outcome of endoscopic drainage for walled-off pancreatic necrosis (WON). It aims to see if the drug helps or harms recovery.
Jinan, ShandongAges 18–80 - NCT07486921RecruitingPhase 2
Etrasimod to prevent pouchitis after ulcerative colitis surgery
This trial tests if etrasimod can prevent pouchitis, which is inflammation of the surgically created internal pouch, in people who have had their colon removed due to ulcerative colitis. If you are at high risk for pouchitis or have had only one episode, this study may help keep your pouch healthy.
New York, New YorkAges 18–65 - NCT07482696Recruiting
Biofeedback training for pelvic floor muscle issues in constipation
This trial tests whether electromyographic biofeedback therapy can help people who have trouble relaxing their pelvic floor muscles during bowel movements, a condition called dyssynergic defecation. It may improve chronic constipation and hard stools.
Kocaeli, IzmitAges 18–70 - NCT07486570Recruiting
Stenting to prevent leaks after colon surgery
This trial tests if placing a small mesh tube (stent) in a major artery can prevent leaks where the colon is reconnected during surgery. It may help people who have a blockage in that artery but no symptoms from it.
Emmen, DrentheAges 40 years+ - NCT07488611RecruitingPhase 3
Progain nutrition program for stomach cancer surgery
This study tests a nutrition program (PROGAIN) for people having surgery for stomach cancer. The goal is to see if it helps with recovery.
Cheonan, Chungcheongnam-doAges 19 years+ - NCT07482891RecruitingPhase 4
Preventing nausea and vomiting from multi-day chemo
This study tests if two medicines given together, fosaprepitant and palonosetron, can prevent nausea and vomiting caused by strong chemotherapy given over several days. It's for people who have never had chemo before and are about to start a multi-day treatment for a solid tumor.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT07481578Recruiting
Exercise and gut health study for active men
This study looks at how your training load affects your gut bacteria and how that relates to exercise performance and muscle health. It may help understand overreaching in healthy men.
Leuven, Vlaams BrabantAges 18–45 - NCT07481110Recruiting
Study of stomach cancer in Algeria
This study looks at how stomach cancer is diagnosed and treated in Algeria. It helps doctors learn more about the disease to improve care for future patients.
Algiers, AlgeriaAges 19 years+ - NCT07485543RecruitingEarly Phase 1
Inhaled genetic therapy for cystic fibrosis patients
This trial tests an inhaled medicine that delivers a corrective genetic message (mRNA) to lung cells in people with cystic fibrosis. It aims to see if the treatment is safe and can improve lung function over time.
Beijing, Beijing MunicipalityAges 12 years+ - NCT07487311Recruiting
Study of guselkumab plus JAK inhibitors for tough-to-treat IBD
This trial tests a combination of two medications—guselkumab and a JAK inhibitor—for people with inflammatory bowel disease that hasn't responded to other treatments. The goal is to see if this combination is safe and effective for patients with hard-to-control Crohn's disease or ulcerative colitis.
Hangzhou, ZhejiangAges 14–80 - NCT07483359RecruitingPhase 2
Combination therapy for advanced liver cancer with portal vein tumor thrombus
This trial tests a combination of liver-directed chemotherapy, targeted therapy, and immunotherapy to shrink advanced liver cancer that has a blood clot in the portal vein (the main vein to the liver). The goal is to make the tumor removable by surgery.
Shenyang, LiaoningAges 18–80
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,599 recruiting gastroenterology studies from the U.S. registry right now, out of 11,991 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.