Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,599 recruiting studies in this area right now.
By phase
- Not applicable4,683
- Phase 21,187
- Phase 1568
- Phase 3457
- Phase 1/Phase 2366
- Phase 4228
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer478
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona189
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,599 total
- NCT07462091Recruiting
Nerve-guided surgery for enlarged spleen and bleeding risk
This study tests a special surgery using a nerve-guided technique to remove the enlarged spleen and reduce bleeding risk in people with cirrhosis and portal hypertension. It may help if you have an enlarged spleen and have had bleeding related to liver disease.
Yangzhou, JiangsuAges 18 years+ - NCT07461545Recruiting
Apixaban for late portal vein clot after spleen surgery
This trial tests if apixaban, a blood thinner, is more effective than aspirin at treating blood clots in the portal vein that form more than a year after laparoscopic spleen removal in people with cirrhosis and an enlarged spleen.
Yangzhou, JiangsuAges 18 years+ - NCT06478030Recruiting
Combined screening for stomach and bowel cancer
This study is testing a combined screening method for finding cancer in the stomach and intestines at an early stage. It is for people in Zhejiang Province who are willing to be screened and followed over time.
Jinhua, ZhejiangAges 40–74 - NCT06643793RecruitingPhase 2
Irinotecan liposome combo for advanced colorectal cancer
This trial tests a new form of the chemotherapy drug irinotecan (called irinotecan liposome) combined with two other chemo drugs and a targeted therapy (bevacizumab) for people with advanced colorectal cancer that has already been treated with oxaliplatin. The goal is to see if this combination can shrink tumors or slow the cancer's growth.
Nanjing, JiangsuAges 18–75 - NCT06522919RecruitingPhase 2
Immunotherapy and chemotherapy for advanced colorectal cancer
This trial tests a sequence of treatments for people with a specific type of advanced colorectal cancer (called pMMR or MSS) that has not responded to earlier therapies. Patients first receive an immunotherapy combination (pembrolizumab plus a personalized dendritic cell vaccine) followed by a chemotherapy pill (trifluridine/tipiracil) plus bevacizumab. The goal is to see if this sequence can help control the cancer.
Meldola, Forlì CesenaAges 18 years+ - NCT06696677Recruiting
Measuring small bowel length in repeat weight-loss surgery
This study compares two ways to measure the length of your small intestine during a second weight-loss surgery. One method uses a 3D CT scan before surgery, and the other uses a special tool during surgery. The goal is to see which method is more accurate and safer.
Cairo, Old CairoAges 16–70 - NCT06707233RecruitingPhase 2
Y-90 radioembolization for large liver cancer (over 7 cm)
This trial tests a treatment called Y-90 radioembolization (SIRT) for people with liver cancer that is too large to be removed surgically. The treatment delivers tiny radioactive beads directly to the tumor through the liver's blood supply, which may shrink the tumor and improve outcomes.
Guangzhou, GuangdongAges 18–75 - NCT06796218Recruiting
Arabic mobility test after abdominal surgery
This study tests how well a new Arabic version of a mobility scale works for people recovering from abdominal surgery. If you are between 40 and 60 years old and can read Arabic, you may be able to help.
Al MansurahAges 40–60 - NCT06132048Recruiting
Testing a smartphone app for cystic fibrosis
This study tests a smartphone app called MuCopilot that helps you track your cystic fibrosis symptoms at home. Researchers want to see if the app is easy to use and can give accurate information about your condition.
RouenAges 18 years+ - NCT04929912Recruiting
Registry for people treated with electroporation for cancer
This study is a real-world registry that collects information about people who have already received cancer treatment using electroporation methods. It may help researchers learn which treatments are used in practice and what outcomes people experience.
LondonAges Any age - NCT05465629Recruiting
Viome nutrition program for IBS symptoms
This trial studies whether a Viome nutrition program (based on supplement/formulation instructions) can improve symptoms in people with IBS. You may be asked to follow a specific nutrition plan and tracking steps for the study period.
Bothell, WashingtonAges 25–75 - NCT05829343Recruiting
Robotic versus laparoscopic surgery for left-sided diverticulitis
This trial compares robotic surgery versus laparoscopic surgery to remove part of the bowel for left-sided diverticulitis. It may help show which approach is safer or leads to better recovery for people needing elective or delayed-urgency surgery.
Grosseto, TuscanyAges 18 years+ - NCT05841420RecruitingPhase 2
Lower-intensity chemo for fragile pancreatic cancer patients
This Phase 2 trial compares a standard gemcitabine approach versus a reduced-dose combination chemotherapy for people with pancreatic cancer that can’t be removed by surgery. It aims to find a treatment that works while being safer for “fragile” patients who can’t tolerate full-dose chemotherapy.
AalborgAges 18 years+ - NCT05937438RecruitingPhase 1/Phase 2
Radiation then immunotherapy after esophagus surgery
This trial studies giving radiation right after esophagus surgery, followed by immunotherapy, to keep the cancer from coming back. It is for people with a specific type and stage of esophageal squamous cell carcinoma.
Hefei, AnhuiAges 18–75 - NCT06492395RecruitingPhase 3
Three treatments for large liver cancer with portal vein spread
This trial tests adding a second liver-directed treatment (hepatic artery infusion) to the usual combination of targeted therapy (lenvatinib) and chemoembolization (DEB-TACE) for people with large liver cancer that has spread into the portal vein, to see if the triple therapy works better.
Guangzhou, GuangdongAges 18–75 - NCT06386094Recruiting
Fatty Liver Disease and Heart Function Study
This study checks how fatty liver disease (a condition where fat builds up in the liver) affects the heart. If you have this liver condition and are between 18 and 65, you may help doctors understand the link between liver health and heart function.
Chandigarh, ChandigarhAges 18–65 - NCT06620627Recruiting
Blood test for early cancer detection before colonoscopy
This study is testing a new blood test that might help find cancer early. If you are 40 or older and planning a routine screening colonoscopy, you may be able to join. You will give a blood sample before the colonoscopy, and the researchers will see if the test can detect signs of cancer.
Austin, TexasAges 40 years+ - NCT06793137RecruitingPhase 2
Antibiotics before surgery for advanced rectal cancer
This trial tests if taking antibiotics before standard treatment can improve outcomes for people with advanced rectal cancer that requires surgery.
São Paulo, São PauloAges 18 years+ - NCT06799793Recruiting
AI screening for early colorectal cancer detection
This study uses an artificial intelligence model to analyze test results from the fecal immunochemical test (FIT) to help find colon cancer early. You may benefit if you are 50-69 and had a positive FIT result as part of a screening program.
Bologna, BolognaAges 50–69 - NCT07445386Recruiting
Nerve block for upper abdominal cancer pain
This trial compares two types of nerve blocks to treat severe pain from upper abdominal cancers like stomach, pancreas, or liver cancer. It may be an option if your pain hasn't been controlled with standard treatments.
AnkaraAges 18 years+ - NCT05636709Recruiting
Follow-up study for adults starting GMA for Crohn’s or colitis
This study follows adults with inflammatory bowel disease (Crohn’s disease or ulcerative colitis) after their doctor starts a treatment called GMA. It mainly looks at safety and how patients do in real-world care, and may help doctors understand how GMA works over time.
Albacete, AlbaceteAges 18 years+ - NCT05358262RecruitingPhase 2
Heated, humid air during stem cell transplant to reduce mouth injury
This Phase 2 study tests whether breathing in warm, very humid air through your nose during stem cell transplant (with high-dose melphalan) can reduce painful mouth or throat injury. It may help your comfort and recovery during and after treatment.
Edmonton, AlbertaAges 18 years+ - NCT06789679RecruitingPhase 2
Adding S-1 to standard chemo for advanced pancreatic cancer
This trial tests whether adding a third drug (S-1, a chemotherapy pill) to the standard two-drug IV chemo (albumin-bound paclitaxel and gemcitabine) can help people with advanced pancreatic cancer live longer. It's for those who haven't had treatment yet for their advanced cancer.
Beijing, Chaoyang DistrictAges 18 years+ - NCT06800326Recruiting
Comparing MRI and ultrasound for Crohn's treatment response
This trial compares two types of scans—MRI and ultrasound—to see how well they detect changes in Crohn's disease after treatment. If you've had one of these scans already and need another to check your response to therapy, you may be able to join.
LondonAges 16–99
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,599 recruiting gastroenterology studies from the U.S. registry right now, out of 11,991 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.