Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,599 recruiting studies in this area right now.
By phase
- Not applicable4,683
- Phase 21,187
- Phase 1568
- Phase 3457
- Phase 1/Phase 2366
- Phase 4228
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer478
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona189
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,599 total
- NCT05245877RecruitingPhase 4
Preventing blood clots before and after pancreatic surgery
This study compares two approaches to preventing blood clots around the time of pancreatic surgery. It may help lower the risk of dangerous clotting events after surgery, especially for people who are high risk.
TorontoAges 18–120 - NCT07400367Recruiting
Probiotics and lifestyle changes for fatty liver disease
This trial tests whether taking probiotics plus making lifestyle changes can improve fatty liver and metabolic health. You may qualify if you have liver fat and at least one sign of metabolic problems like high blood sugar or high blood pressure.
New Taipei CityAges 18–80 - NCT07401303Recruiting
Studying a new way to reduce risks during early stomach cancer surgery
This trial tests a technique called full-time RDI during ESD (a minimally invasive procedure to remove early stomach cancer). The goal is to see if it can lower the chance of serious side effects and shorten the procedure time. If you are scheduled for this surgery and meet the health requirements, you may be able to join.
Xi'an, ShaanxiAges 18–75 - NCT07406698Recruiting
Best timing for endoscopy in infected pancreatitis
This trial studies the best timing for using a camera down your throat to drain infected fluid pockets from severe pancreatitis. It is for people who are still in the hospital with signs of infection and who can have the procedure done within the first 26 days of their illness.
Orlando, FloridaAges 18 years+ - NCT07401173Recruiting
Computer tool to predict stomach cancer surgery complications
This trial uses a computer tool (DeepComp) to analyze your CT scan and predict possible complications after stomach cancer surgery. It may help doctors prepare for your recovery.
Shijiazhuang, None SelectedAges 18–85 - NCT07401680RecruitingPhase 1
Stool transplant for active ulcerative colitis
This trial tests whether a stool transplant (fecal microbiota transplantation) can help manage active ulcerative colitis. You would receive a transplant from a healthy donor to see if it improves your symptoms.
Calgary, AlbertaAges 18 years+ - NCT07406087Recruiting
Navigation support for young adults after cancer
This study tests a navigation program to help cancer survivors ages 21-45 get the follow-up care they need. It may be a good fit if you were diagnosed with certain cancers as a teen or young adult.
Pasadena, CaliforniaAges 21–45 - NCT07407231Recruiting
Chemo and radiation for advanced inoperable pancreatic cancer
This trial tests a combined treatment of chemotherapy followed by a precise type of radiation therapy (SBRT) for people with pancreatic cancer that cannot be surgically removed. It is designed for those who have not yet started treatment for locally advanced disease.
LjubljanaAges 18 years+ - NCT07400237Recruiting
New imaging for tough gallbladder removal
This study compares two advanced imaging methods—laparoscopic ultrasound and fluorescence cholangiography—to help surgeons see bile ducts more clearly during a difficult gallbladder removal. It aims to make the surgery safer for patients like you.
Sant Joan Despí, BarcelonaAges 18 years+ - NCT07398326RecruitingPhase 2
Drug combo for advanced colorectal cancer that hasn't spread to the liver
This trial tests a combination of two drugs (anlotinib and sintilimab) as a first treatment for people with advanced colorectal cancer that has spread to places other than the liver, who do not want chemotherapy. The goal is to see if this targeted therapy can help control the cancer.
ShanghaiAges 18 years+ - NCT07405931Recruiting
Managing chemo side effects with phone calls and a smartphone app
This study tests whether checking in by phone or smartphone app can help manage chemotherapy side effects. If you are starting a new chemo for stomach, lung, breast, or colon cancer, this program may support you from home.
BusanAges 19 years+ - NCT07399353Recruiting
Comparing two surgeries for high anal fistula
This study compares two surgical techniques (fistula rerouting and LIFT) for treating a high perianal fistula, a tunnel that forms in the muscle around the anus. It aims to find which method works better for people with this condition.
Cairo, Al-Manial CairoAges 20–65 - NCT07400328RecruitingPhase 2
Stem cell injection to prevent severe mouth sores in transplant
This trial is testing a single injection called Amimestrocel to prevent severe mouth sores in people getting a stem cell transplant. The study is for adults who are receiving high-dose conditioning with total body irradiation or melphalan, which often cause painful mouth inflammation.
Suzhu, JiangsuAges 18–65 - NCT07400783Recruiting
Study of short bowel syndrome in children
This study looks at short bowel syndrome in children who have had intestinal surgery. It may help doctors understand how to better treat this condition.
Florence, FlorenceAges 4 months–17 years - NCT07402083Recruiting
Testing a treatment from donor breast milk for early preterm babies
This trial studies a treatment made from special particles in donor breast milk, given to very early-born babies who are at risk of a serious gut infection called NEC. It aims to see if these particles can help protect their intestines.
Valencia, ValenciaAges birth–2 weeks - NCT07403136RecruitingPhase 2
Testing Becotatug Vedotin ± Immunotherapy for advanced esophageal cancer
This trial tests a new targeted drug (Becotatug Vedotin) given either alone or with an immunotherapy drug for people with advanced esophageal squamous cell cancer that has EGFR protein on their tumor cells. The goal is to see if this combination can help when standard treatments have stopped working.
ShanghaiAges 18 years+ - NCT07405125Recruiting
Robotic surgery for stomach tumors in tricky spots
This trial tests the safety of using a robot to remove small stomach tumors (GISTs) that are in hard-to-reach places. It aims to see if robotic surgery is a good option for you.
Nanjing, JiangsuAges 18–75 - NCT07401199Recruiting
AI predicts immunotherapy response in advanced stomach cancer
This trial uses artificial intelligence to analyze CT scans, blood, and tumor tissue to predict how well your cancer will respond to chemotherapy and immunotherapy before surgery. It aims to personalize treatment for locally advanced stomach or gastroesophageal junction cancer.
Fuyang, AnhuiAges 18 years+ - NCT07399860RecruitingPhase 2
Botox before hemorrhoid surgery to reduce pain after surgery
This trial tests whether injecting botulinum toxin (Botox) into the anal muscle before hemorrhoid removal surgery can lower pain after the operation. It is for people with advanced hemorrhoids that have not gotten better with other treatments and who are already planning to have surgery.
Moscow, MoscowAges 18 years+ - NCT07405476RecruitingPhase 2
Zanidatamab before surgery for HER2 positive colon or rectal cancer
This trial tests if the drug zanidatamab, given before surgery, can help treat colon or rectal cancer that has a specific marker called HER2. The goal is to see if this approach can shrink tumors and improve outcomes for people whose cancer has not spread to other parts of the body.
Atlanta, GeorgiaAges 18 years+ - NCT07404774Recruiting
stitch and laser treatment for hemorrhoids
This trial is testing a combined treatment for hemorrhoids that are causing symptoms. It uses a technique to stitch the hemorrhoid tissue back in place (suture mucopexy) plus a laser to shrink blood vessels. The goal is to see if this approach works well for people with grades II, III, or IV hemorrhoids, even if they've had other treatments before.
AthensAges 18 years+ - NCT07403604RecruitingPhase 1
Lowering Insulin to Reduce Fat Buildup in the Liver
This study tests if lowering insulin levels can reduce fat buildup in the liver for people with a fatty liver condition called MASLD. It's looking for adults who are overweight and have early signs of insulin resistance but not diabetes.
New York, New YorkAges 18–65 - NCT07399886Recruiting
Plant or dairy shake for cancer and heart patients at risk of malnutrition
This study compares two types of nutrition shakes (one plant-based and one dairy-based) for patients who are undernourished due to cancer, lung disease, heart problems, or recovery from surgery. It aims to see if the plant-based shake is just as good as the dairy shake.
Nijmegen, GelderlandAges 18 years+ - NCT07405086RecruitingPhase 4
Morning versus afternoon immunotherapy for advanced cancer
This trial tests whether getting your immunotherapy infusion in the morning or in the afternoon makes any difference in how well it works. If you have certain types of advanced cancer and are about to start a standard FDA-approved immunotherapy, this study may help you and others by finding the best time of day for treatment.
Portland, OregonAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,599 recruiting gastroenterology studies from the U.S. registry right now, out of 11,991 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.