Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,599 recruiting studies in this area right now.
By phase
- Not applicable4,683
- Phase 21,187
- Phase 1568
- Phase 3457
- Phase 1/Phase 2366
- Phase 4228
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer478
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona189
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,599 total
- NCT07303621Recruiting
Study of Trikafta in children with cystic fibrosis
This study looks at how the drug Trikafta (also called Kaftrio) works in children aged 2 to 17 with cystic fibrosis. The goal is to learn how the body processes the medicine so doctors can find the best dose.
BronAges 2–17 - NCT07305012Recruiting
Healthy lifestyle tool for older liver and kidney transplant recipients
This study tests a new tool designed to help people aged 60 or older who have received a liver or kidney transplant improve their eating and physical activity habits. It aims to see if the tool is easy to use and helpful for maintaining a healthy lifestyle.
Bologna, BOAges 60 years+ - NCT07305454Recruiting
Teaching exercise habits for Crohn's and colitis
This study tests whether structured education sessions about exercise can help people with Crohn's or colitis be more active. It looks at how this education affects your physical activity levels and overall health.
ToulouseAges 18–100 - NCT06876753Recruiting
Advanced liver cancer: TACE with immunotherapy and anti-angiogenesis
This trial is for people with advanced liver cancer (HCC) that has spread outside the liver. It tests whether combining a TACE procedure with immunotherapy and anti-angiogenesis drugs can improve outcomes. You must not have had prior systemic therapy and must have received TACE in a specific time window around starting these drugs.
Nanjing, JiangsuAges 18–80 - NCT06876805Recruiting
Ultrasound contrast to check unclear liver spots
This trial uses a special ultrasound with contrast dye to get a clearer picture of liver spots that other scans (CT, MRI, or PET) couldn't fully identify. The goal is to see if this ultrasound can help doctors make a more accurate diagnosis.
BolognaAges 18 years+ - NCT07293468RecruitingPhase 2/Phase 3
Comparing two treatments for advanced liver cancer
This trial tests two different ways to treat liver cancer that can't be removed with surgery. It compares stereotactic body radiation therapy (targeted high-dose radiation) with selective internal radiation therapy (tiny radioactive beads delivered through a blood vessel), both combined with immunotherapy (medicines that help your immune system fight cancer).
Hong KongAges 18–80 - NCT07289100Recruiting
Smart home monitoring for lung flare-ups in CF and bronchiectasis
This trial tests if a smart home monitoring system (using sensors and AI) can detect sudden lung flare-ups early in people with cystic fibrosis or bronchiectasis. It may help you get treatment sooner when you are admitted to the hospital for IV antibiotics.
Cambridge, CambridgeshireAges 18 years+ - NCT07291141Recruiting
MRI vs. Ultrasound for Liver Cancer Detection in Cirrhosis
This study compares MRI and ultrasound to see which is better at finding liver cancer early in people with liver cirrhosis. It also looks at body composition and other factors that could lead to worsening liver function.
Linköping, Select A State Or ProvinceAges 18 years+ - NCT05385237Recruiting
4D MRI scan to spot liver scarring
This study tests whether a special MRI scan (called 4D-MRI) can identify liver scarring or damage. It may help doctors measure liver fibrosis and inflammation without relying only on invasive tests.
Liestal, Basel-LandschaftAges 18 years+ - NCT07290764Enrolling by invitation
Surgery vs observation for liver cancer that responded to drug therapy
This trial looks at whether people with an initially untreatable liver cancer that has shrunk or disappeared after drug therapy should have surgery or just continue monitoring. It aims to see which approach helps people live longer.
Fuzhou, FujianAges 18–75 - NCT07296692Recruiting
Does a protein drink change stomach emptying in older adults?
This study tests if a special drink with protein and carbs affects how fast the stomach empties in healthy older adults. It aims to improve nutritional care for elderly people.
Belo Horizonte, Minas GeraisAges 60–90 - NCT07290985RecruitingPhase 2
Can biomarkers guide organ-sparing treatment for stomach and esophagus cancer?
This trial tests if using specific biomarkers (like HER2 and PD-L1) can help choose the best treatment to potentially avoid surgery. It aims to preserve the stomach or esophagus while effectively treating the cancer.
Los Angeles, CaliforniaAges 18 years+ - NCT07291180Recruiting
Personalized heated chemo for advanced appendix or colon cancer
This study tests a personalized way to deliver heated chemotherapy directly into the belly during surgery for advanced appendix or colorectal cancer that has spread to the lining of the abdomen. The goal is to see if tailoring the chemo drugs to your tumor can improve outcomes.
New Haven, ConnecticutAges 18–81 - NCT07290010RecruitingPhase 2
Iparomlimab plus chemotherapy for advanced esophageal cancer
This trial tests a combination of two immunotherapy drugs (Iparomlimab and Tuvonralimab) with chemotherapy as a first treatment for advanced esophageal squamous cell carcinoma. It aims to see if this combination is safe and effective for people whose cancer cannot be removed by surgery or has spread.
Shijiazhuang, HebeiAges 18 years+ - NCT07289997RecruitingPhase 2
Combination therapy for advanced AFP-producing gastric cancer
This trial tests a combination of two immunotherapy drugs (iparomlimab and tuvonralimab) plus a targeted therapy (apatinib) and a chemotherapy drug (irinotecan hydrochloride) for people with a rare type of advanced stomach cancer called AFP-producing gastric cancer. It is for patients whose cancer did not respond to previous immunotherapy combined with chemotherapy.
Shijiazhuang, HebeiAges 18 years+ - NCT07288346Recruiting
Predicting success of double-balloon endoscopy
This trial uses a CT scan to predict how well a special endoscope can reach the entire small intestine. It may help doctors plan your procedure and improve results.
Dezhou, ShandongAges 18–80 - NCT07295275Recruiting
Fluorescence-guided surgery for liver cancer
This trial tests a new way to remove liver cancer during surgery. A special dye called ICG is injected into the artery leading to the liver, which makes the tumor glow under a special camera, helping the surgeon remove just the right area. This study checks if this technique is both safe and effective for people with a common type of liver cancer (hepatocellular carcinoma).
Beijing, Beijing MunicipalityAges 18–80 - NCT07290309Recruiting
Remote exercise program for cancer survivors
This study tests a remote guided exercise program for cancer survivors to see if it helps with recovery and well-being. It is designed for people who have finished their main cancer treatments and are not already exercising a lot.
Fort Collins, ColoradoAges 18 years+ - NCT07296887Recruiting
Care tool study for cancer teams and patients
This study tests a new care tool for people with gynecologic, prostate, lung, or colorectal cancer. It helps your care team (doctors, nurses, social workers) and patients like you see if the tool improves support and communication.
Alton, IllinoisAges 18 years+ - NCT07291414Recruiting
Tracking cancer medication safety with a self-monitoring platform
This trial tests a platform where you can track your experiences and concerns about cancer medications. It aims to help you and your care team manage medication safety.
Ann Arbor, MichiganAges 18 years+ - NCT07293624Enrolling by invitation
Diet and inflammation after weight-loss surgery
This study looks at how your diet affects inflammation and stomach symptoms after weight-loss surgery. You'll fill out food records and have blood tests to see how your eating habits relate to your health.
Istanbul, UskudarAges 18–65 - NCT07293650RecruitingPhase 3
Precision medicine for achalasia treatment study
This trial compares different treatments for achalasia or related swallowing problems. It aims to find the best personalized approach to improve your symptoms.
Scottsdale, ArizonaAges 18 years+ - NCT07289568Enrolling by invitation
Comparing surgery types for splenic flexure cancer
This study looks at two types of surgery for cancer in a part of the colon called the splenic flexure. It compares removing just the affected section (segmental colectomy) with removing a larger portion (extended hemicolectomy) to see which has better outcomes.
Istanbul, IstanbulAges 18–80 - NCT07295990Recruiting
Tongue exercises for people with ALS
This trial tests whether simple tongue-strengthening exercises can help people with ALS who have mild swallowing trouble. If you have ALS and notice your tongue getting weaker, this study may help you keep your swallowing strength.
Davie, FloridaAges 18–99
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,599 recruiting gastroenterology studies from the U.S. registry right now, out of 11,991 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.