Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,599 recruiting studies in this area right now.
By phase
- Not applicable4,683
- Phase 21,187
- Phase 1568
- Phase 3457
- Phase 1/Phase 2366
- Phase 4228
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer478
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona189
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,599 total
- NCT07290764Enrolling by invitation
Surgery vs observation for liver cancer that responded to drug therapy
This trial looks at whether people with an initially untreatable liver cancer that has shrunk or disappeared after drug therapy should have surgery or just continue monitoring. It aims to see which approach helps people live longer.
Fuzhou, FujianAges 18–75 - NCT07293689Recruiting
Precision Medicine in Achalasia (PREMEDIA) Study
This study at Northwestern University is looking for people with certain severe esophageal motility disorders (like achalasia) to see if a personalized medicine approach can improve treatment. It focuses on those who haven't had prior surgery or recent endoscopic treatments.
Scottsdale, ArizonaAges 18 years+ - NCT07296692Recruiting
Does a protein drink change stomach emptying in older adults?
This study tests if a special drink with protein and carbs affects how fast the stomach empties in healthy older adults. It aims to improve nutritional care for elderly people.
Belo Horizonte, Minas GeraisAges 60–90 - NCT07287943Recruiting
Medtronic pump study for diabetes and gastroparesis
This study tests whether the Medtronic 780G insulin pump helps people with type 1 diabetes and gastroparesis (slowed stomach emptying) control their blood sugar better than their usual care. It requires continuous glucose monitoring and certain blood sugar levels.
Indianapolis, IndianaAges 18 years+ - NCT07295262RecruitingEarly Phase 1
New imaging to guide liver cancer surgery
This trial tests a new imaging technique that uses a special dye combined with a chemotherapy drug to help surgeons see and remove liver cancer more precisely during surgery. It is for people with a first-time, single liver tumor that is small and can be surgically removed.
Chengdu, SichuanAges 18–75 - NCT07295236Recruiting
Vacuum therapy for a leak after stomach surgery
This trial tests whether a treatment called endoscopic vacuum therapy can help heal a small leak that can happen after stomach removal surgery. If you are stable and the leak is small, this treatment may help you avoid more surgery.
KyivAges 18–90 - NCT07296237Recruiting
Women's sexual health after anal cancer radiation
This study looks at how women feel about their gynecological and sexual health after finishing radiation therapy for anal cancer. It may help doctors learn how to better support their patients after treatment.
AarhusAges 18 years+ - NCT07295886Recruiting
Cream for Protruding Hemorrhoids
This trial tests a cream containing two medicines (nifedipine and lidocaine) for painful, protruding hemorrhoids. The cream may help reduce pain and swelling. You can join if you have moderate to severe hemorrhoids that come out of the anus and have already started the cream in the last five days.
NaplesAges 18–75 - NCT07294638Recruiting
New imaging method to find cancer spread in early gastric cancer
This trial tests a new dye that helps surgeons see if early gastric cancer has spread to nearby lymph nodes. It might help guide the extent of surgery needed.
Guangzhou, GuangdongAges 18 years+ - NCT07289672Enrolling by invitation
Food limits in Crohn's and colitis
This study looks at how diet affects people with Crohn's disease or ulcerative colitis who have moderate inflammation. It aims to understand if certain foods make symptoms worse or better.
MalmöAges 18 years+ - NCT07289997RecruitingPhase 2
Combination therapy for advanced AFP-producing gastric cancer
This trial tests a combination of two immunotherapy drugs (iparomlimab and tuvonralimab) plus a targeted therapy (apatinib) and a chemotherapy drug (irinotecan hydrochloride) for people with a rare type of advanced stomach cancer called AFP-producing gastric cancer. It is for patients whose cancer did not respond to previous immunotherapy combined with chemotherapy.
Shijiazhuang, HebeiAges 18 years+ - NCT07295340Recruiting
New imaging dye test for liver cancer detection
This trial tests a special dye that targets liver cancer cells to help surgeons see tumor edges more clearly during surgery. It may help ensure all cancer is removed in one operation.
Chengdu, SichuanAges 18–80 - NCT07288346Recruiting
Predicting success of double-balloon endoscopy
This trial uses a CT scan to predict how well a special endoscope can reach the entire small intestine. It may help doctors plan your procedure and improve results.
Dezhou, ShandongAges 18–80 - NCT07290985RecruitingPhase 2
Can biomarkers guide organ-sparing treatment for stomach and esophagus cancer?
This trial tests if using specific biomarkers (like HER2 and PD-L1) can help choose the best treatment to potentially avoid surgery. It aims to preserve the stomach or esophagus while effectively treating the cancer.
Los Angeles, CaliforniaAges 18 years+ - NCT07294664RecruitingPhase 2
Drug combo trial for first treatment of advanced stomach cancer
This trial tests a combination of an immunotherapy drug (PD1/TGFβ), another targeted drug (SHR2554 or apatinib), and chemotherapy for people who have not yet been treated for advanced stomach cancer. The goal is to see if this combination works better than standard treatments.
Zhengzhou, HenanAges 18 years+ - NCT07296315RecruitingPhase 2
Testing a new treatment for mild-to-moderate ulcerative colitis
This study tests an investigational drug for people with active mild-to-moderate ulcerative colitis. It aims to see if the drug can improve symptoms without needing advanced treatments like biologics.
Miami, FloridaAges 16 years+ - NCT07291076RecruitingPhase 1/Phase 2
Study of Pumitamig with Ipilimumab for first-line advanced liver cancer
This trial tests a new drug called pumitamig, either alone or with another drug (ipilimumab), for people with advanced liver cancer that hasn't been treated yet. The goal is to see if these drugs can help shrink or control the cancer.
Duarte, CaliforniaAges 18 years+ - NCT07293897Recruiting
Study of Livmarli for Alagille Syndrome and PFIC
This study looks at how well Livmarli works for people with Alagille syndrome or a liver disease called PFIC. It uses data from prescriptions to understand the treatment's effects.
Tokyo, TokyoAges Any age - NCT07288138RecruitingPhase 2
Study of a New Drug for MASH (Fatty Liver Disease)
This study is testing a new drug that targets thyroid hormone receptors in the liver, alone or combined with another drug, to reduce inflammation and scarring in people with MASH (a type of fatty liver disease). If you have MASH with moderate liver scarring and are otherwise healthy, this trial may help find a new treatment option.
Chandler, ArizonaAges 18–75 - NCT07290257RecruitingPhase 4
Long-term safety study of Livmarli for Alagille syndrome or PFIC
This study looks at the long-term safety and effects of Livmarli (maralixibat) in children with Alagille syndrome or progressive familial intrahepatic cholestasis (PFIC). It may help understand how well the medicine works over time for itching and other symptoms.
BrusselsAges 2 months+ - NCT07291700Recruiting
Talcid for acid rebound after stopping long-term PPI therapy
This study tests whether Talcid chewable tablets can relieve the acid reflux symptoms that often happen when you stop taking a long-term daily acid-reducing medicine (like omeprazole). It is for people whose doctor says they no longer need that medicine.
LeverkusenAges 18 years+ - NCT04374175Recruiting
Blood sample bank for pancreatic cancer patients and controls
This study collects and stores blood samples (“serum bank”) from people with pancreatic cancer and from comparison participants. The goal is to help researchers study the disease and improve future diagnosis or treatment planning.
Saint-EtienneAges 18 years+ - NCT05939401Recruiting
Tissue study during and after anal cancer treatment
This study looks at how anal cancer tissue and samples change during and after treatment. Your participation may help doctors understand treatment response, especially for people with newly diagnosed or returning anal cancer.
GothenburgAges 18 years+ - NCT06757244RecruitingPhase 2
Dovipa: Immunotherapy and vitamin D with chemo for advanced pancreatic cancer
This trial tests whether combining the immunotherapy dostarlimab with vitamin D3 and standard chemotherapy (mFOLFIRINOX) can help people with stage IV pancreatic cancer. It aims to see if this new approach is safe and effective.
MarseilleAges 18–75
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,599 recruiting gastroenterology studies from the U.S. registry right now, out of 11,991 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.