Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,606 recruiting studies in this area right now.
By phase
- Not applicable4,686
- Phase 21,188
- Phase 1568
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer479
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Hepatocellular Carcinoma (HCC)114
- Colon Cancer112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Chinese University of Hong Kong56
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona190
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,606 total
- NCT07128966Recruiting
Collect biospecimens and health data for research
This study collects blood, saliva, or other biospecimens and health information from people with certain medical conditions. Your samples and data will help researchers better understand diseases and develop new treatments.
Lexington, MassachusettsAges 18–90 - NCT07128797RecruitingPhase 1
Safety and tolerability of B1344 injections for NAFLD
This trial tests whether multiple injections of B1344 are safe and tolerable in people with nonalcoholic fatty liver disease (NAFLD). It aims to find the right dose and check how the drug works in the body.
Beijing, Beijing MunicipalityAges 18–75 - NCT07132970Recruiting
Leakage rate of sutured bowel connection after right colon removal
This trial is testing how well hand-sewn or partially stitched connections (anastomoses) hold up after right colon removal for cancer. It may help improve surgical techniques for people undergoing this operation.
Göppingen, Baden-WurttembergAges 18 years+ - NCT07127874RecruitingPhase 1
Study of PHN-012 for advanced solid tumors
This trial tests a new drug called PHN-012 for people with advanced colorectal, non-small cell lung, or pancreatic cancer who have already tried at least one standard treatment. The goal is to see if the drug can help shrink or slow tumor growth.
Los Angeles, CaliforniaAges 18 years+ - NCT03959904Recruiting
Compare belly-skin closure methods after kidney transplant surgery
This study looks at which abdominal wall (belly) closure technique helps reduce the chance of an incisional hernia after a kidney transplant. If you’re having a kidney transplant, it may help surgeons choose a method that lowers this complication for future patients.
ManchesterAges 18–70 - NCT07126301Recruiting
Aromatherapy with essential oils for nausea and anxiety during chemotherapy
This study tests whether using essential oils (like lavender, peppermint, or ginger) can help reduce nausea and anxiety in people receiving chemotherapy that often causes these side effects. If you've had significant nausea after your last chemo session, this therapy might offer a natural way to help you feel better during upcoming treatments.
Duarte, CaliforniaAges 18 years+ - NCT07132463RecruitingPhase 3
Study of extra treatment for ultra-low rectal cancer
This trial tests if adding an immunotherapy drug (tislelizumab) to standard chemoradiation and chemotherapy helps patients with ultra-low rectal cancer. It is for patients whose cancer has not spread and can be removed with surgery.
ShanghaiAges 18–75 - NCT07128953Enrolling by invitationEarly Phase 1
Zuoqing San for anal fistula wound healing
This study tests if a traditional Chinese medicine called Zuoqing San can help heal the wound after anal fistula surgery better by reducing certain inflammatory processes. It may be an option for people who have had surgery for a simple anal fistula and whose wound is a specific size.
Hefei, AnhuiAges 18 years+ - NCT07130903RecruitingPhase 2
Fruquintinib plus special radio waves for advanced colon cancer
This trial tests whether combining fruquintinib (a pill) with low-level radio waves can help people whose metastatic colorectal cancer has stopped responding to or is intolerant of standard treatments. It’s for those who have tried certain chemotherapies and anti-VEGF therapy.
Bay City, MichiganAges 22 years+ - NCT07127354RecruitingPhase 4
GLP-1 medications and colonoscopy prep quality
This study tests whether a special bowel preparation plan works better for people taking GLP-1 or GIP medications (like Ozempic, Mounjaro) before a colonoscopy. It aims to improve the quality of the bowel cleaning so doctors can see the colon more clearly.
Cleveland, FloridaAges 18 years+ - NCT07128979RecruitingPhase 4
Studying butcher’s broom for moderate hemorrhoids
This study tests a plant-based medication made from butcher’s broom (Ruscus aculeatus) to see if it safely helps people with moderate hemorrhoids. If you have stage II or III hemorrhoids and are between 18 and 45, you may be able to join.
IstanbulAges 18–45 - NCT07128108Recruiting
Testing a new ultrasound for liver fat and scarring
This study tests a new ultrasound technique called Visual Transient Elastography (ViTE) to measure fat and scarring in the liver. If you recently had a liver biopsy, this noninvasive test could help check your liver health without another needle procedure.
Shanghai, Shanghai MunicipalityAges 18–65 - NCT07130318Recruiting
Mediterranean diet and exercise for fatty liver in FMF
This trial tests if a Mediterranean diet plus aerobic exercise can improve fatty liver in women with Familial Mediterranean Fever (FMF) who are also obese. It aims to see if these lifestyle changes help liver health.
Dokki, Giza GovernorateAges 30–55 - NCT07135427RecruitingPhase 4
Genes and vaccines in alpha-1 antitrypsin deficiency
This study looks at how genetic differences in alpha-1 antitrypsin deficiency affect immune response to a pneumonia vaccine. It may help find better ways to prevent lung infections.
Birmingham, AlabamaAges 19 years+ - NCT07127822RecruitingPhase 2
Testing a new immunotherapy combo for MSI-H gastric cancer
This trial tests a combination of two immunotherapy drugs (iparomlimab and tuvonralimab) for people with advanced gastric cancer that has a specific DNA repair problem (MSI-H/dMMR). It is for those who have not yet had any treatment for their advanced cancer.
Shijiazhuang, HebeiAges 18 years+ - NCT07132541RecruitingPhase 1
New surgical glue technique for pancreas connection after Whipple surgery
This trial tests a new method using a surgical glue called N-butyl-2-cyanoacrylate to seal the pancreas after a Whipple procedure. It may help prevent leaks and improve recovery for patients with a soft pancreas and small pancreatic duct.
Minya, Minya GovernorateAges 18–75 - NCT07131514RecruitingPhase 2
Combination therapy for pancreatic cancer before and after surgery
This trial tests if giving a combination of four drugs before and after surgery can help treat pancreatic cancer. The drugs include HRS-4642, gemcitabine, nab-paclitaxel, and adebrelimab. It may help shrink the tumor before surgery and lower the chance of cancer coming back afterward.
ShanghaiAges 18–80 - NCT07129512Recruiting
Ultrasound vs clips to control bleeding in colon cancer surgery
This study compares two ways to stop bleeding during minimally invasive colon cancer surgery: using a special ultrasound device or standard surgical clips. It aims to see which method works better and is safer for patients like you.
SeoulAges 19–80 - NCT07127952Enrolling by invitation
Nail fold test for stomach blood vessel condition
This study looks at whether a simple nail fold test can detect changes in small blood vessels that match changes seen in the stomach. It may help people with a stomach condition called GAVE, especially if they also have a connective tissue disease.
Jacksonville, FloridaAges 18–95 - NCT07131397Recruiting
Breathing muscle training for GERD
This trial tests whether strengthening your breathing muscles can help reduce GERD symptoms. You may be eligible if you have GERD and are in generally good health without other major conditions.
Athens, AtticaAges 18–70 - NCT07132918RecruitingPhase 2
Heart-Sparing Radiation for Thoracic Cancers
This trial tests a new way to plan radiation for cancers in the chest area (like lung, esophageal, or thymus cancers) that aims to protect the heart from high doses of radiation. It is for people who need daily radiation for at least three weeks and who are expected to live more than a year.
Madison, WisconsinAges 18 years+ - NCT07134790RecruitingPhase 2
Probiotics to improve gut health during pregnancy
This trial tests whether taking probiotics during pregnancy can improve gut health in mothers living in areas where gut infections are common. It is for women who are in their first or early second trimester and who have certain bacteria in their stool.
Bobo-DioulassoAges 18 years+ - NCT07130864Recruiting
Timing of gallbladder surgery after ERCP for bile duct stones
This trial compares having gallbladder removal surgery early versus later after clearing bile duct stones with an ERCP procedure. It aims to find the best timing to prevent future problems.
Peshawar, KhyberpukhtunkhwaAges Any age - NCT07132515RecruitingPhase 4
Blood thinners for cirrhosis with portal vein clot
This study tests whether blood thinners (anticoagulants) are safe and effective for people with cirrhosis and a blood clot in the portal vein. It may also include people with liver cancer (HCC).
Al Mansurah, Dakahlia GovernorateAges 18–70
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,606 recruiting gastroenterology studies from the U.S. registry right now, out of 12,023 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.