Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,896 recruiting studies in this area right now.
By phase
- Not applicable4,922
- Phase 21,186
- Phase 1581
- Phase 3466
- Phase 1/Phase 2394
- Phase 4236
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer492
- Gastric Cancer297
- Pancreatic Cancer292
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer147
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer98
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic74
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California462
- Arizona177
- Texas149
- Florida134
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio80
- Pennsylvania72
Recruiting studies7,896 total
- NCT06805045Recruiting
Image-guided surgery for rectal cancer
This trial uses special imaging to guide surgery for rectal cancer. It studies whether detailed scans taken before surgery can help doctors remove the cancer more precisely.
BolognaAges 18–80 - NCT06805552Recruiting
Sarcopenia and targeted therapy in liver cancer
This study looks at muscle loss in people with liver cancer who are receiving targeted therapy (TKIs). It aims to understand how muscle health affects treatment outcomes. You may qualify if you have intermediate or advanced liver cancer or earlier stage that hasn't responded to prior treatments.
BolognaAges 18 years+ - NCT06805825RecruitingPhase 1
Study of NN3201 for advanced cancers with c-Kit
This trial tests a new drug, NN3201, that targets a protein called c-Kit found on some cancer cells. It may be an option for people with certain advanced solid tumors, including GIST, small cell lung cancer, or other c-Kit-positive cancers, who have already tried standard treatments or cannot take them.
Ann Arbor, MichiganAges 18 years+ - NCT06805903Recruiting
Validating a survey on transanal irrigation adherence
This study tests a new survey to better understand how well people are following their transanal irrigation treatment. If you use this treatment for bowel issues, the researchers want to see if the survey accurately measures your routine.
ParisAges 18 years+ - NCT06805890Recruiting
Tissue repair study in IBD using organoid technology
This study collects tissue samples from people with Crohn's disease or ulcerative colitis during routine colonoscopy or surgery to grow mini-organs (organoids) in the lab. The goal is to learn how the gut heals itself, which could lead to better treatments.
MarseilleAges 18 years+ - NCT06806579Recruiting
Immunotherapy for advanced liver cancer
This trial studies how well immunotherapy drugs (atezolizumab and bevacizumab) work for people with advanced liver cancer that cannot be treated with local procedures. It looks at real-life results to see if these treatments help people live longer and feel better.
Torrette, ANAges 18 years+ - NCT06807437RecruitingPhase 3
Testing lanreotide before pancreas surgery to prevent leaks
This trial tests if a medicine called lanreotide, given before surgery, can prevent a common complication (pancreatic leak) after removing part of the pancreas. It is for people with pancreatic cancer or a growth that could become cancer who are scheduled for a specific type of pancreas surgery.
Birmingham, AlabamaAges 18 years+ - NCT06808074RecruitingPhase 4
Inhaled amikacin to prevent pneumonia in cirrhosis patients on ventilators
This trial tests whether inhaling an antibiotic called amikacin can prevent ventilator-associated pneumonia in patients with severe liver disease (cirrhosis) who are on a breathing machine. If you or your loved one is in the ICU with liver issues and needs a ventilator, this study may help reduce the risk of a serious lung infection.
Hyderabad, TelanganaAges 18 years+ - NCT06808685Recruiting
Study of Elovie for advanced colorectal cancer
This study looks at how well a biosimilar version of bevacizumab (Elovie) works in people with advanced colorectal cancer that has spread and cannot be surgically removed. It aims to see if Elovie is safe and effective when used as the first treatment for this cancer.
Vitória, Espírito SantoAges 18 years+ - NCT06809660Recruiting
Gut bacteria and cancer risk from everyday chemicals
This study looks at how chemicals in the environment (called endocrine disruptors) might affect the natural bacteria in your gut and whether that could play a role in colorectal cancer. If you are having a colonoscopy (endoscopy), you may be able to participate.
PoitiersAges 18 years+ - NCT06810518Recruiting
Studying stool test for digestive disease diagnosis
This trial tests a new stool test to measure calprotectin levels, which could help doctors tell the difference between inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). If you have symptoms like stomach pain, diarrhea, or weight loss and are about to have a colonoscopy, you may be able to join.
Miami, FloridaAges 22 years+ - NCT06812728RecruitingPhase 2
Chemo and radiation before surgery for advanced rectal cancer
This trial tests giving a strong chemotherapy combination (FOLFIRINOX) followed by radiation before surgery for locally advanced rectal cancer. If you have stage 3 or high-risk stage 2 rectal cancer that has not spread, this approach may shrink the tumor and improve outcomes.
Shibīn al Kawm, MenoufiaAges 18–70 - NCT06813079RecruitingPhase 2
Using tumor models to find your best treatment
This trial uses a personalized approach where a sample of your tumor is grown in the lab to test which drugs might work best for you. It is for people with advanced pancreatic cancer that cannot be surgically removed.
Toronto, OntarioAges 18 years+ - NCT06813508Recruiting
Liver cancer and transplant study for MASLD patients
This study looks at factors that predict liver cancer and the need for a liver transplant in people with a liver condition called MASLD (metabolic dysfunction-associated steatotic liver disease). The goal is to better understand the disease and improve care.
Bologna, BolognaAges 18 years+ - NCT06814457Recruiting
Nursing care bundle for swallowing after breathing tube removal in children
This trial tests a special nursing care plan to help children who had a breathing tube eat and drink safely after it's removed. It aims to reduce swallowing problems in the intensive care unit.
Kafr ash Shaykh, Kafr Ash Shaykh, Kafr el-Sheikh, Egypt,Ages 6–18 - NCT06814600Recruiting
Fatty liver study in inflammatory bowel disease patients
This study checks how often people with Crohn's or ulcerative colitis also have fatty liver disease. It uses a painless scan to measure liver stiffness and fat. If you have IBD, you may join to help researchers learn about the link between these conditions.
BrusselsAges 18 years+ - NCT06815406Recruiting
Removing large colon polyps: one piece vs. multiple pieces
This trial compares two ways to remove large, flat polyps (granular type) from the colon or rectum: one that removes the polyp in one piece (endoscopic submucosal dissection) and one that removes it in pieces (endoscopic mucosal resection). The goal is to see which method has a lower chance of the polyp coming back.
BolognaAges 18 years+ - NCT06815822Recruiting
Preventing hernias after emergency surgery
This study tests a way to prevent hernias after emergency belly surgery. If you are having emergency surgery for certain conditions, you may be able to join.
KielceAges 18–100 - NCT06816615Recruiting
Treating gallstones and bile duct problems through the skin
This trial tests a new way to diagnose and treat gallstones or bile duct narrowing without surgery, using a needle through the skin (percutaneous treatment). It is for people whose condition could not be fixed with an endoscope.
Bologna, BOAges 18 years+ - NCT06816823RecruitingPhase 1
CAR-NK Cells for Advanced Pancreatic Cancer
This trial tests a new type of immunotherapy called CAR-NK cells (CL-NK-001) for patients with advanced pancreatic cancer that has a specific marker (eGR1). The goal is to see if these specially grown natural killer cells can attack the cancer after standard treatments have stopped working.
ShanghaiAges 18–70 - NCT06817161RecruitingPhase 3
Nerve stimulation for quality of life during ovarian cancer treatment
This trial tests if a gentle nerve stimulation device on the ear can improve quality of life for people with ovarian cancer who are starting their first chemotherapy. It may help manage symptoms like fatigue or feeling sick.
CaenAges 18 years+ - NCT06817213Recruiting
Decision support for eosinophilic esophagitis (EoE) patients
This study tests a decision aid (a simple tool) to help adults with EoE make choices about their care. You may be able to join if you are a new EoE patient at the University of Michigan, are 18 or older, speak English, and have internet access.
Ann Arbor, MichiganAges 18 years+ - NCT06819215RecruitingPhase 1/Phase 2
VB15010 for advanced solid tumors with HRR gene mutation
This trial tests an oral medication (VB15010) in people with advanced solid tumors that have a specific DNA repair gene mutation (called HRR mutation). The goal is to see if the drug can stop or slow down cancer growth.
Jinan, ShandongAges 18–75 - NCT06819566RecruitingPhase 2
Preventing bleeding from enlarged veins in the esophagus
This study tests whether tying off high-risk veins in the esophagus before starting a common liver cancer treatment can prevent bleeding. It is for people with liver cancer that has spread but who have never had cancer treatment before.
Seoul, Song-paAges 19–80
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,896 recruiting gastroenterology studies from the U.S. registry right now, out of 12,425 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.