Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,903 recruiting studies in this area right now.
By phase
- Not applicable4,926
- Phase 21,187
- Phase 1582
- Phase 3466
- Phase 1/Phase 2395
- Phase 4236
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer493
- Gastric Cancer297
- Pancreatic Cancer292
- Hepatocellular Carcinoma284
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer147
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer101
- Lung Cancer98
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University91
- Mayo Clinic74
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California462
- Arizona177
- Texas149
- Florida135
- Massachusetts127
- New York123
- Alabama122
- Maryland86
- Ohio80
- Pennsylvania72
Recruiting studies7,903 total
- NCT07126158RecruitingPhase 2
Radiation plus targeted drugs for advanced pancreatic cancer
This trial tests a combination of targeted radiation and two oral drugs (defactinib and avutometinib) for people with advanced pancreatic cancer that hasn't spread to distant organs. It may be an option if you've already had at least 2 months of chemo and your cancer is still locally advanced or borderline resectable.
St Louis, MissouriAges 18 years+ - NCT07126535Recruiting
Radiofrequency ablation effects on the esophagus
This study looks at how radiofrequency ablation (RFA) affects the flexibility and lining of the esophagus in people with Barrett's esophagus and early cancer. It may help doctors understand how this treatment works.
Rochester, MinnesotaAges 18 years+ - NCT07128355RecruitingEarly Phase 1
Combined immunotherapy and radiation for colorectal cancer
This trial tests the combination of two immunotherapy drugs (botensilimab and balstilimab) plus targeted radiation to liver tumors. It's for people with colorectal cancer that has spread and hasn't responded to standard treatments.
Boston, MassachusettsAges 18 years+ - NCT07128797RecruitingPhase 1
Safety and tolerability of B1344 injections for NAFLD
This trial tests whether multiple injections of B1344 are safe and tolerable in people with nonalcoholic fatty liver disease (NAFLD). It aims to find the right dose and check how the drug works in the body.
Beijing, Beijing MunicipalityAges 18–75 - NCT07128979RecruitingPhase 4
Studying butcher’s broom for moderate hemorrhoids
This study tests a plant-based medication made from butcher’s broom (Ruscus aculeatus) to see if it safely helps people with moderate hemorrhoids. If you have stage II or III hemorrhoids and are between 18 and 45, you may be able to join.
IstanbulAges 18–45 - NCT07128966Recruiting
Collect biospecimens and health data for research
This study collects blood, saliva, or other biospecimens and health information from people with certain medical conditions. Your samples and data will help researchers better understand diseases and develop new treatments.
Lexington, MassachusettsAges 18–90 - NCT07129512Recruiting
Ultrasound vs clips to control bleeding in colon cancer surgery
This study compares two ways to stop bleeding during minimally invasive colon cancer surgery: using a special ultrasound device or standard surgical clips. It aims to see which method works better and is safer for patients like you.
SeoulAges 19–80 - NCT07130318Recruiting
Mediterranean diet and exercise for fatty liver in FMF
This trial tests if a Mediterranean diet plus aerobic exercise can improve fatty liver in women with Familial Mediterranean Fever (FMF) who are also obese. It aims to see if these lifestyle changes help liver health.
Dokki, Giza GovernorateAges 30–55 - NCT07130864Recruiting
Timing of gallbladder surgery after ERCP for bile duct stones
This trial compares having gallbladder removal surgery early versus later after clearing bile duct stones with an ERCP procedure. It aims to find the best timing to prevent future problems.
Peshawar, KhyberpukhtunkhwaAges Any age - NCT07131293Recruiting
European registry study on lymphatic treatments
This study is for people of any age with a confirmed central lymphatic disorder (a problem in the main lymphatic vessels, often linked to heart conditions or occurring on its own). Researchers want to collect information from different hospitals to learn more about these disorders and the best ways to treat them.
CopenhagenAges Any age - NCT07131397Recruiting
Breathing muscle training for GERD
This trial tests whether strengthening your breathing muscles can help reduce GERD symptoms. You may be eligible if you have GERD and are in generally good health without other major conditions.
Athens, AtticaAges 18–70 - NCT07131514RecruitingPhase 2
Combination therapy for pancreatic cancer before and after surgery
This trial tests if giving a combination of four drugs before and after surgery can help treat pancreatic cancer. The drugs include HRS-4642, gemcitabine, nab-paclitaxel, and adebrelimab. It may help shrink the tumor before surgery and lower the chance of cancer coming back afterward.
ShanghaiAges 18–80 - NCT07132333Recruiting
Personalized inflammation study for chronic conditions
This study uses advanced testing to understand inflammation in people with certain chronic inflammatory diseases, such as psoriasis, psoriatic arthritis, other types of arthritis, or inflammatory bowel disease. The goal is to tailor treatment to your specific needs.
TübingenAges 18 years+ - NCT07132541RecruitingPhase 1
New surgical glue technique for pancreas connection after Whipple surgery
This trial tests a new method using a surgical glue called N-butyl-2-cyanoacrylate to seal the pancreas after a Whipple procedure. It may help prevent leaks and improve recovery for patients with a soft pancreas and small pancreatic duct.
Minya, Minya GovernorateAges 18–75 - NCT07132515RecruitingPhase 4
Blood thinners for cirrhosis with portal vein clot
This study tests whether blood thinners (anticoagulants) are safe and effective for people with cirrhosis and a blood clot in the portal vein. It may also include people with liver cancer (HCC).
Al Mansurah, Dakahlia GovernorateAges 18–70 - NCT07132970Recruiting
Leakage rate of sutured bowel connection after right colon removal
This trial is testing how well hand-sewn or partially stitched connections (anastomoses) hold up after right colon removal for cancer. It may help improve surgical techniques for people undergoing this operation.
Göppingen, Baden-WurttembergAges 18 years+ - NCT07132918RecruitingPhase 2
Heart-Sparing Radiation for Thoracic Cancers
This trial tests a new way to plan radiation for cancers in the chest area (like lung, esophageal, or thymus cancers) that aims to protect the heart from high doses of radiation. It is for people who need daily radiation for at least three weeks and who are expected to live more than a year.
Madison, WisconsinAges 18 years+ - NCT07133490RecruitingPhase 2
Pressurized intraperitoneal aerosol chemotherapy for advanced stomach cancer
This trial tests a new way to deliver chemotherapy directly into the abdomen using a spray (called PIPAC) in people with stomach cancer that has spread to the lining of the belly. The aim is to see if it can help control the cancer with fewer side effects.
AmsterdamAges Any age - NCT07135427RecruitingPhase 4
Genes and vaccines in alpha-1 antitrypsin deficiency
This study looks at how genetic differences in alpha-1 antitrypsin deficiency affect immune response to a pneumonia vaccine. It may help find better ways to prevent lung infections.
Birmingham, AlabamaAges 19 years+ - NCT07135544RecruitingPhase 2
Adebrelimab plus apatinib and chemo for new bile duct cancer
This study tests a combination of three medicines (adebrelimab, apatinib, and standard chemotherapy) for people with newly diagnosed bile duct or gallbladder cancer that cannot be surgically removed. The goal is to see if the combination can shrink the tumor and make it possible to remove later.
Wuhan, HubeiAges 18–80 - NCT07137247Recruiting
How the immune system changes over time in chronic hepatitis B
This study tracks how the immune system works in people with chronic hepatitis B who haven't taken antiviral medication in the last 6 months. It aims to understand the natural history of the infection without treatment.
Guangzhou, GuangdongAges 1–80 - NCT07139366RecruitingPhase 4
Probiotic plus bismuth combo for stubborn H. pylori
This study tests a combination of a probiotic (Saccharomyces boulardii) plus a standard bismuth-based four-drug treatment for people whose H. pylori infection has not been cured by previous treatments. It aims to see if adding the probiotic helps the treatment work better and cause fewer side effects.
Xi'an, ShaanxiAges 18–75 - NCT07139418Recruiting
Studying lymph nodes around the stomach in cancer surgery
This trial studies the importance of checking lymph nodes in the fatty tissue around the stomach during stomach cancer surgery. It helps doctors understand if examining these specific areas can improve treatment decisions.
Hangzhou, ZhejiangAges 18–85 - NCT07140679RecruitingPhase 2
Immunotherapy after surgery for certain colon cancers
This trial tests whether the immunotherapy drug toripalimab can lower the risk of colon cancer coming back after surgery. It is for people with a specific genetic feature called mismatch repair deficiency (dMMR) in their tumor, and whose cancer was at a higher stage (stage IIB, IIC, or III).
Atlanta, GeorgiaAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,903 recruiting gastroenterology studies from the U.S. registry right now, out of 12,451 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.